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7226990 Extendin derivatives  
The present invention relates to novel derivatives of exendin-4 or exendin-4 fragments, wherein the derivatives have a lipophilic substituent attached, optionally via a spacer, to an amino acid...
7226904 Agents and methods for promoting bone growth  
Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively...
7223845 Synthetic glycosulfopeptides and methods of synthesis thereof  
A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewisx group or a...
7220824 Integrin-mediated drug targeting  
The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to αvβ3 integrin antagonists via preferred linking units. The preferred linking units...
7173107 Glycopeptide and preparation thereof  
The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl-β-[1,4]-N-acetylmuramylmonopeptide and...
7169890 Process for the production of ramoplanin-like amide derivatives  
The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC—CO—R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH—...
7169756 Streptogramin antibiotics  
Disclosed is a cyclic peptide antibiotic in which an enzyme-sensitive bond is replaced by an enzyme-resistant bond.
7160856 α-O-linked glycoconjugates, methods of preparation and uses thereof  
The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified...
7157433 Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules  
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of...
7122519 Didemnin analogs and fragments and methods of making and using them  
The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes...
7119061 Dalbavancin compositions for treatment of bacterial infections  
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial...
7115564 Stable pharmaceutical compositions of dalbavancin and methods of administration  
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in...
7112654 Ligand for vascular endothelial growth factor receptor  
The present invention relates to compositions comprised of a peptide ligand or derivatives thereof that are capable of specific binding to the high affinity receptor-1 of vascular endothelial...
7112564 Biodegradable glucosaminemuramyl peptides for apoptosis modulation  
The endopeptidase hydrolysis of cross link peptide bond of the peptidoglycans results in release of the novel glucosaminemuramyl tri, tetra, penta, hexa, and octapeptides. Their structure is...
7109176 Nonsteroidal anti-inflammatory substances, compositions and methods for their use  
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of...
7109165 Conjugates and compositions for cellular delivery  
This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic...
7101967 Transport vectors  
The invention relates to modified and truncated forms of the membrane transport vector penetratin. Such truncated forms include 7-mer peptides that may in themselves include further variation.
7094580 Methods for producing pure perlecan and other heparan sulfate proteoglycans  
A method of perlecan isolation (from the EHS tumor) which produces “clean” (i.e. substantially “pure”) perlecan is disclosed. Clean perlecan is thus produced in sufficient quantities for use in a...
7078480 Process for stabilizing the content of glycated protein of a sample on a matrix material  
The invention concerns a method for stabilizing the content of glycated protein in a sample on a matrix material, which is characterized in that the matrix material is impregnated with boric acid...
7071298 Compounds and methods for treating glycogen storage disease and other pathological conditions resulting from formation of age-proteins  
Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway....
7067618 Medicinal preparations  
The present invention provides a pharmaceutical preparation comprising a compound which can be obtained by reacting a compound having a free amino group with a sugar having the reducing power. The...
7067620 Antibacterial agents  
Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2–10 ligands covalently connected, each of said ligands being capable of...
7064105 Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them  
The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents...
7060678 Peptides comprising furanoid sugar amino acids for the treatment of cancer  
Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid...
7041637 Echinocandin/carbohydrate complexes  
A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also...
7001982 Non-natural C-linked carbo-β-peptides with robust secondary structures  
Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably...
6995140 Peptides and polypeptides useful for regenerating the nervous system  
The invention concerns in particular novel peptides and polypeptides comprising at least the following sequence in amino acids: -W-S-A1-C-S-A2-C-G- in which A1 and A2 are amino acid sequences...
6962970 Glycopeptide derivatives and pharmaceutical compositions containing the same  
Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions...
6958395 Method for producing water-soluble saccharide conjugates and saccharide mimetics by Diels-Alder reaction  
The present invention relates to a method by which saccharide compounds can be prepared in a very easy way. This method comprises the steps of: (a) attaching at least one saccharide to a cyclic or...
6958319 Formulation of boronic acid compounds  
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1): in which Z1 and Z2 are moieties derived from sugar. The invention...
6956119 Polysaccharide-polypeptide conjugate  
Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide...
6951840 Lipoglycopeptide antibiotics  
Provided are novel lipoglycopeptides exhibiting bacterial signal peptidase inhibitory activity. Also provided are actinomycete strains that produce these lipoglycopeptides, methods of producing...
6939947 N1-modified glycopeptides  
The present invention is directed to N1-acylated derivatives of desleucylA82846B. These derivatives are useful as antibacterials.
6924264 Modified exendins and exendin agonists  
Novel modified exendins and exendin agonist analogs having an exendin or exendin agonist analog linked to one or more polyethylene glycol polymers, for example, and related formulations and...
6896887 Bacterial ghosts provided with antigens  
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
6892140 Immunogenic cancer peptides and uses thereof  
This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.
6878805 Peptide-conjugated oligomeric compounds  
The present invention relates to novel amphipathic peptide-conjugated oligomeric compounds and to methods of making and using such compounds. The invention further relates to methods of enhancing...
6872804 Glycopeptide disulfide and thioester derivatives  
Disclosed are disulfide and thioester derivatives of glycopeptides and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as...
6872700 Methods for glucagon suppression  
Methods for use of an exendin, an exendin agonist, or a modified exendin or exendin agonist having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example,...
6867043 Peptides that deliver antisense oligonucleotides which downregulate protein expression in cells  
The present invention provides a peptide that can complex with an oligonucleotide, e.g. an antisense oligonucleotide, and deliver it into a cell. The present invention also provides compositions...
6844318 Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use  
This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and...
6835807 Drug complex and drug delivery system  
A drug complex useful as a DDS compound, which is represented by the following formula: A-R—NH—Y—CH2—O—CO-Q, wherein A is a polymer as a drug carrier; R is a spacer, wherein the spacer is an amino...
6831150 Reductive alkylation process  
The invention provides a novel reductive alkylation method useful for selectively alkylating saccharide-amines of glycopeptide antibiotics.
6828299 Polyhydroxy glycopeptide derivatives  
Disclosed are polyhydroxy derivatives of glycopeptides and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial...
6815435 Pharmaceutical compositions containing DDS compounds  
A pharmaceutical composition having an ensured preservation stability, which contains a compound, wherein a polysaccharide derivative having a carboxyl group is bonded to a camptothecin derivative...
6811996 DDS compounds and method for assaying the same  
A drug delivery system compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran...
6800608 Homogeneous assay of vancomycin using a stable particle-vancomycin conjugate, a novel rate enhancer, and a novel dose response modulator  
This invention relates to stabilized formulations comprising a glycopeptide antibiotic immobilized on carrier particles, and more particularly stabilized vancomycin bidentate conjugate...
6762281 Process for preparing peptide derivatized oligomeric compounds  
Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the...
6740635 Antiviral linear polymers  
An antiviral compound comprises a linear non-carbohydrate polymer having a plurality of side chain groups, wherein at least one of the side chain groups has an anionic- or cationic-containing...
6723831 Neoglycoproteins  
Polyamide conjugates comprising either (a) a xenoantigenic group; or (b) a biologically active group and a macromolecular, macro- or microscopic entity; bound to a polyamide backbone, processes...