|
Match
|
Document |
Document Title |
|
|
6251625 |
Process for preparing peptides and N-carbamoyl-protected peptides
The invention concerns a process for the enzymatic preparation of protected di- and oligopeptides and the separation of the protective groups used. The process according to the invention enables...
|
|
|
6248865 |
Compounds useful for the synthesis of dolastatin analogs
Compounds of the formula ##STR1## where R 1 , R 2 , R 3 and R 4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting...
|
|
|
6248587 |
Method for promoting mesenchymal stem and lineage-specific cell proliferation
The present invention fulfills a need in the art for methods that promote hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of...
|
|
|
6245742 |
Peptide antagonists of cellular mitogenesis and motogenesis and their therapeutic use
The present invention relates to peptides and peptidomimetic compounds and pharmaceutical compositions containing them as useful pharmacological agents in the control or treatment of proliferative...
|
|
|
6245738 |
Cytokine restraining agents
The present invention provides novel cytokine restraining agents, which limit or control the biological activity of cytokines. The invention also provides pharmaceutical compositions comprising a...
|
|
|
6242432 |
Antithrombotic organic nitrates
Compounds or compositions containing compounds of the formula A-(X 1 --NO 2 ) to or salts thereof, for the preparation of antithrombotic medications wherein "to" is the integer 1 or 2X 1 is an...
|
|
|
6239104 |
Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18
Cytostatic linear and cyclo-depsipeptides, "Dolastatin 16", "Dolastatin 18", and "Dolastatin 17", are disclosed which are obtained from Indian Ocean shelless mollusk Dolabella auricularia. Methods...
|
|
|
6239110 |
Synthetic analogs of thrombospondin and therapeutic use thereof
Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
|
|
|
6239107 |
Conjugates of lipophilic moieties and fragments of vasoactive intestinal peptide (VIP)
The invention concerns novel conjugates of peptide fragments of vasoactive intestinal peptide (VIP) or analogues thereof having 3-12 amino acid residues, and lipophilic moieties, which may be...
|
|
|
6235875 |
Process for producing depsipeptide derivatives and novel intermediates therefor
An industrially excellent alternative process for producing cyclodepsipeptide derivatives, as represented in formula (1), having an excellent vermicidal activity as an animal and human...
|
|
|
6235876 |
Liquid phase process for the preparation of GNRH peptides
A liquid phase process for preparing GnRH peptide analogs of the formula: G-AA 1 -(A)D-Phe-AA 3 -AA 4 -(R 2 -AA 5 -AA 6 -AA 7 -AA 8 -Pro-AA 10 -NH 2 Formula 1 which comprises: (a)...
|
|
|
6228841 |
Peptide derivatives
Compounds represented by the following general formula and salts thereof; Y-L-Tyr-Q-NR 1 --CH(R 2 )--CO--X, wherein R 1 represents hydrogen or C 1 -6 alkyl; R 2 represents optionally substituted...
|
|
|
6222020 |
Antigens derived from the core protein of the human mammary epithelial mucin
Antigens are derived from the tandem repeat sequence of the core protein of a human polymorphic epithelial mucin. These antigens include a core protein epitope which is recognized by certain...
|
|
|
6211155 |
Peptide conjugates derived from thymic hormones, their use as a medicament and compositions containing them
The invention relates to peptide conjugates comprising a sequence of at least 3 amino acids derived from a thymic hormone selected amongst thymuline and thymopoietine, the amino acids being...
|
|
|
6211156 |
Peptides for treatment of erectile dysfunction
The present invention relates to small peptides that cause penile erections in male animals when injected into the paraventricular nucleus of the hypothalamus or when given systemically...
|
|
|
6207399 |
Methods of determining endogenous thrombin potential (ETP) and thrombin substrates for use in said methods
A method for determining the endogenous thrombin potential of a sample having a total anticoagulant activity of or equivalent to at least 0.07 U ISH/ml, includes using a thrombin substrate or a...
|
|
|
6204013 |
MSP-5 nucleic acid molecules and uses therefor
The invention provides isolated nucleic acid molecules, designated MSP-5 nucleic acid molecules, which encode novel myocardium secreted proteins. The invention also provides antisense nucleic acid...
|
|
|
6200801 |
Serpin enzyme complex receptor-mediated gene transfer
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may...
|
|
|
6194143 |
Substrates for human cytomegalovirus protease
Human cytomegalovirus (HCMV) protease is a slow-processing enzyme in vitro. Disclosed herein are improved fluorogenic and radiometric peptide substrates for CMV protease. The improved substrates...
|
|
|
6194378 |
Fibronectin peptides-based extracellular matrix for wound healing
The invention provides an extracellular matrix for wound healing comprising peptides from two or more fibronectin domains in a backbone matrix. In one embodiment, the subject invention provides a...
|
|
|
6194544 |
Cyclic semi-random peptide libraries
Cyclic penta- and hexa-peptide libraries containing one or more known amino acids, one or more randomized amino acids and a conformationally constraining element are disclosed. These peptide...
|
|
|
6194543 |
Dendritic polypeptides
A dendritic compound comprises two dendrons, each comprising dendritically linked amino acid units, preferably lysine units, joined to a focal group. One of the dendrons includes terminal branches...
|
|
|
6191256 |
Recombinant factor VIII binding peptides
Peptides that have domains that bind to recombinant factor VIII (rFVIII) are disclosed. A method of rFVIII binding assay using the peptides deduced from a combinatorial library in a filtration...
|
|
|
6180600 |
CD8 antagonists
Compounds that inhibit CD8 mediated T cell activation and that have a molecular surface that corresponds to the molecular surface of human CD8 at amino acids 38-46 and/or 53-56 and/or 60-67 and...
|
|
|
6180610 |
Tetrapeptide
The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same...
|
|
|
6180759 |
Process for the preparation of azacycloalkylakanoyl pseudotetrapeptides
This invention is directed to a process for preparing a pseudotetrapeptide of formula I ##STR1## or a salt or prodrug thereof wherein ##STR2## is optionally nitrogen protected azaheterocyclyl;...
|
|
|
6180095 |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: L 1 is a bifunctional...
|
|
|
6174858 |
Conjugates useful in the treatment of prostate cancer
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are...
|
|
|
6172043 |
Treatments for neurotoxicity in Alzheimer's disease caused by β amyloid peptides
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds...
|
|
|
6172044 |
Acylated enol derivative of α-ketoesters and α-ketoamides
This invention relates to acylated enol derivatives of α-ketoesters and α-ketoamides. The compounds of this invention are either prodrugs of known elastase inhibitors or are elastase inhibitors...
|
|
|
6159940 |
Method for modulating hemopoiesis
A peptide of the formula I X--Glu--Trp--Y (I) wherein X is H or Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal,...
|
|
|
6160087 |
Peptides having an amino acid sequence from the fimbrial protein of porphyromonas gingivalis and their uses
There are provided peptides (each having 5 to 10 amino acid residues) corresponding to fragments derived from the amino acid sequence of the 41 kD sub-unit protein constituting the fimbriae of...
|
|
|
6159938 |
Serine protease inhibitors comprising α-keto heterocycles
Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of...
|
|
|
6153391 |
Interruption of binding of MDM2 and P53 protein and therapeutic application thereof
A method for interfering with the binding between p53 and MDM2 or a protein having a p53 binding site analogous to that of MDM2, which method comprises administering a effective amount of a...
|
|
|
6153393 |
Elimination of interference in diagnostic methods by peptides comprising D-amino acids
The invention concerns the use of peptides which are comprised essentially of D-amino acids to eliminate interference in diagnostic methods, a method for eliminating interference in diagnostic...
|
|
|
6150325 |
Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical compositions
This invention relates to novel compounds of general formula (I): ##STR1## and to pharmaceutical compositions containing them.
|
|
|
6147188 |
α- (1,3- or 1, 2- dicarbonylenol ether methyl ketones as cysteine protease inhibitors
Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease...
|
|
|
6143715 |
Hepatitis C inhibitor peptide analogues
Compound of formula (I) active against the Hepatitis C virus: ##STR1## wherein B is an acyl derivative; a is 0 or 1; R 6 , when present, is carboxy(lower)alkyl; b is 0 or 1; R 5 , when present, is...
|
|
|
6143722 |
Heptapeptide oxytocin analogues
Heptapeptide analogues or pharmaceutically acceptable salts thereof consist of a hexapeptide moiety S and a C-terminal β-aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the...
|
|
|
6143719 |
Bradykinin analogs as selective thrombin inhibitors
Thrombin-induced and ADP-induced platelet and other cell activation is inhibited without affecting thrombin's other proteolytic activity by administration of a bradykinin sequence related analogous...
|
|
|
6140465 |
Bau, a BIN1 interacting protein, and uses therefor
A murine cDNA clone encoding a BIN1-Associated U1-specific protein (Bau) are provided. Also provided are methods of using the nucleic acid sequences, polypeptides, and antibodies directed against...
|
|
|
6140127 |
Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
Endothelial cell attachment to an intravascular stent is promoted by coating the stent with an endothelial cell specific adhesion peptide. Coating is preferably carried out by activating the...
|
|
|
6140068 |
Protease resistant compositions for wound healing
Assays employing fibronectin-depleted substrates are described to identify invasion inducing agents. Such agents are useful for in vivo wound healing, including but not limited to deep wounds and...
|
|
|
6136781 |
LH-RH receptor antagonists
The LH-RH receptor antagonists containing cyclic pentapeptides or salts thereof and novel cyclic pentapeptide or salts thereof are provided. The LH-RH receptor antagonists of the present invention...
|
|
|
6136798 |
Compounds inhibiting the association of the PDGF receptor and phosphatidylinositol 3-kinase and their use
The present invention provides compounds that inhibit the association of platelet-derived growth factor and phosphatidylinositol 3-kinase. The present invention also provides pharmaceutical...
|
|
|
6136787 |
Interleukin 1β protease and interleukin 1β protease inhibitors
There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1β and for a substrate comprising: R 1 -Asp-R 2 -R 3 wherein R 1 ...
|
|
|
6133233 |
Peptide modulation of reperfusion injury
An in vivo method of reducing reperfusion injury in a mammal resulting from reperfusion of a temporarily occluded blood vessel which comprises the steps of administering into the mammal's...
|
|
|
6130315 |
Peptidase inhibitors
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone...
|
|
|
6127339 |
Peptide for binding thereto a low density lipoprotein
Disclosed is a peptide for binding thereto a low density lipoprotein, which has an amino acid sequence represented by the formula (I) or (II) and which has an electric charge (E) satisfying the...
|
|
|
6121240 |
Urokinase receptor ligands
Compounds of the invention inhibit urokinase plasminogen activator or uPAR: ##STR1## where R 10 is --CH(R 9 )XCH(R 1 )(R 11 ) or a capping group, where X is NR 12 , CR 12 R 15 , O, S, SR 12 , or...
|