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6306822 |
Phosphopeptides and methods of treating bone diseases
Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or...
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6303574 |
Scr SH3 binding peptides and methods of isolating and using same
Peptides having general and specific binding affinities for the Src homology region 3 (SH3) domains of proteins are disclosed in the present invention. In particular, SH3 binding peptides have been...
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6303573 |
Heart homing peptides and methods of using same
The present invention provides a heart homing peptide that contains the amino acid sequence GGGVFWQ (SEQ ID NO: 2); HGRVRPH (SEQ ID NO: 3); VVLVTSS (SEQ ID NO: 4); CLHRGNSC (SEQ ID NO: 9); or...
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6303123 |
Methods for the treatment of hormone-dependent tumors with immunogens against gonadotropin releasing hormone
Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal...
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6300083 |
Assaying D-amino acids in body fluids
The rate of degradation in vivo of a body protein is determined by measuring the amount of a D-amino acid containing fragment of the protein in a body fluid using an antibody capable of...
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6294650 |
Inhibition of mammalian telomerase by peptide nucleic acids
The invention relates to peptide nucleic acids that inhibit telomerase activity in mammalian cells.
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6291639 |
Metal-binding cystein-free peptides for diagnostic and therapeutical purposes, methods for their production, and pharmaceuticals containing these compounds
These invention relates to metal-complexing, cysteine-free peptides which may be coupled to an organ-specific probe directly or via a linker and are thus enriched as conjugates specifically in...
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6288035 |
Method of treating cancer with a 43 kD human cancer antigen
A tumor associated protein has been discovered to exhibit immunoreactivity to human monoclonal antibody L92. A ten amino acid peptide segment of the protein and a fourteen amino acid peptide which...
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6287787 |
Dimeric oligopeptide mixture sets
Dimeric oligopeptide mixture sets, their synthesis and use in determining the sequence of an oligopeptide dimer ligand that optimally binds to a receptor are disclosed. A dimeric oligopeptide...
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6287565 |
Modified HGP-30 heteroconjugates, compositions and methods of use
A heteroconjugate is formed by linking a T cell binding ligand (TCBL) such as Peptide J of β-2 microglobulin to a modified HGP-30 antigentic peptide fragment of p17 gag peptide, such as, for...
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6284734 |
Inhibitors against prostate-specific antigen
According to the present invention, there are provided inhibitors against prostate-specific antigen which comprise as a minimum unit a peptide consisting of Gly-Phe-Tyr-Lys-Lys-Lys-Gln-Ser-Arg, and...
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6281331 |
Methods and compositions for peptide synthesis
The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as "DP-178"; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and...
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6280964 |
Binding sites for phosphotyrosine binding domains
The present invention generally provides peptides that comprise a recognition sequence motif for phosphotyrosine binding proteins. In particular, the present invention provides peptides which...
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6281244 |
Therapeutic use for glycine
Glycine is indicated to prevent or treat acute or chronic graft rejection, optionally in combination with an immunosuppressant or an immunomodulating agent.
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6277955 |
Materials and method for the detection and treatment of Wegener's granulomatosis
The subject invention pertains to the identification of peptides useful in the detection and treatment of Wegener's granulomatosis.
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6271198 |
Constrained helical peptides and methods of making same
Provided are cyclized peptides with a constrained region(s) having an α-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use...
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6270777 |
Conserved metalloprotease epitopes
The present invention provides immunogenic compositions comprising peptides derived from the amino acid sequence of P. aeruginosa for protecting susceptible hosts against diseases caused by...
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6268159 |
Imaging of colorectal cancer using ST receptor binding compounds
Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or...
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6268347 |
Prosaposin-derived peptides
The invention provides a method of alleviating neuropathic pain in a subject by administering an effective amount of an active fragment of prosaposin to the subject. The invention also provides a...
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6268346 |
Peptides with organo-protective activity
Peptides having 8 to 15 amine acid residues and a molecular weight between 900 and 1600 Daltons. The peptides have a biological activity comparable to the protein BPC.
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6268164 |
Human goose-type lysozyme
The invention provides a human goose-type lysozyme (GOLY) and polynucleotides which identify and encode GOLY. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6265215 |
Isolated peptides which complex with HLA-Cw16 and uses thereof
This invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and...
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6265552 |
Biotinylation of proteins
Biotinylation peptides can be fused to other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo...
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6265539 |
Prophylaxis and therapy of acquired immunodeficiency syndrome
An active peptide consisting essentially of 7 to about 30 residue and having a sequence that corresponds to a conserved domain of an HIV protein is disclosed, as is a multimer containing that...
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6262228 |
IRAK3 polypeptides and methods
The invention provides methods and compositions relating to a novel kinase, IRAK3. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IRAK3 encoding...
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6262017 |
Peptides for altering osteoblast adhesion
Peptides containing the amino acid sequence, aa 1 -aa 2 -aa 3 -aa 4 -(Gly) n , devices for implantation coated with the peptides and methods for altering cell adhesion using the peptides are...
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6258931 |
Deoxyhypusine reagent and peptides
The invention relates to a method and reagent for the synthesis of peptides containing deoxyhypusine, the reagent having the formula: ##STR1## wherein: Q 1 and Q 2 may be the same or different...
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6255279 |
Cosmetic preparations containing vertebrate proteins and having antibacterial, antimycotical and antiviral action
A peptide which is a monomer, homodimer, heterodimer, homotrimer, heterotrimer, homotetramer or heterotetramer, and is based on the following amino acid sequence: TBL Gly Ile Gly Asp Pro...
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6255452 |
Epidermal growth factor inhibitor
A protein which is capable of inhibiting epidermal growth factor-induced cellular proliferation is disclosed, as well as a method of obtaining it from a host cell, and a method of obtaining the...
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6255462 |
Peptide tag for immunodetection and immunopurification
This invention discloses the incorporation of a peptide QRQYGDVFKGD (SEQ ID NO:1) from glycoprotein gE of Varicella zoster virus into a protein or polypeptide sequence for immunoisolation,...
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6251583 |
Peptide substrates for HCV NS3 protease assays
Novel chromogenic, fluorogenic and fluorescence polarization substrates which are useful in HCV NS3 protease and inhibitor assays.
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6251867 |
Antiangiogenic peptides and methods for inhibiting angiogenesis
Mammalian kringle 5 fragments are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.
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6251667 |
Camp-responsive transcriptional enhancer binding protein
This invention is directed toward the characterization and cloning of a cAMP-responsive transcription enhancer binding protein (CREB). This protein, CREB, is a transcriptional activator which...
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6248328 |
HIV-1 virus isolates of a subtype and its differential diagnostics, a vaccine against HIV-1 virus infections of this subtype and method of producing same, use of the HIV-1 virus isolates
Three new HIV-1 isolates HIV-1 D747(ECACC V92082718), HIV-1 D757(ECACC V92082719) and HIV-1 D760(ECACC V92082720) are disclosed, which represent a further independent subtype of the HIV-1 family...
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6245883 |
Anti-flammatory carbohydrate binding-peptides
The present invention is directed to lectin derived carbohydrate binding peptides or derivatives thereof useful for suppressing inflammatory responses, inducing tolerance to an antigen, and...
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6245742 |
Peptide antagonists of cellular mitogenesis and motogenesis and their therapeutic use
The present invention relates to peptides and peptidomimetic compounds and pharmaceutical compositions containing them as useful pharmacological agents in the control or treatment of proliferative...
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6242174 |
Discrimination between antibodies against HTLV-I, HTLV-II or related retroviruses, new peptides, detection of antibodies and immunoassay kits
A method of discriminating between specific antibodies in samples of sera or other body fluids from humans or other primates containing antibodies arising from infection with HTLV-I, containing...
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6239110 |
Synthetic analogs of thrombospondin and therapeutic use thereof
Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
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6239107 |
Conjugates of lipophilic moieties and fragments of vasoactive intestinal peptide (VIP)
The invention concerns novel conjugates of peptide fragments of vasoactive intestinal peptide (VIP) or analogues thereof having 3-12 amino acid residues, and lipophilic moieties, which may be...
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6239255 |
Versatile surface plasmon resonance biosensors
A method of binding a recognition element to a gold surface (24) comprising the steps of attaching a GBP-AP protein (10) to a gold surface (24), digesting away the AP domain of the protein (10)...
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6235716 |
Multivalent ligands which modulate angiogenesis
Disclosed are novel multivalent ligands represented by the following structural formula: ##STR1## B is a multilinker backbone. n is an integer from two to about twenty. Each L is a...
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6235872 |
Proapoptotic peptides dependence polypeptides and methods of use
The present invention provides substantially pure proapoptotic dependence peptides. The peptides consist substantially of the sequence of an active dependence domain selected from the group of...
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6232437 |
Isolated human tau peptide epitope which specifically binds monoclonal antibody AT120.
An isolated human tau peptide epitope which specifically binds monoclonal antibody AT120 consisting of the amino acid sequence selected from the group consisting of SEQ ID Nos. 2, 3, 4, 15, 16, 17,...
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6225441 |
Human fast-1 protein
hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent...
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6221577 |
Seroreactive regions on HPV 16-proteins E1 and E2
The invention relates to seroreactive regions on protein E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the...
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6218507 |
Synthetic peptides for the detection of trimethylamine (TMA) and their detection method and device
The present invention describes a peptide and analogues thereof, which is a fragment of an olfactory receptor protein capable of selectively binding to trimethylamine so that they are useful for...
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6218131 |
Materials and methods for detection of breast cancer
Disclosed are proteins indicative of breast cancer and of other cancers, and methods for their detection. Methods of the invention provide an improvement in cancer detection assays, especially in...
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6214795 |
Peptide compounds useful for modulating FGF receptor activity
This invention provides peptide compounds that bind to either a fibroblast growth factor (FGF) or a fibroblast growth factor receptor (FGFR) and, accordingly, are useful for modulating FGFR...
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6211151 |
Peptides with organo-protective activity, a process for preparation thereof and their use in therapy
Peptides having 8 to 15 amino acid residues and a molecular weight between 900 and 1600 Daltons. The peptides have a biological activity comparable to the protein BPC.
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6207161 |
Induction of cytolytic T-lymphocytes with cytomegalovirus polypeptides
Immunogens for use in human cytomegalovirus vaccines or skin tests which comprise human cytomegalovirus matrix proteins or fractions thereof are disclosed. It is also disclosed that such matrix...
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