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8993737 Phospholinked dye analogs with an amino acid linker  
In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to...
8981050 N-terminal derivatisation of proteins with polysaccharides  
The present invention relates to methods for producing N-terminal derivatives of proteins in which a polysaccharide, preferably having at least terminal sialic units and preferably consisting...
8975079 Reducible polymers for nonviral gene delivery  
Provided herein are biodegradable copolymers and nanoplex delivery systems comprising the same and a cargo molecule, such as a nucleic acid, a polynucleotide or other biomolecule. The...
8957016 Tumor activated prodrugs  
The instant invention provides compositions comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide selected from the group consisting of the sequences:...
8946144 Phosphonated glycopeptide and lipoglycopeptide antibiotics and uses thereof for the prevention and treatment of bone and joint infections  
The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or...
8911967 One pot desialylation and glycopegylation of therapeutic peptides  
The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to...
8912310 Phase transition biopolymers and methods of use  
The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be...
8895696 Methods for forming peptides and peptide conjugates and peptides and peptide conjugates compositions formed thereby  
Methods for building peptide chains containing sulfonyl modified amines at the N-terminus, or, within amino acid side chains, of a growing peptide in a solid-phase peptide synthesis are described....
8889835 Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites  
The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in...
8889631 Disruptors of early/recycling endosomes  
A delivery system for introducing a cargo molecule into cytosol of a living cell can include: a first membrane binding element linked to an endosomal compartment disrupting element through a first...
8883516 Click chemistry on heterogeneous catalysts  
The present invention relates to new methods and reagents for coupling molecules by a Click reaction using a heterogeneous catalyst system. Further, the present invention refers to novel devices...
8859724 Manufacture and use of modified polysaccharide chitosan bonds and a process to improve the preparation of HES-medicinal substance compounds  
The invention relates to a bonding product suitable as a carrier for medicinal substances and to the compound derived therefrom that carries medicinal substances. The invention further relates to...
8859506 Glycopeptide phosphonate derivatives  
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide...
8859492 Metallodrugs having improved pharmacological properties, and methods of manufacture and use thereof  
It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through...
8846861 Peptide clearing agents  
A peptide clearing agent is provided for clearance of a conjugate of an enzyme and a binding molecule which binds specifically at a target location from a non-target location in a subject. The...
8846863 Heat stable protein ingredients  
The subject invention pertains to methods of making crosslinked protein-carbohydrate conjugates (CPCCs) and uncrosslinked protein-carbohydrate conjugates (PCCs) that are heat, pH and salt stable....
8835380 Therapeutic conjugates  
The invention concerns a novel antimicrobial peptide (AMP) polymer conjugate comprising at least one AMP, typically colistin, and a dextrin polymer wherein said dextrin polymer has a molecular...
8809496 Production method of 11-sugar sialylglycopeptide  
It is an object of the present invention to provide a method for producing an 11-sugar sialylglycopeptide easily and with good yield and a high degree of purity on an industrial scale from...
8809277 Dual secured therapeutic peptide delivery system  
A delivery system is described that includes a polymer network that can incorporate a therapeutic peptide for targeted delivery to a cell, e.g., a cancer cell. The polymer network can secure the...
8785376 Isolation, identification, and uses of antifungal compounds  
In one aspect, the invention relates to isolated compounds useful as antifungal agents, for example, compounds having a structure represented by a formula: wherein R1 is hydrogen or hydroxyl;...
8785594 Glycoproteins and glycosylated cells and a method for the preparation of the same  
The present application discloses novel glycoproteins and a related glycosylcarbamoylation methodology suitable for the preparation of glycopeptides (in particular glycoproteins and glycosylated...
8785595 Functionalising reagents and their uses  
Reagents and methods for functionalizing polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalizing reagent which comprises a...
8778874 Glycopeptide antibiotic monomer derivatives  
Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide...
8772227 Glucosamine pro-drug  
To develop glucosamine (GlcN) pro-drugs with properties superior to the presently available GlcN products, we have synthesized derivatives with improved pharmaceutical properties. The synthesized...
8728496 Functionalized RGD peptidomimetics and their manufacture, and implant having a coating containing such functionalized RGD peptidomimetics  
At least some embodiments of the invention relates to an implant having a coating that contains or is composed of a functionalized RGD peptidomimetic RGD-P1 having the formula (1) and/or a...
8710182 Rapid glycopeptide optimization via neoglycosylation  
The present invention generally relates to methods and compositions for generating vancomycin analogs. Specifically the invention relates to generating a vancomycin library through chemoselective...
8680056 Antiproliferative factor and methods of use  
A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits...
8664181 Dual acting prodrugs  
A prodrug comprising at least two different pharmaceutically and/or diagnostically active compounds independently bound by cleavable linkers and a protein-binding moiety which is capable of...
8660753 Control method of wheel alignment apparatus using motor driven power steering  
The present invention relates to a control method of a wheel alignment apparatus using an MDPS, which determines whether or not to cancel center alignment control due to a trouble or error is...
8629114 Compositions and methods for transport across the blood brain barrier  
Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a...
8623378 Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof  
The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides...
8609368 Process for purifying vancomycin wet body  
Provided is a process for purifying a vancomycin wet body, comprising: dissolving a wet body obtained from a microorganism-fermented solution containing vancomycin into a water soluble solvent to...
8591910 Chemically programmable immunity  
The present invention is related to methods and compositions that are capable of immediately immunizing a human or animal against any molecule or compound. The present invention comprises an...
8574871 Genetically modified yeasts for the production of homogenous glycoproteins  
The present application relates to genetically modified yeasts for the production of glycoproteins having optimized and homogeneous glycan structures. These yeasts comprise an inactivation of the...
8575103 Peptides and methods for inhibiting G alpha protein signaling  
Permeable Switch Region I and II peptides in the range of 9 to 25 amino acid residues in length are provided for specifically inhibiting signaling through Gα subunits. In addition, compositions...
8569241 Composition for improving brain function and method for improving brain function  
Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the...
8563687 Synthetic genes for plant gums and other hydroxyproline rich glycoproteins  
A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs)...
8541375 Glycopeptide phosphonate derivatives  
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide...
8513185 Inhibition of TREM receptor signaling with peptide variants  
Peptides are provided consisting of L- and/or D-amino acids and combinations thereof, which affect myeloid cells by action on the triggering receptors expressed on myeloid cells (TREMs), including...
8487075 Alpha-conotoxin peptides  
The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or...
8481678 Peptide-based tooth whitening reagents  
Peptide-based reagents comprising at least one tooth surface-binding peptide for delivery of at least one polymer-coated white colorant to the surface of teeth are provided. The peptide-based...
8470967 Phase transition biopolymers and methods of use  
The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be...
8450441 Synthetic N-linked sialo-glycan-containing polymer and method for producing the same  
A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a γ-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on...
8435491 Quantification method for remaining liver function and novel liver receptor imaging agent  
A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining...
8431527 Methods for alleviating deleterious effects of 3-deoxyglucosone  
Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway....
8404456 Blood group antigens of different types for diagnostic and therapeutic applications  
The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.
8394362 Gem difluorinated C-glycopeptides, their preparation and their use for the preservation of biological materials and/or in cryosugery  
The invention concerns a gem-difluorinated C-glycopeptide compound of formula (I) in which N is an integer between 1 and 5, R4=H, AA1, AA1-AA2 and R5=OH, AA1, AA1, AA2, with AA1, and AA2 are...
8394921 N-terminal derivatisation of proteins with polysaccharides  
The present invention relates to methods for producing N-terminal derivatives of proteins in which a polysaccharide, preferably having at least terminal sialic units and preferably consisting...
8338140 Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites  
The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in...
8338372 Dehydroxy vancomycin, the preparation, pharmaceutical composition and the use  
The present invention provides a deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy...