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7465784 |
Antimicrobial peptides and methods of identifying the same
Antimicrobial peptides and methods of identifying the same are provided.
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7462688 |
Peptides for diagnostic and therapeutic methods for celiac sprue
Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the...
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7462462 |
Peptide capable of binding to nanographite structures
It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as...
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7462598 |
Antimicrobial theta defensins, analogs thereof, and methods of use
The invention provides theta defensin analogs having antimicrobial activity. The invention also provides a method of reducing or inhibiting growth or survival of a microorganism in an environment...
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7456252 |
Therapeutic peptides for demyelinating conditions
The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition.
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7452856 |
Antibacterial peptide
The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or...
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7452964 |
Compositions and methods of use of targeting peptides against placenta and adipose tissues
The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides...
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7452684 |
Collagen XXII, a novel human collagen and uses thereof
The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid...
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7449303 |
Use of JAG2 expression in diagnosis of plasma cell disorders
The present invention is based on the finding that plasma cell disorders such as Multiple Myeloma and Monoclonal Gammopathy of Unknown Significance are characterized by an increase in the...
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7449545 |
Antimicrobial bolisin peptides
The invention relates to antibiotically effective peptides which are prepared for medical and commercial use by using biotechnological methods and chemical synthesis. The antibiotically effective...
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7446095 |
Peptides modulating caspase activation
The present invention provides structures of small molecules capable of modulating apoptotic cell death. More specifically, the structures relate to the structures of apoptotic active sites of...
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7442762 |
Mutational derivatives of microcin J25
Analogs of bacteriocidal peptide microcin J25 (MccJ25) are provided that have an amino acid sequence that differs from that of MccJ25 by having at least one amino acid substitution; and that...
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7438917 |
Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or...
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7439329 |
GEF-H1b: biomarkers, complexes assays and therapeutic uses thereof
The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell...
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7439323 |
Cysteine-containing peptides having antioxidant properties
Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-I Milano (R173C) and apoA-I Paris , (R151C) were found to exhibit potent...
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7439324 |
ALS-specific peptide composition
The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion...
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7435716 |
Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia
Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing...
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7435721 |
Transport peptides such as C-terminal Erns peptide and analogues thereof
The invention relates to peptides derived from or similar to the E rns protein of pestiviruses for type-specific diagnosis of infection, for eliciting antibiotic activity, and for transport of...
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7435718 |
CXCR4 antagonist treatment of hematopoietic cells
In accordance with various aspects of the invention, CXCR4 antagonists may be used to treat hematopoietic cells, such as progenitor or stem cells, to promote the rate of cellular multiplication,...
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7432343 |
Diagnostic application of mail
The present invention provides nucleic acids. Polypeptides, antibodies and cells related to MAIL (Molecule possessing Ankyrin repeats Induced by LPS; or IκB-ζ), a novel member of the IκB family,...
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7432045 |
Method of inhibiting influenza infection with antiviral peptides
This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral...
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7432342 |
Kinase anchor protein muteins, peptides thereof and related documents
A-kinase anchor protein (AKAPs) muteins, peptides thereof, and nucleic acids encoding the peptides are provided herein. Also provided are transgenic animals, cells comprising transgenes and various...
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7429639 |
SSX-2 peptides presented by HLA class II molecules
The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating to the peptides. The...
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7427590 |
Neurothrophic components of the ADNF I complex
This invention relates to Activity Dependent Neurotrophic Factor I complex (ADNF I complex) and polypeptides of this complex, which produce their neurotrophic effects through multiple proteases...
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7427658 |
Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor
The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. Only lysates of insect cells which have...
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7425608 |
Method of making metallopeptides
Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs,...
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7425540 |
Method for modification of NMDA receptors through inhibition of Src
The present invention provides a method for modifying the activity of NMDA (N-methyl-D-aspartate)receptors in cells by inhibition of the interaction of the unique domain of the tyrosine kinase Src...
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7425541 |
Enzyme-cleavable prodrug compounds
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is...
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7422862 |
Methods for identifying modulators of apoptosis
The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound...
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7423113 |
Leptin antagonist
The present invention relates to an antagonist or inhibitor of leptin signaling via the leptin receptor. The leptin antagonist binds to the leptin receptor, but is unable to induce JAK-STAT signal...
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7423007 |
Cxcr4 antagonist and use thereof
The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt....
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7420030 |
Aminopeptidase A (APA) targeting peptides for the treatment of cancer
The present invention concerns compositions and methods for the treatment of cancer. More specifically, the present invention relates to identification of aminopeptidase A (APA) as a functional...
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7419957 |
Peptides of melanoma antigen and their use in diagnostic, prophylactic and therapeutic methods
Immunogenic peptides of a melanoma antigen recognized by T cells, designated gp100, bioassays using the peptides to diagnose, assess or prognose a mammal afflicted with cancer, more specifically...
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7417124 |
Antibodies specific for phosphorylation sites and screening methods using the same antibodies
Polyclonal antibody specific for a phosphorylated linker region in Smad2 and/or Smad3.
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7414107 |
Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a...
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7408029 |
Peptide epitopes recognized by disease promoting CD4+ T lymphocytes
The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined...
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7405203 |
Pharmaceutical compositions including low dosages of desmopressin
The present invention is directed to a pharmaceutical composition comprising 0.5 ng to 20 μg desmopressin and a pharmaceutically acceptable carrier. The present invention is also directed to a...
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7402563 |
EPF derived peptides and therapeutic compositions
The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind...
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7399747 |
Peptides carrying substances across the blood brain barrier
The invention concerns the use of a linear peptide paired with an active substance for diagnosing or treating a CNS pathology by preparing a medicine capable of crossing the blood brain barrier to...
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7396815 |
Cosmetic or pharmaceutical composition containing peptides
A cosmetic and/or dermatological and/or pharmaceutical composition includes, as the active ingredient, at least one peptide with sequence X 1 -Y-Phe-Thr-X 2 -Ala-Thr-Z-Ile-X 3 -Leu-X 4 -Phe-Leu-X 5...
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7390873 |
Antimicrobial cationic peptides
A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas:
X 1 X 1 PX 2 X 3 X 2 P(X 2 X 2 P) n X 2 X 3 (X 5 ) 0 ; (SEQ ID...
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7388072 |
MAGE peptides presented by HLA class II molecules
The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides...
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7387779 |
Anti-angiogenic proteins and fragments and methods of use thereof
Proteins with anti-angiogenic properties are disclosed, and fragments thereof, and methods of using those proteins and fragments to inhibit or promote angiogenesis.
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7387997 |
α-conotoxin MII analogues
The invention relates to novel conopeptides and/or novel Luses of conopeptides. The conopeptides of the invention are analogs of α-Conotoxin MII that are selective for α6-containing nAChRs as...
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7387998 |
STQ peptides
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured laminin with substantially greater...
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7385025 |
Metallopeptide compounds
Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues,...
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7381705 |
Inhibitors of hepatitis C virus
The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope...
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7381701 |
Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system...
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7381534 |
Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like...
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7381411 |
Aglyco products and methods of use
Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which...
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