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6492491 |
Method of making hypusine peptides
The invention relates to novel peptides synthesized according a method utilizing the hypusine reagent: wherein: Q 1 Q 2 and Q 3 may be the same or different and are amino protective groups,...
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6489131 |
Interference reduction by rheumatoid factors
The invention concerns a method for the determination of an analyte in which rheumatoid factors or rheumatoid-factor-like substances are added as an interference reducing reagent to reduce of avoid...
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6489159 |
Polymeric arrays and methods for their use in binding assays
Arrays of a plurality of different heterogeneous polymeric target compositions immobilized on the surface of a solid support are provided. In the subject arrays, the constituent polymeric targets...
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6486354 |
Solid phase supports
Embodiments of the present invention generally relate to carrying out organic chemistry on solid supports comprising derivatised functionalities, methods for synthesizing said supports, methods for...
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6476186 |
Process for preparing octreotide and derivatives thereof
This invention relates a process for preparing octreotide and derivatives thereof. The starting material, Thr(ol)(tBu)-2-chlorotrityl resin is coupled with the various amino acids. The straight...
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6472184 |
Method for producing nucleic acid polymers
The conventional synthesis of nucleic acid polymers from several oligonucleotides comprises several cycles of intermediate product synthesis, purification of the intermediate products and synthesis...
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6468740 |
Cyclic and substituted immobilized molecular synthesis
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6468969 |
Inhibition of HIV-1 replication using d-amino acid peptides
The Tat-inhibitory polypeptide derivatives of the formula I ...
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6462017 |
Method of reducing side effects of chemotherapy in cancer patients
A method for reducing the severity of chemotherapy side effects in cancer patients by administering thymosin α 1 in conjunction with the administration of a chemotherapy agent to the patient. As...
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6451543 |
Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention...
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6444645 |
Crosslink-stabilized indolicidin analogs
The present invention relates to crosslink-stabilized analogs of indolicidin, which is a naturally occurring peptide having the amino acid sequence...
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6426184 |
Method and apparatus for chemical and biochemical reactions using photo-generated reagents
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. Specifically, the method...
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6420123 |
Spatially defined synthesis
In accordance with the method of the invention and within the framework of the split synthesis technique, compounds are synthesized on macroscopic solid support units which are spatially organized...
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6416949 |
Method of synthesizing diverse collections of oligomers
A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates...
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6416714 |
Remotely programmable matrices with memories
Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The...
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6413785 |
Solid phase synthesis of 1-aminohydantoins
The subject invention involves processes for making 1-aminohydantoin compounds using a solid support resin, comprising the following steps; (a) preparing a resin-bound protected α-hydrazinyl...
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6406844 |
Very large scale immobilized polymer synthesis
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6395559 |
Multiple fluid sample processor with single well addressability
A method for single well addressability in a sample processor with row and column feeds. A sample processor or chip has a matrix of reservoirs or wells arranged in columns and rows. Pressure or...
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RE37686 |
Azahydroxybenzotriazoles and derivatives thereof for peptide coupling reactions
This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence...
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6380358 |
Guanidinylation reagents
Trisubstituted N-protected guanidines and methods for use as guanidinylating reagents to yield N-protected guanidine derivatives.
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6376194 |
Mixed-bed solid phase and its use in the isolation of nucleic acids
Mixed-bed solid phases are provided, with methods for using such solid phases to isolate target nucleic acids, such as plasmid DNA, chromosomal DNA, RNA, or nucleic acids generated by enzymatic...
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6376649 |
Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
Methods for the synthesis of α-hydroxy-β-amino acid and amide derivatives and α-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a...
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6375903 |
Method and apparatus for synthesis of arrays of DNA probes
The synthesis of arrays of DNA probes sequences, polypeptides, and the like is carried out using a patterning process on an active surface of a substrate. An image is projected onto the active...
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6372885 |
Solid-phase technology for the preparation of amides
Method for preparing a combinatorial chemistry library of compounds of the formula R1—C(═O)—NH—R2, wherein R1 and R2 are as defined in the specification, which comprises acylating a...
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6355490 |
Attached tags for use in combinatorial chemistry synthesis
The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split...
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6348445 |
Biologically active peptides with reduced toxicity in animals and a method for preparing same
The present invention relates to biologically active peptides with reduced toxicity and methods of preparing them. The peptides of the invention, which can be unsubstituted or N-terminal...
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6340588 |
Matrices with memories
Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid...
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6331285 |
Structurally determined cyclic metallo-constructs and applications
A metallo-construct, which may be a peptide, is provided for use as a biological, therapeutic, diagnostic imaging, or radiotherapeutic agent, and for use in library or combinatorial chemistry...
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6329210 |
Method and apparatus for high volume polymer synthesis
A scalable synthesis apparatus capable of rapid and efficient oligo synthesis. The apparatus includes a combination of dispensing elements, synthesis elements, and waste removal elements. More...
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6319668 |
Method for tagging and screening molecules
Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid...
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6320025 |
Solid phase peptide synthesis reaction vessel
Reaction vessels suitable for solid phase polymer synthesis generally comprise: a housing defining a chamber for containing a resin, said housing having an operable inlet port and an operable...
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6310180 |
Method for synthesis of proteins
A method for peptide synthesis is disclosed that requires neither protecting groups nor activation of the C-α carboxyl groups. The method comprises ligating a first molecule to a second molecule...
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6310179 |
2-or 3-dimensional geometric structures
Nucleic acid analogues provide a particularly useful tool for the preparation of complex polymeric structures of defined geometry because they are relatively stable to reaction conditions for the...
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6300470 |
Antibiotic cryptdin peptides and methods of their use
The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence: X 1 -C-X 2 -C-R-X 3 -C-X 4 -E-X 5 -C-X 6 -C-C-X 7 wherein X 1 is 3 to 9...
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6291201 |
Fluorescence energy transfer substrates
A method for the preparation of a fluorescence resonance energy transfer (FRET) substrate having donor and acceptor species on opposite sides of a proteolytic cleavage site and wherein the donor...
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6287787 |
Dimeric oligopeptide mixture sets
Dimeric oligopeptide mixture sets, their synthesis and use in determining the sequence of an oligopeptide dimer ligand that optimally binds to a receptor are disclosed. A dimeric oligopeptide...
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6277957 |
Method for production of acylthio derivatives
A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the...
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6277958 |
Method for preparing peptide thiol ester
The present invention provides a method for producing a peptide thiol ester using fluoren-9-ylmethoxycarbonylamino acid (Fmoc-amino acid). The method is for peptide synthesis and involves (1) using...
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6271345 |
Enzyme cleavable linker bound to solid phase for organic compound synthesis
An enzyme cleavable linker is prepared on which organic compounds are synthesized when the linker is bound to a solid phase. The linker contains a functional group on which a synthesized organic...
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6268141 |
Immobilization of unmodified biopolymers to acyl fluoride activated substrates
A method of attaching unmodified biopolymers, particularly, unmodified polynucleotides, directly to a solid support is provided. The method includes the steps of (a) providing unmodified...
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6265219 |
Transponder tagging of constituents used in compound synthesis
A synthesis member preferably comprises two elements: a crown and a stem. The stem includes a tag, such as a transponder, that is used to identify the synthesis member and/or the synthetic history...
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6262230 |
Analogs of thymosin α1
Compounds of the formula: X-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser- (I) Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Z wherein X is an acetyl or pyroglutamyl group and Z is --NH 2 ,...
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6261776 |
Nucleic acid arrays
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6245742 |
Peptide antagonists of cellular mitogenesis and motogenesis and their therapeutic use
The present invention relates to peptides and peptidomimetic compounds and pharmaceutical compositions containing them as useful pharmacological agents in the control or treatment of proliferative...
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6245937 |
Liquid phase parallel synthesis of chemical libraries
This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries...
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6238624 |
Methods for transport in molecular biological analysis and diagnostics
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic...
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6228986 |
Solid-phase synthesis of novel 14-membered macroycles for high throughput screening
The preparation of 14-membered macrocycles from a resin-bound orthogonally protected lysine residue is described. Reductive alkylation of the a-nitrogen followed by acylation with an Fmoc-aminoacid...
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6228988 |
Synthesis of hydroxamic acid derivatives
The present invention describes processes for preparing desired synthetic products that comprise a covalently bonded hydroxamic acid group --CONHOH by forming a mixture of a liquid reaction medium...
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6228372 |
Compounds and methods for the detection and prevention of T. cruzi infection
Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi...
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6225480 |
Sulphonyl compounds for use as linkers in solid phase and combinatorial synthesis
The present invention relates to a linker shown by the following formula (I): X--SO 2 --R 1 --(A) m --R 2 (I) wherein R 1 is a group of the formula (A): ##STR1## [wherein R 3 , R 4 and R 5...
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