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5753629 |
Distamycin A analogues as antitumour or antiviral agents
The present invention relates to compounds of formula (I) ##STR1## The compounds of the invention are useful as antitumor or antiviral agents.
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5747457 |
Linear adhesion inhibitors
Linear peptides of the formula I X-A-Cys(R 1 )-B-Z I, in which A, B, R 1 , X and Z are as defined, are highly active inhibitors of the binding of the...
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5744451 |
N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
The present invention relates to N-substituted derivatives of glutamic acid of pharmaceutical interest, to pharmaceutical compositions which include compounds of the invention and pharmaceutically...
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5741892 |
Pentapeptides as antitumor agents
The present invention provides anti-tumor peptides of Formula I, A-B-N (CH 3 )-CHD-CH(OCH 3 )-CH 2 CO-Pro-Pro-K (I), and the acid salts thereof. A is an amino acid residue of the formula (CH 3...
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5741774 |
Use of a cytokine regulatory agent to treat rheumatoid arthritis
The present invention relates to the use of a cytokine regulatory agent to reduce the severity of rheumatoid arthritis.
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5738838 |
IKVAV peptide radiopharmaceutical applications
Peptides useful for lung imaging, and preferably containing a biological-function domain which includes the sequence Ile-Lys-Val-Ala-Val (IKVAV) (SEQ. ID NO. 1) and a medically useful metal...
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5739279 |
Peptidyl 4-amino-2,2-difluoro-3-oxo-1,6-hexanedioic acid derivatives as antiinflammatory agents
This invention relates to compounds of formula (A) which are derivatives of 4-amino-2,2-difluoro-3-oxo-1,6-hexanedioic acid and their pharmaceutically acceptable base salts. These derivatives and...
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5739350 |
CC-1065 analogs
This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been...
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5739271 |
Thiocationic lipids
Lipid molecules bearing a cationic charge are described. These cationic lipids are useful in the delivery of biomolecules, such as oligonucleotides, nucleic acids, peptides, diagnostic imaging...
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5736394 |
Cellular uptake of modified peptides
Disclosed herein is a cell containing a modified peptide. More specifically, the N-terminal amino acid residue of the peptide is modified by the addition of an aryl ketone group which, when...
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5736509 |
Cyclic peptide surface feature mimics of endothelin
Cyclic peptides and pharmaceutically acceptable salts and esters thereof are provided. The cyclic peptides and pharmaceutically acceptable salts and esters thereof mimic surface features of the...
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5733881 |
Opioid peptide antagonists
Compounds of the formula I as well as methods for their preparation, their pharmaceutical preparations and their use. ##STR1## The compounds of formula I are useful in therapy, especially as...
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5731155 |
Compositions for inhibition of intracellular transcription factors and methods therefor
Novel compositions and methods for inhibiting cytokine-induced intracellular activation of STAT family transcription factors by binding to the transcription factors and inhibiting the...
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5731289 |
Double-chain hemoregulatory peptides
The present invention relates to peptide compounds comprising two single-chain hemoregulatory, for example haemopoiesis-inhibiting, peptides linked by a bridging group terminally attached to the...
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5726156 |
Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels
The present invention relates to novel peptides that are potent cytokine regulatory agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically...
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5726158 |
Peptide derivatives
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which...
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5723307 |
Fluorogenic substrates for assay of angiotensin converting enzyme
Disclosed are new fluorogenic substrates for assay of angiotensin converting enzyme, a process for preparing them and methods for using them to assay angiotensin converting enzyme and to screen...
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5723579 |
Fibrinogen binding peptides
Peptides which bind to fibrinogen are disclosed. These peptides have available fibrinogen binding domains having a Phe-Leu-Leu-Val or Leu-Leu-Val-Pro sequence. The preferred peptide is a 6-mer...
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5721209 |
Iron chelator and inhibitor of iron-mediated oxidant injury
Exochelins can be used to prevent damage to living tissue from the formation or presence of the (OH) radical. In particular, the invention is directed to the administration of exochelins to...
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5721210 |
Cyclic cell adhesion modulation compounds
Cyclized integrin receptor antagonist compounds useful in modulating cell adhesion, including adhesion related to fibronectin, as well as leukocyte adhesion to endothelial cells, are disclosed....
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5719128 |
Factor IIa inhibitors
Disclosed are compounds of the formula: X Y Z A P Q T which are highly potent, selective factor IIa inhibitors, X, when present, may be connected to T, may be H, CH 3 , an acyl group, or a general...
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5717065 |
Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen
Antigens, immunogens, inocula, antibodies, and particularly diagnostic methods and systems relating to Epstein-Barr virus nuclear antigen (EBNA) are disclosed. The diagnostic methods and systems...
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5717058 |
Peptide inhibitors of tax-dependent transcription
The present invention relates to regulators of cellular gene transcription, particularly inhibitors of cellular gene transactivating factors and in particular to inhibition of gene transcription in...
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5710247 |
Process and intermediates for the synthesis of LHRH antagonists
A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
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5710129 |
Inhibitors of SH2-mediated processes
This invention relates to compounds of formula: ##STR1## and pharmaceutically acceptable salts thereof, where A is H, R 1 , --CO--R 1 or --CO--OR 1 where R 1 is a substituted or unsubstituted...
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5710256 |
Methadone derivatives and protein and polypeptide methadone derivative conjugates and labels
The present invention is directed to novel methadone derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or...
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5707965 |
Peptides for control of intestinal motility
Peptides isolated from the bovine posterior pituitary gland are useful for the control of intestinal motility.
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5705481 |
Cyclopeptides
The invention relates to novel cyclopeptides of the formula I cyclo-(A-B-C-D-Arg) I in which A and B are each independently of one another Ala, Asn, Asp,...
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5705486 |
Isolation of novel peptides from green barley leaf extract and use same to inhibit human platelet aggregation
Two penta-peptides, Asp-Asp-Asn-Asp-Asn and Asp-Asp-Ser-Gln-Gln, extracted from green barley leaves, have been found to inhibit the adenosine diphosphate (ADP)-induced aggregation of human blood...
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5703205 |
Laminin a chain polypeptides from the amino terminal golbular domain
Polypeptides derived from domain VI of the amino terminal globule of the A chain of laminin and having sequences of at least about 5 amino acids, and which exhibit cell adhesion and cell spreading...
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5703050 |
Urea derivatives, their preparation and use
Urea derivates are disclosed having the formula (I). ##STR1## in which A, B, W, Z, R, R 1 , R 2 , R 3 and r have the meaning given in the description, as well as a process for preparing the same...
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5700780 |
Antiviral peptide derivatives having a 2-oxoalkyl amino acid side chain
Disclosed herein are peptide derivatives of the formula X --NR 1 --CH(R 2 )--C(W 1 )! n --NH--CR 3 (R 4 )--C(W 2 )--NR 5 --CH CH 2 C(O)--Y!--C(W 3 )--NH--CR 6 -- CR 7 --(R 8 )--COOH!--C(W 4...
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5695761 |
Suppression of nitric oxide production by osteopontin
The present invention relates to compositions and methods for inhibition of the vasoactive and signal transduction agent nitric oxide (NO), and to therapeutic treatment of diseases or disorders...
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5696229 |
Polypeptide with laminin cell adhesion and morphogenesis activity
The present invention provides novel cell adhesion peptides.
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5691315 |
Endothelin antagonistic peptide derivatives
The invention relates to compounds which are antagonists of endothelin, to processes for their preparation, and to their use as pharmaceuticals. The compounds of the invention are Useful in the...
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5691307 |
O.sup.6 -substituted guanine compositions and methods for depleting O.sup.6
Novel O 6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O 6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful...
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5688760 |
Polypeptides having bone resorption inhibitory activity comprising PTHrP-derived sequences
Polypeptides comprising an N-terminal amino acid sequence corresponding to amino acids 107-111 of parathyroid hormone related protein (PTHrP) having bone resorption inhibitory activity are...
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5686575 |
Toxoplasma gondii P28 polypeptides
Genetic material encoding the P28 peptide of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or...
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5686421 |
Hydantoin derivates
Hydantoin derivatives of the formula I ##STR1## in which n is 3 or 4, R 1 is alkyl or a radical of the formula R'--NH--CN--R" with R' and R" being hydrogen or alkyl, and R 2 is hydrogen,...
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5686568 |
Platelet aggregration inhibitors
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and...
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5683886 |
Tumor rejection antigens which correspond to amino acid sequences in tumor rejection antigen precursor bage, and uses thereof
A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor...
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5684127 |
Tetrapeptides deriving from dalbaheptide antibiotics
Tetrapeptides of general formula (I) deriving from dalbaheptide antibiotics ##STR1## wherein: W and Z represent the relative portions of the aglycon of an antibiotic of the dalbaheptide group...
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5681928 |
Betides and methods for screening peptides using same
Compounds are provided termed "betides" which mimic peptides and which contain one or more residues of aminoglycine, C α -aminoalanine, aminosarcosine or the like wherein the side chain amino...
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5681926 |
Thrombin receptor binding peptides
Peptides having the general sequence A-B-C-D-E-F-Z wherein A is Ala, B is pFPhe, C is, for example, Arg, D is Cha, E is, for example, hArg, F is, for example, Tyr, and Z is, for example NH 2 . The...
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5677282 |
Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase
Amino acid amides of 5-amino-1,3,4-thiadiazole-2-thione are disclosed. These compounds inhibit matrix metalloproteinase enzymes and cartilage degradation. Methods of treating diseases caused by...
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5677276 |
Immobilization of peptides to hyaluronate
The present invention provides novel conjugates of a synthetic polypeptide containing RGD or (dR)GD and a biodegradable polymer, hyaluronate. The conjugates are prepared by any one of three...
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5677283 |
α-heteroaryloxymethyl ketones as interleukin - 1 β converting enzyme inhibitors
Compounds which Inhibit interleukin-1β protease activity, pharmaceutical compositions containing the compounds and methods using the compounds are provided. The compounds have the formula ##STR1##...
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5674848 |
Bioreactor compositions with enhanced cell binding
Compositions of the invention include packing materials having compounds thereon with enhanced cell binding with respect to collagen. These packing materials are useful for in vitro uses such as...
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5674978 |
Peptides derived from glutamic acid decarboxylase
Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.
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5674977 |
Branched synthetic peptide conjugate
The invention is a branched synthetic peptide conjugate which can be designed to bind to a target cell surface receptor, to penetrate into target cells, and to deliver a diagnostic probe or...
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