Patents in Class 530/332

Matches 1 - 50 out of 280

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Match	Document	Document Title
1	7632816	Treatment of Alzheimer amyloid deposition The present invention is directed to a method of preventing or treating Alzheimer's Disease or of inhibiting accumulation of amyloid-β deposits in a subject by administering to the subject an...
2	7629318	Immunosuppressant compounds, methods and uses related thereto The present invention relates to compositions and methods for suppressing an immune response, e.g., by inhibiting class II MHC-mediated activation of T cells. The subject compounds and methods may...
3	7569660	Recombinant prion-like proteins and materials comprising same The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected...
4	7566742	Phosphoprotein preparations for bioactive metal ion delivery and teeth remineralisation The invention provides, in one aspect, compositions for delivering a bioactive metal ion to a mammal, the compositions comprising (a) an effective amount of a source of the bioactive metal ion, (b)...
5	7504381	Antimicrobial agents A novel class of antimicrobial polymeric agents, which include a plurality of amino acid residues, such as positively charged amino acid residues, and at least one hydrophobic residue linking there...
6	7498406	Substantially cell membrane impermeable compound and use thereof The present invention relates to a compound according to Formula (I): A-(L-Y) p , wherein A comprises at least one substantially cell- membrane impermeable pendant group; L comprises any suitable...
7	7449544	p21 peptides The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides...
8	7449546	Method for extending storage of glutathione solutions and methods for treating Parkinson's disease with said stored glutathione solutions A method of storing solutions of reduced glutathione for extended periods of time, by dissolving reduced glutathione in an aqueous medium having a pH of between 5.0 and 8.0 to produce a reduced...
9	7429639	SSX-2 peptides presented by HLA class II molecules The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating to the peptides. The...
10	7423115	ARTS C-terminus fragments and mimetics thereof This invention provides isolated peptides comprising a C-terminal fragment of an ARTS protein, isolated nucleotides encoding same, mimetics and small molecule analogues of same, and therapeutic...
11	7405267	Method for purifying teicoplanin A₂ Disclosed is a method for purifying teicoplanin A 2 comprising: (i) a primary pre-purification step of purifying a filtrate of fermentation broth of a strain using a synthetic adsorbent; (ii) a...
12	7402556	Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or...
13	7385029	Method of making tetrapeptide derivative TZT-1027 crystal The invention provides crystals of N 2...
14	7368421	Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in...
15	7354723	Assay of isomerised and/or optically inverted proteins and protein fragments Disclosed are compositions and methods for performing an immuno-assay that includes measuring the amount of an isomerised or optically inverted non-collagen protein derived from cartilage.
16	7345020	Mimetics of CD4 that inhibit immune response The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4 + T cell immune responses by identifying compounds that block the interaction of CD4 and...
17	7335644	Anti-hypertensive molecules and process for preparation thereof The present invention relates to novel anti-hypertensive molecules. The present invention also provides a process for the preparation of novel antihypertensive molecules. The present invention...
18	7285525	Suppression of immune response via inhibition of cathepsin S Methods and products for suppressing a class II MI-IC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by...
19	7276484	Dipeptide inhibitors of β-secretase Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a...
20	7250401	Therapeutic compositions A method is provided for the preparation of compounds of the formula (R 1 )(R 2 )NC(═X)S(O) n R 3 or (R 1 )(R 2 )NC(═X)OS(O) n R 3 , wherein R 1 , R 2 and R 3 , X and n have any of the...
21	7223846	Urocortin proteins and uses thereof A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted...
22	7198791	Compositions and methods for the generation of protective immune responses against malaria The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory...
23	7192713	Stabilized compounds having secondary structure motifs The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds...
24	7186695	Treatment of arthritis with arsenoxide compounds The present invention provides a method of treatment and/or prophylaxis of arthritis in a vertebrate comprising administering to said vertebrate in need of said treatment and/or prophylaxis a...
25	7176185	Short peptide carrier system for cellular delivery of agent A dipeptide or tripeptide carrier system for active agent delivery to cells has an N-terminus natural amino acid and an active agent covalently bonded to a side chain of one of the remaining amino...
26	7173013	Treatment of tuberculosis using immunomodulator compounds Tuberculosis in an animal is treated by administration of a therapeutically effective amount of an immunomodulator of formula A. In formula (A), n is 1 or 2, R is hydrogen, acyl, alkyl or a peptide...
27	7157091	MAGE-A1 peptides presented by HLA class II molecules The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0–10 amino acids added to either or both ends of the amino acid...
28	7094870	Crystals of oxidized glutathione and process for producing the same The present invention provides crystals of glutathione oxidized n hydrate (wherein n is an integer or a fraction of not less than 0 and less than 8) useful, for example, as final products of, as...
29	7081495	Cationic compounds and their use as macro molecular carriers Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C 6-24 -alkyl group containing α-amino acyl groups,...
30	7074892	Thrombin generation inhibitors Peptides derived from amino acids 307 to 356 of the human blood coagulation factor Va are provided. Such peptides comprise: i) a length of between 3 and 50 amino acids, ii) a minimum of 3...
31	7074766	Substantially cell membrane impermeable compound and use thereof The present invention relates to a compound according to Formula (I): A-(L-Y) p , wherein A comprises at least one substantially cell-membrane impermeable pendant group; L comprises any suitable...
32	7074620	Controlling protein levels in eucaryotic organisms Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having...
33	7060678	Peptides comprising furanoid sugar amino acids for the treatment of cancer Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar...
34	7012129	Antiviral composition comprising glycine amide Embodiments relate to the discovery that certain tripeptide amides and glycine amide can be used to inhibit viral infection, including human immunodeficiency virus (HIV) infection. More...
35	7001982	Non-natural C-linked carbo-β-peptides with robust secondary structures Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably...
36	6958384	Polypeptides containing γ-amino acids Disclosed are polypeptide compounds containing at least one residue comprising a cyclically-constrained γ-amino acid residue. The compounds have the formula where A is a hydrogen, hydroxy,...
37	6921747	Basic amino acid derivatives The present invention provides a basic amino acid derivative represented by the formula (1): The present invention also provides a method of making a gelled product by employing the...
38	6914048	Method for delivery of molecules to intracellular targets Disclosed are β-peptides and β-peptide conjugates that are capable of diffusing or otherwise being transported across the cell membranes of living cells. The β-peptides contain at least six...
39	6906199	Process for preparing distamycin derivatives It is described a process for preparing, in high yields and purity and without the need of carrying out several steps and/or isolating many intermediates which could lead to undesired by-products,...
40	6906171	Process for the deprotection of protected thiols The synthesis of peptides comprising disulphide bridges is challenging since it is difficult to ensure that the correct cysteine residues combine to form the desired disulphide bridges. The present...
41	6867284	Peptide inhibitors of hepatitis C virus NS3 protease Fluorinated oligopeptides, especially those having 4,4-difluoro-2-amino butyric acid at the C terminus, may be effective inhibitors of hepatitis C virus NS3 protease. Examples of hexapeptides of...
42	6858114	Laser hydrolysis of polypeptides The present invention relates to methods of hydrolyzing a protein (or peptide) by treating a protein (or peptide)-containing sample with a laser and associated apparatus for effectuating the...
43	6835811	Extended storage of reduced glutathione solutions A method of storing solutions of reduced glutathione for extended periods of time, by dissolving reduced glutathione in an aqueous medium having a pH of between 5.0 and 8.0 to produce a reduced...
44	6794365	Malonic acid derivatives, processes for their preparation their use and pharmaceutical compositions containing them The present invention relates to new malonic acid derivatives of the formula I, wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated in the claims. The compounds of formula...
45	6780970	Cell-permeable peptide inhibitors of the JNK signal transduction pathway The invention provides cell-permeable peptides that bind to JNK proteins and inhibit JNK-mediated effects in JNK-expressing cells.
46	6770741	Bradykinin antagonist peptides The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts...
47	6770740	Crosslinked DNA condensate compositions and gene delivery methods Disclosed are improved compositions and methods for use in gene delivery and expression. A range of surprisingly effective cross-linking agents and peptides are provided, as are peptide-DNA carrier...
48	6753316	Acryloyl derivatives analogous to distamycin, process for preparing them, and their use as antitumor agents Compounds which are acryloyl substituted distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; m is 1 or 2; X and Y are the same or different and are selected, independently for each...
49	6750202	Phosphinate peptide analogs for the treatment of fibrotic disorders The invention relates to a method of treating a fibrotic disease, comprising administering to a mammal an effective amount of a phospinate-peptide analog of the general formula (I).
50	6737409	Dolastatin 10 derivatives Novel anti-tumor compounds of formula, are disclosed. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), the use of compounds of formula (I) for the treatment of...

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