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6395874 |
Retinal pigment epithelial protein which suppresses neutrophil macrophage superoxide generation
This invention presents a novel protein consisting essentially of purified retinal pigment epithelial protective protein (RPP) or purified biologically active variants thereof, or immunogenic...
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6391305 |
Conjugates useful in the treatment of prostate cancer
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA), hydrophilic oligopeptide blocking...
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6392014 |
Cloning of gene encoding the GP28.5 protein of Toxoplasma gondii; peptide fragments of said protein and their applications
The invention relates to cloning of the gene for the toxoplasma GP28.5 antigen. It also encompasses purified GP28.5 antigen preparations and antigenic polypeptides derived from said antigen, and...
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6391855 |
Compounds and methods for modulating junctional adhesion molecule-mediated functions
Methods for using modulating agents to enhance or inhibit junctional adhesion molecule (JAM)-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. The modulating agents...
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6387700 |
Cationic peptides, Cys-Trp-(Lys)n, for gene delivery
Compositions and methods are described for nucleic acid formulation for gene delivery. A new class of low molecular weight condensing agents, namely aromatic amino acid—containing peptides, are...
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6384188 |
Lipopolysaccharide-binding and neutralizing peptides
Substance which bind with high affinity to endotoxin (lipopolysaccharide [LPS]), and which are useful for the prevention or treatment of, for example, Gram-negative and Gram-positive bacterial...
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6380161 |
Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions
The present invention provides methods and compositions for treating cancer and chemotherapy-resistant cancers comprising a chemotherapeutic agent conjugated to or coadministered with a peptide.
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6368877 |
Self-assembling peptide surfaces for cell patterning and interactions
This invention describes self assembled monolayers (SAMs) manufactured by imprinting reactive peptides onto solid supports. The invention further relates to methods of preparing and using these...
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6369195 |
Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
Disclosed are nucleic acid and amino acid sequences encoded by a novel, prostate specific gene (UC41) and diagnostic techniques for the detection of human prostate cancer utilizing such nucleic...
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6365570 |
Pharmaceutical and diagnostic use of Serum Amyloid P component
The invention relates to the new use of Serum Amyloid P component (SAP) and/or endotoxin-binding fragments thereof for the preparation of a pharmaceutical composition for neutralizing...
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6365124 |
Compositions for detecting and surgically removing lymphoid tissue involved in tumor progression
Compositions are provided for detecting Tn antigen expressing-shed tumor antigen. The compositions include peptides having binding specificity for the Tn antigen; and a detector molecule comprising...
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6358511 |
Inhibitors of HIV infection
The present invention is directed to novel inhibitory compounds which are capable of reducing, eliminating, or preventing human immunodeficiency virus (HIV) infection. These compounds may be...
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6359112 |
Peptides used as agonists and/or inhibitors of amyloid formation and cytotoxicity and also for use in alzheimer's disease, in type II diabetes mellitus and in spongiform encephalophathies
Certain peptide molecules can be used as the basic structures (template molecules) for inhibiting and analysing amyloid formation and cytotoxicity in amyloid illnesses. These peptides have an...
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6358928 |
Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases
Novel α-amino and peptidyl sulfonyl imidazolides, a method for their synthesis, and a method for inhibiting serine proteases therewith are disclosed. Pharmaceutical compositions containing...
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6355616 |
Derivative compounds derived from or based on bactericidal/permeability-increasing protein
The present invention relates generally to derivatized antifungal compounds that are peptide-based constructs derived from or based on subsequences of Domain III (amino acids 142-169) of...
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6355617 |
Peptide derivatives
The invention concerns pharmaceutically useful peptide derivatives of the formula (I): P—R 1 —R 2 —R 3 —R 4 , in which P, R 1 , R 2 , R 3 and R 4 have various meanings defined herein, and...
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6355619 |
Peptide tumor cell growth inhibitors
Disclosed are peptide-based compositions and methods for inhibiting and modulating the actions of CXC intercrine molecules. The antileukinate peptides described inhibit IL-8, GRO and MIP2β binding...
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6350731 |
Platelet-derived growth factor analogues
Novel peptide analogues of platelet-derived growth factor, for use in inhibiting or stimulating growth and/or chemotaxis of cells, for example, smooth muscle cells, are provided. Also provided are...
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6348571 |
Corticotropin release inhibiting factor and methods of using same
The invention includes a substantially pure preparation of a corticotropin release inhibiting factor (CRIF) peptide having from three to twenty one or to twenty five contiguous amino acids...
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6348447 |
Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein
The invention relates to the new use of gastrointestinal peptide hormones selected from the class consisting of glucagon-like peptide-1 (GLP-1) and derivatives thereof having anti-secretory effects...
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6346375 |
NANBV diagnostics and vaccines
We have discovered epitopes of the HCV viral proteins which are immunoreactive with immune serum. The epitopes are useful in immunodiagnostic assays and as immunogens.
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6346379 |
Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro...
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6344442 |
Zona pellucida proteins for contraception
The present invention relates to the use of peptides which are derived from zona pellucida proteins and are used for contraception, and pharmaceutical formulations which contain the peptides...
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6344443 |
Peptide antagonists of tumor necrosis factor alpha
There is provided a method of inhibiting TNF-α from binding to TNF receptors by administering an effective amount of an inhibitory peptide. Also provided is a method of inhibiting TNF-α functions...
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6342218 |
Method for treatment of SLE
Treatments have been developed for lupus patients using either anti-ID antibodies to dsDNA to block anti-dsDNA antibodies and/or kill the B cells producing the anti-dsDNA antibodies or ribosomal...
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6337316 |
Pharmaceutical compositions thereof, and methods of using same
The present invention relates to peptidomimetics capable of inhibiting CD28 and/or CTLA-4 interaction with CD80 (B7-1) and CD86 (B7-2) and having a core amino acid sequence,...
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6337180 |
Peptide reagent enabling a primary Epstein-Barr virus infection to be detected by testing for the corresponding antibodies, and method for using this reagent
The use of a peptide reagent for detecting the presence or absence of a primary Epstein-Barr virus infection in a patient by testing for IgM antibodies, recognizing said reagent, in a biological...
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6337070 |
Polypeptides for use in generating anti-human influenza virus antibodies
The invention provides an anti-human influenza virus antibody which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity but does...
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6337315 |
Anti-inflammatory compositions comprising peptide derivatives of α-MSH/algal extracts
Anti-inflammatory compositions, well suited for a wide variety of therapeutic/cosmetic applications, comprise combinatory immixture of (1) an effective anti-inflammatory amount of at least one...
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6335320 |
Method of treating fibrotic conditions
The present invention is related to a peptidic product comprising the tetrapeptide Acetyl-glutamyl-glutamyl-glutamyl-aspartyl (SEQ ID No:5) associated with a chemical entity that is able to...
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6333189 |
Method of making an electrotransport device
Method of making an electrotransport device containing an analog of a parent polypeptide having one or more amino acid residues substituted relative to the parent polypeptide with an amino acid...
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6329499 |
Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
The present invention is directed toward peptide analogues of human myelin basic protein. The peptide analogue is at least seven amino acids long and derived from residues 86 to 99 of human myelin...
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6329501 |
Methods and compositions for targeting compounds to muscle
Compositions for use in targeting therapies to muscle cells are provided. The compositions comprise peptides which are capable of binding muscle cells in vivo.
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6326465 |
Immunomodulatory polypeptides derived from the invariant chain of MHC class II
Polypeptides derived from a proteolytically cleaved portion of the invariant chain of MHC class II, termed CLIP, have been found to have immune modulatory properties. Depending on the portions of...
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6322964 |
Synthetic HIV-2 gag and env oligopeptides reactive with HIV-2 specific antibodies
Peptide sequences are disclosed which immunologically mimic proteins encoded by the env and gag regions of LAV-2, a retrovirus associated with AIDS. The peptide can be used in various specific...
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6323324 |
Test kits for detecting the presence of C-terminal hGPIIb fragments
Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
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6320022 |
Adrenomedullin peptides
The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving...
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6319897 |
Peptides which inhibit complement activation
Peptides capable of inhibiting complement activation are provided. Methods of inhibiting complement activation and complement-mediated tissue injury using these peptides are also provided. In...
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6319890 |
Inhibition of binding of complement Factor H
Pathogen-specific peptide chains are provided which prevent pathogens from escaping complement-mediated lysis. The peptide chains bind to known binding sites on pathogens to which complement...
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6316412 |
Polypeptides for promoting cell attachment
Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue 1394...
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6316593 |
Synthesis of VIP analog
This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)-NH2 from four protected peptide fragments.
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6316405 |
Cyclosporin a conjugates and uses therefor
Disclosed are conjugates of Aβ-binding peptides and CsA analogs and conjugates of Aβ-binding peptides and FK506 Binding Peptide inhibitors. These conjugates chemically induce dimerization of...
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6313092 |
Method for increasing the electrotransport flux of polypeptides
Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming...
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6310180 |
Method for synthesis of proteins
A method for peptide synthesis is disclosed that requires neither protecting groups nor activation of the C-α carboxyl groups. The method comprises ligating a first molecule to a second molecule...
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6309643 |
IBD-associated microbial antigens and methods of using same
The present invention provides nucleic acid and amino acid sequence of the novel I-1 and I-2 polypeptides, which are associated with human inflammatory bowel disease (IBD). Methods of diagnosing...
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6306822 |
Phosphopeptides and methods of treating bone diseases
Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or...
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6303574 |
Scr SH3 binding peptides and methods of isolating and using same
Peptides having general and specific binding affinities for the Src homology region 3 (SH3) domains of proteins are disclosed in the present invention. In particular, SH3 binding peptides have been...
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6303573 |
Heart homing peptides and methods of using same
The present invention provides a heart homing peptide that contains the amino acid sequence GGGVFWQ (SEQ ID NO: 2); HGRVRPH (SEQ ID NO: 3); VVLVTSS (SEQ ID NO: 4); CLHRGNSC (SEQ ID NO: 9); or...
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6303123 |
Methods for the treatment of hormone-dependent tumors with immunogens against gonadotropin releasing hormone
Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal...
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6300083 |
Assaying D-amino acids in body fluids
The rate of degradation in vivo of a body protein is determined by measuring the amount of a D-amino acid containing fragment of the protein in a body fluid using an antibody capable of...
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