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RE35706 Lipophila derivatives of muramylpeptides having properties of activating macrophages and compositions containing them  
The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group...
5691304 Improved process for preparing polymyxin B/dextran conjugates  
An improved process for producing a water-soluble polymyxin B/dextran conjugate comprises the step of reacting polymyxin B or pharmaceutically acceptable salt thereof with dextran in an aqueous...
5688931 Polysaccharide derivatives and drug carriers  
A novel polysaccharide derivative, a drug carrier comprising a novel polysaccharide derivative, and a drug complex are disclosed. The polysaccharide derivative according to the present invention...
5684127 Tetrapeptides deriving from dalbaheptide antibiotics  
Tetrapeptides of general formula (I) deriving from dalbaheptide antibiotics ##STR1## wherein: W and Z represent the relative portions of the aglycon of an antibiotic of the dalbaheptide group...
5679769 Synthesis of asparagine-linked glycopeptides on a polymeric solid support  
The present invention provides a process for synthesizing a glycopeptide having the structure: ##STR1## wherein R1, R2, R3, R4, R5, R6, R7 and R8 are each independently H, OH, OR1, NH2, NHCORi, F,...
5677276 Immobilization of peptides to hyaluronate  
The present invention provides novel conjugates of a synthetic polypeptide containing RGD or (dR)GD and a biodegradable polymer, hyaluronate. The conjugates are prepared by any one of three...
5677285 Derivatives of neuraminic acid  
Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including...
5674837 Stable bleomycin sulfate solution suitable for injection  
A method of stabilizing bleomycin solutions and to the stable bleomycin solutions resulting therefrom are described. In the method described, bleomycin solution is stabilized by solubilizing...
5674838 Hirudin derivatives and a process for their preparation  
Hirudin derivatives can be prepared by the selective enzymic replacement of a part of the molecule with an amino derivative. The hirudin derivatives are suitable for preparing pharmaceuticals...
5668272 Method for producing synthetic N-linked glycoconjugates  
A transamination reaction of glycosyl-1-amine with a nucleophilic reagent containing an --NH2 or --NHNH2 group is used to prepared a broad spectrum of glycoconjugates by substitution of the...
5648456 Pentapeptide antibiotics  
Pentapeptide antibiotics of the formula ##STR1## wherein W, Z, X1, X2 and T represent the relative portions of an antibiotic of the dalbaheptide group (glyccpeptide antibiotics), Y represents a...
5646255 Immunogens and the use thereof for obtaining antibodies against HBA1C  
Immunogens of formula I are provided for obtaining HbA1c -specific antibodies ##STR1## M is 1 to 40, T is a carrier protein and A is a 10-20 atoms spacer and is ##STR2## where X is S or --NH--, n...
5629412 Synthetic glycoamines that promote or inhibit cell adhesion  
A class of molecules that alter cell adhesion. A cell adhesion affector according to the present invention essentially consists of an amino acid linked to a carbohydrate wherein the amino acid and...
5624903 Phosphoinositol-glycan-peptide with insulin-like action  
Phosphoinositol-glycan-peptide with insulin-like actionPhosphoinositol-glycan-peptides obtainable by cleavage of adenosine 3',5'-cyclic monophosphate-binding protein, which contain glucosamine,...
5622934 Peptides with an insulin-like action  
Peptides with an insulin-like action, of formula I: ##STR1## in which G is a hydrogen atom, an amino add residue, or a monosubstituted or polysubstituted amino acid; D is an amino acid residue, a...
5620675 Radioactive peptides  
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing label radiodiagnostic agents. Specifically, the invention relates to...
5601799 Partially delipidated D25 polysaccaride composition for imaging and diagnosis  
The present invention relates to a D 25 polysaccharide compound whose lipid has been partially removed and to its derivatives, wherein at least 85% by weight, preferably 90% of the compound,...
5594102 Chemical process for preparing antibiotic L 17932 (deglucoteicoplanin) and its salt  
The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a...
5591714 Derivatives of A82846  
New N-alkyl and N-acyl derivatives of A82846A, A82846B, A82846C and PA-42867-A are provided. The new glycopeptide derivatives are useful for the treatment of susceptible bacterial infections,...
5585467 Proteoglycan(G009) effective in enhancing antitumor immunity  
This invention relates to a proteoglycan G 009 possessed of antitumoral and immunostimulating effects, and separated from the cultured Ganoderma lucidum (KFCC-10709), containing:β-glucose,...
5574135 Process for making vancomycin  
A process for the manufacture of vancomycin which does not require preparation of a phosphate intermediate. The process consists of passing a vancomycin broth through a suitable adsorbent,...
5571785 Biologically active compounds  
The present invention provides polymer-bound anthracyclines of formula A which consists essentially of three units represented by formulae 1, 2 and 3: ##STR1## wherein: Gly represents glycine; n...
5571701 Antibiotic, balhimycin, a process for its production and its use as pharmaceutical  
Balhimycin, a compound of the molecular formula C66 H73 C12 N9 024, is a novel Glycopeptide antibiotic and has the following structure: ##STR1##
5556941 Glycopeptide derivatives, a process for their preparation and pharmaceutical agents containing these compounds  
Glycopeptide derivatives, a process for their preparation and pharmaceutical agents containing these compounds N-Glycopeptide derivatives of the formula I ##STR1## where aromatic is an...
5556836 Use of D-glucopyranuronic acids and their derivatives for incorporation in pharmacologically active peptides and their salts  
Use of 7-amino-L-glycero-L-gulo-2,6-anhydro-7-desoxy-heptonic acid and 2-benzoxycarbonylamino-01 -methyl-2-desoxy-β-glucopyranuronic acid, their derivatives and the enantiomorphous compounds for...
5545721 Conjugates for the prevention and treatment of sepsis  
Compositions and methods are described for preventing and treating sepsis in humans and other animals. Surgical patients, low birth weight infants, burn and trauma victims, as well as other...
5543505 Synthetic compounds which bind to H. pylori, and uses thereof  
The present invention provides a compound having the structure: ##STR1## wherein A is selected from the group consisting of (i) an amino acid bearing an ω-amino group or an ω--(CO)-- group, (ii)...
5541159 Calcitonin derivatives  
Peptide derivatives selected from (i) a calcitonin peptide and a LHRH antagonist peptide modified by at least one sugar residue and/or at least one short polyhydroxy compound or derivative, and...
5539087 Antibiotic A/16686 recovery process  
The present invention is directed to a process for recovering the antibiotics produced by fermentation of Actinoplanes sp. ATCC 33076 or a producing mutant thereof, from a fermentation broth or a...
5525474 Piperidine analogs and conjugates of procainamide and NAPA  
Novel derivatives of procainamide and N-acetylprocainamide (NAPA) are disclosed having the following formula: ##STR1## wherein: X=hydrogen or acetyl; n=1 to p where p=MW of Z/1000; Z=a poly(amino...
5521155 Amides of teicoplanin compounds  
The present invention is directed to an amide derivative of the glycopeptide, teicoplanin. This compound is an antibiotic that is active against gram positive bacteria. This compound is produced...
5519113 Process for the diastereoselective reductive pinacol coupling of homochiral α-aminoaldehydes  
Process for the diastereoselective reductive pinacol coupling of homochiral α-aminoaldehydesA process for the preparation of optically pure symmetrical compounds of the formula I ##STR1## is...
5519005 Method of inhibition of cellular and molecular level biological interactions utilizing non-peptidic surrogates of the Arg-Gly-Asp sequence  
A method of inhibition of cellular and molecular level biological interactions which are dependent on RGD interactions is disclosed. The method comprises administering a compound of the formula I...
5514654 N-acyldipeptides, processes for the preparation thereof and pharmaceutical compositions containing the same  
N-acyldipeptides of formula I ##STR1## wherein R represents a rest of formula ##STR2## and R4, Y, m, n and Z have the meaning as defined in the description, R1 represents hydrogen, a 1-10 C....
5506204 Muramyl compounds for treatment of septic shock  
Muramyl peptide compounds which: (a) are non-pyrogenic; and/or (b) ameliorate endotoxin-induced weight loss and/or hypophagia; and/or (c) reduce TNF production; and/or (d) stimulate macrophage to...
5500410 Substituted alkylamide derivatives of teicoplanin  
The present invention is directed to new C63 amide derivatives of teicoplanin wherein the amide moiety is derived from a di- or poly-alkylamine, and to a process for preparing them. The...
5498601 Platelet aggregation-inhibiting peptides  
Novel peptide derivatives having RGD as a basic structure were found which have a platelet aggregation-inhibiting action, blood coagulation-inhibiting action and cell adhesion-inhibiting...
5475094 Salmycins, a process for their preparation and their use as a pharmaceutical  
Salmycins, a process for their preparation and their use as a pharmaceutical Compounds of formula I, ##STR1## wherein R denotes NOH (a), O (b); --OH and --H (c), --NH2 and --H (d) or...
5464821 Small peptidic compounds useful for the treatment of glaucoma  
Small peptidic compounds containing a small and branched chained amino acid residue, pharmaceutical compositions containing at least one such compound active against glaucoma and intraocular...
5463022 N-acetylcarboxymethylchitosan derivatives and process for preparation thereof  
N-acetylcarboxymethylchitosan derivatives are provided by the present invention. They are represented by the following formula (I): ##STR1## wherein R1 and R2 individually mean H or carboxymethyl...
5446026 Potent non-opiate analgesic  
The present invention is directed to Cholic, Chenodeoxycholic and deoxycholic acid derivatives of a peptide having the sequence: Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-amide and use thereof in...
5444150 Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides  
A new amino acid derivative, Nα -tert-butoxycarbonyl-Ne -(N-bromoacetyl-β-alanyl)-L-lysine (BBAL), has been synthesized as a reagent to be used in solid-phase peptide synthesis for introducing a...
5441932 Sugar compounds for inhibition of the biosynthesis of sugar chains containing sialic acid  
An inhibitor of the biosynthesis of sugar chains containing sialic acid that is excellent in the suppression of inflammation or allergy, which comprises as an active ingredient a sugar compound of...
5432260 High affinity mannose receptor ligands  
Polypeptide backbones containing sugar residues at repetitive intervals are capable of binding the mannose receptor when said sugars are mannosyl, fucosyl, or N-acetyl glucosamine residues. These...
5430133 Semi-synthetic glycosaminoglycans with heparin or heparan structure of α-L-iduronic-2-O-sulfate acid modified in position 2  
New heparin and heparan sulfate derivatives having antithrombotic activity, also endowed with reduced haemorrhagic and anticoagulant activity, are obtained by nucleophilic addition to heparin and...
5430132 Semi-synthetic glycosaminoglycans containing α-L-galacturonic acid substituted with nucleophilic groups in position 3  
New heparin and heparan sulfate derivatives having antithrombotic activity, also endowed with reduced haemorrhagic and anticoagulant activity, are obtained by nucleophilic addition to heparin and...
5420228 Fluorescent-labelled bleomycin analogues  
A fluorescent-labelled bleomycin analog useful as a probe for measuring cellular uptake of bleomycin and bleomycin derivatives, including methods of making and using same. The analog may further...
5416070 Composition for macrophage activation  
The present invention provides novel lipophilic disaccharide-dipeptide compounds. The compounds of the invention are preferably encapsulated into multilamellar liposomes, which can be formed from...
5411942 Peptide derivative, pharmaceutical preparation containing it and method for treatment of glaucoma  
Peptide derivatives of 3-5 optionally substituted amino acids, a process for preparing the peptides, a pharmaceutical composition containing at least one peptide derivative active against glaucoma...
5412072 Water soluble high molecular weight polymerized drug preparation  
This invention is a water-soluble high molecular polymerized drug comprising a water-soluble clock copolymer having a hydrophilic segment and a hydrophobic pharmacological-functioning segment to...