Matches 501 - 550 out of 1239 < 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >
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5756467 Adipocyte differentiation inhibiting peptide and adipocyte differentiation inhibiting agent using the peptide as active component thereof  
This invention aims to provide a peptide having an amino acid sequence of Val-Tyr-Pro or Val-Thr-Leu and having the ability to inhibit adipocyte differentiations, adipocyte differentiation...
5756700 Nucleic acid encoding human signal transducer and activator of transcription 4  
The invention provides methods and compositions relating to interleukin 12 signal transducers, particularly an isolated human signal transducer and activator of transcription 4 (hStat 4), or a...
5753629 Distamycin A analogues as antitumour or antiviral agents  
The present invention relates to compounds of formula (I) ##STR1## The compounds of the invention are useful as antitumor or antiviral agents.
5750648 Retroviral protease inhibitors and combinations thereof  
The present invention is directed to the preparation and use of retroviral protease inhibitors and combinations of retroviral protease inhibitors which are effective in preventing the replication...
5747304 Fungicidal agents LL-15G256γ,δ, and ε produced by LL-15G256 (Hypoxylon oceanicum)  
This invention provides new antifungal compounds of Formula I or II: ##STR1## wherein R, R 1 and R 2 are defined in the specification produced by culture LL-15G256 (Hypoxylon oceanicum), NRRL...
5747460 Method of treatment and prophylaxis of venous thrombosis  
The invention relates to new competitive inhibitors of thrombin, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as...
5747459 Method for insuring adequate intracellular glutathione in tissue  
A method is provided for increasing and/or maintaining the level of intracellular glutathione. Pursuant to the invention, compositions including denatured and at least partially hydrolyzed proteins...
5744451 N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity  
The present invention relates to N-substituted derivatives of glutamic acid of pharmaceutical interest, to pharmaceutical compositions which include compounds of the invention and pharmaceutically...
5739106 Appetite regulating compositions  
Compositions and methods for reducing food intake, suppressing appetite and controlling body weight are provided. Such compositions may include an amylin agonist and a CCK agonist or a hybrid peptide.
5739280 Para-nitroanilide peptides  
A compound of the formula R 1 --A 2 --A 1 -Asp-p-nitroanilide wherein: A 1 is a residue of any of the naturally occurring α-amino acids or a homolog, analog or derivative of a natural...
5739350 CC-1065 analogs  
This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been...
5736518 Peptide compounds of (L) amino acids and ring molecules, and therapeutical applications thereof  
Compounds of general formula A--B--C in which: A is a monovalent radical of a L-ring molecule; B is a bivalent radical of a L-α-aminoacid; and C is a monovalent radical of a L-aromatic molecule....
5736521 Method of treatment and prophylaxis of arterial thrombosis  
A method is disclosed for treatment or prophylaxis of arterial thrombosis employing the compound HOOC-CH 2 -(R)Cha-Pic-Nag or a stereoisomer thereof or a physiologically acceptable salt thereof.
5733881 Opioid peptide antagonists  
Compounds of the formula I as well as methods for their preparation, their pharmaceutical preparations and their use. ##STR1## The compounds of formula I are useful in therapy, especially as...
5731413 Method of synthesis of peptidyl aldehydes  
This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel! reagents useful therein.
5726158 Peptide derivatives  
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which...
5723442 Peptide derivatives  
The present invention relates to certain peptide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such...
5714580 Trypsin Inhibitors  
Novel compounds having activity against trypsin are disclosed. Specifically, novel peptide aldehyde analogues that have substantial potency and specificity as inhibitors of mammalian pancreatic...
5710247 Process and intermediates for the synthesis of LHRH antagonists  
A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
5710256 Methadone derivatives and protein and polypeptide methadone derivative conjugates and labels  
The present invention is directed to novel methadone derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or...
5707965 Peptides for control of intestinal motility  
Peptides isolated from the bovine posterior pituitary gland are useful for the control of intestinal motility.
5705607 Procedures for the isolation and titration of sarcocystine or parasite toxin of sarcocystis genus  
The present invention provides the technique for isolating the toxin of the Sarcocystis protozoa, which may be later used in the production of specific antibodies against the sarcocystine...
5703050 Urea derivatives, their preparation and use  
Urea derivates are disclosed having the formula (I). ##STR1## in which A, B, W, Z, R, R 1 , R 2 , R 3 and r have the meaning given in the description, as well as a process for preparing the same...
5703208 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors  
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof,...
5700780 Antiviral peptide derivatives having a 2-oxoalkyl amino acid side chain  
Disclosed herein are peptide derivatives of the formula X --NR 1 --CH(R 2 )--C(W 1 )! n --NH--CR 3 (R 4 )--C(W 2 )--NR 5 --CH CH 2 C(O)--Y!--C(W 3 )--NH--CR 6 -- CR 7 --(R 8 )--COOH!--C(W 4...
5698674 Triheterocyclic peptides capable of binding the minor and major grooves of DNA  
The present invention provides a triheterocyclic peptide having first, second, and third 5-member heterocyclic moieties having the following formula CR 3 CONH--Q 1 --CONH--Q 2 --CONH--Q 3 ...
5696134 Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof  
Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection: ##STR1## wherein A, B, R 1 to R 4 and n have the same meanings as defined in the...
5693617 Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein  
Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain proteasome inhibitors. The structure of the...
5691315 Endothelin antagonistic peptide derivatives  
The invention relates to compounds which are antagonists of endothelin, to processes for their preparation, and to their use as pharmaceuticals. The compounds of the invention are Useful in the...
5686420 Thyrotropin-releasing hormone analogs and method of use  
A series of novel thyrotropin-releasing hormone analogs wherein the C-terminal prolineamide moiety has been preserved, the N-terminal moiety comprises one of five different ring structures and the...
5686421 Hydantoin derivates  
Hydantoin derivatives of the formula I ##STR1## in which n is 3 or 4, R 1 is alkyl or a radical of the formula R'--NH--CN--R" with R' and R" being hydrogen or alkyl, and R 2 is hydrogen,...
5686423 Di-and tri-peptide mimetic compounds for Parkinson's disease  
A series of di- and tri-peptide mimetic dopamine prodrugs are synthesized in which D-phenylglycine or D-p-hydroxyphenylglycine is attached as tools for delivery of L-dopa through the intestine via...
5681927 Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy  
Chelated radionuclide compositions are provided for conjugation to polypeptides and carbohydrates. The resulting conjugates may be used in diagnosis and therapy.
5677282 Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase  
Amino acid amides of 5-amino-1,3,4-thiadiazole-2-thione are disclosed. These compounds inhibit matrix metalloproteinase enzymes and cartilage degradation. Methods of treating diseases caused by...
5677281 Use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16  
The invention relates to the use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16. These peptide derivatives are in accordance with the formula:...
5674848 Bioreactor compositions with enhanced cell binding  
Compositions of the invention include packing materials having compounds thereon with enhanced cell binding with respect to collagen. These packing materials are useful for in vitro uses such as...
5672586 Herpes ribonucleotide reductase inhibitors  
Disclosed herein are compounds of the formula ##STR1## wherein R 1 is hydrogen or (1-4C) alkyl, R 2 is (1-4C) alkyl or a therapeutically acceptable salt thereof. The compounds are useful for...
5672582 Thrombin inhibitors  
4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like...
5670133 Peptides method for radiolabeling them, and method for detecting inflammation  
High affinity chemotactic peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and...
5663296 Hydroxamate inhibitors of endothelin converting enzyme  
Hydroxamate compounds of the following formula are disclosed: R--AA 3 --AA 4 --AA 5 --AA 6 --NH--OR 2 wherein AA 3 --AA 6 represent amino acid residues. The disclosed compounds are...
5663148 Anaphylatoxin receptor ligands containing lipophilic residues  
Oligopeptide compounds or oligopeptide analague compounds of the formula, A-B-D-E-G-J-L-M-N(R 4 )Arg-OH, which are ligands for the anaphylatoxin receptor and are useful in the treatment of...
5663297 Antithrombic peptides  
Disclosed herein are peptide of the formula R--CONH--CH 2 --CONH--CH(R')--CH 2 COOH I wherein R and R' are as defined herein. The claimed peptide derivatives inhibit platelet...
5663139 Inhibitors of retroviral proteases  
The present invention relates to a compound of the formula ##STR1## in which A, Q, R 2 , R 3 and R 4 , and also the corresponding, asterisked radicals, are defined as indicated in the description,...
5663150 Cyclopentane-β-amino acid tripeptides  
The present invention relates to cyclopentane-β-amino acid tripeptides, a process for their preparation and their use as antimicrobial, in particular antimycotic, medicaments.
5661129 Organic nitrates containing a disulfide group as cardiovascular agents  
The invention relates to novel nitrates containing a disulphide group, and to processes for their preparation. The compounds can be used for the therapy of disorders of the cardiovascular system.
5658885 Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes  
This invention relates to Novel α-aminoacid and α-aminoboronic acid and corresponding peptide analogs of the following formula: ##STR1##
5656604 Peptide compound and its preparation  
Peptide compounds of the formula (I') ##STR1## in which R 1 is acyl, R 2 is lower alkyl, cyclo(lower)alkyl(lower)alkyl or optionally substituted heterocyclic(lower)alkyl, R 3 is optionally...
5652220 Encapsulation of TRH or its analog  
The present invention relates to a microcapsule containing TRH, its analog or a salt thereof and a method of producing the same which attains the release of the active ingredient stably for a...
5650393 Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems  
Amphiphilic derivatives of amino acids or peptides are provided, comprising a polyhydroxylated hydrophilic part derived from a sugar, from a polyol, from an aminopolyol or from an oligosaccharide,...
5646121 Pseudopeptides with antiviral activity  
The present invention relates to novel pseudopeptides with antiviral activity of the general formula (I) ##STR1## in which the substituents have the meaning given in the description, to a process...
Matches 501 - 550 out of 1239 < 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >