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4101721 Solid phase synthesis of protected peptides  
The invention is addressed to the preparation of 3-nitro-4-bromomethyl benzoic acid, as a new compound from which 3-nitro-4-bromomethyl benzoyl amide polystyrene resin can be prepared for solid...
4100117 Somatostatin analogs and intermediates thereto  
The tetradecapeptide ##STR1## is described along with corresponding non-toxic pharmaceutically-acceptable acid addition salts as well as intermediates useful in the synthesis of the...
4098777 Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn  
This invention is directed to the chemical process for the preparation of the polypeptide, pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn and to intermediates in said process. The polypeptide...
4093609 Somatostatin synthesis  
A mixed solid phase-solution phase synthesis for somatostatin which combines the speed of conventional solid phase synthesis with the advantage of solution phase isolation and purification techniques.
4089821 Synthesis of peptide amides  
Peptide amides having biological activity and resin peptide amides useful in the preparation of peptides having biological activity, particularly such peptides containing the structure ##STR1## in...
4086196 Parathyroid hormone  
A peptide chosen from the group comprising [Ala 1 ]-HPTH-(1-X) and HPTH-(1-X) wherein X is an integer from 27 to 34.
4076659 L-Val.sup.10 -somatostatin and intermediates thereto  
The tetradecapeptide ##STR1## is described along with corresponding non-toxic pharmaceutically-acceptable acid addition salts as well as intermediates useful in the synthesis of the...
4062815 Resin peptides  
Resin peptides useful in the preparation of salmon calcitonin are disclosed along with processes for preparing the same. The invention also embraces peptides from which the resin moiety has been...
4062816 D-Ala.sup.5 -somatostatin and intermediates thereto  
The tetradecapeptide ##STR1## is described along with corresponding non-toxic pharmaceutically-acceptable acid addition salts as well as intermediates useful in the synthesis of the...
4061608 Arg .sup.4 -somatostatin and analogues thereof  
Polypeptides of the formula: ##STR1## THE LINEAR PRECURSORS, INTERMEDIATES AND NON-TOXIC ACID ADDITION SALTS THEREOF, WHEREIN R is hydrogen or Ala-Gly And X 8 is L-Trp or D-Trp Are...
4060689 Vinylbenzyl esters of n-boc-amino acids  
There is described herein the preparation of vinylbenzyl esters of N-BOC amino acids which upon polymerization with styrene and divinylbenzene provide insoluble polymers useful as starting...
4043994 New pentapeptides and methods for their production  
New pentapeptides having the formula X-R-Ser-(benzyl)-Tyr(benzyl)-R 1 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment or a dipeptide fragment utilizing...
4028315 Solid phase synthesis of peptides  
A process for bonding an amino acid to an insoluble hydroxymethyl polymer by esterifying the C-terminal carboxyl group of an N-terminal protected amino acid with the hydroxyl group of an insoluble...
4024121 (Pyro)-Glu-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHR and intermediates  
[D-Ser 4 ,D-Leu 6 ,desGly-NH 2 10 ]-LH-RH (lower alkyl)amides, salts thereof, and intermediates used for the synthesis thereof are disclosed. The compounds have potent LH- and FSH-releasing...
4021387 Eosinophilotactic tetrapeptides  
Two eosinophilotactic tetrapeptides of amino acid sequence Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu have been isolated from extracts of human lung fragments. These tetrapeptides have been synthesized by...
4018726 [D-Phe.sup.6 ]-LH-RH and intermediates therefor  
The decapeptide [D-Phe 6 ]-LH-RH, salts thereof, and intermediates used for the synthesis thereof are disclosed. The decapeptide has potent LH- and FSH-releasing hormone properties.
4012345 Des-(Ala.sup.1, Gly.sup.2), Met.sup.11 -SRIF and intermediates  
The dodecapeptide H-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Met-Thr-Ser-Cys-OH, its oxidized form, D-Trp 6 analogue and intermediates obtained in their synthesis are described. These dodecapeptides...
4011182 Cyclic undecapeptide analogs of somatostatin and intermediates  
Cyclic undecapeptide analogs of somatostatin without cysteine amino acid residues and intermediates obtained in the synthesis of such compounds are described. These cyclic undecapeptides inhibit...
4010125 [D-Trp.sup.6 ]-LH-RH and intermediates therefor  
The decapeptide [D-Trp 6 ]-LH-RH, salts thereof, and intermediates used for the synthesis thereof are disclosed. The decapeptide has potent LH- and FSH-releasing hormone properties.
4008126 Immobilization of proteins by in-situ polymerization  
Disclosed is a method for chemically immobilizing proteins, particularly enzymes, containing in their molecular structure specified proportions cystine and cysteine groups on a support to form a...
3997517 Cyclic somatostatin disulfide analogues  
Cyclized somatostatin analogues containing the Cys-Cys disulfide linkage, their pharmaceutically acceptable acid addition salts as well as their cyclic disulfhydryl precursors and intermediates...
3988308 (Tyr.sup.3, Tyr.sup.14)-SRIF and intermediates  
The tetradecapeptide Ala-Gly-Tyr-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Tyr-OH is described as well as novel intermediates used in the synthesis of such tetradecapeptide. This tetradecapeptide...
3988307 Solid phase synthesis of peptides with carboxyl-terminal amides  
The method of utilizing α,β-unsaturated amino acids, acyl, and N-acyl derivatives as linking agents in the solid phase synthesis of peptides with the corresponding production of carboxyl terminal...
3987014 Secretin intermediates and derivatives  
[6-TYR] Secretin is biologically active and can be radio-iodinated for use in the radioimmunoassay of secretin. The peptide can be produced by solid phase synthesis using benzhydrylamine resin as...
3974110 Modification of polystyrene by Friedel-Crafts reaction with substituted halo ethyl benzenes and haloethylphenols to make supports for solid phase peptide synthesis  
A process for producing reagents useful in organic synthesis, of the general formula ##SPC1## Wherein Z designates the ##EQU1## part of a polymeric backbone of a polymer like polystyrene, a...
3971737 [2-Methyl-Ala.sup.6 ]LRH  
[2-Methyl-Ala 6 ]LRH is described, as well as its preparation by solid phase methodology and intermediates in its production. The decapeptide is a luteinizing hormone releasing agent and is useful...
3960830 Polyalkylene glycols used for the preparation of peptides  
A process for the synthesis of peptides in a liquid phase wherein the peptide product, and intermediates in the peptide synthesis, are bound to a polyalkylene glycol polymer and wherein the...
3956219 Crosslinked polystyrene and substituted polystyrene compositions  
A composition which is either polystyrene or a substituted polystyrene crosslinked with divinylbenzene and swollen by N-methyl-2-pyrrolidone, which composition is useful in purifying blocked...
3956260 Hypocalcaemic peptides and processes for their manufacture  
Synthetic hypocalcaemic dotriacontapeptide of the formula H-Cys-Ser-Asn-Leu-Ser--Thr-Cys-Val-Leu-Ser-Ala-Tyr-Try-Arg-A sn-Leu-Asn-Asn- Phe-His-Arg-Phe-Ser-Gly-Met-Gly-Phe-Gly-Pro-Glu-Thr-Pro-OH I...
3954709 Phenylethyl group containing resins for the synthesis of peptides  
The phenylethyl group, ##SPC1## In polymer carriers for the synthesis of peptides and peptide amides, particularly polymer carriers such as styrene-1% divinyl benzene polymers for use in solid...
3948821 Solid amino acid products for polypeptide synthesis and method of manufacture thereof  
Macroreticular polystyrene resin having a surface area of at least 5 and preferably at least 50 square meters/gram and a majority of pores of at least 30 Angstroms diameter is utilized as a solid...
3941763 PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH.sub.2 and intermediates  
The synthesis of the decapeptide pGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH 2 by solid-phase techniques is described. The decapeptide inhibits LH release.
3940380 P-Glu-D-Phe-Trp-Ser-Tyr-2-Me.Ala-Leu-Arg-Pro-NH.sub.2 and intermediates  
D-Phe 2 -2-Me.Ala 6 -LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. The novel decapeptide possess anti-ovulatory activity...
3937695 P-Glu-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH.sub.2 and intermediates  
D-Lys 6 -des-His 2 -LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. The novel nonapeptide exhibits anti-ovulatory activity...
3929758 Cyclization of cysteine-containing peptides  
The synthesis of a disulfide cyclic peptide by preparing peptide containing at least two cysteine moieties in its amino acid chain one of which is protected by an n-alkylthio group, and subjecting...
3926938 Synthesis of salmon calcitonin  
Resin peptides useful in the preparation of salmon calcitonin are disclosed along with processes for preparing the same. The invention also embraces peptides from which the resin moiety has been...
3915949 Solid phase synthesis of ACTH  
Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R --CH 2 --Phe--Glu at one end of an amino acid chain, R being the...
3912711 Synthetically produced undecapeptide, Substance P  
A polypeptide L arginyl-L prolyl-L lysyl-L prolyl-L glutaminyl-L glutaminyl-L phenylalanyl-L phenylalanyl-L glycyl-L leucyl-L methionine amide. The polypeptide is synthesized by building up the...
3896105 (N-propionyl) -gly-cys-lys-asn-phe-phe-trp-lys-thr-phe-thr-ser-cys-oh and intermediates  
The tridecapeptide (N-propionyl)-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Se r-Cys-OH, its oxidized form as well as novel intermediates used in the synthesis of such tridecapeptides are...
3896104 P-Glu-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH2 and intermediates  
D-Lys 6 -LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. This novel decapeptide stimulates the release of luteinizing hormone...
3892723 P-Glu-Trp-Ser-Tyr-D-Pgl-Leu-Arg-Pro-Gly-NH2 and intermediates  
D-Pgl 6 -des-His 2 -LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. The novel nonapeptide exhibits anti-ovulatory activity...
3891614 Solid phase synthesis of calcitonins on benzhydrylamine type resins  
A novel process for synthesizing calcitonins composed of 32 amino acid units, which comprises bonding a proline residue through an acid amide linkage to a resin support containing an amino group...
3886135 P-GLU-D-PHE-TRP-SER-TYR-D-PGL-LEU-ARG-PRO-GLY-NH2 and intermediates  
D-Phe 2 -D-Pgl 6 -LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. This novel decapeptide exhibits anti-ovulatory activity in...
3872074 Method for the aminolysis of activated esters in the presence of N-hydroxy compounds as catalysts  
A process for the manufacture of peptides by reacting a protected amino acid or a protected peptide ester with an optionally protected amino acid or a peptide having a free amino group, which may...
3867269 Process for producing peptides  
In producing a peptide by coupling an amino acid or oligomer thereof with an amino acid or its oligomer bound to a resin to form a peptide on the resin, cleaving the peptide from the resin and...
3864481 Anti disease producing synthetic material for the prevention suppression and diagnosis of multiple sclerosis and method of treatment therefor  
Anti disease producing synthetic material for the prevention, suppression or diagnosis of multiple sclerosis in mammals and method of treatment therefor is disclosed. A therapeutic preparation of...
3855199 P-GLU-D-PHE-T RP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2-AND INTERMEDIATES  
D-Phe 2 -D-Ala 6 -LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. The novel decapeptide exhibits anti-ovulatory activity in...
3853833 SYNTHETIC HUMAN GROWTH-PROMOTING AND LACTOGENIC HORMONES AND METHOD OF PRODUCING SAME  
Synthetic human growth-promoting and lactogenic hormones, e.g., pituitary growth hormone (HGH) is produced by attaching phenylalanine, the COOH terminal amino acid of HGH, to a solid resin support,...
3853832 SYNTHETIC HUMAN PITUITARY GROWTH HORMONE AND METHOD OF PRODUCING IT  
Synthetic human pituitary growth hormone (HGH) is produced by attaching phenylalanine, the COOH terminal amino acid of HGH, to a solid resin support, and then coupling stepwise to the supported...
3714140 PEPTIDE SYNTHESIS  
An improved solid phase process for peptide synthesis wherein all steps of the synthesis are carried out in a solvent which produces a highly swollen state in the resin and wherein the coupling...
Matches 451 - 500 out of 527 < 1 2 3 4 5 6 7 8 9 10 11 >