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7413537 |
Directed evolution of disulfide-bonded micro-proteins
The invention relates, in part, to a library of chimeric proteins, each chimeric protein including a mini-protein between about eight and about forty amino acids long, wherein the mini-protein has...
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7414107 |
Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a...
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7408029 |
Peptide epitopes recognized by disease promoting CD4+ T lymphocytes
The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined...
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7402654 |
PHI 15 DNA polymerase
A purified recombinant DNA polymerase having high processivity and strand-displacement activity. An isolated nucleic acid that encodes the bacteriophage DNA polymerase. A kit and method for...
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7399742 |
Anti-osteolytic therapy involving adiponectin
This invention is directed to administering an effective amount of adiponectin into an osteolytic region for treating osteolysis.
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7396909 |
Toxoplasma gondii proteins
The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such...
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7393831 |
Peptide compositions and their use against HCV
The invention relates to novel peptide compositions. In particular, the invention relates to a peptide composition comprising at least two peptides which are selected from among the following...
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7393828 |
Modified MscL protein channel
The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles...
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7393829 |
Pharmaceutical compositions comprising fragments and homologs of troponin subunits
The present invention relates to pharmaceutical compositions comprising therapeutically effective amounts of fragments or homologs of troponin C, I or T subunits for the treatment of diseases or...
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7390872 |
NF-κB peptides designed to disrupt NEMO oligomerization
The present invention relates to polypeptides that inhibit the NF-κB signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of...
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7390785 |
τ-conotoxin peptides
The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or...
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7388089 |
Anti-arthropod vector vaccines method of selecting and uses thereof
The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent...
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7387879 |
Diagnosis of tauopathies
The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the...
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7387779 |
Anti-angiogenic proteins and fragments and methods of use thereof
Proteins with anti-angiogenic properties are disclosed, and fragments thereof, and methods of using those proteins and fragments to inhibit or promote angiogenesis.
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7384636 |
Polypeptide
The present invention provides a polypeptide inducing the production of an antibody in permucosal administration in the presence of no immunological adjuvant, a composition containing the...
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7385026 |
Modified ghrelin polypeptides
The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at...
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7381790 |
Copolymers for suppression of autoimmune diseases, and methods of use
Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein...
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7381705 |
Inhibitors of hepatitis C virus
The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope...
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7381699 |
Reagents and methods for smooth muscle therapies
The present invention provides novel polypeptides comprising heat shock protein 20(HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth...
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7381701 |
Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system...
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7378098 |
CXC chemokine receptor 4 agonist peptides
In accordance with various aspects of the invention, CXCR4 agonists, including SDF-1 polypeptides and SDF-1 polypeptide homologues, may be used in reducing the rate of hematopoietic cell...
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7374875 |
Peptides having affinity for the gp120 viral protein and use thereof
The present invention relates to a family of peptides exhibiting high affinity and specificity for the viral protein gp120, to methods for producing these peptides, and to the use of these peptides.
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7371721 |
Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
The present invention relates to methods for prevention and treatment of bone-related disorders and calcium homeostasis related syndromes using a GLP-2 molecule or GLP-2 activator either alone or...
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7371726 |
Neutralizing GDF8 epitope-based growth enhancing vaccine
The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new...
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7368118 |
Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV envelope, and are...
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7368432 |
Conotoxin peptides
The invention relates to relatively short conotoxin peptides, about 10-20 residues in length as described herein, which are naturally available in minute amounts in the venom of the cone snails or...
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7368119 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
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7368529 |
Agent and compositions comprising the same for inhibiting lipases and phospholipases in body fluids, cells and tissues
The present invention deals with a protein and compositions comprising the same for inhibition of lipases and phospholipases in the body fluids, cells, and tissues for the prevention and treatment...
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7368427 |
GLP-1 analogues
The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to...
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7368127 |
Biomedical devices with peptide containing coatings
Biomedical devices with stable peptide coatings are provided. The coatings are formed by incorporating at least one latent reactive component into the reactive mixture, forming a medical device...
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7365172 |
Loop peptide and TGFα for stimulating stem cell proliferation and migration
There is disclosed a novel genus of small peptides, much smaller than human TGFα, was discovered as having TGFα biological activity and therefore are useful as pharmacologic agents for the same...
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7364889 |
Catalytically active peptides
A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher...
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7361642 |
Canine specific growth hormone releasing hormone
A composition and a method of increasing growth hormone (“GH”) values in a canine or dog, and more specifically, a canine- or dog-specific growth hormone releasing hormone (“dGHRH”), or...
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7358254 |
Method for treating atherosclerosis employing an aP2 inhibitor and combination
A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG...
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7354994 |
Recombinant IGF expression systems
The present invention provides nucleic acid sequences, expression systems, host cells, polypeptides and methods of producing mature insulin-like growth factor (IGF) using a fusion construct which...
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7354999 |
PRO1481 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7354900 |
Treatment and inhibition of ocular infections and wounds by CAP37 and CAP37 peptides
A method for treating ocular conditions such as bacterial keratitis, bacterial conjunctivitis, corneal ulcers and wounds, endophthalmitis, and blebitis in mammals, by using a native, synthetic, or...
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7354722 |
Modulators of Smurf and BMP/TGFβ signaling pathways
This invention provides unique members of the Hect family of ubiquitin ligases that specifically target BMP and TGFβ/activin pathway-specific Smads. The novel ligases have been named Smurf1 and...
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7351792 |
Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor
Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which...
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7351414 |
Method of reducing the risk of bone fracture
The invention relates to a method for increasing the toughness and/or stiffness of bone and/or reducing the likelihood and/or severity of bone fracture by administering a parathyroid hormone. The...
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7351693 |
Peptides and nucleic acids of the cathelicidin family, derived from fish, and uses thereof
The invention relates to anti-microbial and immunostimulatory molecules of the cathelicidin family derived from fish. The invention provides a novel cathelicidin molecule, fragments, derivatives...
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7348400 |
α-conotoxin peptides with analgesic properties
This invention relates to novel α-conotoxin-like peptides comprising the following sequence of amino acids: Xaa 1 CCSXaa 2 Xaa 3 Xaa 4 CXaa 5 Xaa 6 Xaa 7 Xaa 8 Xaa 9 Xaa 10 Xaa 11 C—NH 2 in...
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7341723 |
Nucleic acid construct encoding a processing component derived from the N-terminal region of the hepatitis virus ORF2, and an antigenic polypeptide
A method for enhancing an immune response to a nucleic acid vaccine comprising administering to an animal a nucleic acid construct encoding a fusion protein comprising a processing component and an...
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7341730 |
Inhibitors of angiogenesis and tumor growth
This invention provides for polypeptides that have surprising anti-angiogenic activity. These peptides are derived from Saposin B, a previously known protein involved in the hydrolysis of...
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7342093 |
Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins
Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds.
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7342092 |
Cancer antigen peptide formulations
Cancer antigen peptides derived from WT1 which have an in vivo efficacy, particularly a clinical usefulness, and cancer vaccines as dosage forms suitable for said cancer antigen peptides, are...
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7341727 |
M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
The invention discloses the Moraxella catarrhalis outer membrane protein-106 (OMP106) polypeptide, polypeptides derived therefrom (OMP106-derived polypeptides), nucleotide sequences encoding said...
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7341998 |
Conus californicus neurotoxins
Novel conotoxin polypeptide and polynucleotide sequences are provided.
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7338935 |
Chromatographic separation of therapeutic polypeptides
The present invention is directed to the purification and commercialization of therapeutic polypeptides that have. In one aspect of the invention, a method of purifying Interferon β-1b using size...
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7338653 |
Amino-terminally truncated MCP-2 as chemokine antagonists
The present invention relates to amino-terminally truncated MCP-2, lacking NH 2 -terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3, 1-4 or 1-5 of the naturally-occurring MCP-2...
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