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7470658 |
Methods for inhibiting tumor metastasis, and peptides useful therefor
In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention...
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7456294 |
Hairpin polyamide
It is intended to provide a pyrrole-imidazole polyamide type functional molecule having enhanced abilities of alkylating DNA and recognizing a sequence, compared with the existing functional...
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7456253 |
Growth hormone releasing peptides
Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R 1 -A 2 -A 3 -A 4 -A 5 -R 2 ...
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7452679 |
Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
Branched peptide amphiphilic compounds incorporating one or residues providing a pendant amino group for coupling one or more epitope sequences thereto, such compounds and related compositions for...
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7447595 |
Heterologous protein production using the twin arginine translocation pathway
Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided,...
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7445903 |
Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis
The invention concerns citrulline polypeptide derived from fibrin useful for diagnosing or treating rheumatoid arthritis.
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7439345 |
Supramolecular pairing system, its preparation and use
The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula:
and oligomers thereof.
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7435718 |
CXCR4 antagonist treatment of hematopoietic cells
In accordance with various aspects of the invention, CXCR4 antagonists may be used to treat hematopoietic cells, such as progenitor or stem cells, to promote the rate of cellular multiplication,...
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7425608 |
Method of making metallopeptides
Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs,...
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7425541 |
Enzyme-cleavable prodrug compounds
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is...
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7423116 |
Pentapeptide compounds and uses related thereto
Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieties, as well as precursors thereof are also...
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7423020 |
Treatment of mood disorders by administration of SMR1
This invention relates to the use of an agent that modulates the interaction between a SMR1 peptide and a metal-lopeptidase for the preparation of a medicament for preventing or treating a Central...
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7417028 |
Human glucagon-like-peptide-1 modulators and their use in treatment of diabetes and related conditions
The present invention provides novel human glucagon-like peptide-1 (GLP-1)-receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the...
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7417027 |
Linear and cyclic melanocortin receptor-specific peptides
Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity. In one embodiment, a linear peptide...
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7417030 |
Indazole peptidomimetics as thrombin receptor antagonists
The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
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7413537 |
Directed evolution of disulfide-bonded micro-proteins
The invention relates, in part, to a library of chimeric proteins, each chimeric protein including a mini-protein between about eight and about forty amino acids long, wherein the mini-protein has...
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7410950 |
Peptides of CaV2.2 that inhibit pain
The present invention relates to peptides of CaV2.2 and their use in the treatment of pain. The sequence of the peptides is derived from the C-terminus of CaV2.2. and is believed to inhibit the...
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7404948 |
Peptidic conjugates for alopecia prevention and treatment
The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall.
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7402556 |
Prodrugs activated by plasmin and their use in cancer chemotherapy
The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or...
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7399825 |
Synthetic peptide, inhibitor to DNA viruses
The present invention relates to the identification of the active domain of Herpoxin, a DNA virus-inhibiting-protein which was isolated from cobra venom in U.S. Pat. No. 5,648,339 and has a...
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7396814 |
Metallopeptide compositions for treatment of sexual dysfunction
Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The...
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7390874 |
Peptide, method of production thereof, and pharmaceutical composition containing the same
A biologically active peptide having the amino acid sequence tyrosine-glycine-serine-arginine-serine (SEQ ID NO: 1), as well as compositions prepared from such peptide, possessing anti-cancer...
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7387778 |
Therapeutic methods and compositions for the treatment of impaired interpersonal and behavioral disorders
The invention relates to the field of psychopharmacology. More particularly, the invention relates to the treatment of mental disorders, such as impaired interpersonal and behavioral disorders,...
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7387879 |
Diagnosis of tauopathies
The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the...
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7385028 |
Derivatization of non-natural amino acids and polypeptides
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural...
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7385029 |
Method of making tetrapeptide derivative TZT-1027 crystal
The invention provides crystals of N 2...
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7385025 |
Metallopeptide compounds
Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues,...
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7381707 |
Treatment of dry eye
The present invention relates to methods to treat dry eye in a mammal by intraocularly administering a composition comprising a peptide.
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7378396 |
Therapeutic agents and methods for cardiovascular disease
The present invention provides methods and agents for treating subjects who have or are at risk of developing or having cardiovascular disease. Such agents inhibit binding of myeloperoxidase (MPO)...
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7378397 |
TRH-degrading ectoenzyme inhibitors
Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula I a :
wherein:
R 1 is an optionally substituted 4-, 5-...
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7375083 |
Pharmaceutical compositions for prevention of overdose or abuse
The invention relates to pharmaceutical compositions comprised of a chemical moiety attached to an active agent in a manner that substantially decreases the potential of the active agent to cause...
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7368119 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
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7368528 |
Antineoplastic peptides
The present invention provides antineoplastic peptides of formula I,
R 1 R 2 N—CHX—CO-A-B-D-E-(G) s -K I
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7368421 |
Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in...
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7365047 |
Use of pentagastrin to inhibit gastric acid secretion or as a diuretic
This invention pertains to the discovery that pentagastrin, when administered in conjunction with a proton pump inhibitor (PPI) is synergistic with the PPI and significantly increases the efficacy...
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7365155 |
Immunoregulator
The invention relates to the field of immunology, more specifically to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease or inflammatory...
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7351690 |
Knockout identification of target-specific sites in peptides
The invention provides methods for identification and determination of target-specific sites in peptides and proteins, including a method for determining the primary sequence of a secondary...
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7344884 |
Peptides promoting cell adherence, growth and secretion
The present invention provides specific peptides identified as having cell adhesion, growth, expression or secretion-enhancing activities. Many of the peptides of the invention may be produced in...
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7338939 |
Abuse-resistant hydrocodone compounds
The present invention decreases the potential for abuse of opioids, particularly hydrocodone, by covalent modification. The invention provides methods of delivering hydrocodone as conjugates that...
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7335722 |
Peptides used as angiotensin converting enzyme inhibitor and preparation process thereof
The invention discloses five peptides which can be used as angiotensin converting enzyme inhibitor. The subject invention also discloses a process for the preparation of the products having...
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7335724 |
Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis
The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The...
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7332571 |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural...
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7314866 |
Ku-70-derived Bax-suppressing peptides and use thereof for the protection of damaged cells
A method of protecting cells from cell death comprising the step of supplying to the cell an effective amount of a Bax-inhibiting peptide is disclosed.
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7307063 |
Melanocortin metallopeptides for treatment of sexual dysfunction
Metallopeptides are provided for use in treatment of sexual dysfunction in mammals. The metallopeptides are agonists for at least one of melanocortin-3 or melanocortin-4 receptors. The...
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7304032 |
CD-10 activated prodrug compounds
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and,...
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7304129 |
Peptides that stimulate cell survival and axon regeneration
Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any amino acid, Xaa...
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7304037 |
Cytostatic conjugates with integrin ligands
The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to α v β 3 integrin antagonists via preferred linking units which can be selectively...
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7294615 |
Compounds that associate on the intermolecular level and aggregate bodies that contain them
Compound of the general formula (I)
X(B) m (I)
wherein
X is an m-valent...
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7288522 |
Method of promoting erythropoiesis
The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with...
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7285525 |
Suppression of immune response via inhibition of cathepsin S
Methods and products for suppressing a class II MI-IC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by...
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