Patents in Class 530/325

Matches 1 - 50 out of 775

Match	Document	Document Title
1	7635681	Cell-permeable peptide inhibitors of the JNK signal transduction pathway The invention provides cell-permeable peptides that selectively block the branch of the JNK signaling pathway controlled by the islet-brain (IB) proteins. The provided cell-permeable peptides block...
2	7632812	Methods to stimulate insulin production by pancreatic ��-cells The invention features a method of treating deficiency of insulin in a patient, comprising administering to a patient in need thereof hedgehog protein or nucleic acid in an amount effective to...
3	7629317	Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for...
4	7622550	Mussel bioadhesive The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a...
5	7615533	TPO peptide compounds for treatment of anemia Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
6	7611711	VEGFR-3 inhibitor materials and methods The present invention relates to the diagnosis, evaluation, and therapeutic intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated...
7	7612168	Modified HIV peptides, antigens, compositions, immunoassay kit and a method of detecting antibodies induced by HIV The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
8	7605150	Drug therapy for Celiac Sprue Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the...
9	7598344	Composition, method and use of bi-functional biomaterials The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a...
10	7598343	Pharmaceutical formulations of bivalirudin and processes of making the same Pharmaceutical batch(es) or pharmaceutical formulation(s) comprising bivalirudin as the active ingredient, and a method of preparing the pharmaceutical batch(es) or pharmaceutical formulation(s)....
11	7589058	Ghrelin analogs The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.
12	7582438	EphB receptor-binding peptides The application is related to the identification of peptides that selectively bind to Eph receptors of the B class. Also disclosed are uses of such peptides in the treatment of a variety of...
13	7579165	Methods for derivatizing protein or peptide with sulfonic acid groups The present invention provides a method for effectively introducing sulfonic acid groups into the N-terminus of a protein or a peptide. The method comprises a modification step to react a...
14	7576056	Peptides and compounds that bind to a receptor Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
15	7576176	Neisseria meningitidis antigens and compositions The invention provides proteins from Neisseria meningitidis , including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for...
16	7566768	Promyostatin peptides and methods of using same The present invention provides substantially purified peptide portions of a promyostatin polypeptide. For example, the invention provides proteolytic fragments of a promyostatin polypeptide such as...
17	7566695	Multimeric apoprotein agonists The present invention provides multimeric apoprotein agonists. Pharmaceutical compositions which include a multimeric apoprotein agonist and a pharmaceutically acceptable carrier, excipient or...
18	7563864	Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
19	7557087	Compositions and methods for treating diseases This invention relates to compositions and methods for treatment of vascular conditions. The invention provides arginine polymers and arginine homopolymers for the treatment and/or prevention of...
20	7553926	Compositions containing anti-HIV peptides and methods for use Peptides representing sequences from region 45-74 of the human CD38 leukocyte surface antigen (SEQ ID NO:1) are provided which may be used to inhibit or prevent transmission or replication of the...
21	7544772	Methods for regulating inflammatory mediators and peptides useful therein The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators...
22	7528105	Heterodimeric chain synthetic heparin-binding growth factor analogs The invention provides synthetic heparin-binding growth factor analogs having at least two different peptide growth factor analog chains, or alternatively two groups of two different peptide chains...
23	7521528	Conformationally constrained parathyroid hormone (PTH) analogs with lactam bridges The present invention relates to methods of treatment of mammalian conditions characterized by decreases in bone mass with conformationally constrained parathyroid hormone (PTH) analogs and...
24	7517855	Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell...
25	7511012	Myostatin binding agents The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one...
26	7507790	Fiber-shaping peptides capable of interacting with self-assembling peptides The present invention relates to a fiber-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of...
27	7498306	Peptides binding to the phosphatase 2A protein The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids...
28	7491701	Peptides that bind to HSP90 proteins YSLPGYMVKKLLGA (SEQ ID NO:1) and its active analogs, compositions, and methods of use.
29	7491699	Peptide nanostructures and methods of generating and using the same A tubular or spherical nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino acids...
30	7488481	Polypeptides derived from anti-HIV-1 gp120 antibodies that abrogate gp120 binding to CCR5 The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral...
31	7482008	Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several...
32	7470776	Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
33	7462462	Peptide capable of binding to nanographite structures It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as...
34	7452858	Treatment of gestational diabetes Methods for treating gestational diabetes which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that...
35	7438917	Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or...
36	7432342	Kinase anchor protein muteins, peptides thereof and related documents A-kinase anchor protein (AKAPs) muteins, peptides thereof, and nucleic acids encoding the peptides are provided herein. Also provided are transgenic animals, cells comprising transgenes and various...
37	7427658	Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. Only lysates of insect cells which have...
38	7422862	Methods for identifying modulators of apoptosis The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound...
39	7417025	Use of poly-α2,8-sialic acid mimetic peptides to modulate NCAM functions The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a...
40	7414107	Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a...
41	7411039	GLP-2 compounds, formulations, and uses thereof The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as...
42	7408029	Peptide epitopes recognized by disease promoting CD4+ T lymphocytes The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined...
43	7388072	MAGE peptides presented by HLA class II molecules The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides...
44	7387779	Anti-angiogenic proteins and fragments and methods of use thereof Proteins with anti-angiogenic properties are disclosed, and fragments thereof, and methods of using those proteins and fragments to inhibit or promote angiogenesis.
45	7381705	Inhibitors of hepatitis C virus The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope...
46	7371812	Antiangiogenic peptides The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1, or a fragment thereof, which is effective to inhibit endothelial cell...
47	7368119	Compositions and methods for WT1 specific immunotherapy Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
48	7368527	HADDE71 polypeptides The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or...
49	7351792	Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which...
50	7342093	Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds.

Matches 1 - 50 out of 775

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