Patents in Class 530/331

Matches 1 - 50 out of 1232

Match	Document	Document Title
1	7608592	HCV inhibitors The present invention is directed to compounds that are antiviral agents. Specifically the compounds of the present invention inhibit replication of HCV and are therefore useful in treating...
2	7608590	HCV NS-3 serine protease inhibitors Compounds of the formula where the variables are as defined in the specification inhibit the NS3 protease of flavivirus such as hepatitis C virus (HCV). The compounds comprise a novel linkage...
3	7605126	Acylaminoheteroaryl hepatitis C virus protease inhibitors The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the...
4	7595173	Low-cost production of peptides The subject invention relates to a low cost method of producing peptides, including antimicrobial peptides (AMPs), by using microbes. The subject methods enable greatly improved yields of the...
5	7592316	Peptides as NS3-serine protease inhibitors of hepatitis C virus The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
6	7585845	Hepatitis C inhibitor compounds Compounds of formula (I): wherein B, X, R 3 , L 0 , L 1 , L 2 , R 2 , R 1 and R C are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis...
7	7582605	Phosphorus-containing hepatitis C serine protease inhibitors The present invention relates to phosphorus-derived compounds of Formula I or Formula II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof, which inhibit serine protease activity,...
8	7579323	Hemiasterlin analogs This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as cytotoxic and anti-mitotic agents.
9	7576175	Alpha-4 beta-1 integrin ligands for imaging and therapy The present invention provides α 4 β 1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino...
10	7576062	Compounds with growth hormone releasing properties Disclosed are compounds of formula I wherein R 1 , R 2 , R 5 , R 6 , R 7 , R 8 , G, J, L, M, a, b, c, d, e, and f are as defined in the specification, and compositions containing them. These...
11	7569548	Method of preparing peptide The present invention provides a method of preparing an intermediate for LHRH antagonists, which requires fewer steps than conventional methods and provides the intermediate in high yield and high...
12	7566765	Heterocyclic compounds containing a nine-membered carbon-nitrogen ring The present invention provides heterocyclic compounds having a nine-membered ring of three repeating C—C—N subunits covalently bound to each other through amide bonds, and variable side groups...
13	7553816	p-amidobenzylethers in drug delivery agents Compounds of the formulas L A n -Z-X—W w D and B Z-X—W w D wherein: D is...
14	7550559	Acylsulfonamide compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
15	7547760	Peptides and chemical compound for inhibition of SHP2 function The present invention relates to the inhibition of the function of SHP2 by both anti-SHP2 peptides and the chemical compound 4-(2-sulfaminoethyl)benzoic acid, SEBA, and SEBA derivatives binding to...
16	7544781	Polypeptide and process for producing the same A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound...
17	7521477	Vitamin C derivatives with peptide, preparation method thereof and composition comprising the same Disclosed are vitamin C derivatives linked with a peptide or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a composition comprising the same.
18	7521427	Peptidyl allyl sulfones The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure...
19	7517857	Immune-modulating peptide Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood...
20	7517855	Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell...
21	7507791	Solid phase peptide synthesis of tri-peptide derivatives The present invention relates to a process for the preparation of a peptide derivative, and more preferably tri-peptide derivatives, of the formula wherein Tos has the meaning of...
22	7504092	Cosmetic or pharmaceutical composition comprising peptides, uses and treatment processes A peptide, with the sequence (AA)n-Arg-Gly-Ser-(AA)n, where (AA) is any amino acid or a derivative thereof and n=0 to 3, as an active ingredient in or for the preparation of a cosmetic and/or...
23	7498406	Substantially cell membrane impermeable compound and use thereof The present invention relates to a compound according to Formula (I): A-(L-Y) p , wherein A comprises at least one substantially cell- membrane impermeable pendant group; L comprises any suitable...
24	7498405	Halogen-substituted thienyl compounds Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds. A representative thienyl compound has the structure
25	7491699	Peptide nanostructures and methods of generating and using the same A tubular or spherical nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino acids...
26	7491689	Compositions comprising the biologically active peptide YSL Thirty substantially pure and biologically active peptides are disclosed. Nucleic acids that have sequences coding for the biologically active peptides and pharmaceutical formulations produced...
27	7485625	Inhibitors of hepatitis C virus NS3/NS4a serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
28	7470664	HCV NS3 protease inhibitors The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or...
29	7465710	Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the...
30	7449447	Peptidomimetic NS3-serine protease inhibitors of hepatitis C virus The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said...
31	7446094	Cytotoxic depsipeptides Compounds of general formula (I) wherein R 1 , R 2 , R 3 are as defined and R 4 groups are each independently selected from NR 2 , O and S; are of use in treatment of cancers.
32	7427599	Biologically active peptide comprising Tyrosyl-seryl-valine(YSV) The tripeptide Tyrosyl-seryl-valine is disclosed with its use as a pharmaceutical composition in treating a condition whose effects can be reduced by stimulating T-cell transformation and a cell...
33	7425608	Method of making metallopeptides Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs,...
34	7423012	Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and...
35	7423010	Nonporous microparticle-prodrug conjugates for treatment of infection This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such...
36	7417030	Indazole peptidomimetics as thrombin receptor antagonists The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
37	7417029	Prodrug of an ice inhibitor This invention describes an ICE inhibitor prodrug (I) having good bioavailability Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel...
38	7417027	Linear and cyclic melanocortin receptor-specific peptides Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity. In one embodiment, a linear peptide...
39	7410951	Biologically active peptides and compositions, their use Derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by formula I wherein Y, n, R 1 , R 2 , R 3 , R 7 ,...
40	7404948	Peptidic conjugates for alopecia prevention and treatment The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall.
41	7402556	Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or...
42	7399749	Substituted prolines as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
43	7396814	Metallopeptide compositions for treatment of sexual dysfunction Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The...
44	7396812	Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1; and bringing said cells into contact with a molecule related to...
45	7390789	Thio-containing inhibitors of aminopeptidase P, and compositions thereof The present invention is directed to an α thio-containing compound that is capable of inhibiting the enzyme, membrane aminopeptidase P (mAPP or APP), whose natural substrate is bradykinin. The...
46	7385025	Metallopeptide compounds Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues,...
47	7378397	TRH-degrading ectoenzyme inhibitors Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula I a : wherein: R 1 is an optionally substituted 4-, 5-...
48	7375085	Melanocyte-stimulating hormone inhibitors In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl...
49	7375083	Pharmaceutical compositions for prevention of overdose or abuse The invention relates to pharmaceutical compositions comprised of a chemical moiety attached to an active agent in a manner that substantially decreases the potential of the active agent to cause...
50	7368421	Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in...

Matches 1 - 50 out of 1232

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