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6743769 |
Antimicrobial peptides and derived metapeptides
The peptides and derivative metapeptides based upon natural antimicrobial peptides have potent and broad spectrum activity against pathogens exhibiting multiple antibiotic resistance. In addition,...
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6737507 |
Antiangiogenic peptides and compositions thereof
The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1 or a portion thereof which is effective to inhibit endothelial cell...
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6737406 |
Cryptic peptides and method for their identification
The present invention relates to immunologically cryptic peptides; methods for their identification in individuals and populations and their use in diagnosis and therapy of pathological conditions...
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6734166 |
Method of reducing aluminum levels in the central nervous system
A method of reducing aluminum concentrations in the central nervous system of a subject (e.g., a patient afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease) comprises...
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6723830 |
Short peptides which selectively modulate the activity of protein kinases
Peptides which are peptide derivatives of the αD region of a protein kinase can modulate the activity of protein kinases. The activity of a protein kinase in a subject can be modulated by...
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6723695 |
CTL epitopes from EBV
The present invention provides cytotoxic Epstein-Barr virus (EBV) T-cell epitopes derived from EBV structural antigens. Preferred epitopes include YLLEMLWRL (SEQ ID NO:1), YFLEILWGL (SEQ ID NO:32),...
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6716809 |
Mage-A3 peptides presented by HLA class molecules
The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides...
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6716810 |
Composition and method for regulation of body weight and associated conditions
Described are methods and compositions for regulating body weight and/or regulating the rate of weight gain or loss, and particularly, for treating or preventing obesity. Specifically, methods of...
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6713449 |
E2F activity inhibitory compounds
E2F-inhibiting compounds are represented by the formula: R 1 —A—R 2 wherein A represents a peptide sequence comprising a partial amino acid sequence having at least 12 continuous residues in...
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6713062 |
Acinetobacter outer membrane protein and gene sequence compositions and methods
Disclosed are new outer membrane proteins and nucleic acids from Acinetobacter and related biological compositions and methods. The biological materials provided are useful in diagnostic,...
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6706859 |
HIV peptides, antigens, vaccine compositions, immunoassay kit and a method of detecting antibodies induced by HIV
The present invention comprises novel and modified peptides capable of inducing an HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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6706685 |
Compounds and methods for stimulating β-catenin mediated gene expression and differentiation
Modulating agents for inhibiting degradation of cytoplasmic β-catenin are provided. The modulating agents comprise one or more of: (1) the peptide sequence SYLDS(PO 4 )GIHS(PO 4 )G (SEQ ID NO:1)...
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6706487 |
Monoclonal antibody and the method of using the antibody
Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
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6703480 |
Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R 1 and a second...
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6699965 |
Peptides that activate the G-protein coupled receptor protein, 0T7T175
G Protein-coupled receptor proteins originating in the vicinity of rat brain stem and human brain or salts thereof, or peptide fragments thereof or amides, esters or salts of the same; ligands...
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6699834 |
Method for treating cancer
The present invention relates to peptides of one or more portions of the human chorionic gonadotropin β-chain as well as methods for treatment of cancer, using human chorionic gonadotropin,...
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6699838 |
Antiangiogenic peptides
Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also...
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6699833 |
Pharmaceutical formulations for sustained drug delivery
Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high...
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6699656 |
Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
The present invention relates to β-hCG, particularly β-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention...
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6696559 |
Antimicrobial peptides and methods of use
Novel antimicrobial peptides from bovine and murine neutrophils are provided. The peptides, designated bovine granulocyte peptide A (BGP-A) and murine granulocyte peptide A (MGP-A) were purified to...
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6696274 |
Ligand for enhancing oral and CNS delivery of biological agents
Provided herein is a novel and useful Ligand comprising a peptide comprising an amino acid sequence of SEQ. ID. NO.:6, an analog, a derivative, or a variant thereof, which increases the absorption...
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6696061 |
Immunomodulatory peptides
A purified preparation of a peptide consisting essentially of an amino acid sequence identical to that of a segment of a naturally-occurring human protein, said segment being of 10 to 30 residues...
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6693170 |
ARIP4 gene and protein
This invention relates to a novel nuclear protein which interacts with the androgen receptor in vivo and in vitro, and which also possesses ATPase activity. The invention concerns also mRNA and DNA...
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6689363 |
Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions
This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application...
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6686333 |
Inhibition of HIV replication using soluble Tat peptide analogs
Methods and compositions for inhibiting replication of HIV in a mammalian cell. The compositions can be a peptide, or a nucleic acids encoding a peptide, which inhibits transactivation of the HIV...
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6686444 |
Osteopontin derived chemotactic peptides and methods of use
Novel osteopontin derived chemotactic peptides are described. The peptides (or antagonists thereof) are useful in treating conditions or diseases associated with chemotaxis.
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6682740 |
Peptides derived fram complement peptide C3a sequence and antiallergic compositions comprising them
Peptides corresponding partially or entirely to positions 50-77 of the sequence of the complement-derived peptide C3 a and analogs thereof are capable of inhibiting IgE-mediated triggering and/or...
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6677431 |
Design, preparation, and properties of antibacterial β-peptides
An antibacterial β-peptide having the following formula: wherein R 1 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; R 2 is an amine-containing alkyl...
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6673770 |
Peptides for the treatment, prophylaxis, diagnosis and monitoring of autoimmune diseases
The invention provides a peptide suitable for the prophylaxis, treatment, diagnosis or monitoring of arthritis. The peptide contains a contiguous sequence element of 9 amino acid residues...
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6669946 |
METHOD FOR IDENTIFYING INDIVIDUALS SUFFERING FROM A CELLULAR ABNORMALITY SOME OF WHOSE ABNORMAL CELLS PRESENT COMPLEXES OF HUMAN LEUKOCYTE ANTIGEN TYROSINASE DERIVED PEPTIDES, AND METHODS FOR TREATING SAID INDIVIDUALS
The invention relates to complexes of human leukocyte antigen molecules and tyrosinase derived peptides SEQ ID NO: 2, on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications...
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6652860 |
Peptide, apoEp 1.B, compositions and uses thereof
A peptide derived from apolipoprotein E termed apoEp1.B which includes amino acids 239-252 of the apolipoprotein E is described. The apoEp1.B peptide is a potent immune modulator that acts on a...
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6653445 |
Human CCV polypeptides
The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and...
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6649739 |
Protein, its gene, reagents for inducing apoptosis, and anticancer agent
Novel proteins which have cell death inducing activity or proliferation inhibitory activity on cancer cells; fragments of such proteins; genes coding such proteins; monoclonal antibodies to such...
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6649166 |
Peptides and proteins for desensitizing subjects allergic to bee venom and compositions containing same
The invention concerns peptides and proteins for desensitizing specifically the vast majority of subjects allergic to bee venom and compositions containing said peptides or proteins. The peptides...
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6649746 |
Biological production of stable glutamine, poly-glutamine derivatives in transgenic organisms and their use for therapeutic purposes
The invention provides a bioproduction of glutamine rich peptides. These peptides are used for rehydration and nutrition therapy in patients and for enhanced nutrition in animals. The peptides may...
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6645934 |
Peptide with radio protective effect
The invention makes available a peptide having a radioprotective effect that comprises a modified form and/or an optionally modified fragment of the Bowman-Birk protease inhibitor (BBI).
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6642356 |
Peptides which function as hinge regions in protein
Peptides comprising the amino acid sequence set forth in SEQ ID NO:1 are described wherein the amino acid at position 7 of SEQ ID NO:1 and the amino acid at position 8 of SEQ ID NO:1, which may...
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6641815 |
Sequestrin
In this application is described the expression cloning and functional characterization of the CD36-binding domain of Sequestrin. Sequestrin is a surface protein of 215-250 kD size which does not...
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6638531 |
Antimicrobial peptides
The present invention relates to peptides with antimicrobial activity, consisting of an amino acid chain which contains a domain of 10 to 25 amino acids, wherein the majority of the amino acids of...
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6635740 |
Ligand/lytic peptide compositions and methods of use
Amphipathic lytic peptides are ideally suited to use in a ligand/cytotoxin combination to specifically inhibit cells that are driven by or are dependent upon a specific ligand interaction; for...
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6630583 |
Antibiotics and methods of using the same
The present invention discloses novel antibiotic peptides, including naturally occurring peptides. The present invention also includes the nucleic acid sequences encoding such peptides and the...
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6630572 |
Thrombin derived polypeptides: compositions and methods for use
Thrombin is now known to mediate a number of potent biological effects on cells bearing high-affinity thrombin receptors. These effects depend, at least in part, upon receptor occupancy signals...
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6630570 |
Short-chain peptide-dye conjugates as contrast media for optical diagnosis
The invention relates to compounds for tumor diagnosis that consist of conjugates of dyes with short-chain peptides, which are derived from vaso-active intestinal peptide, somatostatin or...
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6627729 |
TML peptides
The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in...
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6627730 |
Staphylococcal ABC transporter protein
The present invention concerns the treatment and diagnosis of Staphylococcal infections, particularly those of Staphylococcus aureus, and provides a protein, epitopes of same, and antibodies and...
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6627604 |
Memno peptides, process for their preparation and use thereof
The invention relates to novel peptide derivatives, called memno peptides, of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and (A)n have the meaning herein, obtainable...
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6624289 |
Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor
Novel polypeptides or derivatives comprising the factor VIIIa binding site on factor IXa are disclosed. The novel polypeptides or derivatives have anti-coagulation activity. Nucleic acids encoding...
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6620416 |
Method for treating HIV
The present invention relates to peptides of one or more portions of the human chorionic gonadotropin β-chain as well as methods for treatment and prevention of diseases, including HIV infection,...
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6617425 |
Peptides
The invention provides novel β-peptides comprising 2 or more different β-amino acid residues, preferably compounds of formula I wherein the R residues, X and n are as defined. Compounds of the...
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6617424 |
Undecapeptides containing cysteinesulfinic and cysteinesulfenic acid
Disclosed are peptides represented by IVC 1 SLC 2 SC 3 TAW and C 1 SLC 2 SC 3 wherein I stands for isoleucine, V for valine, C 1 for cysteine, C 2 for cysteinesulfinic acid, C 3 for...
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