Match Document Document Title
9040663 Melanocortin receptor-specific peptides  
The invention relates to melanocortin receptor-specific cyclic peptides of Formula (I) or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4a, R4b, R4c, R5, x and y are as defined in...
9035023 Bombesin analog peptide antagonist conjugates  
To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one...
9035024 Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins  
Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds.
9034824 Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof  
Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such...
9029321 Methods and compositions for targeting adipose cells in mammals  
Methods and compositions are presented for use in diagnostic, imaging or targeting of therapeutic agents to treat obesity/adiposity-associated disorders, where such as compositions and methods...
9029329 Caspase-14 activator peptides and compositions comprising said peptides  
The invention relates to peptidic compounds of general formula (I) R1-(AA)n-X1-X2-Ile-Gln-Ala-Cys-Arg-Gly-X3-(AA)p-R2 as caspase-14 activators. The invention also relates to a cosmetic or...
9029327 Vaccine  
Vaccine comprising a peptide bound to a pharmaceutically acceptable carrier, said peptide having the amino acid sequence (Formula I)(SEQ ID NO: 1)(X1)m(X2)n(X3)oX4X5HPX6, for treating and/or...
9029502 Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction  
Provided herein are compounds that inhibit a binding interaction between an epidermal growth factor receptor (EGFR) and a heat shock protein 90 (HSP90), as well as compositions, e.g.,...
9023957 Compound for use in peptide synthesis  
The present invention generally relates to processes and methods of peptide and protein synthesis. The present invention also relates to specific compounds for use in such processes and methods....
9023803 Cancer therapy based on tumor associated antigens derived from cyclin D1  
The present invention relates to cyclin D1-derived peptides for use in the improved treatment of cancer in a patient, particularly in the form of a combination therapy using a vaccine. Other...
9018351 Peptide aptamers against tenascin C  
The present invention relates to an anti-tenascin C peptide aptamer having a specific amino acid sequence and a diagnosis kit comprising it. The anti-tenascin C peptide aptamer of the instant...
9012403 Peptides as active agents to stabilize biological barriers  
The present invention relates to compounds, in particular peptides which are capable of stabilizing barrier functions of epithelium and endothelium. The peptides and other compounds of the present...
9011816 Fibronectin targeting contrast agent  
Example systems and methods enhance contrast in MRI images. To facilitate imaging of atherosclerotic plaques, arterial and venous, cardiac, and even tumor tissues and fibrosis, a...
9006404 Endometriosis cell targeting peptide and uses thereof  
Provided herein are compositions and methods for selectively targeting an endometriosis cell.
9006183 Methods of protecting against apoptosis using lipopeptides  
The use of lipopeptides as inducers of NF-κB for the protection of mammals from the effects of apoptosis is described.
9000125 Approach to treat intraocular hypertension  
The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the...
8999925 Arenavirus inhibiting peptides and uses therefor  
The present invention describes peptides which inhibit fusion of an arenavirus (e.g., Pichinde virus; PICV) with a host cell membrane. The arenavirus inhibiting (AVI) peptides described herein...
8999349 HMGB1-derived peptides enhance immune response to antigens  
The invention provides an immunostimulatory peptide containing the amino acid sequence SAFFLFCSE and uses thereof. The invention also provides an immunostimulatory peptide containing the amino...
8999919 Compositions and methods for inhibiting the interaction between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8999937 Glucocorticoid induced leucine zipper mimetics as therapeutic agents in multiple sclerosis  
Polypeptide compositions that mimic the activity of glucocorticoid induced leucine zipper (GILZ) on the immune system are described. Also described is a method of treating multiple sclerosis using...
8999939 Hair treatment agents having low-dose oligopeptides  
A hair treatment agent having advantageous properties is provided. The hair treatment agent contains, based on weight of the agent, 0.00001 to ≦0.05% by weight of at least one oligopeptide having...
8993720 Methods for the treatment of X-linked hypophosphatemia and related disorders  
The disclosure provides methods of treating X-linked hypophosphatemia, related bone demineralization and renal phosphate wasting disorders in a mammalian subject. The methods comprise...
8987377 Poly(amide) polymers for the delivery of oligonucleotides  
The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
8986655 Compositions, devices, and methods related to prostate-specific membrane antigen  
PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino...
8986712 Peptides derived from HIV-1 gp41 transmembrane domain for t-immunomodulation  
The present invention relates to peptides, derivatives and analogs comprising an amino acid sequence derived from the transmembrane domain of HIV gp41 protein, pharmaceutical compositions...
8975371 Melanoma antigen peptide and uses thereof  
The present invention relates to novel melanoma antigen peptides and specific T lymphocytes directed to said peptides and the use thereof for treating melanoma.
8968745 Method of treating cancer with an HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same  
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid...
8969252 Peptide mediated synthesis of metallic and magnetic materials  
The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific...
8969296 TGFP-CAP peptide and its uses  
The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence...
8961989 Methods for producing an immune response to tuberculosis  
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
8961971 Bispecific T-cell activator antibody  
This invention relates to bispecific antibodies having combinations of linker and hinge sequences to create linker-hinge interface domains with biological significance. Such linker-hinge interface...
8962797 Halogenated compounds for photodynamic therapy  
Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such...
8962565 Peptides involved in the SCF c-Kit signaling pathway and compositions comprising same  
Peptide compounds of general formula (I) R1-(AA)n-X1—X2—X3-Asp-Leu-Lys-Lys-X4—X5-(AA)p-R2, cosmetic or pharmaceutical compositions comprising at least one peptide compound of general formula (I)...
8961985 Immunotherapy against several tumors including neuronal and brain tumors  
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present...
8957030 Methods for preventing or treating mitochondrial permeability transition  
The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at...
8956869 Peptide inhibiting differentiation of hematopoietic stem cells or hematopoietic precursor cells and use of same  
The present invention provides a novel peptide that can be effectively used to produce or grow tissue-specific stem cells or tissue-specific progenitor cells in vitro. The peptide of the invention...
8957185 MUC-1 cytoplasmic domain peptides as inhibitors of cancer  
Peptides from the MUC1 cytoplasmic domain and methods of use therefor are described. These peptides can inhibit MUC1 oligomerization, thereby preventing tumor cell growth, inducing tumor cell...
8957022 Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis  
The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates...
8957032 Inhibition of gliadin peptides  
Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers are identified. Assays for determining...
8956878 Polypeptides with affinity for heat shock proteins (HSPS) and HSP associated complexes (HACS) and their use in diagnosis and therapy  
The present application is directed to a peptides comprising an a-helix forming-amino acid sequence that binds a heat shock protein. Also included is a polypeptide comprising (a) a first peptide...
8951963 Active cores of peptide triazole HIV-1 entry inhibitors  
The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use. The invention also provides an antibody to the peptide triazole conjugate. The invention...
8952128 Somatostatin-dopamine chimeric analogs  
The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors,...
8951975 ECT2 peptides and vaccines including the same  
Isolated peptides derived from SEQ ID NO: 42 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer...
8952127 Peptoids useful for catalyzing the mineralization of calcium carbonate  
The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.
8945578 Method of treating cancer with an HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same  
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid...
8946150 Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof  
The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of...
8940864 Stabilized therapeutic small helical antiviral peptides  
Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting...
8940865 Myocardial peptide, preparation method and uses thereof  
Disclosed are two myocardial peptides, whose amino acid sequences are Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe and Lys-Gly-Ala-Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe respectively,...
8940545 Mass spectrometry quantitation of P450 isoforms in hepatocytes  
A method for screening a drug for cytochrome P450 (CYP) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one...
8937154 Stabilized therapeutic small helical antiviral peptides  
Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting...