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6498243 |
Epimorphin antagonist and process for producing it
This invention provides an epimorphin antagonist comprising part of the functional domain of epimorphin (e.g., a polypeptide specified by the amino acid sequence: ...
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6498027 |
Targeted delivery through a cationic amino acid transporter
The invention relates to the targeted delivery of substances to cells. The invention provides a virus-like particle or gene delivery vehicle provided with a ligand capable of binding to a human...
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6495663 |
Method and composition for enhancing transport across biological membranes
Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention includes a method for enhancing transport of a...
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6495516 |
Method for killing gram-negative bacteria with biologically active peptides from functional domains of bacterial/permeability-increasing protein
The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a...
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6495661 |
DNA encoding the outer membrane protein of Pasteurella multocida
An isolated nucleic acid molecule encoding the outer membrane protein of Pasteurella multocida is provided. Also provided are methods to detect the presence of the nucleic acid molecule, and...
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6495138 |
PRRSV antigenic sites identifying peptide sequences of PRRS virus for use in vaccines or diagnostic assays
The invention provides antigenic sites of PRRSV isolates. The antigenic sites are neutralizing, conserved, non-conserved and conformational, can elicit antibodies and are found on protein GP4 and N...
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6492328 |
Novispirins: antimicrobial peptides
Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other...
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6489298 |
Contulakin-G, analogs thereof and uses thereof
The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr 10 -contulakin-G), and derivatives thereof, to a cDNA clone...
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6489131 |
Interference reduction by rheumatoid factors
The invention concerns a method for the determination of an analyte in which rheumatoid factors or rheumatoid-factor-like substances are added as an interference reducing reagent to reduce of avoid...
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6485900 |
Synthetic antigen for the detection of AIDS-related disease
Novel peptides are provided having substantially the same sequence as immunologically significant fragments of AIDS-related viruses. The polypeptides can be used as reagents in the determination of...
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6479642 |
Cortistatin: neuropeptides
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with...
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6479630 |
Human purinergic P2U receptor
The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic P U2 receptor (PNR) expressed in human placenta. The present invention also provides...
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6479633 |
Chemokine alpha 2
Human chemokine Alpha-2 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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6475775 |
PARG, a GTPase activating protein which interacts with PTPL1
The invention describes nucleic acids encoding the PARG protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by...
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6476188 |
Clock gene and methods of use thereof
The present invention discloses the identity of the first enzyme that has been demonstrated to be involved in maintaining circadian rhythms. This enzyme, the Drosophila DOUBLETIME protein is also...
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6468537 |
Localization of major peptide autoepitopes for nucleosome specific T cells of systemic lupus erythematosus
The present invention includes peptides derived from nucleosomal histone proteins which are useful for delaying the onset and progression of systemic lupus erythematosus (i.e. lupus or SLE). The...
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6465614 |
High-affinity response-selective C-terminal analogs of C5a anaphylatoxin
High-affinity response-selective C-terminal analogs of C5 a anaphylatoxin are provided. Whereas natural C5 a has considerable flexibility in the C-terminal region, the analogs of the invention...
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6465253 |
Vectors and methods for gene transfer to cells
The present invention provides a chimeric adenovirus coat protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence. Such a chimeric adenovirus...
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6465616 |
Interleukin-5 antagonist
The present invention relates to modified and variant forms of Interleukin-5 molecules capable of antagonizing or reducing the activity of IL-5 and their use in ameliorating, abating or otherwise...
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6464980 |
MAGE-1 c-terminal immunogenic peptides
The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the C-terminal are used to define epitopes that stimulate HLA-restricted...
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6462017 |
Method of reducing side effects of chemotherapy in cancer patients
A method for reducing the severity of chemotherapy side effects in cancer patients by administering thymosin α 1 in conjunction with the administration of a chemotherapy agent to the patient. As...
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6462171 |
Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
Novel peptides capable of interacting with a hydrophobic β-sheet forming cluster of amino acid residues on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and...
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6462170 |
UPAR mimicking peptide
Peptides comprising the SRSRY sequence (SEQ ID NO: 7) derived from the uPAR (urokinase receptor) are endowed with chemotactic activity, making them useful for preventing or activating the migration...
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6458527 |
HIV immunoassays using gag polypeptides
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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6458528 |
Diagnosis of feline immunodeficiency virus infection using ENV/GAG polypeptide markers
Methods for determining whether a feline is infected with feline immunodeficiency virus (“FIV”). The methods involve the use of an antibody-binding composition that includes two enhanced...
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6455267 |
Methods and kits useful for determining the status of and detecting pancreatic B-cell associated autoimmune diseases
Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.
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6451971 |
Physiologically active peptides
Physiologically active peptides possessing cell adhesion inhibitory activity are provided. A physiologically active peptide of this invention is characterized by possessing cell adhesion...
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6448374 |
Production of phosphopeptides from casein
A method for the preparation of selected phosphopeptides having anticariogenic and other activities, comprising the steps of completely digesting a soluble monovalent cation salt of casein in...
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6444644 |
Anticoagulant peptide fragments derived from apolipoprotein B-100
The present invention provides a peptide compound of formula Z 1 —K—A—Q—X 1 —K—K—N—K—H—R—H—S—X 2 —T—Z 2 (SEQ ID NO:1) where: X 1 represents S or Y, X 2 represents T...
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6440656 |
Methods for the inhibition of respiratory syncytial virus transmission
Fusion of the viral envelope, or infected cell membranes with uninfected cell membranes, is an essential step in the viral life cycle. Recent studies involving the human immunodeficiency virus type...
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6440935 |
Inhibition of eucaryotic pathogens and neoplasms and stimulation of fibroblasts and lymphocytes with lytic peptides
Inhibition of eucaryotic pathogens and neoplasms and stimulation of lymphocytes and fibroblasts with lytic peptides such as cecropins and sarcotoxins. Eucaryotic cells are contacted with cecropin...
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6432920 |
Nck SH3 binding peptides
Peptides having general and specific binding affinities for the Src homology region 3 (SH3) domains of proteins are disclosed in the present invention. In particular, SH3 binding peptides have been...
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6429286 |
Immunoregulatory molecules for costimulatory signal transduction
An immunoregulatory molecule that regulates costimulatory signal transduction through interaction with the molecules involved in costimulatory signal transduction present on antigen presenting...
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6429024 |
Test method for IgA nephropathy
A test method for IgA nephropathy involves determining antibody, which recognizes the core peptide of the hinge region in IgA1, in specimens. The method is a rapid and sample test method for IgA...
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6426205 |
Methods and compositions for modulating ubiquitin dependent proteolysis
The invention relates to methods and compositions for modulating ubiquitin dependent proteolysis.
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6426330 |
Satiety inducing composition comprising Neuropeptide Y analogues and methods of inducing satiety and treating a disease or condition associated with it
Satiety inducing composition comprises Neuropeptide Y analogues which are effective for inducing satiety and for treating diseases and conditions associated with a lacking of, or having lowered,...
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6423825 |
Therapeutic derivative compounds derived from domain II of bactericidal/permeability-increasing protein
The present invention relates generally to small derivatized peptide-based constructs and their therapeutic uses. The sequences of these derivatized peptide-based constructs are based on a reverse...
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6423822 |
Human CIF130 polypeptides
A human gene termed CIF130 and its expression products can alter the spatial or temporal patterns of mitosis or cell cycle progression of a human cell. Methods of treating disorders involving...
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6423315 |
Synthetic peptide for treatment of autoimmune arthritis
Peptides that are capable of suppressing autoimmune arthritis are disclosed. The polypeptides described by the present invention which are capable of suppressing autoimmune arthritis in mammals...
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6423824 |
CAIP-like gene family
CAIP polypeptide, nucleic acid, and uses thereof.
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6419924 |
Antibodies of isolated domains of type IV collagen modify cell interactions
The instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and...
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6417333 |
Modified human parathyroid hormone
The present invention is related to novel synthetic and/or recombinant biologically active peptide derivatives of parathyroid hormone (PTH). In particular, the invention relates to PTH derivatives...
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6417327 |
Peptide capable of regulating physiological function of FGF-5 and pharmaceutical composition containing the peptide
The present invention provides a peptide partially comprising an amino acid sequence of FGF-5 or FGF-5S (i.e., the alternatively spliced form of FGF-5), the peptide being capable of controlling...
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6417338 |
Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy
The present invention relates, in general, to autotaxin. In particular, the present invention relates to a DNA segment encoding autotaxin; recombinant DNA molecules containing the DNA segment;...
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6416926 |
Thiabicyclo compound, a polymer-containing said compound, and a photoresist micro pattern forming method using the same
The present invention provides heterobicyclo compounds of the formula: and a method for preparing the same, where Z, X, R 1 , R 2 , and m are those defined herein. Compounds of the present...
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6417324 |
Synthetic peptides that bind to the hepatitis B virus core and e antigens
The present invention relates generally to the field of virology. More particularly, the invention relates to the discovery that peptides, which bind to the Hepatitis B virus (HBV) core and e...
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6414113 |
Peptides binding to bone marrow stromal cell antigen
Peptides capable of binding to bone marrow stromal cell antigen-1 (BST-1), and peptides capable of binding to BST-1 and inhibiting ADP-ribosyl cyclase activity and cADP-ribose hydrolase activity...
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6414114 |
Disulfides and thiol compounds
The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example, is a compound of the formula (1): A—B—C—S—S—D—E—F, wherein:...
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6410693 |
Inhibitors of the JNK signal transduction pathway and methods of use
JNK-interacting protein 1 (JIP-1), an inhibitor of the JNK1 protein, and methods of treating a pathological condition or of preventing the occurrence of a pathological condition in a patient by the...
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6407063 |
Tumor antigens and CTL clones isolated by a novel procedure
The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for MAGE-1 and MAGE-4,...
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