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7381701 |
Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system...
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7381534 |
Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like...
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7381411 |
Aglyco products and methods of use
Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which...
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7378396 |
Therapeutic agents and methods for cardiovascular disease
The present invention provides methods and agents for treating subjects who have or are at risk of developing or having cardiovascular disease. Such agents inhibit binding of myeloperoxidase (MPO)...
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7378506 |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs)...
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7374875 |
Peptides having affinity for the gp120 viral protein and use thereof
The present invention relates to a family of peptides exhibiting high affinity and specificity for the viral protein gp120, to methods for producing these peptides, and to the use of these peptides.
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7371726 |
Neutralizing GDF8 epitope-based growth enhancing vaccine
The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new...
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7371813 |
Method for use of IGF-binding protein for selective sensitization of target cells in vivo
New methods for the treatment of human disease are provided. IGFBP-3 is administered together with a co-administered agent to subjects having disease, thereby alleviating the symptoms of the...
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7368119 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
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7368127 |
Biomedical devices with peptide containing coatings
Biomedical devices with stable peptide coatings are provided. The coatings are formed by incorporating at least one latent reactive component into the reactive mixture, forming a medical device...
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7365047 |
Use of pentagastrin to inhibit gastric acid secretion or as a diuretic
This invention pertains to the discovery that pentagastrin, when administered in conjunction with a proton pump inhibitor (PPI) is synergistic with the PPI and significantly increases the efficacy...
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7365153 |
Biologically active peptide and agent containing the same
A peptide having any one of the amino acid sequences of SEQ ID NO: 1 or 13, preferably a peptide having any one of the amino acid sequences of SEQ ID NOS: 2 to 9 or a peptide having any one of the...
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7361731 |
Peptide derivatives, and their use for the synthesis of silicon-based composite materials
Methods for forming peptide derivatives using functional moieties and peptide derivatives are provided. Further, methods for using peptide derivatives to form silicon-based composite materials and...
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7358230 |
Conserved diaphanous-related formin autoregulatory domain (DAD)
The Diaphanousrelated formins (DRFs) constitute a subclass of FH proteins known for their ability to bind activated Rho subfamily of small GTP-binding proteins which link FH proteins to cellular...
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7358336 |
Fluorescent protein from Montastraea cavernosa
mcFP encoding nucleic acids, polypeptides and antibodies immunologically specific therefore are disclosed. Methods of use thereof are also provided.
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7354739 |
TML polynucleotides
The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in...
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7354900 |
Treatment and inhibition of ocular infections and wounds by CAP37 and CAP37 peptides
A method for treating ocular conditions such as bacterial keratitis, bacterial conjunctivitis, corneal ulcers and wounds, endophthalmitis, and blebitis in mammals, by using a native, synthetic, or...
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7351855 |
Chemically defined non-polymeric valency platform molecules and conjugates thereof
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
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7351690 |
Knockout identification of target-specific sites in peptides
The invention provides methods for identification and determination of target-specific sites in peptides and proteins, including a method for determining the primary sequence of a secondary...
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7351792 |
Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor
Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which...
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7351693 |
Peptides and nucleic acids of the cathelicidin family, derived from fish, and uses thereof
The invention relates to anti-microbial and immunostimulatory molecules of the cathelicidin family derived from fish. The invention provides a novel cathelicidin molecule, fragments, derivatives...
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7348401 |
Peptides that inhibit complement activation
The present invention relates to compositions, including pharmaceutical compositions that inhibit complement activation, and contain amino acid sequences X 1 -X 2 -X 3 -W-E-X 4 -X 5 -X 6 and/or Z...
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7348308 |
Glycogen synthase kinase-3 inhibitors
Peptide inhibitors of glycogen synthase kinase-3 (GSK-3) having an amino acid sequence motif of XZXXXS(p)X, wherein S(p)=phosphorylated serine or phosphorylated threonine, X=any amino acid, and...
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7348400 |
α-conotoxin peptides with analgesic properties
This invention relates to novel α-conotoxin-like peptides comprising the following sequence of amino acids: Xaa 1 CCSXaa 2 Xaa 3 Xaa 4 CXaa 5 Xaa 6 Xaa 7 Xaa 8 Xaa 9 Xaa 10 Xaa 11 C—NH 2 in...
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7348010 |
Vaccine against cancer diseases that are associated with the her-2/neu oncogene
The present invention relates to peptides of the extracellular domain of a HER-2/neu protein, conjugates comprising said peptides linked to an immunogenic carrier, compositions thereof, nucleic...
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7348155 |
Method for identifying compounds for treating aging processes in the coronary circulatory system
The invention relates to a method for identifying a compound which modifies the activity of the urotensin II receptor, with genes or gene products which are involved in the structure, formation or...
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7348409 |
Antimicrobially active peptide
An antimicrobially active peptide comprises the DCD protein or a fragment of DCD, preferably derived from the C-terminal region.
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7348402 |
Antimicrobial peptide, its analogs and antimicrobial composition comprising them
Disclosed is a novel antimicrobial peptide having excellent antimicrobial activities, its analogs and an antimicrobial composition comprising them. The antimicrobial peptide alternatively comprises...
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7342105 |
Antibody and use thereof
The antibody of the present invention, which specifically reacts with the N-terminal or C-terminal partial peptide of TGR23-2 ligand, is useful in detecting and quantifying the TGR23-2 ligand....
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7342093 |
Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins
Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds.
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7342094 |
Tumor vaccines for MUC1-positive carcinomas
Tumor vaccines for the use against MUC1 positive carcinomas are presented. A tumor vaccine containing synthetic peptides comprising sequences of the human epithelial mucin MUC1 containing the...
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7335724 |
Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis
The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The...
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7332586 |
Nanoparticle delivery vehicle
A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the...
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7332567 |
Fret protease assays for clostridial toxins
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus...
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7332474 |
Peptides and related compounds having thrombopoietic activity
The present invention relates generally to novel peptides and related compounds that have thrombopoietic activity. The compounds of the invention may be used to increase production of platelets or...
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7329650 |
Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein...
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7329725 |
Phage displayed Trp cage ligands
Trp cage binding domain polypeptides are disclosed. The Trp cage binding domains have the generic formulas of SEQ ID NO: 2, 7, 10 or 11. They can be efficiently produced and screened using phage...
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7326688 |
Analogs of gastric inhibitory polypeptide and their use of treatment for diabetes
The present invention provides peptides which stimulate the release of insulin. The peptides, based on GIP 1-42 include substitutions and/or modifications which enhance and influence secretion...
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7326535 |
Immunoreactive peptides from Epstein-Barr virus
Epstein-Barr virus (EBV) specific polypeptides are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment...
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7326767 |
Immunotherapeutic methods using epitopes of WT-1 and GATA-1
A peptide comprising the amino acid sequence RMFPNAPYL (SEQ ID NO:1) or a portion or variant thereof provided that the peptide is not intact human WT-1 polypeptide or a peptide comprising the amino...
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7323541 |
Polypeptide DNA thereof and use of the same
The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the...
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7314858 |
Retrocyclins: antiviral and antimicrobial peptides
Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical...
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7314856 |
Adrenomedullin agonists
A method for promoting bone growth in a patient (e.g., a mammal such as a human) said method including the step of administering a therapeutically effective amount of adrenomedullin or an...
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7312195 |
Cyclised conotoxin peptides
This invention relates to cyclised conotoxin peptides, processes for their preparation and their pharmaceutical use.
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7312190 |
Pharmaceutical compositions of apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a...
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7312302 |
Compositions for the detection of enzyme activity in biological samples and methods of use thereof
The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone conjugated...
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7312080 |
Plant resistance to insect pests mediated by viral proteins
The invention involves combining a peptide toxin effective against insects, including but not limited to thrips, leaf hoppers, and beetles, with a transport peptide capable of facilitating transfer...
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7309759 |
Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues...
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7304035 |
Stimulation of bone growth with thrombin peptide derivatives
Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of...
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7304127 |
Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
The present invention provides, among other things, a polypeptide that binds with the gp120 envelope protein of HIV, in particular HIV-1, under physiological conditions, a nucleic acid that encodes...
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