Match Document Document Title
9035021 Somatostatin analogues  
The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)- Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has...
9029507 Copolymer-1, process for preparation and analytical methods thereof  
The present invention relates to analytical methods such as molecular weight determination of polypeptide, in particular Glatiramer acetate. The present invention further relates to an improved...
9029503 Method for native ligation of polypeptides  
The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X″—X2 (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue...
8981055 Methods for manufacturing an antifungal agent  
The present invention relates to an improved process for the preparation of Micafungin.
8980581 Site-specific incorporation of amino acids into molecules  
The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified...
8981049 Aziridine mediated native chemical ligation  
Improved methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) under mild...
8980845 Biotechnological production of cyanophycin dipeptides  
The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation...
8975370 Inhibitor proteins of a protease and use thereof  
The present invention relates to a chimeric inhibitor protein of a protease comprising an inhibiting polypeptidic sequence and at least one polypeptidic sequence of a substrate-enzyme interaction...
8969516 Method of hydrolysis of peptide bond  
This invention relates to a method of hydrolysis of the peptide bond between R1 and B in a specific designed amino acid sequence R1BXJZR3R2, where R1 represents a polypeptide of interest, R2...
8895694 Glucagon-Like Peptide-1 derivatives and their pharmaceutical use  
The invention relates to protracted Glucagon-Like Peptide-1 (GLP-1) derivatives and therapeutic uses thereof. The GLP-1 derivative of the invention comprises a modified GLP-1(7-37) sequence having...
8895696 Methods for forming peptides and peptide conjugates and peptides and peptide conjugates compositions formed thereby  
Methods for building peptide chains containing sulfonyl modified amines at the N-terminus, or, within amino acid side chains, of a growing peptide in a solid-phase peptide synthesis are described....
8877252 Polymer-based sustained release device  
This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically...
8871903 Palladium catalyzed reactions executed on solid-phase peptide synthesis supports for the production of self-assembling peptides embedded with complex organic electronic subunits  
Methods to synthesize self-assembling peptides embedded with complex organic electronic subunits are provided.
8871904 Processes and intermediates  
The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV...
8865658 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides  
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The...
8859730 Native chemical ligation at serine and threonine sites  
A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and...
8859727 Bioactive FUS1 peptides and nanoparticle-polypeptide complexes  
A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that...
8859731 Selective modification of proteins  
A method of selectively introducing a substituent into a protein proximal to a binding site on the protein for a homing peptide, comprising: (a) contacting the protein with a compound comprising a...
8846862 Microwave-assisted peptide synthesis  
An instrument and method for accelerating the solid phase synthesis of peptides are disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase...
8816050 Method of preparing glycopeptides  
A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coopled with a C-terminal...
8802818 Prostaglandin-F2 alpha receptor modulators and uses thereof  
Prostaglandin-F2 alpha (PGF2α) receptor (FP) modulators of formula I, as well as the use of PGF2α receptor modulators for the treatment of conditions associated with FP activity such as preterm...
8796418 Stabilized alpha helical peptides and uses thereof  
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino...
8791234 Intestinal peptide targeting ligands  
Peptide ligands for transporting therapeutic agents across the intestinal epithelial barrier that ordinarily are inadequately absorbed and must be delivered by alternative means, which contain an...
8791236 Method of acylating a peptide or protein  
A method for selectively acylating an amino group in a peptide or protein which has two or more reactive nucleophilic functional groups is described.
8765910 Method for amidating polypeptides with basic amino acid C-terminals by means of specific endoproteases  
The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and,...
8759259 Compositions and methods for producing cyclic peptoid libraries  
Embodiments of the invention are directed to a one-bead-two-compound method for the creation of encoded cyclic peptoid libraries. This scheme is useful for the creation of cyclic peptoid...
8748575 Therapeutic peptides  
Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino...
8741576 Heteroclitic analogs and related methods  
Heteroclitic analogs of Class I epitopes are prepared by providing conservative or semi-conservative amino acid substitutions at positions 3 and/or 5 and/or 7 of these epitopes. The analogs are...
8735354 Endothelium mimicking nanomatrix  
Disclosed herein are peptide amphiphiles for use in producing a natural endothelium mimicking nanomatrix. The disclosed natural endothelium mimicking nanomatrix can be used to coat medical devices...
8729228 Method of producing a modified (poly) peptide  
This invention relates to a method of producing a modified (poly)peptide, said method comprising the step of modifying in an organic solvent a crown ether-bound (poly)peptide at one or more...
8729229 Processes for preparing a polypeptide  
The present invention relates to processes for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or...
8716245 Tissue protective peptides and uses thereof  
Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on...
8716438 Matricryptic ECM peptides for tissue reconstruction  
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in...
8716439 Method of producing peptide  
The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition...
8703912 Processes for removal of dibenzofulvene  
A dibenzofulvene amine adduct is removed by contacting a reaction mixture containing the dibenzofulvene amine adduct, which is obtained by reacting, for deprotection, an amino acid compound...
8691943 Antimicrobial activity of chicken NK-2 peptide against apicomplexan protozoa  
NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To...
8691949 Peptide having anti-diabetic activity and use thereof  
The present invention provides a composition (a blood glucose increase inhibitor) that has an effect of lowering blood glucose level in a hyperglycemic patient and that is therefore used to reduce...
8686113 Antibiotic peptides  
The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17 /Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar,...
8669231 Activation of peptide prodrugs by hK2  
The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific...
8669226 Antimicrobial compositions and methods of use thereof  
The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
8669418 Means and methods for mediating protein interference  
The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of...
8669356 Linker and support for solid phase synthesis of nucleic acid  
The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of...
8669345 Nogo receptor antagonists  
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding...
8664356 Gamma amino acid building blocks  
The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline...
8664355 Cell-free protein synthesis method with the use of linear template DNA and cell extract therefor  
It is provided a simple and efficient process for producing a large amount of protein in a cell-free protein synthesis system, through a continuous synthesis reaction over a long time using a...
8658763 Amphiphilic peptides and hydrogel matrices thereof for bone repair  
The present invention relates to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and...
8653237 Peptide analogues  
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
8648170 Peptide-presenting surfaces for long-term culture of pluripotent cells  
The present invention relates to methods of growing and maintaining pluripotent cells on an insoluble substrate that presents a peptide that binds to glycosaminoglycans, such as heparin....
8642536 Method of making biologically active alpha-beta peptides  
Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide or biologically active fragment...
8637636 Peptide synthesis apparatuses  
Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.