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7619059 |
Bimolecular optical probes
Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically...
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7619057 |
MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1
The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are...
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7615533 |
TPO peptide compounds for treatment of anemia
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7612171 |
DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7612168 |
Modified HIV peptides, antigens, compositions, immunoassay kit and a method of detecting antibodies induced by HIV
The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7612162 |
Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for...
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7611711 |
VEGFR-3 inhibitor materials and methods
The present invention relates to the diagnosis, evaluation, and therapeutic intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated...
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7605227 |
Melanoma antigen peptide analogues
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
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7605150 |
Drug therapy for Celiac Sprue
Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the...
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7601801 |
HLA-A24 binding cancer antigen peptide derived from livin
The present invention provides a partial peptide consisting of 8-11 contiguous amino acids in the amino acid sequence of livin set forth in SEQ ID NO: 1, which binds to HLA-A24 antigen and is...
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7601694 |
CLK-peptide and SLK-peptide
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially...
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7598344 |
Composition, method and use of bi-functional biomaterials
The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a...
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7597904 |
Metalloproteinase inhibitory agent
The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The...
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7592424 |
Ion channel-like polypeptide and use thereof
A single polypeptide is disclosed that without the need of any direct ion flow, is capable of converting electrical signals to chemical signals. The polypeptide of at least one embodiment of the...
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7592421 |
HLA class II peptide mimics
The present invention provides peptide mimics for HLA class II antigens. The peptide mimics were identified by panning phage display peptide libraries with anti-HLA class II monoclonal antibodies....
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7589170 |
Synthesis of cyclic peptides
This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in...
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7589063 |
Molecules which promote hematopoiesis
Peptides, methods for the preparation thereof, medicaments containing the peptides, and their use in selected indications, such as the treatment of various forms of anemia and stroke.
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7589058 |
Ghrelin analogs
The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.
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7585939 |
Chromatin peptides blocking human HIF-1α gene and modulating the downstream related genes
Chromatin peptide drug molecules, which can block human cell hypoxia responsive pathway, are DNA affinity structural domain of related transcription genes or their imitating molecules or...
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7582610 |
Melanocortin receptor templates, peptides and use thereof
The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to...
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7579435 |
Somatostatin-dopamine chimeric analogs
Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is:...
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7579434 |
Peptide having ability to activate cancer-related gene
To provide a cancer diagnostic reagent for determining malignancy of a cancer patient or a cancer cell and a tendency of canceration of a healthy subject, the reagent including a peptide having an...
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7579165 |
Methods for derivatizing protein or peptide with sulfonic acid groups
The present invention provides a method for effectively introducing sulfonic acid groups into the N-terminus of a protein or a peptide. The method comprises a modification step to react a...
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7576176 |
Neisseria meningitidis antigens and compositions
The invention provides proteins from Neisseria meningitidis , including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for...
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7576175 |
Alpha-4 beta-1 integrin ligands for imaging and therapy
The present invention provides α 4 β 1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino...
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7576056 |
Peptides and compounds that bind to a receptor
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7572883 |
Somatostatin-dopamine chimeric analogs
Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is:
...
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7569547 |
Inhibiting furin with polybasic peptides
Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can...
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7569542 |
Anti-microbial targeting chimeric pharmaceutical
The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target...
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7569225 |
Immunogenic lipopeptides comprising T-helper and B-cell epitopes
The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary...
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7566697 |
Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides
The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the...
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7566695 |
Multimeric apoprotein agonists
The present invention provides multimeric apoprotein agonists. Pharmaceutical compositions which include a multimeric apoprotein agonist and a pharmaceutically acceptable carrier, excipient or...
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7563864 |
Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
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7563762 |
Composition and process for stabilizing of biomolecules
The present invention relates in general to the field of biotechnology. The invention particularly relates to a composition and process for stabilizing or preserving biological molecules, as well...
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7553926 |
Compositions containing anti-HIV peptides and methods for use
Peptides representing sequences from region 45-74 of the human CD38 leukocyte surface antigen (SEQ ID NO:1) are provided which may be used to inhibit or prevent transmission or replication of the...
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7550558 |
Antimicrobial peptides and methods for identifying and using such peptides
This invention relates to a method for identifying peptides having antimicrobial activity and to the antimicrobial peptides identified thereby and methods for their use.
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7550438 |
Methods for production of growth-promoting proteins and peptides for kidney epithelial cells
Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney...
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7550436 |
Compositions containing peptide and electrolyte excretion promoter and foods containing the same
A composition containing a peptide and an electrolyte excretion promoter, which comprises a peptide or a peptide mixture which is obtained by lysing a food-origin protein with a protease and has an...
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7550425 |
Diuretic peptide conjugates
Disclosed are a variety of peptide conjugates represented by the following general formula:
R 1 -Z-X-Z′-R 2
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7547677 |
Plant virus transmission inhibitor and methods
Provided is a peptide, peptide multimer or fusion protein containing such peptide which binds to the gut of sap-sucking insects, e.g., aphids. When bound, this peptide inhibits the binding of...
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7547676 |
Antagonist peptides to the C5A chemotactic function of vitamin D binding protein
It has been demonstrated that one of Vitamin D Binding Protein (DBP) biological functions is to enhance the chemotactic activity of C5 a and C5 a des Arg. The present invention has found that...
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7547440 |
T-cell epitope peptides
The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen...
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7544772 |
Methods for regulating inflammatory mediators and peptides useful therein
The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators...
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7541430 |
Peptides for use in treating obesity
Novel cyclic and linear peptides of the formula R 1 —X—X 1 —X 2 —X 3 —X 4 —X 5 —X 6 —X 7 —X 8 —X 9 —X 10 —X 11 —R 2 are useful in the treatment of obesity are provided.
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7541429 |
Comparative ligand mapping from MHC positive cells
The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the...
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7541027 |
Use of an epitope of vascular endothelial growth factor receptor KDR/Flk-1
The present invention relates to the use of the epitope which comprises the tyrosine at position 1214 in the amino acid sequence of the vascular endothelial growth factor receptor, KDR/Flk-1, as a...
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7538083 |
Compositions and methods for the potentiation of immune responses against target antigens
The present invention provides novel adjuvant systems for the potentiation of immune responses against antigenic targets.
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7537757 |
Methods of facilitating vascular growth in cardiac muscle and methods for the production of recombinant EMAP II
A method of facilitating vascular growth in cardiac muscle of a subject in need of such treatment comprises inhibiting EMAP II activity in said subject by an amount effective to stimulate vascular...
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7534857 |
Methods and compositions for the treatment and prevention of staphylococcal infections
A biologically pure RNAIII inhibiting peptide (RIP), that includes five contiguous amino acids of the sequence YX 2 PX 1 TNF, where X 1 is C, W, I or a modified amino acid, and X 2 is K or S is...
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7531516 |
Peptidic compounds selectively binding to P-selectin
The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XA x...
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