Patents in Class 530/323

Matches 1 - 50 out of 332

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Match	Document	Document Title
1	7622552	Ligation method A method of ligating two or more molecules, for example, peptides to peptides or peptides to labels is provided. The method may comprise the steps: a) providing a first oligopeptide having a...
2	7622440	Cyclic natriuretic peptide constructs Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: ...
3	7618635	Super-antigen fusion proteins and the use thereof The present invention relates to a super-antigen fusion protein, comprising: a peptide fragment whose sequence corresponds to a partial SARS E2 spike protein; and a translocating peptide fragment...
4	7611711	VEGFR-3 inhibitor materials and methods The present invention relates to the diagnosis, evaluation, and therapeutic intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated...
5	7592419	Macrocyclic inhibitors of hepatitis C virus NS3-serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat...
6	7589171	Polyamides for treating human papilloma virus The present invention relates to polyamide compositions and therapies for treating cells infected with human papilloma virus (HPV).
7	7569660	Recombinant prion-like proteins and materials comprising same The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected...
8	7544364	Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a...
9	7528105	Heterodimeric chain synthetic heparin-binding growth factor analogs The invention provides synthetic heparin-binding growth factor analogs having at least two different peptide growth factor analog chains, or alternatively two groups of two different peptide chains...
10	7528104	Peptides that bind to the erythropoietin receptor The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
11	7507790	Fiber-shaping peptides capable of interacting with self-assembling peptides The present invention relates to a fiber-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of...
12	7446099	Compositions and methods for biodegradable polymer-peptide mediated transfection Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.
13	7446094	Cytotoxic depsipeptides Compounds of general formula (I) wherein R 1 , R 2 , R 3 are as defined and R 4 groups are each independently selected from NR 2 , O and S; are of use in treatment of cancers.
14	7429639	SSX-2 peptides presented by HLA class II molecules The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating to the peptides. The...
15	7427590	Neurothrophic components of the ADNF I complex This invention relates to Activity Dependent Neurotrophic Factor I complex (ADNF I complex) and polypeptides of this complex, which produce their neurotrophic effects through multiple proteases...
16	7423020	Treatment of mood disorders by administration of SMR1 This invention relates to the use of an agent that modulates the interaction between a SMR1 peptide and a metal-lopeptidase for the preparation of a medicament for preventing or treating a Central...
17	7408026	Synthesis of proteins by native chemical ligation Proteins of moderate size having native peptide backbones are produced by a method of native chemical ligation. Native chemical ligation employs a chemoselective reaction of two unprotected peptide...
18	7402556	Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or...
19	7378485	Peptide nucleic acids with polyamide-containing backbones A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands...
20	7368528	Antineoplastic peptides The present invention provides antineoplastic peptides of formula I, R 1 R 2 N—CHX—CO-A-B-D-E-(G) s -K I
21	7348310	Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.
22	7348010	Vaccine against cancer diseases that are associated with the her-2/neu oncogene The present invention relates to peptides of the extracellular domain of a HER-2/neu protein, conjugates comprising said peptides linked to an immunogenic carrier, compositions thereof, nucleic...
23	7345020	Mimetics of CD4 that inhibit immune response The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4 + T cell immune responses by identifying compounds that block the interaction of CD4 and...
24	7312190	Pharmaceutical compositions of apolipoprotein A-I agonists and their use to treat dyslipidemic disorders The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a...
25	7273615	Reaction solution for cell-free protein synthesis, method of preparing the same, and protein synthesis method using the same The present invention provides a cell-free protein synthesis method characterized by a cell-free protein synthesis reaction solution that is weakly reducing and suitable for protein folding,...
26	7256043	Transfection complexes The invention provides a peptide having at least 3 amino acids comprising an amino acid sequence selected from a) X 1 SM [SEQ.ID.NO.:1] b) LX 2 HK [SEQ.ID.NO.:2] c) PSGX 3 ARA [SEQ.ID.NO.:9] d) SX...
27	7244704	Peptide scaffolds for transfer of molecules into eukaryotic cells Compositions and methods of using compositions with a nuclear targeting peptide containing a nonclassical nuclear localization signal to deliver selected molecules to the nucleus of eukaryotic...
28	7223833	Peptide nucleic acid conjugates A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached...
29	7205273	Fusogenic liposomes The present invention relates to liposomes and virosomes and, more particularly, to liposomal and virosomal delivery systems for transporting materials such as drugs, nucleic acids and proteins.
30	7202050	Methods for measuring phosphatase activity A method for determining the level of kinase activity or phosphatase activity in a sample without the use of antibodies or radioactive labels is disclosed. The method employs a...
31	7189801	Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360–386 of human p53, said peptides and peptidomimetics...
32	7189692	Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same Cyclic to Synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP(10-14) which are capable of enhancing bone cell proliferation and bone formation. Pharmaceutical...
33	7163695	Histidine copolymer and methods for using same The invention provides a pharmaceutical agent delivery composition comprising: (i) a transport polymer comprising a linear or branched peptide having from about 10 to about 300 amino acid residues,...
34	7157091	MAGE-A1 peptides presented by HLA class II molecules The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0–10 amino acids added to either or both ends of the amino acid...
35	7153931	Transport vectors The invention relates to modified and truncated forms of the membrane transport vector penetratin. Such truncated forms include 7-mer peptides that may in themselves include further variation.
36	7144986	Polypeptides comprising IL-6 ligand binding receptor domains The present invention provides, among other things, a polypeptide, and a pharmaceutically acceptable salt thereof, that inhibits the binding of IL-6 ligand with IL-6 receptor under physiological...
37	7122519	Didemnin analogs and fragments and methods of making and using them The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes...
38	7112654	Ligand for vascular endothelial growth factor receptor The present invention relates to compositions comprised of a peptide ligand or derivatives thereof that are capable of specific binding to the high affinity receptor-1 of vascular endothelial...
39	7112565	Stabilized pharmaceutical composition in lyophilized form A stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by the general formula (I): wherein R 1 is a hydrogen atom or an acyl group...
40	7094548	Purification of recombinant proteins fused to multiple epitopes The present invention provides novel identification polypeptides containing multiple copies of an antigenic domain joined in tandem to provide increased sensitivity for the detection and...
41	7084245	Peptides that bind to the erythropoietin receptor The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
42	7081515	CIDE-B polypeptides The present invention relates to a purified or isolated polynucleotide encoding human CIDE B protein, the regulatory nucleic acids contained therein, polymorphic markers thereof, and the resulting...
43	7074620	Controlling protein levels in eucaryotic organisms Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having...
44	7070807	Branched histidine copolymers and methods for using same The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport...
45	7067133	Methods and compositions for diseases associated with amyloidosis The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of...
46	7064105	Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents...
47	7056884	Reduced FK228 and use thereof The present invention relates to reduced FK228 of the formula (I) wherein R 1 and R 2 are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and...
48	7041787	Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases The present invention relates to MMP regulators that comprise new synthetic peptides, that comprise amino acid sequences structurally similar to those of MMP binding region of TIMPs, coupled to...
49	7015306	Labeled neurotensin derivatives Peptide analogs of neurotensin are disclosed which are resistant to enzymatic degradation and which retain high binding affinity for neurotensin receptors. Pharmaceutical compositions of these...
50	7012127	Analogues of lipopolysaccharide-binding protein (LBP)-derived peptides that efficiently neutralize lipopolysaccharides (LPS) The present invention relates to analogues of peptides from lipopolysaccharide-binding protein (LBP) region whose primary sequence have been substituted at particular amino acid sites to obtain...

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