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6716961 Chiral peptide nucleic acids with a N-aminoethyl-d-proline backbone  
Chiral peptide nucleic acids are provided which hybridise strongly with complementary nucleic acids and have potential as antigene and antisense agents and as tools in molecular biology. The...
6699836 Vancomycin analogs  
Compounds that are vancomycin analogs bearing terminal carboxyl group modifications as well as modifications to the vancosamine nitrogen and, optionally, modifications to the C6 position of the...
6696412 High purity lipopeptides, Lipopeptide micelles and processes for preparing same  
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential...
6670446 N1 modified glycopeptides  
Described herein are N′-acylated derivatives of desleucylA82846B. The compounds are useful as antibacterial agents.
6664233 Combination therapy including 9-nitro-20(S)-camptothecin and bleomycin  
A method for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation such as cancer and restenosis is provided. The method comprises: delivering to the...
6627604 Memno peptides, process for their preparation and use thereof  
The invention relates to novel peptide derivatives, called memno peptides, of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8 and (A)n have the meaning herein, obtainable by cultivation of...
6617456 Camptothecin derivatives  
A camptothecin derivative comprising a compound of the formula [I]: wherein R1, R2, R3, R4 and R5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining...
6610822 Purification process  
There is disclosed a process for purifying a natural product using a two-phase, multi-solvent system followed by vacuum concentration and back extraction. The method allows for the removal of...
6602982 Process for the preparation of regular glycopeptides  
The present invention provides a method for easily producing glycopeptides which are useful as a material for scientific studies, medicaments and foodstuffs. The glycopeptides can be produced by...
6590092 Process for preparing a “universal support” and the reagents used for generating such support  
Universal solid supports suitable for use synthesizing of oligonucleotides. The solid supports may be used irrespective of the first RNA or DNA nucleotide to be synthesized, and irrespective of...
6565842 Crosslinkable polypeptide compositions  
In accordance with the present invention, there are provided rapidly crosslinkable polypeptides which are obtained upon introduction of unsaturated group(s) into the polypeptide via linkage to...
6555659 Process for isolating glycomacropeptide from dairy products with a phenylalanine impurity of 0.5% w/w  
The present invention is related to a method for the purification of glycomacropeptide (GMP) with an amino acid composition containing no greater that 0.5% (w/w) phenylalanine, comprising the...
6552166 Process for the preparation of conjugates useful in the treatment of prostate cancer  
The present invention is directed to the improved synthesis of compounds of formula I: which may be useful in the treatment of prostate cancer. Such compounds are synthesized in the presence of a...
6548476 Dimeric inhibitors of influenza neuraminidase  
This invention relates to novel dimeric compounds, methods for their preparation, pharmaceutical formulations thereof, and their use as antiviral agents. The compounds are particularly useful...
6521595 Nonimmunosuppressive &lsqb &ggr -hydroxy-methylleucine4&rsqb cyclosporin A, hair growth stimulator and external composition for skin using the same  
The present invention relates to methods for treating alopecia and stimulating hair growth and pharmaceutical compositions using nonimmunosuppressive [γ-hydroxy-methylleucine4] cyclosporin A...
6521599 Stable pharmaceutical formulation for intravenous or intramuscular administration of active peptide compounds  
A stable pharmaceutical formulation for intravenous or intramuscular administration of Octreotide, which is characterized in that the vehicle for injection of the peptide or pharmaceutically...
6518242 Derivatives of glycopeptide antibacterial agents  
Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of...
6518243 Desleucyl glycopeptide antibiotics and methods of making same  
Compounds that are analogs of glycopeptide antibiotics are disclosed. The compounds have the formula A1-A2-A3-A4-A5-A6-A7 wherein each of the groups A2 to A7 is a modified or unmodified α-amino...
6509315 Didemnin analogs and fragments and methods of making and using them  
The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes...
6500916 Carrier polymers migrating into target organs and drug-containing polymers  
Polymers derived from polymers represented by Formula (A) (d is 20˜500; and Rs, which may be the same or different, represent each H, alkyl or benzyl) by substituting a part or all of the...
6500801 Treatment for Dutch elm disease  
A preventative treatment for Dutch elm disease is disclosed which provides susceptible elm trees with induced resistance to Dutch elm disease-causing fungi such as Ophiostoma ulmi. The treatment...
6492136 Solid phase organic synthesis  
A method of synthesis of a material corresponding to the general formula: R3—X—Hcharacterized in that it comprises a material corresponding to the following general formula: being cleaved as...
6475985 Nucleosides with antiviral and anticancer activity  
The invention provides nucleosides of formulae (I), (II), (V) and (VII) as described in the specification which possess antiviral and anticancer activity. Treatment of breast cancer is a preferred...
6472506 Polysaccharide-peptide-conjugates  
The invention relates to a polysaccharide-peptide conjugate wherein the polysaccharide is advantageously immunogenic, which comprises a polysaccharide chain composed of repeat units and a...
6455025 Polysaccharide-peptide derivatives  
Polysaccharide-somatostatin analogs of the formula: wherein the somatostatin analog is directly or indirectly coupled from a terminal N-amino group of the somatostatin analog to a polysaccharide,...
6436912 Drug complexes  
A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that...
6391851 Hydrochlorides of vancomycin antibiotics and process for producing the same  
Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from −1° C. to...
6361777 Method of coupling polysaccharides to proteins  
A novel method of covalently coupling polysaccharides to other biopolymers is provided, using an amino-thiol linker represented by formula (1): H2N—[(CH2)m—CHR1—CR2R3—A]q—CHR4—(CHR5)p—CHR6—S—R7...
6355611 Salt form of a conjugate useful in the treatment of prostate cancer  
The present invention is directed to the sodium salt of formula 5: which may be useful in the treatment of prostate cancer and benign prostatic hyperplasia. Also described are lyophilized...
6329497 Sandramycin analogs  
Analogs of sandramycin (1) are synthesized and shown to have cytoxicity against various tumor cell types. The relative cytotoxic properties of the sandramycin analogs are approximately parallel tp...
6306837 Heavy metal chelating agent for oral administration, its synthesis and its uses in medicine and health protection  
The present invention relates to a new kind of heavy metal chelating agents and a preparation process and uses thereof. The said heavy metal chelating agents are expressed in...
6291671 Process for producing drug complexes  
A method for preparing a drug complex in which a polysaccharide derivative having carboxyl groups and a residue of a drug compound are bound to each other by means of a spacer comprising an amino...
6288028 BPC peptide salts with organo-protective activity, the process for their preparation and their use in therapy  
The present invention discloses new pharmaceutical compositions useful for the treatment of various human and animal diseases. These pharmaceutical compositions contain one or more peptides.
6271342 Sugar-modified cytostatics  
The invention relates to cytostatics which, by modification with sugar, are tumor-specific. Suitable spacers ensure serum stability and at the same time an intracellular action.
6265374 Peptide T and related peptides in the treatment of inflammation, including multiple sclerosis  
A method of treating inflammation in patients in need of such treatment by administering an effective amount of I-A-B-C-D-E-F-G-H-II (General Formula), wherein A is Ala, Gly, Val, Ser, Thr or...
6262251 Method for solution phase synthesis of oligonucleotides  
This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture...
6251858 Derivatives of oligosides, their process of preparation and their applications  
The invention relates to compounds comprising one or several oligosides, each of said oligosides being fixed in a covalent manner on one or many molecules, matrixs or particles, specifically one,...
6245738 Cytokine restraining agents  
The present invention provides novel cytokine restraining agents, which limit or control the biological activity of cytokines. The invention also provides pharmaceutical compositions comprising a...
6239101 Thrombin binding polypeptides  
Small, buffer soluble polypeptides having amino acid structures corresponding to residues 234-486, 310-486, and 407-486, of thrombomodulin and functionally equivalent analogs thereof inhibiting...
6218160 Site-specific conjugation of glycoproteins  
The present invention describes a site specific conjugation method for glycoproteins wherein a stable dihydrazone bond is formed between the glycoproteins and the glycoproteins retain full...
6218505 Chemical process for preparing amide derivatives of antibiotic A 40926  
Improved chemical process for preparing the compounds of formula (I), wherein: R1 represents (C9 -C12)alkyl; M represents hydrogen, α-D-mannopyranosyl or 6-O-acetyl-α-D-mannopyranosyl and Y...
6214793 Method of treating tumors with thiodepsipeptide isolated from a marine actinomycete  
The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic...
6204359 Form of amphiregulin, methods for producing and using the same and compositions comprising the same  
An isolated and purified polypeptide having heparin binding properties with the amino acid sequence of SQ ID No: 1 and pharmaceutical compositions for treating skin wounds.
6177404 Conjugates useful in the treatment of benign prostatic hyperplasia  
Novel pharmaceutical compositions useful for the treatment of benign prostatic hyperplasia which comprises novel oligopeptides, which are selectively cleaved by enzymatically active PSA, in...
6160100 Treatment for wilt diseases of trees  
A preventative treatment for wilt diseases in trees is disclosed which provides susceptible trees with induced resistance to wilt disease-causing organisms. The treatment comprises administering...
6150325 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical compositions  
This invention relates to novel compounds of general formula (I): ##STR1## and to pharmaceutical compositions containing them.
6150461 Carriers targettable to organ  
A carrier for delivering a foreign substance to a target organ which comprises a graft copolymer in which hyaluronic acid is grafted on a polymer composing main chain, wherein the main chain has a...
6143864 Peptides  
Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise...
6120997 Nucleic acid binders having an hydroxyamine motif  
The invention relates to the combination of hydroxyamines with nucleic acid binding motifs to generate molecules and libraries of molecules targeting specific nucleic acid sequences. In...
6117842 Fibrinogen receptor antagonists  
Compounds of this invention have the formula: X--(CH2)n --C(O)NH--A--C(COOR5)R3 R4or a pharmaceutically acceptable salt thereof, e.g. ##STR1## which are useful for inhibiting fibrinogen binding to...