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5037651 Dihydro derivatives of LL-E33288 antibiotics  
Dihydro derivatives of LL-E33288, BBM-1075 FR-900405, FR-900406, PD 114759, PD 115028, CL-1577A, CL-1577B, CL-1577D, CL-1577E and CL-1724 antibiotics/antitumor agents are disclosed and described,...
5013550 Antibiotics called "chloropolysporins B and C", a process for their preparation, and their therapeutic and veterinary use  
Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They...
5004818 Method for preparation of nephritogenoside  
In a method for preparing nephritogenoside from human placenta, rat kidney or other organs, tissues containing many microvessels are excised from the organ and treated with a nonionic surface...
4994555 Process for recovery of glycopeptidic antibiotics  
This invention concerns the recovery of glycopeptidic antibiotics from aqueous solutions resulting from fermentation broths or process streams. Examples of glycopeptidicantibiotics to which the...
4994440 Method for the treatment of renal cell carcinoma  
The present invention relates to a method for the treatment of renal cell carcinoma comprising administering to a warm blooded mammal in need thereof a therapeutically effective amount of...
4987237 Derivatives of monophosphoryl lipid A  
Novel derivatives of monophosphoryl lipid A and a process for their preparation are provided. The derivatives contain one or more free groups, such as an amine, on a side chain attached to the...
4985405 Therapeutic product based on organic silicon derivatives  
Therapeutic produced based on an organic derivative of silicon, notably of silanol complexed with an amino acid, with a pharmaceutically acceptable salt of such an acid, or with a protide. The...
4970300 Modified factor VIII  
Disclosed are conjugates of a protein having antihemophilic factor (Factor VIII) activity linked to nonantigenic ligands. The conjugates have longer half life than the unconjugated protein but...
4968672 Adenosine receptor prodrugs  
A functionalized congener approach to drugs acting at A1 and A2 adenosine receptor types is applicable to prodrug design. The prodrugs affect a more efficient delivery of the drug at the...
4963653 Sialic acid-bonded octapeptide and preparation thereof  
A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an...
4963356 Stable antigenic extracts methods  
A storage-stable, high potency allergenic extract is prepared by ultrafiltration, retaining fractions having molecular weights of from 1000 to 100,000, and drying the retained fraction to a...
4960755 BU-3608 derivatives  
Disclosed herein are N-alkyl derivatives of antibiotics BU-3608, BU-3608 B, C, D and E as well as the corresponding desxylosyl compounds. These novel compounds are useful as antifungal agents.
4954482 New glycopeptide antibiotic  
A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active...
4950738 Amine derivatives of anthracycline antibiotics  
Novel antineoplastic amine-containing derivatives and methods for synthesizing such derivatives of anthracycline antibiotics are disclosed. The derivatives are useful to prepare site-selectively...
4946941 Novel glycopeptide antibiotics  
The compounds of the formula: ##STR1## wherein R is ##STR2## or H, wherein X is NH2 and Y is CH3 ; or X is OH and Y is H, and their pharmaceutically acceptable salts. The compounds have a potent...
4939122 Lipophile derivatives of muramylpeptides having properties of activating macrophages and compositions containing them  
The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group...
4933179 Feline leukemia virus antigen vaccines  
A vaccine for immunizing animals against Feline Leukemia Virus (FeLV) infections contains an FeLV antigen emulsified with a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based...
4914087 Nikkomycin derivatives, antimycotic compositions of nikkomycin derivatives and azole antimycotics  
Nikkomycin derivatives have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a...
4908351 Antibiotic a 42867 derivative  
The present invention is directed to a new antibiotic substance denominated antibiotic A 42867 pseudoaglycon, a pharmaceutically acceptable salt thereof, a process for its preparation from...
4906612 Method for animal growth promotion using glyclopeptides  
An agent for animal growth promotion which comprises, as an essential component, a compound of the formula I: ##STR1## wherein R is ##STR2## or H, or a salt thereof. A method for growth promotion...
4895835 Muramyl peptide derivatives and use thereof  
Muramyl peptide derivatives having the formula (I) ##STR1## wherein R3 is a long chain acyloxyacyl group, R1 is hydrogen or hydroxy mercapto, acyloxy or acylthio group, R2 is hydrogen or alkyl...
4885275 Vancomycin-HCL solutions and the lyophilization thereof  
Gel-free concentrated aqueous formulations of vancomycin hydrochloride are provided which comprise the antibiotic salt at a concentration between about 12% and about 50% w/v and a gel-inhibiting...
4882313 Carboxamide derivatives of glycopeptides  
Carboxamide derivatives of glcopeptide antibiotics and their salts are useful for treating or preventing infection in an animal by gram-positive bacteria and also increase feed-utilization...
4876332 Polypeptides with type IV collagen activity  
A composition which can bind heparin and promote cellular adhesion is provided which consists essentially of a polypeptide of the formula:...
4874843 Chromatographic purification process  
This invention relates to a new chromatographic process for purifying fermentation products, particularly the antibiotic LY146032, from fermentation broths by use of a reverse phase non-functional...
4868285 Antibiotic production  
Imidazole/vancomycin complexes are prepared by containing an imidazole, preferably imidazole or N-methylimidazole, with a member of the vancomycin family, preferably Vancomycin itself.The...
4855283 Novel pharmaceutically active N-(2-aminoacylamido-2-deoxy-hexosyl)-amides, -carbamates and -ureas  
Compounds of the formula ##STR1## in which R1 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, X represents --CH2 --, --O-- or --NH--,...
4845194 Glycopeptide recovery process  
An improvement in the large-scale recovery of vancomycin-type glycopeptide antibiotics which comprises (1) commingling the fermentation medium in which the antibiotic is produced with a...
4812409 Hydrolyzable fluorescent substrates and analytical determinations using same  
Hydrolyzable substrates comprise blocked dye moieties which, when cleaved from the substrate during hydrolysis, provide fluorescent dyes having maximum absorptions above about 530 nm and maximum...
4808703 Novel 3-(4'-aminobutylamino) propylaminobleomycin derivatives  
Disclosed is a 3-(4'-aminobutylamino) propylaminobleomycin having low pulmonary toxicity, which expressed by the following general formula [BX]--NH--(CH2)3 --A--(CH2)4 --Bwherein [BX] represents a...
4801578 Muramylpeptide-glycoprotein immunostimulant derivatives, their preparation and their use in medication  
Macromolecular conjugates of muramylpeptides useful as a stimulant of the cellular immune systems have the formula (R--X)m --(LAM) wherein R is an N-acetylmuramylpeptidyl group or a derivative...
4770874 Polyoxypropylene-polyoxyethylene block polymer based adjuvants  
An adjuvant composition contains an immunopotentiating amount of an immunostimulating glycopeptide, a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, and,...
4742045 Glycopeptide antibiotics  
Novel glycopeptide antibiotics of the CWI-785 complex are produced by the Actinomycete SKF-CWI-785.
4725669 Assay for detecting infection by human T-cell lymphotropic virus-III  
A first glycoprotein having a molecular weight of approximately 120,000 daltons in the H9/HTLV-III cell line, of which approximately 90,000 daltons is the unglycosylated moiety, is obtained from...
4702908 Composition containing platelet factor 4 and method for restoring suppressed immune responses  
Compositions and methods for modulating immune responses in a mammal comprising immunomodulating-effective amounts of platelet factor 4 are disclosed herein. Immunomodulation includes one or more...
4699977 Antibiotic L 17046 and process for preparing it  
The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called...
4698327 Novel glycopeptide derivatives  
Novel glycopeptide antibiotics of formula (I) can be prepared from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D by reaction with a ketone or aldehyde followed, if...
4694069 Kibdelosporangium aridum SK&F-AAD-609  
A novel subspecies of Kibdelosporangium aridum, subsp. largum (SK&F-AAD-609) produces AAD-216 antibiotics and AAD-609 antibiotics, the ADD-609 antibiotics differing from the AAD-216 antibiotics in...
4668661 Sleep inducing agents  
A compound capable of inducing sleep in mammals comprising a peptidoglycan monomer obtained by lysozyme digestion of linear non-crosslinked peptidoglycan polymer chains present in culture fluids...
4666697 Radioactive diagnostic agent  
A radioactive diagnostic agent which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating...
4650855 Glycopeptide antibiotic L 17046  
The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called...
4647656 Aminoglycoside compounds  
An aminoglycoside compound represented by the following formula (1) ##STR1## wherein R1 and R2 are different from each other and each represents a hydrogen atom or a methyl group, R3 represents a...
4645827 Glycopeptide antibiotic L 17054  
The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known...
4643987 Modified glycopeptides  
Novel aracyl glycopeptide derivatives of formula 1 and methods for their preparation from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D, are provided. The new...
4639512 Conjugates of haptenes and muramyl-peptides, endowed with immunogenic activity and compositions containing them  
The invention relates to an immunogenic principle containing a specific antigen determinant of a predetermined native antigen. This immunogenic principle is constituted by a conjugate between a...
4639433 Glycopeptide derivatives  
Novel glycopeptide derivatives of formula 1 and methods for their preparation from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D, are provided. The new glycopeptide...
4629782 Crystalline form of N-acetylmuramyl-L-α-aminobutyryl-D-isoglutamine  
Crystalline N-acetylmuramyl-L-α-aminobutyryl-D-isoglutamine monohydrate useful as an adjuvant for vaccines and as an immunostimulant.
4629692 Immunoassay for nonenzymatically glucosylated proteins and protein fragments an index of glycemia  
An immunoassay method and reagent system for determining nonenzymatically glucosylated proteins and protein fragments in a biological fluid based on the specific binding of such proteins and...
4587044 Linkage of proteins to nucleic acids  
A nucleic acid-protein conjugate which is specific with respect to a selected living cell is prepared by linking said nucleic acid to a protein specific to said living cell.
4585761 Antibiotics, a process for their preparation and their use as plant protection agents  
A method of combating arthropods, comprising applying to the arthropods, or to a habitat infested therewith an arthropodicidally effective amount of an antibiotic which (a) is colorless, very...