Match Document Document Title
4574058 Antigen derivatives and processes for their preparation  
The invention relates to novel antigen derivatives comprising an antigen and at least one muramylpeptide covalently bonded thereto, if appropriate via a spacer, to pharmaceutical preparations...
4568490 Aminopropylaminobleomycin derivatives and process for preparation thereof  
An aminopropylaminobleomycin represented by the following formula or a salt thereof, which is minimized in side effects such as pulmonary toxicity: [BX]--NH--(CH2)3 --A--)CH2)3 --Bwherein [BX]...
4565781 Antibiotic, Spicamycin  
An antibiotic, Spicamycin, having the physicochemical properties set forth below is produced by aerobically cultivating a Spicamycin-producing Streptomyces strain in a suitable culture medium, and...
4563442 Glycopeptide bioconversion products  
New glycopeptide antibiotics of the formula: ##STR1## wherein W is the remaining portion of a glycopeptide antibiotic selected from actaplanin factors B1, B2, B3, C1, C2, C3, D1, D2, E1, G, K, L,...
4560748 Streptothricin-group compounds  
A streptothricin-group compound having the formula: ##STR1## in which R represents ##STR2## is disclosed along with methods for producing this compound and a microorganism useful in its production.
4559221 P-Glyoxyloylphenylalkanoic acid bis(thiosemicarbazone) derivatives, and their production and use  
A radioactive diagnostic agent which comprises a physiologically active substance and a radioactive metallic element combined with a compound of the formula: ##STR1## wherein R is a hydrogen atom...
4558036 Actaplanin antibiotics  
Antibiotic A4696 factor H is isolated from the purified antibiotic complex produced by Actinoplanes missouriensis ATCC 31683 and exhibits excellent activity vs. gram-positive bacteria.
4552701 Glycopeptide antibiotics and process of preparation  
Desvancosaminyl- and des(vancosaminyl-O-glucosyl) glycopeptides, and methods for their preparation by treating a glycopeptide selected from vancomycin, A51568A, A51568B, M43A and M43D with...
4552867 Antibiotic LL-BO1208α and LL-BO1208β, process of preparation, pharmaceutical composition and method of use  
This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208α and LL-BO1208β produced during microbiological fermentation, under controlled conditions, using the...
4548924 Antibiotics M43B and M43C, pharmaceutical composition and method of use  
Antibiotics M43B and M43C, new glycopeptide antibiotics of the vancomycin class, are produced by Nocardia orientalis NRRL 2452. M43B and M43C have antibacterial activity.
4548925 Antibiotic M43A, pharmaceutical composition and method of use  
Antibiotic M43A, a new glycopeptide antibiotic of the vancomycin class, is produced by Nocardia orientalis strains NRRL 2450 and NRRL 2452. M43A has excellent antibacterial activity comparable to...
4547488 Antibiotic M43D, pharmaceutical compositions and method of use  
Antibiotic M43D, a new glycopeptide antibiotic of the vancomycin class, is produced by Nocardia orientalis NRRL 2450. M43D has excellent antibacterial activity comparable to that of vancomycin.
4545932 Glucosaminyl muramyl peptide derivatives  
Novel glucosaminyl muramyl peptide derivatives of the formula: ##STR1## wherein X is hydrogen atom or a group of the formula: R1 CO--, Y is hydroxy group or a group of the formula: --OR2, ##STR2##...
4536207 Nematocidally active chitin-protein complex  
A chitin-protein complex is prepared from chitin-containing biological waste material such as crustacean shells. The complex is different from both chitin and chitosan, and has useful nematostatic...
4521335 Aglycone and pseudo-aglycones of the AAD 216 antibiotics  
Novel aglycone and pseudo-aglycones of the AAD 216 antibiotics are prepared by partial acid hydrolysis of the AAD 216 antibiotic complex or its individual factor antibiotics. AAD 216 aglycone, AAD...
4511550 1-(p-Substituted or unsubstituted aminoalkyl)phenylpropane-1,2-dione bis(thiosemicarbazone) derivatives, and their production and use  
A radioactive diagnostic agent which comprises a physiologically active substance and a radioactive metallic element combined with a compound of the formula: ##STR1## wherein R, R', R1 and R2 are...
4504467 Glycopeptide derivatives  
Method of preparing compounds of formula 1: ##STR1## by oxidative deamination of a glycopeptide antibiotic of formula 2: ##STR2## the antibiotic being selected from A35512 factors A, B, C, E and...
4500452 (Amido)N-substituted bleomycins, salts thereof and process for preparation thereof  
A promising carcinostatic (amido)N-substituted bleomycin represented by the following formula, or a salt thereof and a process for the preparation thereof: ##STR1## wherein BM represents a moiety...
4497802 N-Acyl glycopeptide derivatives  
N-Acyl-glycopeptide antibiotics having the formula ##STR1## and their salts are useful new antibiotics. The N-acyl actaplanin derivatives also increase feed-utilization efficiency and promote...
4495179 A51568 Antibiotic and process for producing thereof  
Antibiotic A51568 is produced by submerged, aerobic fermentation of new Nocardia orientalis NRRL 15232. The antibiotic is gram-positive.
4488991 Bacterial toxoids and gram-negative immune globulin therefrom  
ADP-Ribosylating toxins are rendered enzymatically inactive by reactions with photolabile affinity reagents. The toxoids retain the antigenic and immunogenic properties of the original toxins....
4485100 Elastase inhibitors, a process for their preparation and medicaments containing these inhibitors  
The invention relates to elastase inhibitors from bovine serum identified herein as BI-I-E and BI-I-E+. Said inhibitors are peptides of the specified amino acid sequence defined herein and they...
4481137 Glycoproteins and processes for their production  
A glycoprotein obtained from the cells of human or non-human warm-blooded animals having an anti-tumor effect and characterized by the following properties: (a) molecular weight: in the range from...
4479897 Actaplanin antibiotics  
Actaplanin antibiotics (A4696) designated as C2a, D1, D2, K, L, M, N, and O are obtained by the partial acidic hydrolysis of known actaplanins at about pH 1.85 for 2.5 hours at about 90° C. The...
4478744 Method of obtaining antibodies  
Antibodies specific to glycosylated hemoglobin and substantially free of cross-reactivity with nonglycosylated forms of hemoglobin are obtained by administering a synthetic antigen to a host...
4461761 Oligomers of compounds of the muramyl-peptide type and medicaments containing them  
The novel products are water-soluble oligomers, free of N-acetyl-glucosamine units, and of which the monomer elements include a group derived from muramic acid on which is fixed a chain of the...
4456593 Ristocetin ψ-aglycone as an antibacterial agent  
Described is the use of ψ-aglycone and other derivatives of ristocetin A as antibacterial agents.
4436656 Novel antitumor glycoprotein substance and its preparation  
A novel glycoprotein substance possessing a high antitumor activity is provided, which is recovered and isolated from the liquid portion coming from cooking of raw scallop shellfish with a hot...
4430265 Glucosamine derivatives  
Compounds of the following formula and their physiologically acceptable salts are novel and have excellent immunostimulatory activity: ##STR1##
4421683 Substance effective for prevention or therapy of nephritis and method for preparation thereof  
Glucopeptide in the form of a white powder, which is effective for prevention or treatment of nephritis, is produced by: preparing a concentrated extract from watermelon pulp juice; adding a lower...
4402947 Pesticidally active nikkomicin heavy metal salts  
Arthropodicidally and fungicidally active heavy metal salts of nikkomicin are produced by reacting nikkomicin with a water-soluble heavy metal salt in an aqueous medium.
4401592 Pharmaceutical composition having antitumor activity  
Disclosed is a novel pharmaceutical composition having antitumor (anti-cancer) activity without causing pyrexia and anaphylaxis, formed by an amide bonding between an antibody obtained by the...
4396607 Muramyl peptide derivatives and pharmaceutical compositions  
The invention relates to new compounds useful notably as regulator of immune responses and which are derivatives of muramyl peptides substituted at the end of the peptide chain by a group...
4395399 Glycopeptides and method for preparing same  
Glycopeptides according to the present invention have the formula: ##STR1## wherein n=1 or 2; R is a residue of an aminoacid or linear peptides built of 2 to 5 amino acid residues.These compounds...
4390468 Preparation of antitumor agent from shellfish  
A new antitumor agent is provided which consists essentially of water-soluble, macromolecular glycoprotein substances having a range of molecular weights within the limits of from 10,000 to...
4386026 Cell-specific glycopeptide ligands  
Cell-specific ligands comprising conjugates of saccharides and amino acids or peptides are synthesized from amino acids such as ornithine, lysine, peptides such as dilysine, diornithine or...
4382887 Novel glycopeptide and methods of isolating and using the same  
A novel glycopeptide is disclosed, which consists of a sugar moiety having a structural formula ##STR1## and a peptide moiety linking to the sugar moiety through N-glycoside bond. The glycopeptide...
4369178 Glucosamine peptide derivatives, their production and use  
Novel glucosamine-peptide derivatives of the formula: ##STR1## wherein m is 0 or 1; n is 0 or an integer of 1 to 9; R is lower alkyl which may be substituted with hydroxyl, or aryl; R1 is hydrogen...
4367309 Glycoprotein derivative compositions, process for producing the same and uses thereof as diagnostic reagents or hydrolytic catalysts  
Highly stable glycoprotein derivative compositions showing little tendency to decrease in physiological activity thereof are produced by reacting an aldehyde-group-containing glycoprotein (A) with...
4359415 Isolation of an antineoplastic protein fraction and an antineoplastic peptide fraction from human urine  
The passage of human urine through a bed of adsorbent material results in the adsorption from the urine of antineoplastic substances as determined by in vitro tissue culture techniques utilizing...
4357323 Polysaccharide RBS substance and antitumor agent containing same  
A polysaccharide RBS substance having the ultraviolet absorption spectrum depicted in FIG. 1 and the infrared absorption spectrum depicited in FIG. 2 is obtained from rice bran by extraction with...
4350687 Platelet derived cell growth factor  
A purified cell growth factor is produced which comprises a substantially purified glycoproteinaceous factor from platelets which has mitogenic activity toward transformed cells, a molecular...
4339426 Bleomycin analog  
Bleomycin's affinity for tumorous tissue and its ability to complex with cobalt has lead to its use in vivo as a complex with 57 Cobalt. This complex has given excellent tumor images and has been...
4336188 Method for the preparation of macromolecularized adenine derivatives  
A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted...
4326054 Cleomycins and process for producing same  
Novel antibiotics cleomycins represented by the formula ##STR1## wherein R is a terminal amino residue of the cleomycin. These compounds are useful as a chemotherapeutic agent for treating cancer...
4323559 Compounds derived from N-acetyl-nor-muramyl-L-alanyl-D-isoglutamic acid and other compounds and biologically active compositions containing such compounds  
The invention relates to water-soluble biologically active agents, having anti-infectious and adjuvant properties. They have the general formula ##STR1## wherein X, Y, Z, R2, R4 and R6 have the...
4322343 Pseudo-aglycone of actaplanin  
Antibiotic A-4696 pseudo-aglycone, produced by mild acid hydrolysis of the actaplanin antibiotic A-4696 complex, has antibacterial and growth promotant activity.
4317771 Muramyldipeptide derivatives  
Muramyldipeptide derivatives of the formula (I): ##STR1## wherein X represents an amino acid residue such as of L-alanine, L-serine, L-valine, glycine, etc., and Y represents a group ##STR2##...
4315913 Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation  
Immunologically active compounds of the formula: ##STR1## wherein R1 is C1-7 alkyl, substituted C1-7 alkyl; phenyl; or substituted phenyl; R2 is hydrogen; or C1-10 alkyl; R3 and R4 may be the same...
4314999 N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity  
N-acyl derivatives of D-hexosamine made by linking an oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl residue to the amino groups of two hexosamine molecules by a peptide bond, are...