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7615534 |
Antimicrobial peptides and use thereof
Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid...
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7615533 |
TPO peptide compounds for treatment of anemia
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7612171 |
DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7612168 |
Modified HIV peptides, antigens, compositions, immunoassay kit and a method of detecting antibodies induced by HIV
The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7611711 |
VEGFR-3 inhibitor materials and methods
The present invention relates to the diagnosis, evaluation, and therapeutic intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated...
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7608681 |
Methods and compositions for prolonging elimination half-times of bioactive compounds
Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may...
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7605227 |
Melanoma antigen peptide analogues
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
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7605150 |
Drug therapy for Celiac Sprue
Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the...
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7605120 |
Antagonists of the brandykinin B1 receptor
The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the...
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7598344 |
Composition, method and use of bi-functional biomaterials
The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a...
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7597904 |
Metalloproteinase inhibitory agent
The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The...
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7595297 |
Method of reducing injury to mammalian cells
A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron the method comprising administering to the neuron an effective inhibiting amount of a...
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7595294 |
Vasoactive intestinal polypeptide pharmaceuticals
Pharmaceutical compositions relating to vasoactive intestinal polypeptides and methods for the treatment of metabolic disorders, including diabetes, insulin resistance, metabolic acidosis and...
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7592421 |
HLA class II peptide mimics
The present invention provides peptide mimics for HLA class II antigens. The peptide mimics were identified by panning phage display peptide libraries with anti-HLA class II monoclonal antibodies....
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7592315 |
Peptide viral entry inhibitors
The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., hepatitis C virus) infections.
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7589063 |
Molecules which promote hematopoiesis
Peptides, methods for the preparation thereof, medicaments containing the peptides, and their use in selected indications, such as the treatment of various forms of anemia and stroke.
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7589058 |
Ghrelin analogs
The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.
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7585938 |
Gamma-secretase inhibitors
Disclosed, as a γ-secretase inhibitor, is a compound consisting of an amino acid sequence which consists of at least three consecutive amino acids of the amino acid sequence...
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7582727 |
Pharmaceutical formulations of bivalirudin and processes of making the same
Pharmaceutical batch(es) or pharmaceutical formulation(s) comprising bivalirudin as the active ingredient, and a method of preparing the pharmaceutical batch(es) or pharmaceutical formulation(s)....
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7582438 |
EphB receptor-binding peptides
The application is related to the identification of peptides that selectively bind to Eph receptors of the B class. Also disclosed are uses of such peptides in the treatment of a variety of...
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7579433 |
Methods and compositions for treatment of arthritis and cancer
The present invention provides a new 18-residue homodimerized peptide, designated PIP [59-67] dimer (SEQ ID NO: 1), which is a mutant of the optimized anti-inflammatory peptide P-NT.II, the patent...
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7579321 |
Pharmaceutical compositions including low dosages of desmopressin
The present invention is directed to a pharmaceutical composition comprising 0.5 ng to 20 μg desmopressin and a pharmaceutically acceptable carrier. The present invention is also directed to a...
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7579318 |
Cell penetrating peptides for intracellular delivery of molecules
The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX 9 WRAX 9 WRX 1 LX 2 RSLX 9 WX 3 X 4 X 5 X 6 X 7 X 8 (SEQ ID No: 1), wherein X 1 is...
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7579165 |
Methods for derivatizing protein or peptide with sulfonic acid groups
The present invention provides a method for effectively introducing sulfonic acid groups into the N-terminus of a protein or a peptide. The method comprises a modification step to react a...
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7576176 |
Neisseria meningitidis antigens and compositions
The invention provides proteins from Neisseria meningitidis , including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for...
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7576175 |
Alpha-4 beta-1 integrin ligands for imaging and therapy
The present invention provides α 4 β 1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino...
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7576056 |
Peptides and compounds that bind to a receptor
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7569850 |
Lipid bilayers on nano-templates
A lipid bilayer on a nano-template comprising a nanotube or nanowire and a lipid bilayer around the nanotube or nanowire. One embodiment provides a method of fabricating a lipid bilayer on a...
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7569547 |
Inhibiting furin with polybasic peptides
Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can...
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7569546 |
Apolipoprotein A1 mimetics and uses thereof
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also...
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7569542 |
Anti-microbial targeting chimeric pharmaceutical
The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target...
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7566768 |
Promyostatin peptides and methods of using same
The present invention provides substantially purified peptide portions of a promyostatin polypeptide. For example, the invention provides proteolytic fragments of a promyostatin polypeptide such as...
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7566767 |
Synthetic peptides and methods of use for autoimmune disease therapies
The invention provides peptide compositions, and methods of making and using therapeutic compositions for treatment of a subject for an autoimmune or an inflammatory disease. The invention also...
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7566695 |
Multimeric apoprotein agonists
The present invention provides multimeric apoprotein agonists. Pharmaceutical compositions which include a multimeric apoprotein agonist and a pharmaceutically acceptable carrier, excipient or...
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7563864 |
Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
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7563761 |
PNA conjugate for the treatment of diseases associated with HIV
The invention relates to peptide nucleic acid (PNA) conjugates which can be used for treating diseases correlated with HIV, wherein the peptide nucleic acid (PNA) inhibits the gene expression of...
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7560227 |
Biomarkers of vulnerable atherosclerotic plaques and methods of use
The present invention provides compositions suitable for use as biomarkers of vulnerable plaques as well as methods for the use of such compositions. In preferred embodiments, specific molecular...
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7560102 |
Method for reducing neuronal degeneration so as to ameliorate the effects of injury or disease
Compositions and methods to promote nerve regeneration or to confer neuroprotection and prevent or inhibit neuronal degeneration within the nervous system, either the central nervous system or the...
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7553926 |
Compositions containing anti-HIV peptides and methods for use
Peptides representing sequences from region 45-74 of the human CD38 leukocyte surface antigen (SEQ ID NO:1) are provided which may be used to inhibit or prevent transmission or replication of the...
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7550438 |
Methods for production of growth-promoting proteins and peptides for kidney epithelial cells
Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney...
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7550425 |
Diuretic peptide conjugates
Disclosed are a variety of peptide conjugates represented by the following general formula:
R 1 -Z-X-Z′-R 2
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RE40789 |
Mammalian checkpoint proteins polypeptides and encoding sequences thereof
The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The...
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7547676 |
Antagonist peptides to the C5A chemotactic function of vitamin D binding protein
It has been demonstrated that one of Vitamin D Binding Protein (DBP) biological functions is to enhance the chemotactic activity of C5 a and C5 a des Arg. The present invention has found that...
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7547440 |
T-cell epitope peptides
The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen...
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7544772 |
Methods for regulating inflammatory mediators and peptides useful therein
The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators...
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7544664 |
Sequences facilitating penetration of a substance of interest
The present invention relates to an amino acid sequence being able to facilitate penetration of a substance of interest inside cells and/or cell nuclei and having the following formula (I) [(X 1 )...
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7538083 |
Compositions and methods for the potentiation of immune responses against target antigens
The present invention provides novel adjuvant systems for the potentiation of immune responses against antigenic targets.
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7537760 |
Monoclonal antibodies recognizing BAG3 protein sequences and their use in diagnostic and therapy of cell death-involving diseases
The present invention provides BAG3 nucleotide and protein sequences to be used in research, diagnostics and therapy for modulation of cell survival and/or death, in particular in leukemias, other...
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7537758 |
Antibodies against a peptide epitope of apolipoprotein B
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
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7531516 |
Peptidic compounds selectively binding to P-selectin
The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XA x...
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