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6111067 A-82846-type glycopeptide antibiotics  
A82846-related glycopeptide compounds are prepared by treating an antibiotic selected from A82846 components A, B and C with trifluoroacetic acid to remove 1) the α-L-O-4-epi-vancosaminyl group...
6111084 Fuopeptide mimetics  
Bioactive fucopeptides and libraries of fucopeptides having advanced activities against P-selectin as sialyl Lewis X mimetics with IC50 values in the low mM range are synthesized by solid phase...
6106866 In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites  
A drug carrier composition comprising a drug complexed with dermatan sulfate is disclosed. The drug is preferably an anti tumor drug and may be taxol, a peptide onco-agent or vincristine. The most...
6107459 Technetium-99m labeled peptides for diagnostic imaging  
This invention relates to reagents, radiolabeled reagents and methods for producing such reagents and radiolabeled reagents. Specifically, the invention relates to technetium-99m (Tc-99m) labeled...
6106828 Conjugation of polypeptides  
The present invention provides polypeptide conjugates with reduced allergenicity comprising a polymeric carrier molecule having two or more polypeptide molecules coupled thereto. The invention...
6093694 Antitumor active substances  
By extracting hot water-insoluble and ethanol-insoluble components of the fruit body of Agaricus blazei Murill belonging to the genus Agaricus with 5% ammonium oxalate aqueous solution, degrading...
6087335 RNase-CV (Coriolus versicolor)  
A method of obtaining a novel polypeptide from a crude extraction product of polysaccharide peptide Coriolus versicolor comprising: a) boiling a water soluble powder of polysaccharide peptide...
6077822 Drug salts  
It has been found that sugar acid salts represent beneficial controlled release forms for basic organic drug compounds. Examples of appropriate salts include mono, di, oligo and polysaccharide...
6075006 Soluble tachykinin antagonists, the preparation and use thereof  
PCT No. PCT/EP97/00917 Sec. 371 Date Aug. 28, 1998 Sec. 102(e) Date Aug. 28, 1998 PCT Filed Feb. 26, 1997 PCT Pub. No. WO97/31941 PCT Pub. Date Sep. 4, 1997The compounds of formula (I)...
6063380 Enhanced immunogenic vaccine  
Vaccines, composed of antigens absorbed on alum or formulated in an alum-containing composition, have enhanced immunogenicity over existing vaccines. The vaccines of the invention are...
6046306 PNA synthesis using an amino protecting group which is labile to weak acids  
PNA synthesis using an amino protective group which is labile to weak acids.
6037447 Glycopeptide compounds  
The present invention is directed to certain glycopeptide dimers in which two glycopeptide units are covalently linked to one another through their disaccharide amine, via a linking radical. This...
6030942 Peptides peptide analogs peptidomimetics and other small molecules useful for inhibiting the activity of ribonucleotide reductase  
The invention relates to compositions which are useful for inhibiting ribonucleotide reductase enzymes, including the mammalian ribonucleotide reductase enzyme. The compositions include, but are...
6013779 Process for preparation of glycosides of tumor-associated carbohydrate antigens  
Glycoconjugate antigens are prepared by preparing a hapten glycoside, especially an alpha glycoside prepared by the Fischer method, with an olefinic aglycon moiety, especially one having a...
5998581 Reductive alkylation of glycopeptide antibiotics  
This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial...
5994502 Inhibitors of oligosaccharyl transferase  
The present invention provides novel inhibitors of oligosaccharyl transferase, methods for producing Glc3 Man9 (GlcNAc)2 --P--P--Dol, and methods for producing glycopeptides.
5976820 Detection of antibodies to bacterial antigens by flourescence polarization  
In a homogeneous immunoassay, fluorophore-conjugated lipopolysaccharide derived bacterial antigens are reacted with antibodies specific for the antigens. Quantitative detection of the formation of...
5977062 Glycopeptide antibiotic derivatives  
The present invention provides glycopeptide antibiotic derivative compounds. These derivative compounds possess antibacterial activity against a wide variety of bacteria, including activity...
5977063 Alkylated hexapeptides  
The present invention is directed to N1 -alkylated derivatives of desleucyl A82846B. These derivatives are useful as antibacterials and also as starting materials from which further antibacterial...
5968513 Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin  
The present invention relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of human chorionic gonadotropin, β-human...
5962660 Sialyl Lewis X mimetics incorporating fucopeptides  
Sialyl Lewis X mimetics incorporating fucopeptides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The fucopeptides exhibit...
5948681 Non-viral vehicles for use in gene transfer  
The invention relates to a compositions and methods for transfection of cells, particularly airway epithelial cells, with DNA complexed to polylysine substituted with glycosyl residues. The...
5948895 Process for producing a glycosylated amino compound  
A process which makes possible to produce a glycosylated amino compound (e.g. protein) easily in short period without denaturation of protein. The sugar (e.g. glucose) and protein (e.g. serum) are...
5948750 Conjugates useful in the treatment of prostate cancer  
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are...
5939382 Reducing agent for reductive alkylation of glycopeptide antibiotics  
This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics, the improvement residing in employing pyridine.borane as reducing agent.
5935927 Compositions and methods for stimulating amyloid removal in amyloidogenic diseases using advanced glycosylation endproducts  
The present invention relates generally to methods and compositions for treating amyloidogenic diseases such as Alzheimer's disease and the development of type II diabetes, in which deposition of...
5919756 Amides  
The present invention is directed to amides of antibiotic A82846B (also known as chloroorienticin A), and of N4 -derivatives of A82846B. The present amide compounds are useful as antibacterials,...
5888969 Use of cytokine restraining agents to treat inflammatory bowel disease  
The present invention relates to the use of cytokine restraining agents to treat inflammatory bowel disease.
5888978 Method for reducing the severity of gastro-intestinal damage  
The present invention provides methods for reducing the severity of GI damage in an individual by administering a cytokine regulatory agent to an individual that is susceptible to developing such...
5886143 Hepatic-directed compounds and reagents for preparation thereof  
Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are discussed. Hepatic-directed compounds are processed by metabolic mechanisms, which...
5877147 Compounds for medicinal use  
Muramyl peptide compounds are useful in the prophylaxis of cancers and particularly in the treatment of precancerous lesions associated with cancers of the mucosa or epithelium.
5869449 38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibiotics and a process for preparing them  
The present invention is directed to novel 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antiobiotics and a process for preparing them which includes submitted the corresponding lower...
5863905 2',5'-phosphorothioate/phosphodiester oligoadenylates and anti-viral uses thereof  
Optically active antiviral compounds having the formula ##STR1## wherein m is 0, 1, 2, or 3; n and q are selected from the group of 0 and 1, provided that n and q may not both be zero; and R, R1,...
5856299 Highly reactive esters of carboxy polysaccharides and carboxy polysaccharides derived therefrom  
Provided are active esters of carboxy polysaccharides and semisynthetic derivatives of carboxy polysaccharides, wherein all or part of the carboxy groups thereof are esterified with an aromatic...
5854211 Compounds with growth hormone releasing properties  
Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. These peptide derivatives have...
5854391 Glycosylation of peptides using glycosyl phosphite reagents  
A method for synthesizing glycosylated peptides employs a blocked carbohydrate donor and a blocked peptide acceptor. The carbohydrate donor includes an acid labile phosphite leaving group attached...
5849709 Saccharopeptides and derivatives thereof  
Saccharopeptides and methods of using the novel saccharopeptides are described having the following structural formula I: W-- --Y--W--!m (I)wherein W is independently one or more saccharide(s); Y...
5837862 Sialyl Lewis X mimetics incorporating mannopeptides  
Sialyl Lewis X mimetics based on mannose glycosides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The mannose based mimetics...
5834435 Inhibition of TNF-α pleiotropic and cytotoxic effects  
The pleiotropic effects of TNF alfa in a wide variety of mammalian cell types is decreased and treated by administering glucosaminylmuramyl peptides with D-amino acid residue in a second or third...
5830995 Fanphiregulins: a family of heparin-binding epithelial cell growth factors  
The present invention is directed to a family of heparin-binding epithelial cell growth factors termed amphiregulins (AR). In particular, it relates to the isolation of AR genes from different...
5817618 Anti-microbial composition  
The present invention relates to an anti-microbial composition for non-pharmaceutical cleaning of contaminated materials, bodies and surfaces, especially contaminated liquids and gases. The...
5795958 Library of glyco-peptides useful for identification of cell adhesion inhibitors  
Glycopeptides having the following structure are described: ##STR1## wherein: X1 is hydrogen, an acetyl group, an acyl group or amino acid; R is α-L-fucose, α-D-fucose, β-L-fucose or β-D-fucose,...
5786332 Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels  
The present invention relates to novel peptides that are potent cytokine restraining agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically...
5767254 Method for making amino acid glycosides and glycopeptides  
A compound of the formula ##STR1## is disclosed. X is selected from the group consisting of aryl, alkyl, imte ester, imino ester, amidine, azide, isocyanate, and dithiocarbonate. R' is a group...
5763397 Glycopeptides, a process for their preparation and their use  
Desmethylbalhimycin, a compound of the formula C65 H71 Cl2 N9 O24, desmethylleucylbalhimycin, a compound of the formula C59 H60 Cl2 N8 O23, desglucobalhimycin, a compound of the formula C60 H63...
5750360 Method for quantitatively measuring apoptosis  
The invention encompasses methods of detecting and/or quantifying ε(γ-glutamyl)lysine isodipeptide by catalytically releasing lysine, then measuring free lysine.
5750509 Amide derivatives of antibiotic A 40926  
The present invention is directed to novel antibiotic A 40926 derivatives characterized by having a carboxy, (C1 -C4) alkoxy-carbonyl, aminocarbonyl, (C1 -C4) alkylaminocarbonyl, di (C4...
5741774 Use of a cytokine regulatory agent to treat rheumatoid arthritis  
The present invention relates to the use of a cytokine regulatory agent to reduce the severity of rheumatoid arthritis.
5726156 Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels  
The present invention relates to novel peptides that are potent cytokine regulatory agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically...
5719121 Use of balhimycin as production promoter in animals, and production promoter compositions  
Balhimycin, where appropriate in combination with one or more of its derivatives, is suitable for promoting production in monogastric or polygastric animals.