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7615244 |
Glycopeptide and peptide having a kokumi taste imparting function, and method of imparting the kokumi taste to foods
Glycopeptides and peptides having the formula:
where X represents a hydrogen atom or a sugar chain, provide a taste improving function, particularly a kokumi taste imparting function. Such...
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7608591 |
Targeted delivery to legumain-expressing cells
The present invention relates to new agents and methods useful for preventing, treating and diagnosing diseases such as cancer. For example, the invention relates to prodrug agents useful for...
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7550146 |
Glycopeptide conjugates and uses thereof
The present invention provides novel glycoconjugates such as glycopeptides, as well as convergent methods for the synthesis thereof. An exemplary preparative approach is exemplified by the...
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7538186 |
Exendins and exendin agonists modified with polyamino acids
Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more molecular weight increasing compounds, for example, polyamino acids, polyethylene glycol polymers,...
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7514404 |
PNA-neamine conjugates and methods for producing and using the same
The present invention relates to methods and compositions pertaining to conjugates composed of a peptide nucleic acid (PNA) moiety and a neamine derivative moiety. Methods for using such conjugates...
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7482018 |
Use of oligomers and polymers for drug solubilization, stabilization, and delivery
The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action....
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7473671 |
Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
A glycopeptide of the formula A 1 -A 2 -A 3 -A 4 -A 5 -A 6 -A 7 , in which each dash represents a covalent bond; wherein A 1 comprises a modified or unmodified α-amino acid residue, alkyl, aryl,...
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7470776 |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
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7468420 |
Process for purifying glycopeptide phosphonate derivatives
Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods...
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7462687 |
Prodrugs of vancomycin with hydrolysis resistant polymer linkages
Vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are hydrolysis resistant in vitro, are selectively attached to the sugar amino and/or N-methyl amino groups...
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7439322 |
Glycopeptides produced using Amycolatopsis orientalis glycosyltransferase gtfE
The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme,...
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7432246 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from...
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7368422 |
Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the...
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7351791 |
Intermediate for preparing glycopeptide derivatives
This invention provides 9-fluorenylmethoxycarbonyl compounds that are useful as intermediates for preparing glycopeptide antibiotics.
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7351691 |
Glycopeptide phosphonate derivatives
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide...
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7301004 |
Process for preparing glycopeptide phosphonate derivatives
Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without...
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RE39887 |
Dehydrodidemnin B
Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.
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7273845 |
Polymeric prodrugs of vancomycin
Methods of preparing vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are preferably releasable, are selectively attached to the sugar amino and/or N-methyl...
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7265086 |
Glycopeptide carboxy-saccharide derivatives
Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical...
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7262177 |
Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use
A conjugate of formula A-L-P, in which:
A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise...
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7244705 |
Polyacid glycopeptide derivatives
Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO 2 H) groups; and pharmaceutical...
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7226990 |
Extendin derivatives
The present invention relates to novel derivatives of exendin-4 or exendin-4 fragments, wherein the derivatives have a lipophilic substituent attached, optionally via a spacer, to an amino acid...
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7226904 |
Agents and methods for promoting bone growth
Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively...
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7223845 |
Synthetic glycosulfopeptides and methods of synthesis thereof
A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a...
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7223725 |
Exendin agonist compounds
The present invention relates to novel exendin agonist compounds useful in treatment of Type I and II diabetes, and useful in lowering plasma glucose levels, reducing body weight, and delaying...
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7220824 |
Integrin-mediated drug targeting
The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to α v β 3 integrin antagonists via preferred linking units. The preferred linking units...
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7173107 |
Glycopeptide and preparation thereof
The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl-β-[1,4]-N-acetylmuramylmonopeptide and...
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7169890 |
Process for the production of ramoplanin-like amide derivatives
The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC—CO—R (I), wherein the radical R represents a hydrocarbon radical and the portion...
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7169756 |
Streptogramin antibiotics
Disclosed is a cyclic peptide antibiotic in which an enzyme-sensitive bond is replaced by an enzyme-resistant bond.
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7160856 |
α-O-linked glycoconjugates, methods of preparation and uses thereof
The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified...
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7157433 |
Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules
The present invention relates (a) to new compounds represented by Formula I:
wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of...
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7153825 |
Methods for glucagon suppression using modified exendins
We claim a method of lowering plasma glucagon in a subject in need thereof comprising administering to the subject a composition comprising a modified exendin or modified exendin analog, wherein...
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7122519 |
Didemnin analogs and fragments and methods of making and using them
The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes...
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7119061 |
Dalbavancin compositions for treatment of bacterial infections
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial...
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7115564 |
Stable pharmaceutical compositions of dalbavancin and methods of administration
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in...
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7112654 |
Ligand for vascular endothelial growth factor receptor
The present invention relates to compositions comprised of a peptide ligand or derivatives thereof that are capable of specific binding to the high affinity receptor-1 of vascular endothelial...
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7109176 |
Nonsteroidal anti-inflammatory substances, compositions and methods for their use
The present invention relates (a) to new compounds represented by Formula I:
wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of...
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7109165 |
Conjugates and compositions for cellular delivery
This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids...
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7101967 |
Transport vectors
The invention relates to modified and truncated forms of the membrane transport vector penetratin. Such truncated forms include 7-mer peptides that may in themselves include further variation.
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7101964 |
Intermediate for preparing glycopeptide derivatives
This invention provides 9-fluorenylmethoxycarbonyl compounds that are useful as intermediates for preparing glycopeptide antibiotics.
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7094580 |
Methods for producing pure perlecan and other heparan sulfate proteoglycans
A method of perlecan isolation (from the EHS tumor) which produces “clean” (i.e. substantially “pure”) perlecan is disclosed. Clean perlecan is thus produced in sufficient quantities for...
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7078480 |
Process for stabilizing the content of glycated protein of a sample on a matrix material
The invention concerns a method for stabilizing the content of glycated protein in a sample on a matrix material, which is characterized in that the matrix material is impregnated with boric acid...
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7074760 |
Polyacid glycopeptide derivatives
Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO 2 H) groups; and pharmaceutical...
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7071298 |
Compounds and methods for treating glycogen storage disease and other pathological conditions resulting from formation of age-proteins
Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway....
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7067620 |
Antibacterial agents
Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2–10 ligands covalently connected, each of said ligands being capable of...
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7067618 |
Medicinal preparations
The present invention provides a pharmaceutical preparation comprising a compound which can be obtained by reacting a compound having a free amino group with a sugar having the reducing power. The...
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7064105 |
Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them
The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents...
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7060678 |
Peptides comprising furanoid sugar amino acids for the treatment of cancer
Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar...
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7041637 |
Echinocandin/carbohydrate complexes
A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also...
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7001982 |
Non-natural C-linked carbo-β-peptides with robust secondary structures
Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably...
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