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7550438 |
Methods for production of growth-promoting proteins and peptides for kidney epithelial cells
Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney...
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7550425 |
Diuretic peptide conjugates
Disclosed are a variety of peptide conjugates represented by the following general formula:
R 1 -Z-X-Z′-R 2
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RE40789 |
Mammalian checkpoint proteins polypeptides and encoding sequences thereof
The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The...
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7547440 |
T-cell epitope peptides
The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen...
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7547676 |
Antagonist peptides to the C5A chemotactic function of vitamin D binding protein
It has been demonstrated that one of Vitamin D Binding Protein (DBP) biological functions is to enhance the chemotactic activity of C5 a and C5 a des Arg. The present invention has found that...
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7544664 |
Sequences facilitating penetration of a substance of interest
The present invention relates to an amino acid sequence being able to facilitate penetration of a substance of interest inside cells and/or cell nuclei and having the following formula (I) [(X 1 )...
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7544772 |
Methods for regulating inflammatory mediators and peptides useful therein
The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators...
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7538083 |
Compositions and methods for the potentiation of immune responses against target antigens
The present invention provides novel adjuvant systems for the potentiation of immune responses against antigenic targets.
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7537758 |
Antibodies against a peptide epitope of apolipoprotein B
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
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7537760 |
Monoclonal antibodies recognizing BAG3 protein sequences and their use in diagnostic and therapy of cell death-involving diseases
The present invention provides BAG3 nucleotide and protein sequences to be used in research, diagnostics and therapy for modulation of cell survival and/or death, in particular in leukemias, other...
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7531512 |
Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes
A method for preventing or delaying the onset of autoimmune diseases is disclosed.
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7531502 |
Diagnostic conjugate useful for intracellular imaging and for differentiating between tumor- and non-tumor cells
Described is a diagnostic conjugate comprising (a) a transmembrane module (TPU), (b) an address module (AS), preferably an antisense peptide nucleic acid (PNA), and (c) a signaling module (SM). The...
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7531516 |
Peptidic compounds selectively binding to P-selectin
The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XA x...
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7531515 |
Peptides selectively lethal to malignant and transformed mammalian cells
The present invention provides peptides corresponding to all or a portion of amino acid residues 12-26 of human p53 protein, which peptides are lethal to malignant or transformed cells when fused...
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7528104 |
Peptides that bind to the erythropoietin receptor
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
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7527795 |
Peptide epitopes of apolipoprotein B
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
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7527787 |
Multivalent immunoglobulin-based bioactive assemblies
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred...
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7528227 |
Histone H2A peptide derivatives and uses thereof
Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury...
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7528226 |
TGFβ1-inhibitor peptides
Antagonistic synthetic peptides, obtained from TGFβ1 or from its receptors in the organism, that can be used in the manufacture, both on their own, as well as the gene sequences that encode them...
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7527947 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
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7524818 |
Prosaposin as a neurotrophic factor
Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is...
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7524926 |
Mucin hypersecretion inhibitors and methods of use
Peptides are provided that comprise less than 24 amino acids. The peptides have an amino acid sequence selected from the group consisting of: (a) an amino acid sequence having from 4 to 23...
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7521528 |
Conformationally constrained parathyroid hormone (PTH) analogs with lactam bridges
The present invention relates to methods of treatment of mammalian conditions characterized by decreases in bone mass with conformationally constrained parathyroid hormone (PTH) analogs and...
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7517855 |
Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell...
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7511012 |
Myostatin binding agents
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one...
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7511118 |
PSMA peptide analogues
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
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7511119 |
PRAME peptide analogues
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
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7507420 |
Peptidyl prodrugs and linkers and stabilizers useful therefor
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming...
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7504381 |
Antimicrobial agents
A novel class of antimicrobial polymeric agents, which include a plurality of amino acid residues, such as positively charged amino acid residues, and at least one hydrophobic residue linking there...
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7504380 |
Antimicrobial peptide isolated from halocynthia aurantium
The present invention relates to an antimicrobial peptide isolated from Halocynthia aurantium , more particularly, to an antimicrobial peptide isolated from the body fluid of Halocynthia...
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7501397 |
Helical peptidomimetics with enhanced activity
Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors have sequences with lengths from 11 to 16 amino acids, inclusive. These inhibitors potently...
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7498306 |
Peptides binding to the phosphatase 2A protein
The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids...
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7494979 |
Method for treating congestive heart failure and other disorders
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders,...
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7491701 |
Peptides that bind to HSP90 proteins
YSLPGYMVKKLLGA (SEQ ID NO:1) and its active analogs, compositions, and methods of use.
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7491699 |
Peptide nanostructures and methods of generating and using the same
A tubular or spherical nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino acids...
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7491691 |
Connective tissue stimulating peptides
Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or...
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7488793 |
Isolated peptide which binds to HLA-Cw*07 and uses thereof
Peptides which consist of amino acid sequences found in MAGEA3 bind to HLA-Cw*07 molecules to form T cell epitopes. The therapeutic and diagnostic ramifications of this are the subject of this...
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7488792 |
Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
The present invention provides a conjugate containing a therapeutic agent linked to a homing molecule that selectively homes to tumor vasculature and selectively binds collagen such as non-helical...
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7488713 |
Cancer treatment using C-type natriuretic peptides
The present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the...
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7488481 |
Polypeptides derived from anti-HIV-1 gp120 antibodies that abrogate gp120 binding to CCR5
The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral...
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7482010 |
Non-anaphylactic forms of grass pollen Phl p 6 allergen and their use
The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule...
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7482433 |
Peptides and compounds that bind to the IL-5 receptor
Interleukin-5 receptor (IL-5R) ligands comprising amino sequences of formula TGGGDGYVX 3 VEX 4 ARCPTCK, EGYVX 3 VEX 4 ARCPTCK, EGYVX 3 VEX 4 ARCPTCR, GYVX 3 VEX 4 ARCPTCG, EGYVX 3 VEX 4 ARCPTCG,...
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7482429 |
Kahalalide F and related compounds
A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.
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7482329 |
Single domain TDF-related compounds and analogs thereof
The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing,...
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7482008 |
Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several...
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7482328 |
Antimicrobial polypeptide and utilization thereof
The present invention provides an artificially synthesized antimicrobial polypeptide that does not occur in nature and an antimicrobial agent comprising this polypeptide as the main component. This...
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7476509 |
Compounds and methods for modulating functions of nonclassical cadherins
Modulating agents and methods for enhancing or inhibiting nonclassical cadherin-mediated functions, such as atypical or desmosomal cadherin-mediated functions, are provided. The modulating agents...
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7470776 |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
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7468421 |
Depilatories and agents for external use
This invention relates to depilatories and external preparations, each of which contains endothelin or its agonist, and also to a depilating method characterized by administering endothelin or its...
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7465453 |
Polypeptide fragments of CKLF1
Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also...
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