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5410039 Process for the synthesis of glycosaminoglycans containing α-L-galacturonic acid substituted with nucleophilic groups in position 3  
A process for the synthesis of glycosaminoglycans in which one of the α-L-iduronic-2-O-sulfate acid saccharide units, which is characteristic of glycosaminoglycans with heparin or heparan...
5405939 2',5'-phosphorothioate oligoadenylates and their covalent conjugates with polylysine  
Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide...
5405949 Process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid  
A process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part,...
5401628 Polypeptides derived from the human immunodeficiency virus endonuclease protein  
A polypeptide linked to a solid matrix useful as a solid support of a diagnostic kit is disclosed. The polypeptide has the formula:...
5376369 Vaccine adjuvant  
This invention is directed to an adjuvant composition in the form of an emulsion which is comprised of an emulsion-forming amount of a non-toxic tetra-polyol or of a POP-POE block polymer and an...
5374539 Process for purifying collagen and generating bioprosthesis  
A process is described to purify collagen fibers while allowing the individual constituent molecules to retain their native configuration and 3-dimensional arrangement characteristic of the...
5374714 Purified coriolus versicolor polypeptide complex  
A method of obtaining a novel polypeptide from a crude extraction product of polysaccharide peptide Coriolus versicolor comprising: a) boiling a water soluble powder of polysaccharide peptide...
5352667 Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmaceutical compositions comprising them  
Non-peptidic RXD analogues are provided that inhibit biological cellular and molecular interactions which are dependent on RXD recognition, wherein X is one of the amino acid residues G, E, Y, A...
5336666 Immunostimulant drug based on polar glyopeptidolipids of mycobacterium chelonae  
A pharmaceutical composition having as the active ingredient an at least partially purified extraction fraction of polar glycopeptidolipids of Mycobacterium chelonae having formula (1). The...
5317088 C-terminal conglutinin fragments coupled to solid support  
Peptide fragments of conglutinin are provided for use in binding to complementary ligands. Particularly, an N-proximal region is provided having a hypervariable region with a collagen type...
5302582 Enkastins: new glycopeptides which act to inhibit enkephlinase, processes for their preparation, and their use as pharmaceutical products  
The invention relates to new biologically active glycopeptides of the general formula Sacch--A--B--Rin which Sacch represents a monosaccharide residue with, where appropriate, the OH groups being...
5300630 Oncofetal fibronectin epitope  
An onco-developmentally regulated α-N-acetylgalactosaminyltransferase isolated as a component of a particulate membrane fraction separated from cell and tissue homogenates and having the following...
5298391 Use of the SP-2 monoclonal antibody for the clinical diagnostics and for the monitoring of the HIV infection progress  
A method for in vitro immunoassaying an antigen from biological fluids or tissues. The antigen is present in individuals infected with the AIDS virus. The antigen is of cytoplasmic origin and is...
5298488 CM-chitin derivatives and use thereof  
A CM-chitin derivative which has, as an essential unit, a cohesive peptide represented by the following general formula (I), bonded to the side chain of CM-chitin, wherein the bond connecting...
5290576 Tert-butyloxycarbonyl-L-tyrosyl-peptidoglycan monomer and 125 I-labeled derivative thereof, their preparation and use  
The present invention relates to the novel tert-butyloxycarbonyl-L-tyrosylpeptidoglycan monomer ##STR1## and to its 125 I-labelled Boc-Tyr-PGM derivative; to the preparation and use thereof as...
5288856 Method of isolating acid-stable, biologically active proteins  
A method of isolating cystine rich acid-stable, biologically active proteins comprising the steps of co-precipitation by acidification of said proteins together with at least one acid-sensitive...
5288606 Reagent for specific determination of fructosamine  
The present invention provides a process for the specific determination of the serum fructosamine content in blood or samples derived from blood by reaction with an appropriate color reagent and...
5280107 Process for producing K-casein glycomacropeptides  
The present invention provides a process for producing κ-casein glycomacropeptides which comprises contacting milk raw materials containing κ-casein glycomacropeptides having the pH value of 4 or...
5278288 Process for producing κ-casein glycomacropeptides  
The present invention provides a process for producing a κ-casein glycomacropeptide comprising contacting milk raw materials containing the κ-casein glycomacropeptide with an ion exchanger;...
5258495 Process for making vancomycin HC1  
A process for the manufacture of vancomycin.HCl which does not require preparation of a phosphate intermediate. The process consists of loading a vancomycin onto a suitable adsorbent and eluting...
5235037 Vancomycin precipitation process  
The invention is an improvement in isolating vancomycin from an aqueous solution of pH 5 to 9 which comprises separating the vancomycin from the solution by adding an alkali or alkaline earth...
5225529 Synthetic amphiphilic glycoconjugates for neurological use  
Chemically and sterically pure synthetic amphiphilic glycoconjugates for neurological use of the formula (I): ##STR1## in which: the saccharide ring represents a monosaccharide such as glucose,...
5210072 Muramyl dipeptide derivatives  
The 3-O-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn- glycerol derivative of formula I ##STR1## wherein the carbon atom marked with an asterisk * has the R or, respectively, the S...
5202416 Protease absorbent for isolating and purifying proteases, a process for the preparation therefor, and the method for purifying a protease  
Peptide derivatives of the Formula I R--Y--Leu--Pro--NH--CH(CH2 --CH2 --CH2 --NH--C(NH)--NH2)--Xin which Y is HN--(CH2)n --CO with n=1 to 8 or a bond, X is CN, CH2 OH or CHO and R is a support or...
5198418 Substituted alkylamides of teicoplanin compounds  
The present invention is directed to teicoplanin derivatives in which position 63 of the glycopeptide core is substituted with a substituted alkylamide.
5196512 Synthetic peptides useful as universal carriers for the preparation of immunogenic conjugates and their use in the development of synthetic vaccines  
The synthetic peptide TT3, the amino acid sequence of which corresponds to the region 947-967 of the tetanus toxin is recognized by different human Th cell clones in association with a wide range...
5194424 C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics  
C63 -Amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin wherein the amide moiety is derived from a di- or poly-amine. The derivatives are prepared by reacting...
5192742 Compounds and compositions for the treatment of bacterial infections in animals  
New glycopeptide antibiotics MM 49728, MM 55266, MM 55267/1, MM 55267/2 and MM 55268 are produced by fermentation of Amycolatopsis sp. NCIB 40089.
5185320 O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin  
The present invention is directed to a new class of teicoiplanin derivatives, a process for preparing them and their use as pharmaceutically active substances.
5185321 Process for producing immunostimulants  
Immunostimulant products are prepared by adding lysozyme to a culture of L.bulgaricus at a pH of from 4-8 and then incubating the culture to hydrolyze peptidoglycans of cell walls of the bacteria....
5177059 Polymyxin B conjugates  
Polymyxin B carrier conjugates, especially polymyxin B-dextran, are water soluble, have a greater half-life in the bloodstream and are significantly less toxic than native polymyxin B.
5164484 De-(acetylglucosaminyl-di(dehydro)-deoxy teicoplanin derivatives  
The present invention is directed to new de-(acetylglucosaminyl)-di(dehydro)deoxy teicoplanin derivatives which possess antibiotic activity mainly against gram positive bacteria.The new compounds...
5162512 Amine derivatives of anthracycline antibodies  
Novel antineoplastic amine-containing derivatives and methods for synthesizing such derivatives of anthracycline antibiotics are disclosed. The derivatives are useful to anthracycline antibiotic...
RE34091 Sialic acid derivatives having active carbonyl group  
A sialic acid derivative having an active carbonyl group represented by the formula [I]: ##STR1## wherein R1 represents hydrogen or acetyl group; R2 represents hydrogen, a metal or a lower alkyl...
5153173 N-acyl derivatives of the peptidoglycan monomer, pharmaceutically acceptable salts thereof, their preparation and use as immunomodulators and immunoadjuvants  
N-acyl derivatives of the peptidoglycan monomer of the formula I ##STR1## wherein R stands for an acyl group of a straight-chain C2-18 alkyl carboxylic acid, or a branched-chain C5-18 alkyl...
5149782 Molecular conjugates containing cell membrane-blending agents  
Molecular conjugates which facilitate the attachment of macromolecular drugs onto cellular surfaces and their entry into cells are described. The molecular conjugates comprise a macromolecular...
5132286 Composition of antibiotic L 17054 and a method for the treatment of bacterial infections using the antibiotic  
The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known...
5124437 Galactosamine substitute of poly-ω-substituted-L-glutamic acid (or aspartic acid)  
A galactosamine substituted poly-ω-alkyl (or benzyl)-L-glutamic acid (or aspartic acid) is provided and comprises a polypeptide having the recurring unit represented by the formula: ##STR1##...
5118665 Anti-oxidative and anti-inflammatory metal:peptide complexes and uses thereof  
Compositions and methods for enhancing or restoring the resistance of a warm blooded animal to oxidative or inflammatory damage caused be release of reactive oxygen species by certain immune cells...
5115096 Amphiregulin: a bifunctional growth modulating glycoprotein  
A novel cell growth regulatory factor, named Amphiregulin, is described. This extremely hydrophilic glycoprotein, having a median molecular weight of 22,500 daltons, demonstrates unusual...
5089470 Compositions containing poly (γ-glutamylcysteinyl)glycines  
A method of removing heavy metals from aqueous solution, a composition of matter used in effecting said removal, and apparatus used in effecting said removal. One or more of the polypeptides, poly...
5080896 Synthetic immunogen  
The present invention concerns novel immunogens. These immunogens comprise novel compounds which consist of an antigen or antigenic determinant couple dot an amphiphilic adjuvant molecule and...
5075424 Process for producing κ-casein glycomacropeptides  
A process for producing κ-casein glycomacropeptides which comprises adjusting the pH of a solution of milk starting materials containing the κ-casein glycomacropeptides to below 4, treating the...
5075287 Muramyl peptide derivatives and immunoregulating compositions containing them  
Muramyl peptide derivatives of the formula: ##STR1## wherein "Ala" is ##STR2## "isoGln" is ##STR3## R1 is R3 O-- or ##STR4## (k is an integer from 8 to 12; q is an integer from 10 to 22) or R3 is...
5071749 Glycopetide antibiotic PA-45052-B  
Glycopeptide antibiotics PA-45052 which are produced by Nocardia orientalis PA-45052, show potent activity against gram-positive bacteria, especially against methicillin-resistant bacteria, and...
5071767 Process for the determination of fructosamine in body fluids and calibration solution  
For the determination of fructosamine in body fluids a solution containing fructosamine and albumin is used as the standard solution for calibration which standard solution is essentially free of...
5070190 Substituted N-glycosylamides, process for their preparation, and their use as medicaments  
The invention relates to new N-glycosylamides of the general formula I ##STR1## in which R1 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to...
5047227 Novel and improved antibodies for site specific attachment of compounds  
Novel and improved antibody compositions comprising an antibody or antibody fragment having an increased number of sites on a carbohydrate side chain available for the site specific attachment of...
5041534 Process for preparing antibiotic L 17054  
The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known...
5037804 Agent for preventing and treating thrombocytopenia  
The present invention relates to an agent for preventing and treating thrombocytopenia which comprises, an an active ingredient, a muramyldipeptide derivative of the formula: ##STR1## wherein X...