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7615244 |
Glycopeptide and peptide having a kokumi taste imparting function, and method of imparting the kokumi taste to foods
Glycopeptides and peptides having the formula:
where X represents a hydrogen atom or a sugar chain, provide a taste improving function, particularly a kokumi taste imparting function. Such...
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7608591 |
Targeted delivery to legumain-expressing cells
The present invention relates to new agents and methods useful for preventing, treating and diagnosing diseases such as cancer. For example, the invention relates to prodrug agents useful for...
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7601333 |
Use of a tetrapeptide AcSDKP (SEQ ID No. 1) analog resistant to the angiotensin I converting enzyme for measuring glomerular filtration rate in a human or an animal and kit containing same
The invention concerns the use of ACE-resistant N-acétyl-Ser-Asp-Lys-Pro analogues for preparing a reagent or marker adapted to measure a glomerular filtration rate.
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7598342 |
Alpha-fetoprotein peptides and uses thereof
The invention relates to compounds that include peptide and peptidomimetics that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell...
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7595374 |
Heparin binding motif and use thereof
A method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide...
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7595173 |
Low-cost production of peptides
The subject invention relates to a low cost method of producing peptides, including antimicrobial peptides (AMPs), by using microbes. The subject methods enable greatly improved yields of the...
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7589170 |
Synthesis of cyclic peptides
This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in...
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7579436 |
Peptide compound for measuring sulfur compound and ammonia
A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the...
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7579435 |
Somatostatin-dopamine chimeric analogs
Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is:...
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7576175 |
Alpha-4 beta-1 integrin ligands for imaging and therapy
The present invention provides α 4 β 1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino...
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7576174 |
Compositions capable of reducing elevated blood urea concentration
The invention includes a method of reducing urea concentration in a subject's serum. Such a method comprises administering to the subject (e.g., a mammal such as a human) a composition comprising...
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7576061 |
Methods for preventing mitochondrial permeability transition
The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at...
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7572884 |
Method for making acylated polypeptides
The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent...
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7572450 |
Composition for preventing cell death and/or tissue necrosis resulting from contact with neural thread proteins
Disclosed is a method of preventing, inhibiting, and/or ameliorating cell death and/or tissue necrosis in live tissue by contacting live tissue with at least a segment of NTP, or homologue,...
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7569547 |
Inhibiting furin with polybasic peptides
Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can...
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7553816 |
p-amidobenzylethers in drug delivery agents
Compounds of the formulas
L A n -Z-X—W w D and B Z-X—W w D
wherein: D is...
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7550439 |
Methods for reducing oxidative damage
The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic...
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7547760 |
Peptides and chemical compound for inhibition of SHP2 function
The present invention relates to the inhibition of the function of SHP2 by both anti-SHP2 peptides and the chemical compound 4-(2-sulfaminoethyl)benzoic acid, SEBA, and SEBA derivatives binding to...
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7547676 |
Antagonist peptides to the C5A chemotactic function of vitamin D binding protein
It has been demonstrated that one of Vitamin D Binding Protein (DBP) biological functions is to enhance the chemotactic activity of C5 a and C5 a des Arg. The present invention has found that...
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7544665 |
Synthesis using peptide intermediate fragments
Methods for the solid phase synthesis of T-1249 peptides and peptide intermediates, in particular methods involving synthesizing T-1249 peptide intermediates at low loading factors to produce...
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7541339 |
Par-2-activating peptide derivative and pharmaceutical composition using the same
The present invention relates to a peptide derivative represented by the general formula (I) or a salt thereof: Z-(CH 2 ) n —CO—NH-Leu-Ile-Gly-AA 1 -AA 2 -CO—R (I) wherein Z represents an...
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7538091 |
Intracellular delivery of biological effectors
The invention relates to a sequence of amino acids with the capacity to facilitate transport of an effector across a biological membrane. More specifically, the present invention relates to novel...
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7538083 |
Compositions and methods for the potentiation of immune responses against target antigens
The present invention provides novel adjuvant systems for the potentiation of immune responses against antigenic targets.
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7534857 |
Methods and compositions for the treatment and prevention of staphylococcal infections
A biologically pure RNAIII inhibiting peptide (RIP), that includes five contiguous amino acids of the sequence YX 2 PX 1 TNF, where X 1 is C, W, I or a modified amino acid, and X 2 is K or S is...
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7534438 |
Product and process for liquefaction of mucus or sputum
Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The...
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7534431 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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7531622 |
Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells
A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or...
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7528228 |
Method for synthesizing peptides comprising at least one glycine molecule
Method for preparing a peptide or a peptide derivative comprising at least 2 enantiopure amino acids and at least one glycine molecule, comprising the reaction of a compound of general formula XCH...
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7528227 |
Histone H2A peptide derivatives and uses thereof
Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury...
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7521477 |
Vitamin C derivatives with peptide, preparation method thereof and composition comprising the same
Disclosed are vitamin C derivatives linked with a peptide or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a composition comprising the same.
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7517857 |
Immune-modulating peptide
Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood...
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7517855 |
Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell...
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7514531 |
Specific binding sites in collagen for integrins and use thereof
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the...
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7507719 |
Use of peptidic conjugates for preparing compositions for alopecia preventive and curative treatment
The invention relates to the use of peptidic conjugates containing Gly-His-Lys for producing dermatological or cosmetological compositions for stimulating hair growth or stopping hair fall.
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7504383 |
Peptide nanostructures encapsulating a foreign material and method of manufacturing same
A composition comprising a material at least partially enclosed by a tubular, spherical or planar nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides...
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7501486 |
Peptides that selectively home to heart vasculature and related conjugates and methods
The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has...
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7501391 |
Treatment of transplant survival
The invention relates to the field of transplantation medicine and to the prevention and treatment of rejection, in particular of chronic rejection, of a transplant by a recipient of the...
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7498405 |
Halogen-substituted thienyl compounds
Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds. A representative thienyl compound has the structure
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7498310 |
Cosmetic or dermatological preparations comprising oligopeptides for lightening the skin of age marks and/or for preventing tanning of the skin, in particular tanning of the skin caused by UV radiation
Cosmetic or pharmaceutical preparations which are distinguished by an effective content of one or more monomeric or homo- or heterodimer or homo- or heterotrimeric or homo- or heterotetrameric...
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7491704 |
Compounds for enzyme inhibition
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
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7491703 |
Tetrapeptide regulating blood glucose level in diabetes mellitus
The invention refers to the field of medicine and can be applied as a substance capable of regulating glucose level while treating and preventing diabetes mellitus. There is proposed a biologically...
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7491699 |
Peptide nanostructures and methods of generating and using the same
A tubular or spherical nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino acids...
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7491691 |
Connective tissue stimulating peptides
Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or...
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7470658 |
Methods for inhibiting tumor metastasis, and peptides useful therefor
In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention...
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7456294 |
Hairpin polyamide
It is intended to provide a pyrrole-imidazole polyamide type functional molecule having enhanced abilities of alkylating DNA and recognizing a sequence, compared with the existing functional...
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7456253 |
Growth hormone releasing peptides
Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R 1 -A 2 -A 3 -A 4 -A 5 -R 2 ...
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7452679 |
Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
Branched peptide amphiphilic compounds incorporating one or residues providing a pendant amino group for coupling one or more epitope sequences thereto, such compounds and related compositions for...
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7447595 |
Heterologous protein production using the twin arginine translocation pathway
Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided,...
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7445903 |
Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis
The invention concerns citrulline polypeptide derived from fibrin useful for diagnosing or treating rheumatoid arthritis.
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7439345 |
Supramolecular pairing system, its preparation and use
The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula:
and oligomers thereof.
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