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9029417 Compositions for prevention/prophylactic treatment of poison ivy dermatitis  
The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak...
9023801 Topical palmitoyl glutathione formulations  
A topical composition for application to aging skin, including an effective amount of S-acyl glutathione derivative of formula (I) wherein R1 consists of an unsaturated or saturated C16 acyl group...
9000126 Crystalline oxidized glutathione and production method therefor  
Provided is a novel crystal of oxidized glutathione hexahydrate. Crystal of oxidized glutathione hexahydrate is produced by cooling an aqueous solution containing oxidized glutathione to 15° C. or...
8957025 Enkephalin analogues  
The present invention relates to dipeptide enkephalin analogues of Formula (I) and their tautomers, ionic forms and pharmaceutically acceptable salts, and their use in medicine, in particular as...
8957030 Methods for preventing or treating mitochondrial permeability transition  
The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at...
8940697 Compositions and methods for the treatment of myocardial ischemia/reperfusion injury with Annexin A1 short peptide  
The present invention provides a method of treating, ameliorating or preventing myocardial ischemia/reperfusion injury in a subject in need thereof, by administering to the subject a...
8936781 Macrocyclic compounds as hepatitis C virus inhibitors  
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of...
8927503 Modulations of protease activated receptors  
The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as...
8901085 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Modulations of protease activated receptors
 
The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as...
8895515 Cosmetic composition for skin cell regeneration mimicking extracellular matrix  
The present invention relates to a cosmetic composition which mimics the extracellular matrix to stimulate the regeneration of skin cells, and more particularly to a cosmetic composition which...
8889828 Conformations of divergent peptides with mineral binding affinity  
A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the...
8865857 Medical device with predefined activated cellular integration  
A medical device includes a substrate having at least a portion thereof functionalized with at least one reactive member and a chemotactic agent functionalized with at least one complementary...
8859505 Cysteine protease inhibitors  
Compounds of the formula I wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a andR2b together with the carbon atom to which they are attached form a...
8852883 Rapid FRET-based diagnosis of bacterial pathogens  
Substrates for detecting microorganisms are provided, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties, to a di-, or tripeptide...
8852599 Immunoconjugates, compositions for making them, and methods of making and use  
An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an...
8846615 MNTF peptides  
The present invention relates to novel Motoneuronotrophic Factors (MNTF) peptides and analogs thereof, including compositions capable of promoting the growth and viability of neurons. MNTF...
8835393 Inhibitors of IAP  
The invention provides novel compounds that are inhibitors of IAPs having the general formula: wherein X1, X2, X3, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein. The...
8829044 Stabilized vitamin C derivatives having a peptide molecule, preparation method thereof, and composition containing the same  
The present invention relates to a stabilized vitamin C derivative with a peptide molecule linked to vitamin C or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a...
8828401 Cytotoxic peptides and antibody drug conjugates thereof  
The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
8815266 Peptide derivatives useful in the treatment, care or cleansing of the skin, mucosae, scalp or nails  
The invention relates to peptide derivatives of general formula (I): R1-AA1-AA2-R3-AA4-R2 (I) their stereoisomers, mixtures thereof, and their cosmetically or pharmaceutically acceptable salts, a...
8809262 Multimeric forms of antimicrobial peptides  
The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be...
8802818 Prostaglandin-F2 alpha receptor modulators and uses thereof  
Prostaglandin-F2 alpha (PGF2α) receptor (FP) modulators of formula I, as well as the use of PGF2α receptor modulators for the treatment of conditions associated with FP activity such as preterm...
8791076 Agonists of neurotrophin receptors and their use as medicaments  
The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are...
8791235 Selective caspase inhibitors and uses thereof  
The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the...
8785374 Inhibitors of mammalian tight junction opening  
The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides...
8778891 Dermatopontin-activating peptides and cosmetic compositions including same  
Peptides activating dermatopontin in the skin and cosmetic compositions including such peptide, in a physiologically suitable medium, are described. Methods of treating the cutaneous signs of...
8772244 Tubulin inhibitors  
The present invention relates to novel tubulin binding molecules of formula (I) and their use for the treatment of cancer and other diseases.
8759104 Cationic lipids  
The invention provides a cationic lipid comprising: (i) one head group, comprising one or more amino acids, in which at least one amino acid has a side chain that comprises a cationic moiety or a...
8754190 Controlled release from macromolecular conjugates  
The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and...
8729014 Specific HCV NS3 protease inhibitors  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HCV in human patients or other animal hosts.
8728486 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds  
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using...
8722934 Diphenylmethane compound  
Compounds having a diphenylmethane skeleton are superior in broad utility and stability, and are useful as a protecting reagent (anchor) of amino acid and/or peptide in the liquid phase synthesis...
8722627 Proteasome-activating lightening peptidic hydrolyzates and compositions containing them  
A peptidic hydrolyzate enriched in bioactive peptides is disclosed that is a proteasome activator. Cosmetic and pharmaceutical compositions are disclosed that include the peptidic hydrolyzate...
8716472 Tripodal cyclohexane derivatives and their use as carbohydrate receptors  
A tri-podal compound according to formula (I) wherein, each Z is the same and is a substituted or unsubstituted N-heteroaromatic single-, multiple-, or fused-ring; and each A is the same, and can...
8710178 Macrocyclic cysteine protease inhibitors and compositions thereof  
The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the...
8697641 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication
 
The invention provides 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Formula I and the pharmaceutically salts thereof. The variables are defined herein. Certain compounds of...
8697656 Compounds, in particular peptides, compositions comprising them and cosmetic and dermo-pharmaceutical uses  
The present invention concerns a peptide of following formula I: R being a side chain having at least one heteroatom selected from sulfur, nitrogen and oxygen in a carbonyl form (C═O); R1 being...
8685927 Cosmetic and/or pharmaceutical composition comprising a relieving peptidic hydrolyzate  
A cosmetic or pharmaceutical composition that includes a peptide hydrolyzate which is enriched in soothing bioactive peptide in a physiologically acceptable medium is described. Methods for...
8673863 Glutathione-based delivery system  
A delivery system is provided. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound...
8664356 Gamma amino acid building blocks  
The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline...
8664177 Peptide compositions and methods for treating patients  
The present invention is directed to peptide compositions and methods of using the peptide compositions to treat prediabetes, diabetes, obesity, high blood pressure and metabolic syndrome.
8642048 Multiple antigenic peptides immunogenic against Streptococcus pneumonia  
The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae. The invention also provides purified polypeptides encoded by...
8636977 Integrin targeted synthetic ligands for diagnostic and therapeutic applications  
The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety...
8618249 Peptides having an ACE inhibiting effect  
Use of the tripeptide ITP and salts thereof for the preparation of a functional food angiotensin-converting enzyme inhibitor. Also provided is the use of the combination of tripeptide MAP and the...
8613905 Diagnostic agent  
The invention provides an agent comprising an amino acid sequence for use in a method of diagnosis of a synucleinopathic disease.
8613930 Cross-linkers and their uses  
Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.
8614180 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication  
The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y, and Z are defined...
8609618 Topical palmitoyl glutathione formulations  
A topical composition for application to aging skin, comprising an effective amount of S-acyl glutathione derivative of formula (I) wherein R1 consists of an unsaturated or saturated C16 group and...
8609610 Inhibitors of the trypsin-like site of the proteasome and methods of use thereof  
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an...
8598124 Peptides derived from HMG-CoA reductase and cosmetic and/or pharmaceutical composition containing same  
The present invention relates to peptides derived from human HMG-CoA reductase of general formula (I): R1-(AA)n-X1-Gly-Lys-X2-(AA)p-R2, And of sequence SEQ ID No. 1 to SEQ ID No. 10. The present...