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7001883 |
Cyclized conotoxin peptides
This invention relates to cyclized conotoxin peptides, processes for their preparation and their pharmaceutical use.
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6995136 |
Peptide fragments of murine epidermal growth factor as laminin receptor targets
A peptide factor, its analogs and methods of using such peptide factor derived from murine epidermal growth factor peptide is disclosed wherein the peptide factor is modified to protect it from...
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6982315 |
Process for the preparation of carboxamides
The invention relates to a process for the preparation of carboxamides, in particular peptides, from an acid component in the form of a compound containing at least one carboxyl group and an amine...
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6977292 |
Nucleophile-stable thioester generating compounds, methods of production and use
The invention is directed to nucleophile-stable thioester generating compounds comprising a carboxyester thiol. The compounds have wide applicability in organic synthesis, including the generation...
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6939847 |
Use of colostrinin, constituent peptides thereof, and analogs thereof, as oxidative stress regulators
The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress...
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6929907 |
Methods and compositions for determining the purity of chemically synthesized nucleic acids
This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which...
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6921636 |
Method and apparatus for conducting an array of chemical reactions on a support surface
The invention provides apparatus and methods for determining the nucleotide sequence of target nucleic acids using hybridization to arrays of oligonucleotides. The invention further provides...
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6919211 |
Polypeptide arrays
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6906035 |
Antimicrobial cationic peptides
A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH 2 -KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH 2...
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6893614 |
Reaction device for organic synthesis
The present invention relates to a reaction vessel for organic synthesis and a block device for the reaction vessel and synthetic method of compound using thereof. More particularly, the present...
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6887665 |
Methods of array synthesis
Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of...
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6875620 |
Tiling process for constructing a chemical array
A process of constructing an array of chemical moieties having the following steps: forming multiple discrete physical entities (tiles) from a substantially planar material having one or more...
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6875594 |
Methods of ligating expressed proteins
The present invention provides a method of cleaving a recombinantly expressed protein from an intein and ligating the protein to a peptide containing an N-terminal cysteine having an unoxidized...
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6864357 |
Process for the preparation of peptides
The present invention relates to a process for the preparation of peptides using an excess of an activated carboxylic component to acylate an amino component, wherein after the acylation an amine...
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6849596 |
Regulatory/unfolding peptides of ezrin
This invention describes novel charged molecules which specifically bind to the Hepreceptor, a regulatory site which I have discovered in human ezrin. My invention is that when peptides or other...
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6797522 |
Synthetic receptors
The invention is directed to synthetic receptor(s) which comprises a polyfunctional organic template covalently linked to two or more oligomers which may independently be the same or different and...
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6774103 |
Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)
This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the...
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6774102 |
Extracorporeal endotoxin removal method
This invention describes blood treating material having the capacity to selectively remove endotoxin and cytokine inducing substances from blood or plasma by extracorporeal adsorption for...
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6770436 |
Chemical amplification for the synthesis of patterned arrays
Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of...
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6753449 |
Cleavable linker for solid phase synthesis
Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of...
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6750312 |
Process for the preparation of supports for solid phase synthesis
A method for preparing a solid support material for carrying out a chemical reaction, said method comprising the following steps: (i) reacting an amino functionalised solid material with a...
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6749756 |
Reaction and separation methods
A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second...
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6713580 |
Quaternary amino acids on solid supports
The present invention relates to novel templates useful for generating novel compounds and to compounds produced utilizing the templates. The templates comprise quaternary amino acids that may be...
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6703480 |
Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R 1 and a second...
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6699665 |
Multiple array system for integrating bioarrays
A multiple level micro-array system for integrating micro-arrays of biomolecules, including biological, chemical and biochemical elements. The multiple level micro-arrays are formed using soft...
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6693168 |
Chiral cyanoamines and methods of preparation
Methods for preparing chiral non-racemic cyanoamines are provided. The methods are useful, e.g., for preparing chiral amino acids.
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6683052 |
Lipopeptides containing an interferon-&ggr fragment, and uses thereof in pharmaceutical compositions
The invention concerns any lipopeptide characterized in that it comprises: a peptide part comprising the peptide sequence consisting of about 30 to about 50 of the last contiguous amino acids of...
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6680178 |
Profiling of protease specificity using combinatorial fluorogenic substrate libraries
A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general substrate libraries to rapidly identify the primary and extended...
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6670447 |
Amino acid N-carboxyanhydrides with acyl substituents on nitrogen atoms thereof
This invention provides amino acid N-carboxyanhydrides, each of which has an N-acyl substituent on its nitrogen atom, is represented by the following formula (1): readily reacts with...
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6664372 |
Azatide peptidomimetics
Peptidomimetic azatides and combinatorial oligoazitide libraries are produced by means of a stepwise synthesis. Combinatorial library construction of this new biomimetic polymer provides a means to...
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6660466 |
Di-nitrogen heterocycle compositions
Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as...
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6649348 |
Methods for manufacturing arrays
Apparatus and methods are disclosed for synthesizing a plurality of compounds on the surface of supports. Biopolymer features are attached to the surfaces of the supports. The synthesis generally...
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6624144 |
Matrix metalloproteinase inhibitors and down-regulators
The present invention relates to novel matrix metalloproteinase (MMP) inhibitors and down-regulators, to a process for the preparation of these inhibitors, to pharmaceutical compositions comprising...
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6617307 |
Peptide and osteogenetic accelerator
A peptide has any one of the sequences SEQ ID NO.1 to SEQ ID NO.8, or has a sequence derived from any one of the sequences SEQ ID NO.1 to SEQ ID NO.8 by substitution, deletion or addition of one or...
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6613876 |
β-polypeptide foldamers of well-defined secondary structure
Disclosed are β-peptides containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the α and β carbons of the peptide backbone. The β-peptides adopt stable helical and...
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6613745 |
Therapeutic molecules derived from snake venom
The present invention relates generally to peptide molecules and to derivatives, homologues, analogues and mimetics thereof capable of inducing or facilitating analgesia or partial analgesia alone...
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6600016 |
Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same
Multifunctionalized support resin for the solid phase synthesis of combinatorial libraries is disclosed. The support resin comprises a resin backbone to which is attached a template containing at...
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6593455 |
Tripeptide amides that block viral infectivity and methods of use thereof
Embodiments relate to the discovery that tripeptide amides, which correspond to viral capsid sequences, can be used to inhibit viral infection, including human immunodeficiency virus (HIV)...
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6590092 |
Process for preparing a “universal support” and the reagents used for generating such support
Universal solid supports suitable for use synthesizing of oligonucleotides. The solid supports may be used irrespective of the first RNA or DNA nucleotide to be synthesized, and irrespective of the...
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6586187 |
Methods for solid phase combinatorial synthesis of integrin inhibitors
Compounds of the formula are useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer,...
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6566520 |
Support for synthesis and purification of compounds
A method for the preparation and purification of compounds using a novel support, a tetrabenzo [a, c, g, i]-fluorene group (Tbf) comprising reacting a building block (A) containing a Tbf group...
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6566495 |
Very large scale immobilized polymer synthesis
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6566494 |
Support material for solid phase organic synthesis
A support material for solid phase synthesis is provided having an amine-containing organic group attached to it through a linker. The support material is of the following general formula (Formula I):
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6562944 |
Amide library formation using a “by-product-free” activation/coupling sequence
Disclosed is an improved method for preparing an activated carboxylic acid in the form of a pentafluorophenyl ester, an improved method for making a carboxamide from a pentaflourophenyl ester, and...
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6558904 |
Method for producing structured, self-organized molecular monolayers of individual molecular species, in particular substance libraries
The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded...
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6548644 |
Site protected protein modification
Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of...
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RE38073 |
Products for peptide coupling
This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence...
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6534627 |
Synthesis and use of amino acid fluorides as peptide coupling reagents
The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: or the acid fluoride salts...
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6512092 |
Processes for coupling amino acids using bis-(trichloromethyl) carbonate
A process is disclosed for using triphosgene as an efficient and effective coupling reagent during peptide synthesis, by in situ generation of amino acid chloride from a protected amino acid. This...
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6492136 |
Solid phase organic synthesis
A method of synthesis of a material corresponding to the general formula: R 3 —X—H characterized in that it comprises a material corresponding to the following general formula: being cleaved...
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