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7001595 |
Chemokine β-7 variants
The present invention relates to deletion and substitution mutant polypeptides of human chemokine β-7 (Ckβ-7), as well as nucleic acid molecules encoding such polypeptides and processes for...
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6998387 |
Human appetite control by glucagon-like peptide receptor binding compounds
A composition including a compound which binds to a receptor for glucagon-like peptide-1 and a pharmaceutical carrier. The amount of the compound present is effective to control appetite in a...
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6998383 |
Inhibitors of receptor activator of NF-κB and uses thereof
The present invention provides a RANK (receptor activator of NF-κB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide...
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6995237 |
Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions
Peptide constructs including a first peptide segment which includes an amino acid sequence associated with autoimmune disease, asthma, allergy or xeno- or allograft transplantation rejections...
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6995140 |
Peptides and polypeptides useful for regenerating the nervous system
The invention concerns in particular novel peptides and polypeptides comprising at least the following sequence in amino acids: -W-S-A1-C-S-A2-C-G- in which A1 and A2 are amino acid sequences...
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6989369 |
Kunitz domain peptides
The invention relates to a Kunitz domain peptide, designated DPI-14 herein, for inhibiting human neutrophil elastase. The invention also relates to a method of using a DPI-14 for treating cystic...
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6989366 |
Exendins, exendin agonists, and methods for their use
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
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6987173 |
Process for the preparation of active somatotropin from inclusion bodies
A process for the preparation of biologically active somatotropin from inclusion bodies of a recombinant host cell containing an inactive form of said somatotropin protein comprises the steps of:
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6984621 |
Wound contraction inhibitor
The pharmaceutical formulation for inhibiting wound contraction of the present invention includes secretory leukocyte protease inhibitor as an active ingredient. The SLPI concentration in the...
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6984486 |
Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof
The invention pertains to synthetic (s) peptides derived from the viral regulatory protein R (Vpr) of the human immunodeficiency virus type 1 (HIV-1), particularly the chemical synthesis of the 96...
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6982314 |
Lawsonia intracellularis proteins, and related methods and materials
Isolated polynucleotide molecules contain a nucleotide sequence that encodes a L. intracellularis HtrA, PonA, HypC, LysS, YcfW, ABC1, or Omp100 protein, a substantial portion of the sequences, or...
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6982249 |
Bradykinin analogs as selective inhibitors of cell activation
The present invention provides bradykinin peptide analogs, compositions, and methods of inhibiting thrombin-induced platelet and other cell activation. The bradykinin analogs comprise single or...
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6982248 |
Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like...
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6982317 |
C21 polypeptide that modulates the stability of transcriptional regulatory complexes regulating nuclear hormone receptor activity
A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (α and β) produced by alternative splicing has been identified...
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6979443 |
Chemokine α-6
The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6...
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6977077 |
Method of increasing bone toughness and stiffness and reducing fractures
The invention relates to a method for increasing the toughness and/or stiffness of bone and/or reducing the likelihood and/or severity of bone fracture by administering a parathyroid hormone. The...
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6977071 |
Amino-terminally truncated RANTES as chemokine antagonists
The present invention relates to amino-terminally truncated RANTES, lacking NH 2 -terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3 or 1-4 of the naturally-occurring RANTES and...
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6977144 |
Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
The present invention relates to nucleic acids encoding SID® polypeptides which bind selectively to a polypeptide encoded by a pathogenic strain of the hepatitis C virus, as well as to the SID®...
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6974861 |
Pharmaceutical compositions and methods using natriuretic peptides
The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the...
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6974864 |
Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents
The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes...
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6969702 |
Compounds and methods for increasing neurogenesis
The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis increasing agents. Novel methods for treating neurological disorders using...
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6965013 |
Intermedin and its uses
Intermedin nucleic acid compositions and their encoded polypeptides and variants thereof are provided. Intermedin is a novel ligand for the calcitonin receptor-like receptor. In addition to its use...
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6962706 |
Synthetic peptides containing protective epitopes for the treatment and prevention of periodontitis associated with porphyromonas gingivalis
This invention relates to a peptide selected from the group: FLLDADHNTFGSVIPATGPLFTGTASS LYSANFESLIPANADPVVTTQNIIVTG LYSANFEYLIPANADPVVTTQNIIVTG TNPEPASGKMWIAGDGGNQP RYDDFTFEAGKKYTFTMRRAGMGDGTD...
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6962899 |
Method for reducing the inflammation and inducing an analgesic effect and compounds thereof
Pharmaceutically acceptable compounds for administering to a subject, comprising the general structure II:
wherein R 1 is an L-amino acid or salt or ester thereof, or an L-amino acid...
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6960647 |
Stat3 protein fragments and mutants
The present invention relates to methods for identifying interacting regions of transcription factors, and methods for identifying agents which modulate the interactions, useful for affecting gene...
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6958151 |
Miniprotein ligands and other polypeptides and methods for making and using same
Disclosed are polypeptides which include an amino acid sequence corresponding to CCXXXCKEGXXC (SEQ ID NO:1). Also disclosed are methods for inhibiting the activity of a flavivirus or other virus by...
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6956026 |
Use of exendins for the reduction of food intake
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
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6955891 |
Reagents for assaying Bacillus anthracis lethal factor protease
The present invention features a Bacillus anthracis lethal factor substrate. The substrate can be used for example to measure lethal factor activity. Preferred substrates contain one or mare...
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6953683 |
Compositions and methods of inhibiting bacterial spore germination
The present invention is directed to compositions comprising nisin and sublancin in amounts that are effective to inhibit bacterial spore germination. Additionally, the present invention is...
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6953844 |
Isolation of neurotrophins from a mixture containing neurotrophin variants using hydrophobic interaction chromatography
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable...
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6953674 |
Inhibitors of human plasmin derived from the kunitz domains
The invention features novel polypeptides homologous to the first Kunitz domain (K1) of lipoprotein associated coagulation inhibitor (LACI) that are capable of inhibiting plasmin, and nucleic acids...
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6951652 |
Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases
A vaccine is disclosed which is useful for protecting a host from Gram negative infections and the effects of endotoxin, therefore preventing sepsis and septic shock. The vaccine is prepared by...
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6951647 |
T cell binding ligand peptides and method of inducing a cellular immune response
The present invention is based, in part, on the discovery that a modified version of Peptide G (Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO:2) obtained by replacing Asn...
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6949349 |
Insulin-like growth factor agonist molecules
Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful...
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6949506 |
Relaxin-like factor and methods and uses thereof
The present invention relates to a relaxin-like factor, its derivatives or analogs, and uses thereof. The present invention further relates to compositions comprising a relaxin-like factor, its...
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6946261 |
Efficient methods for producing anti-microbial cationic peptides in host cells
Endogenously produced cationic antimicrobial peptides are ubiquitous components of host defenses in mammals, birds, amphibia, insects, and plants. Cationic peptides are also effective when...
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6946133 |
Prostate specific antigen oligo-epitope peptide
The invention is a prostate specific antigen oligo-epitope peptide which comprises more than one PSA epitope peptide, which conforms to one or more human HLA class I motifs. The prostate specific...
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6942852 |
N-terminal modifications of RANTES and methods of use
N-terminally modified RANTES derivatives are disclosed. The derivatives effectively block the inflammatory effects of RANTES, and are useful for the treatment of asthma, allergic rhinitis, atopic...
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6943147 |
Cancer treatment using proANP peptides
The present invention includes a method of utilizing four peptide hormones to inhibit theasein the number of human pancreatic adenocarcinoma cells (i.e., the type of cancer with the highest...
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6943150 |
Survivin, a protein that inhibits cellular apoptosis and its modulation
The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this...
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6943145 |
Compounds and method for the prevention and treatment of diabetic retinopathy
The invention provides peptide derivatives designed to deliver peptides having growth factor inhibitory activity, especially somatostatin analogs, to the retina by sequential metabolism. The...
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6939690 |
Polynucleotides encoding motilin homologs
The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of...
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6939953 |
Leukotriene receptor
The present invention provides an isolated mammalian leukotriene receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids...
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6939853 |
Combined use of a GLP-1 compound and another drug for treating dyslipidemia
Methods and uses for treatment of dyslipidemia comprising administration of a GLP-1 compound and another antidyslipidemic drug.
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6939847 |
Use of colostrinin, constituent peptides thereof, and analogs thereof, as oxidative stress regulators
The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress...
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6936688 |
Human chemokine beta-10 mutant polypeptides
Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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6936475 |
Chimeric GFP-aequorin as bioluminescent Ca++reporters at the single cell level
A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified...
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6936687 |
Compositions for the detection of enzyme activity in biological samples and methods of use thereof
The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone each end...
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6936584 |
Mixed amylin activity compounds
Compounds which inhibit certain activities of amylin but which also act as amylin agonists with respect to other amylin activities are disclosed. Such compounds are useful in treating disturbances...
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6933272 |
Use of non-peptidyl compounds for the treatment of insulin related ailments
The present invention relates to the use of at least a non-peptidyl compound as a biological modulator of insulin activity or insulin-related activity, which compound possesses ionic and...
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