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7582608 |
Selective VPAC2 receptor peptide agonists
The present invention encompasses peptides that selectively activate the VPAC2 receptor and are useful in the treatment of diabetes.
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7582727 |
Pharmaceutical formulations of bivalirudin and processes of making the same
Pharmaceutical batch(es) or pharmaceutical formulation(s) comprising bivalirudin as the active ingredient, and a method of preparing the pharmaceutical batch(es) or pharmaceutical formulation(s)....
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7582726 |
VEGF receptor antagonists
The present invention describes an approach to cancer therapy utilizing novel VEGF receptor antagonists. Specifically, the invention provides peptides and polynucleotides encoding VEGF receptor...
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7582311 |
Injection vehicle for polymer-based formulations
The invention provides injection vehicles suitable for administering particulate suspensions, such as polymer-based formulations, as well as associated pharmaceutical formulations, articles of...
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7579444 |
Polymer-factor IX moiety conjugates
Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided (among...
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7579004 |
Naturally processed measles virus peptides eluted from class II HLA molecules
A preparation of peptides eluted from class II HLA molecules is disclosed. Methods of decreasing measles infections comprising inoculating human patients with a vaccine comprising one or more of...
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7579010 |
Botulinum toxin pharmaceutical compositions with a recombinant human serum albumin
A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and...
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7579165 |
Methods for derivatizing protein or peptide with sulfonic acid groups
The present invention provides a method for effectively introducing sulfonic acid groups into the N-terminus of a protein or a peptide. The method comprises a modification step to react a...
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7576056 |
Peptides and compounds that bind to a receptor
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7576059 |
Peptide derivatives
A pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a...
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7576050 |
GLP-1 exendin-4 peptide analogs and uses thereof
The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's...
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7575758 |
Acaricidal compositions and methods of use thereof
A method of controlling acarine pests comprises applying to the locus of the acarine pests, an isolated polypeptide toxin, wherein the polypeptide toxin has acaricidal activity. In one embodiment,...
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7576176 |
Neisseria meningitidis antigens and compositions
The invention provides proteins from Neisseria meningitidis , including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for...
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7572884 |
Method for making acylated polypeptides
The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent...
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7572591 |
Construct comprising recognition domain of antibody against von Willebrand factor-specific cleaving enzyme
The present invention provides an epitope recognized by an antibody (hereinafter, also referred to as an anti-ADAMTS-13 antibody) against a cleaving protease (hereinafter, also referred to as...
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7572771 |
Multi-domain amphipathic helical peptides and methods of their use
Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods...
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7569540 |
Method for enhanced parenteral nutrition
A method for improved administration of nutrient is provide. The method includes co- or separate administration of a source of nutrients, especially carbohydrates, and insulinotropic peptides and...
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7569392 |
Multiplex spatial profiling of gene expression
The present invention provides mass tag complexes that permit simultaneously obtaining information of a plurality of biological molecules. The biological molecules may be RNA or protein, and the...
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7569661 |
Polypeptide scaffolds and use thereof
Novel peptide having a sequence according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 are disclosed and also polypeptide scaffold consisting of a four helix bundle formed of two...
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7569542 |
Anti-microbial targeting chimeric pharmaceutical
The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target...
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7569662 |
Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer
Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers,...
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7569543 |
Compositions of Angiopoietin, fragments, mutants and analogs thereof and uses of the same
The present invention relates to Ang-1, Ang-2, and Ang-3, and to methods and uses of the same. The present invention also relates to ECM-binding fragments, non-ECM-binding fragments, proteolytic...
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7569660 |
Recombinant prion-like proteins and materials comprising same
The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected...
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7566691 |
Vasoactive intestinal polypeptide pharmaceuticals
Pharmaceutical compositions relating to vasoactive intestinal polypeptides and methods for the treatment of metabolic disorders, including diabetes, insulin resistance, metabolic acidosis and...
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7566764 |
Truncated BARD1 protein, and its diagnostic and therapeutic uses
The invention concerns a novel polypeptide derived from the cleavage of the BARD1 protein, a nucleic acid coding for said polypeptide, and their diagnostic and therapeutic uses, in particular for...
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7566766 |
Peptides which enhance transport across tissues and methods of identifying and using the same
A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or a...
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7566768 |
Promyostatin peptides and methods of using same
The present invention provides substantially purified peptide portions of a promyostatin polypeptide. For example, the invention provides proteolytic fragments of a promyostatin polypeptide such as...
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7566695 |
Multimeric apoprotein agonists
The present invention provides multimeric apoprotein agonists. Pharmaceutical compositions which include a multimeric apoprotein agonist and a pharmaceutically acceptable carrier, excipient or...
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7563864 |
Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
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7563767 |
Beta defensin proteins
This invention relates to novel proteins, termed INSP 108 and INSP 109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences...
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RE40850 |
Analogs of parathyroid hormone
The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in...
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7557087 |
Compositions and methods for treating diseases
This invention relates to compositions and methods for treatment of vascular conditions. The invention provides arginine polymers and arginine homopolymers for the treatment and/or prevention of...
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7557183 |
Polyethylene glycol linked GLP-1 compounds
The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower...
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7553926 |
Compositions containing anti-HIV peptides and methods for use
Peptides representing sequences from region 45-74 of the human CD38 leukocyte surface antigen (SEQ ID NO:1) are provided which may be used to inhibit or prevent transmission or replication of the...
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7550427 |
Poly-pegylated protease inhibitors
Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties...
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7550144 |
Prion inhibition
The invention relates to the use of an agent such as an antibody capable of reacting with PrP in the prevention of prion replication in a subject, in the treatment or prevention of prion infection,...
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7550143 |
Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular...
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7550561 |
p16INK4 polypeptides
The present invention relates to the discovery in eukaryotic cells, particularly human cells, a novel polypeptide of 16 kDa (hereinafter “p16 INK4 ” or “p16”) can function as an inhibitor...
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RE40789 |
Mammalian checkpoint proteins polypeptides and encoding sequences thereof
The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The...
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7550426 |
Acetylated therapeutic procytotoxins
A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by...
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7550434 |
Stabilized teriparatide solutions
A stabilized pharmaceutical composition in the form of a solution for parenteral administration of a parathyroid hormone is described wherein the therapeutically active ingredient is stabilized...
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7547662 |
Target recognizing binding agents
The invention is directed to binding agents having binding loops and a stable beta barrel conformation. The binding loops of these agents can easily be altered so that the binding agent can bind...
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7544771 |
Protein and its use in diagnosing Alzheimer's disease
Embodiments are directed to a peptide and protein containing that peptide, nucleic acids, antibodies, as well assays detecting the peptide or protein, and methods of identifying patients with or at...
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7544665 |
Synthesis using peptide intermediate fragments
Methods for the solid phase synthesis of T-1249 peptides and peptide intermediates, in particular methods involving synthesizing T-1249 peptide intermediates at low loading factors to produce...
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7544658 |
Rotary motor molecule V1-ATpase
A complex rotating in the presence of ATP, which has three A subunits, three B subunits and one D subunit constituting the V 1 portion of a V 0 V 1 ,-ATPase.
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7544767 |
HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds...
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7544657 |
Stabilized Exendin-4 compounds
The present invention disclosed compositions comprising a stabilized Exendin-4 (1-39) and related compounds. The invention describes stabilized Exendin-4 agonists that include at least one modified...
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7538187 |
Coloring compositions with peptide-based dispersants and binders
Coloring compositions comprising peptide-based dispersants and/or binders are provided. The compositions are particularly useful for the coloring or dyeing of substrates such as paper and textile...
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7538090 |
Exogenous surfactant protein B mimic
A composition including a C terminal region having residues corresponding to a peptide identified by PDB ID: 1RG3; an N terminal region having residues corresponding to a peptide identified by PDB...
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7537771 |
Expression system
An immunogenic reagent which produces an immune response which is protective against Bacillus anthracis, said reagent comprising one or more polypeptides which together represent up to three...
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