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7244701 |
Diuretic peptide conjugate
Disclosed are a variety of peptide conjugates represented by the following general formula:
R 1 -Z-X-Z′-R 2
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7241740 |
Peptides as solubilizing excipients for transforming growth factor beta proteins
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension...
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7241580 |
Immunoaffinity chromatography using epitope tags to polyol-responsive monoclonal antibodies
Disclosed is a method of isolating, purifying, or concentrating a target compound. The method includes the steps of onjugating the target compound to an epitope for a polyol-responsive monoclonal...
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7238671 |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or...
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7238668 |
Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof
The present invention relates to a method for inhibiting the adhesion of one cell to another comprising interfering with the interaction between the extracellular matrix receptor and its ligand. ...
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7238665 |
Peptide marker targeting to nasopharyngeal carcinoma cell and application thereof
The present invention provides a peptide marker targeting to nasopharyngeal carcinoma (NPC) cells and application thereof. The peptide binds specifically to the cell surface of NPC cells. After...
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7235531 |
Tachykinin-like polypeptides and use thereof
The present invention relates to amino acid sequences for novel tachykinin polypeptides and base sequences encoding them, agonists and antagonists of such polypeptides, pharmaceutical compositions...
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7232881 |
Peptide containing Ser-Ser-Ser-Arg
A peptide, wherein the peptide is selected from the group consisting of Ser-Ser-Ser-Arg (SEQ ID NO: 1),
Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro (SEQ ID NO: 4), Ser-Ser-Ser-Arg-Arg (SEQ ID NO: 5),...
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7230074 |
Inhibitors of dipeptidyl-aminopeptidase type IV
Peptide inhibitors of dipeptidyl-aminopeptidase type IV (DP-IV) are provided. The peptide inhibitors have an isomeric purity of about 96–99 percent. The peptide inhibitors include one or more...
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7226991 |
Phenylalanine derivatives
Disclosed herein are phenylalanine derivative compounds of the following formula
W—Y—(AA) n —Z
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7226749 |
Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the...
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7223835 |
VEGF peptides and their use for inhibiting angiogenesis
A peptide having part or all of the amino acid sequence QKRKRKKSRYKSWSVP (which is part of VEGF) has the ability to inhibit angiogenesis.
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7223845 |
Synthetic glycosulfopeptides and methods of synthesis thereof
A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a...
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7220405 |
Peptide-based conditioners and colorants for hair, skin, and nails
Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants are...
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7220827 |
Compound binding to leukocytes and medicinal composition containing the compound in labeled state as the active ingredient
A compound that comprises Met-Leu-Phe or Nle-Leu-Phe serving as the leukocyte-binding site of a formyl peptide receptor (FPR), a binding part comprising Ser or Thr that increases the binding ratio...
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7220421 |
Moraxella bovis cytotoxin, cytotoxin gene, antibodies and vaccines for prevention and treatment of Moraxella bovis infections
Moraxella bovis cytotoxin and a gene encoding Moraxella bovis cytotoxin. Identification, isolation, cloning and identification of nucleotide sequence of the Moraxella bovis genes mbxA, mbxB,...
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7217690 |
Compositions of sunflower trypsin inhibitors
The present invention provides methods of using small cyclic peptides that can inhibit or prevent skin irritation caused by proteolytic activity.
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7214766 |
Peptides with enhanced stability to protease degradation
Disclosed are peptides that have enhanced stability against plant proteases and are useful in the control of plant diseases. The peptides also have the ability to protect other peptides,...
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7211424 |
Mammalian Subtilisin/kexin isozyme SKI-1: a proprotein convertase with a unique cleavage specificity
Using RT-PCR and degenerate oligonucleotides derived from the active site residues of subtilisin-kexin-like serine proteinases, we have identified a highly conserved and phylogenetically ancestral...
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7205382 |
Peptides, the production and use thereof for binding immunoglobulins
Peptides having the following amino acid sequence as well as peptides or proteins which contain this amino acid sequence:
R 1...
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7202331 |
Therapeutic anti-cytomegalovirus compounds
The present invention provides synthetic compounds, antibodies that recognize and bind to these compounds, polynucleotides that encode these compounds, and immune effector cells raised in response...
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7198903 |
Binding domains between presenilins and their substrates as targets for drug screening
The present invention relates to the identification of the molecular binding domains between presenilins and its substrates such as amyloid precursor protein and telencephalin. These binding...
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7192930 |
Method and peptide for regulating cellular activity
Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used...
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7193039 |
Synthesis of a potent parmagnetic agonist (epm-3) of the melanocyte stimulating hormone containing amino acid-type stable free radical
The present invention refers to the chemical synthesis and potentiality for application in several biochemical assays, of a potent agonist of the α-melanocyte stimulating hormone (α-MSH), labeled...
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7192928 |
T cell antigen receptor peptides
The present invention provides peptides which affect T-cells, presumably by action on the T-cell antigen receptor. The present invention further relates to the therapy of various inflammatory and...
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7193038 |
Extraction and utilization of cell growth-promoting peptides from silk protein
Peptides are provided having an excellent safety, stability due to relatively low molecular weights thereof, and cell growth promotion, which are different from cell growth factors produced by...
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7193043 |
Tropoelastin derivatives
The disclosure relates to derivatives of tropoelastin and variants of those derivatives. The disclosure further provides expression products and hybrid molecules of the derivatives and variants of...
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7193034 |
Synthetic peptides, conjugation reagents and methods
The invention provides methods and compositions useful for making synthetic peptide conjugates. In one embodiment, the invention provides compositions comprising the structure:
wherein R is...
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7192713 |
Stabilized compounds having secondary structure motifs
The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds...
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7192723 |
G protein-coupled receptor protein, its DNA and ligand thereof
The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various...
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7189694 |
Inhibitors of autophosphorylation protein kinases
The subject invention concerns peptide molecules that specifically inhibit the enzymatic function of tyrosine kinases, including the JAK and EGF receptor (EGFR) family of kinases, to...
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7183373 |
MNTF peptides and compositions and methods of use
The present invention is directed to novel peptides and compositions capable of modulating viability and growth in neuronal cells, and to methods of modulating neuronal cell viability and growth...
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7179785 |
Compounds that bind to p185 and methods of using the same
Novels peptides and pharmaceutical compositions comprising the same are disclosed. Conjugated compositions peptides linked to detectable agents and/or cytotoxic agents. are disclosed. Method of...
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7176281 |
Phospholipase A2-inhibitory peptide with anti-arthritic and neuroprotective activities
Peptides that have potent PLA 2 -inhibitory activity are disclosed. Homology searches of known PLA inhibitory molecules were used to identify and subsequently design potent peptide molecules that...
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7169574 |
Fluorescence detection of proteases or peptidases
The invention concerns the use of a PyA-(Z) x -pNF group in a substrate for detecting, identifying and/or analyzing by fluorometry peptidases or proteases capable of cleaving the or a bond between...
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7169814 |
Guanidinium transport reagents and conjugates
Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either...
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7169752 |
Compounds and compositions for prevention of overdose of oxycodone
The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of...
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7166695 |
Affinity markers for human serum albumin
Methods and compositions are provided for identifying compounds having affinity or complementarity to a target molecule. Compounds according to the invention may be described by the formula E-C a...
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7166694 |
Vaccine against cancerous diseases which is based on mimotopes of antigens expressed on tumor cells
The present invention provides a method for producing a vaccine against cancerous disease, and the vaccine itself. This method involves first using one or more antibodies that are specifically...
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7160554 |
Enhanced circulation effector composition and method
A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the...
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7160862 |
Integrin binding motif containing peptides and methods of treating skeletal diseases
Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan...
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7157091 |
MAGE-A1 peptides presented by HLA class II molecules
The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0–10 amino acids added to either or both ends of the amino acid...
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7157423 |
Fumaric acid amides
Fumaric acid amides of the general formula (I)
wherein R 1 represents OR 3 or a D- or L-amino acid radical —NH—CHR 4 —COOH bonded via an amide bond, wherein R 3 is hydrogen, a...
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7157225 |
Nucleotide sequences of HIV-1 type (or subtype) O retrovirus antigens
An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies...
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7153931 |
Transport vectors
The invention relates to modified and truncated forms of the membrane transport vector penetratin. Such truncated forms include 7-mer peptides that may in themselves include further variation.
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7148019 |
Recombinant polypeptides having Ph1 p I epitope antigenicity and methods of diagnosing allergy in vitro
A recombinant DNA molecule comprising a nucleotide sequence (I) which codes for a polypeptide displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 45,...
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7144854 |
Long lasting anti-angiogenic peptides
Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly...
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7144569 |
Diagnosis of coeliac disease using a gliadin epitope
A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope...
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7144982 |
Polypeptides with therapeutic activity and methods of use
Polypeptides and methods of use including treating bacterial infection and/or endotoxemia, decreasing the amount of TNF-α, inhibiting endothelial cell proliferation, inhibiting angiogenic-factor...
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7138488 |
Polypeptides having anti-HIV activity and compositions comprising same
Polypeptides of A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7 (I) or their salts (wherein A1 is hydrogen or a residue of arginine, lysine, ornithine, citrulline, alanine, or the like; A2 is an...
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