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6835382 |
Ii peptide therapeutics to enhance antigen presentation
Disclosed is a class of compounds referred to herein as effector compounds. Effector compounds are useful in connection with the modulation of an immune response. Modulation refers to the ability...
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6835809 |
Thrombopoietic compounds
The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase...
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6831156 |
Nuclear myosin I βwith a 16 amino acid N-terminal extension
The present invention relates to a molecular motor actin binding protein, in particular, to Nuclear Myosin Iβ (NMIβ) containing a 16 amino acid N-terminal extension involved in transcription....
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6830894 |
Compounds and methods for modulating claudin-mediated functions
Methods for using modulating agents to enhance or inhibit claudin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating...
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6828306 |
Charged lipid compositions and methods for their use
The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or...
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6828417 |
Polypeptide and process for measuring living body components using the same
A living body component in a sample derived from a living body can be rapidly and accurately measured by reacting the sample with a reagent comprising a combined product of an affinity substance...
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6825318 |
Mimetic peptides for an epitope of apolipoprotein B-100, concatemers of the peptides, and modified peptides, and compositions comprising the same
The present invention relates to a vaccine composition for treatment of obesity. More particularly, the present invention is directed to a vaccine composition which comprises a mimetic peptide...
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6821735 |
Protein involved in abscisic acid signalling
An isolated protein capable of affecting an ABA response and comprising one or more of the following: (i) a hydrophobic C-terminus; (ii) an epimorphin pattern; (iii) a hydrophilic N-terminus; and...
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6821948 |
Conjugate for mediating cell, compartment or membrane-specific transport of active substances
The present invention relates to conjugates for mediating a cell-specific, compartment-specific or membrane-specific to methods of active substances. The invention also relates to methods of...
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6822079 |
Plant nitrogen regulatory P-PII polypeptides
The present invention generally relates to plant nitrogen regulatory PII gene (hereinafter P-PII gene), a gene involved in regulating plant nitrogen metabolism. The invention provides P-PII...
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6821950 |
Cyclic agonists and antagonists of C5a receptors and G protein-coupled receptors
The present invention relates to novel cyclic or constrained acyclic compounds which modulate the activity of G protein-coupled receptors and are useful in the treatment of conditions mediated by G...
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6818217 |
Immunoreactive peptides
The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with antibodies or T-cells in subjects having pre-clinical or...
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6818617 |
EC-3, an inhibitor of α4β1 and α4β7 integrins
This invention relates to the identification, purification, and characterization of a novel heterodimeric disintegrin, EC-3, from Echis carinatus viper venom. EC-3 inhibits α4 integrins in an...
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6818741 |
Alpha-fetoprotein peptides and uses therof
The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises...
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6818612 |
Use of parvovirus capsid particles in the inhibition of cell proliferation and migration
The invention described herein relates to the discovery of methods and compositions for the inhibition of growth and/or migration of cells that have a receptor that interacts with a parvovirus B19...
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6815421 |
Polypeptides for use in ameliorating effects of aging in mammals
Method of ameliorating effects of aging in an animal, the method comprising administering to the animal an effective amount of a synthetic polypeptide comprising an amino acid sequence that has...
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6806255 |
Compounds and methods for modulating adhesion molecule function
Modulating agents and methods for enhancing or inhibiting cadherin-mediated functions are provided. The modulating agents comprise at least an HAV binding motif, an analogue or peptidomimetic...
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6803203 |
DNA-PK assay
The present invention provides a method for detecting DNA-activated protein kinase (DNA-PK) activity in a biological sample. The method includes contacting a biological sample with a...
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6800492 |
Chimeric GFP-aequorin as bioluminescent Ca&plus &plus reporters at the single cell level
A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified...
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6800732 |
Human collagenase inhibitor, recombinant vector system for using same and recombinant DNA method for the manufacture of same
A portable DNA sequence is disclosed which is capable of directing intracellular production of metalloproteinase inhibitors. Vectors containing this portable DNA sequence are also set forth,...
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6797808 |
α-conotoxin peptides
The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or...
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6797807 |
Compounds and methods for cancer therapy
Methods for using modulating agents to enhance or inhibit occludin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating...
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6797690 |
Carrot antifreeze polypeptides
Novel antifreeze polypeptides which can be easily obtained from an abundant natural source. Antifreeze polypeptides obtained from carrots show markedly better properties as compared to polypeptides...
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6790951 |
Expression system in microorganism and its use for expressing heterologous and homologous proteins
The present invention concerns the discovery of a new regulatory mechanism for gene expression in lactic acid bacteria (LAB), especially Lactobacillus sake LTH673 or Lactobacillus plantarium ...
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6790648 |
DNA fragmentation factor involved in apoptosis
The invention provides methods and compositions relating to DNA Fragmentation Factor (DFF) polypeptides and related nucleic acids. More particularly, the present invention provides the sequence for...
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6787141 |
Peptide having for fibrinogen fragment E activity, analogs, antibodies and uses thereof
Fibrin degradation products stimulate cell proliferation and angiogenesis. The present invention provides peptides, analogs, and antibodies which are useful in the modulation of binding fibrin...
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6784283 |
Peptide antibiotics
N- and C-modified linear cationic peptides having antibiotic activity are disclosed, which peptides are particularly active against gram positive bacteria.
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6784155 |
Inhibitor and stimulator of stem cell proliferation and uses thereof
Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery....
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6780969 |
Synthetic peptide composition as immunogens for prevention of urinary tract infection
The invention provides a peptide immunogen comprising a FAFSD target peptide or an anlogue thereof, covalently linked to a helper T cell epitope and optionally to an invasin immunostimulatory...
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6780970 |
Cell-permeable peptide inhibitors of the JNK signal transduction pathway
The invention provides cell-permeable peptides that bind to JNK proteins and inhibit JNK-mediated effects in JNK-expressing cells.
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6774210 |
Frozen food product
Anti-freeze protein which can be derived from Lichen, said protein having an apparent molecular weight of from 20 to 28 kDa and having an N-terminal amino acid sequence which shows at least 80%...
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6764995 |
Endostatin protein and fragments thereof
The present invention provides anti-angiogenic compositions, and more particularly provides endostatin protein fragments. The compositions of the present invention may be used for the treatment of...
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6762280 |
High throughput assays for the proteotytic activities of clostridial neurotoxins
In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic...
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6759508 |
Compositions and methods for the therapy and diagnosis of lung cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic...
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6759512 |
Human neuronal attachment factor-1
A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such...
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6756205 |
Methods for inhibiting CGRP binding
This invention relates to antagonists of calcitonin gene related peptide and in particular the invention relates to amino terminal modifications to peptides to improve their ability to bind to a...
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6756206 |
Adsorption and removal of endotoxin from physiological fluids using cationic helix peptides
The present invention provides endotoxin-binding peptides which are useful in the treatment and prevention of sepsis. The present invention further provides a method for treating or preventing...
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6756211 |
Neutropohil inhibitors
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein...
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6753407 |
Antimicrobial peptides isolated from fish
Antimicrobial peptides (endobiotic peptides), isolated from fish are described. Such endobiotic peptides may be isolated as 22 amino acid peptides having molecular weights of about 2500 Da from the...
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6753313 |
Multimeric Apoa-I agonist compounds
The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a...
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6750197 |
Activators of endothelial nitric oxide synthase
The regulatory peptides for constitutive nitric oxide synthase enzymes, and a peptide specific to inducible nitric oxide synthase, as well as derivatives of the peptides, homologous peptides,...
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6750058 |
Transfecting peptide vector, composition containing same and applications
The invention concerns transfecting peptide vector, a composition containing said vector and their applications for treating and preventing diseases in human beings and animals. Said vector for...
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6750200 |
M2GlyR derived channel forming peptides
The present invention provides a family of peptides based upon the M2GlyR sequence. These peptides are derivatives of the M2GlyR sequence and can be modified at their ends to include a plurality of...
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6750008 |
Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of...
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6747007 |
Antimicrobial peptides and methods of use thereof
A class of cationic, polyphemusin-like peptides having antimicrobial activity is provided. Examples of such peptides include FRWCFRVCYKGRCRYKCR (SEQ ID NO:3), RRWCFRVCYKGFCRYKCR (SEQ ID NO:4), and...
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6743470 |
Method of modifying a surface molecules, adhesives, articles, and methods
Adhesive compositions that include self-assembling molecules, adhesives and adhesive articles produced therefrom, and methods of making and using such adhesives.
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6743778 |
Apo-AI/AII peptide derivatives
The present invention concerns therapeutic agents that mimic the activity of Apo-AI amphipathic helix peptide. In accordance with the present invention, the compounds of the invention comprise: a....
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6743769 |
Antimicrobial peptides and derived metapeptides
The peptides and derivative metapeptides based upon natural antimicrobial peptides have potent and broad spectrum activity against pathogens exhibiting multiple antibiotic resistance. In addition,...
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6740525 |
Adenoviral capsid containing chimeric protein IX
The present invention provides a chimeric protein IX (pIX). The chimeric pIX protein has an adenoviral pIX domain and also a non-native amino acid. Where the non-native amino acid is a ligand that...
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6737507 |
Antiangiogenic peptides and compositions thereof
The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1 or a portion thereof which is effective to inhibit endothelial cell...
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