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6737406 |
Cryptic peptides and method for their identification
The present invention relates to immunologically cryptic peptides; methods for their identification in individuals and populations and their use in diagnosis and therapy of pathological conditions...
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6737407 |
Treatment of obesity
A method for the treatment of obesity in an animal such as a human, comprises administering to the animal an effective amount of a peptide which comprises an analogue of the carboxyl-terminal...
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6737508 |
DNA sequences from staphylococus aureus bacteriophages 3A, 77, and 96 that encode anti-microbial polypeptides
The disclosure concerns particular bacteriophage open reading frames, and portions and products of those open reading frames which have antimicrobial activity. Methods of using such products are...
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6733755 |
Ligand for vascular endothelial growth factor receptor
The present invention relates to compositions comprised of a peptide ligand or derivatives thereof that are capable of specific binding to the high affinity receptor-1 of vascular endothelial...
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6734166 |
Method of reducing aluminum levels in the central nervous system
A method of reducing aluminum concentrations in the central nervous system of a subject (e.g., a patient afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease) comprises...
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6730659 |
Antimicrobial peptides and methods of use thereof
Novel peptide analogs derived from the native sequences of CAP37 peptides 20-44 and 23-42, and their use as therapeutics against bacterial infections and diseases caused by bacterial infection. The...
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6727226 |
Mu-conopeptides
The present invention is to μ-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and...
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6723830 |
Short peptides which selectively modulate the activity of protein kinases
Peptides which are peptide derivatives of the αD region of a protein kinase can modulate the activity of protein kinases. The activity of a protein kinase in a subject can be modulated by...
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6723832 |
Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof
The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
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6720305 |
Injectable formulations containing ramoplanin
The present invention relates to a pharmaceutical composition for intravenous administration that contains ramoplanin or a member of the ramoplanin family.
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6716809 |
Mage-A3 peptides presented by HLA class molecules
The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides...
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6713062 |
Acinetobacter outer membrane protein and gene sequence compositions and methods
Disclosed are new outer membrane proteins and nucleic acids from Acinetobacter and related biological compositions and methods. The biological materials provided are useful in diagnostic,...
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6713444 |
Buforin I as a specific inhibitor and therapeutic agent for botulinum toxin B and tetanus neurotoxins
The compounds of the invention are generally described by the formula: X 1 X 2 B 3 X 4 B 5 X* 6 X 7 X 8 B 9 X 10 B 11 X 12 B 13 X 14 B 15 X 16 B 17 X* 18 X* 19 B 20 X 21 X 22 X 23 Q 24 F 25 Z* 26...
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6709657 |
BASB013 DNA and proteins from Neisseria meningitidis
The invention provides BASB013 polypeptides and polynucleotides encoding BASB013 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6709828 |
PROCESS FOR THE DETERMINATION OF PEPTIDES CORRESPONDING TO IMMUNOLOGICALLY IMPORTANT EPITOPES AND THEIR USE IN A PROCESS FOR DETERMINATION OF ANTIBODIES OR BIOTINYLATED PEPTIDES CORRESPONDING TO IMMUNOLOGICALLY IMPORTANT EPITOPES, A PROCESS FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM
This invention is directed toward a peptide corresponding to an immunologically important viral epitope. Specifically, the peptide corresponds to an immunodominant epitope identified in the...
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6709649 |
RANTES derived peptides with anti-HIV activity
Peptides having 12 to 30 amino acids with sequence homologous or corresponding to the sequence 1o-34 of RANTES having inhibitory activity against the human immunodeficiency virus (HIV) as well as...
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6706859 |
HIV peptides, antigens, vaccine compositions, immunoassay kit and a method of detecting antibodies induced by HIV
The present invention comprises novel and modified peptides capable of inducing an HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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6706685 |
Compounds and methods for stimulating β-catenin mediated gene expression and differentiation
Modulating agents for inhibiting degradation of cytoplasmic β-catenin are provided. The modulating agents comprise one or more of: (1) the peptide sequence SYLDS(PO 4 )GIHS(PO 4 )G (SEQ ID NO:1)...
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6706487 |
Monoclonal antibody and the method of using the antibody
Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
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6703207 |
Method of screening substances with a glycidyl methacrylate covered styrene-glycidyl methacrylate polymer
A compound possessing physiological activity is coupled to a styrene-glycidyl methacrylate polymer through a spacer. Compounds that may be used include receptors such as proteins, and...
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6703480 |
Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R 1 and a second...
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6699965 |
Peptides that activate the G-protein coupled receptor protein, 0T7T175
G Protein-coupled receptor proteins originating in the vicinity of rat brain stem and human brain or salts thereof, or peptide fragments thereof or amides, esters or salts of the same; ligands...
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6699834 |
Method for treating cancer
The present invention relates to peptides of one or more portions of the human chorionic gonadotropin β-chain as well as methods for treatment of cancer, using human chorionic gonadotropin,...
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6699838 |
Antiangiogenic peptides
Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also...
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6699833 |
Pharmaceutical formulations for sustained drug delivery
Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high...
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6699656 |
Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
The present invention relates to β-hCG, particularly β-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention...
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6696408 |
Contulakin-G, analogs thereof and uses therefor
The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr 10 -contulakin-G), and derivatives thereof, to a cDNA clone...
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6696061 |
Immunomodulatory peptides
A purified preparation of a peptide consisting essentially of an amino acid sequence identical to that of a segment of a naturally-occurring human protein, said segment being of 10 to 30 residues...
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6693170 |
ARIP4 gene and protein
This invention relates to a novel nuclear protein which interacts with the androgen receptor in vivo and in vitro, and which also possesses ATPase activity. The invention concerns also mRNA and DNA...
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6693166 |
Cdk5—specific inhibitory peptides
The activation of cyclin dependent kinase 5 (Cdk5) depends on the binding of its neuronal specific activator Nck5a. The minimal activation domain of Nck5a has been experimentally determine comprise...
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6689750 |
Bactericide compositions prepared and obtained from microccus varians
A bacteriocin is obtained by culturing cells of a strain of Micrococcus varians which, upon culturing in a culture medium, produces a bacteriocin which has agar well incubation inhibition test...
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6686444 |
Osteopontin derived chemotactic peptides and methods of use
Novel osteopontin derived chemotactic peptides are described. The peptides (or antagonists thereof) are useful in treating conditions or diseases associated with chemotaxis.
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6683052 |
Lipopeptides containing an interferon-&ggr fragment, and uses thereof in pharmaceutical compositions
The invention concerns any lipopeptide characterized in that it comprises: a peptide part comprising the peptide sequence consisting of about 30 to about 50 of the last contiguous amino acids of...
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6683050 |
Compounds with anti-KS and anti-HIV activity
The present invention relates to a compound having anti-KS and anti-HIV pharmaceutical activity which comprises an HCG-like inhibitory protein and fragments or derivatives thereof, said protein and...
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6682740 |
Peptides derived fram complement peptide C3a sequence and antiallergic compositions comprising them
Peptides corresponding partially or entirely to positions 50-77 of the sequence of the complement-derived peptide C3 a and analogs thereof are capable of inhibiting IgE-mediated triggering and/or...
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6683048 |
Compounds and methods for stimulating gene expression and cellular differentiation
Modulating agents for inhibiting an interaction between α-catenin and β-catenin are provided. The modulating agents comprise one or more of: (a) a β-catenin HAV motif; (b) a peptide analogue or...
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6677431 |
Design, preparation, and properties of antibacterial β-peptides
An antibacterial β-peptide having the following formula: wherein R 1 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; R 2 is an amine-containing alkyl...
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6673895 |
Pro-apoptotic fragments of the dengue virus envelope glycoproteins
The present invention relates to pro-apoptotic fragments of the Dengue virus pRM and E glycoproteins, methods of screening for molecules capable of inducing apoptosis and methods of inducing...
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6673770 |
Peptides for the treatment, prophylaxis, diagnosis and monitoring of autoimmune diseases
The invention provides a peptide suitable for the prophylaxis, treatment, diagnosis or monitoring of arthritis. The peptide contains a contiguous sequence element of 9 amino acid residues...
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6669945 |
Universal T-cell epitopes for anti-malarial vaccines
The present invention provides methods and compositions for eliciting protective immunity against malaria. In particular, the invention relates to universal T-cell epitopes that elicit T-cell...
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6669946 |
METHOD FOR IDENTIFYING INDIVIDUALS SUFFERING FROM A CELLULAR ABNORMALITY SOME OF WHOSE ABNORMAL CELLS PRESENT COMPLEXES OF HUMAN LEUKOCYTE ANTIGEN TYROSINASE DERIVED PEPTIDES, AND METHODS FOR TREATING SAID INDIVIDUALS
The invention relates to complexes of human leukocyte antigen molecules and tyrosinase derived peptides SEQ ID NO: 2, on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications...
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6660842 |
Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
The present invention generally relates to compositions and methods for preventing and treating human diseases including, but not limited to, pathogens such as bacteria, yeast, parasites, fungus,...
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6656906 |
Hybrid polypeptides with enhanced pharmacokinetic properties
The present invention relates to enhancer peptide sequences originally derived from various retroviral envelope (gp41) protein sequences that enhance the pharmacokinetic properties of any core...
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6653445 |
Human CCV polypeptides
The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and...
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6652859 |
PTANS: testis specific proteins expressed in prostate cancer
Novel testis-specific genes and encoded proteins (PTANs) are described. PTANs are over-expressed in prostate cancer. The nucleotide and amino acid sequences of three distinct PTAN isoforms,...
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6649379 |
Method and deregulated enzyme for threonine production
Mutagenesis of the gene encoding homoserine dehydrogenase (hom) for production of the amino acid threonine is described. The mutation causes an alteration in the carboxy terminus of the enzyme that...
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6649739 |
Protein, its gene, reagents for inducing apoptosis, and anticancer agent
Novel proteins which have cell death inducing activity or proliferation inhibitory activity on cancer cells; fragments of such proteins; genes coding such proteins; monoclonal antibodies to such...
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6649171 |
Moraxella catarrahalis polynucleotides and polypeptides
The invention provides BASB021 polypeptides and polynucleotides encoding BASB021 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6649746 |
Biological production of stable glutamine, poly-glutamine derivatives in transgenic organisms and their use for therapeutic purposes
The invention provides a bioproduction of glutamine rich peptides. These peptides are used for rehydration and nutrition therapy in patients and for enhanced nutrition in animals. The peptides may...
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6642353 |
Peptide ligands for the erythropoietin receptor
Clones isolated from phage display libraries that bound to an erythropoietin (EPO) receptor probe are disclosed. Peptides encoded by sequences of those clones that bound to the EPO receptor are...
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