Match Document Document Title
8268963 Process for the purification of macrolide antibiotics  
The present invention concerns a process for the purification of macrolide antibiotics. More specifically it concerns a process for the purification of macrolide antibiotics that result in a white...
8198404 Mutated immunoglobulin-binding protein  
The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than glutamine or aspartic acid, which mutation...
8163872 Purification of glycopeptides  
A novel and improved method for purification of glycopeptides, especially glycopeptide antibiotics. The method comprises contacting a solution of the glycopeptide to an ion exchange chromatography...
8158750 Preparation and standardization of immunomodulatory peptide-linked glucans with verifiable oral absorbability from coriolus versicolor  
This invention provides compositions and methods for stimulating the immune system. Such methods include administering an extract, purified peptide-linked glucan or active component thereof from...
8138304 Neural regeneration peptides and formulations thereof  
Neural regeneration peptide consisting of a sequence comprised in the sequence of REGRRAAPGRAGG(SEQ ID NO:1).
8129342 High purity lipopeptides  
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential...
8124724 Peptides and related molecules that modulate nerve growth factor activity  
The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the...
8101575 Glycopeptide phosphonate derivatives  
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide...
8093354 Process for preparing glycopeptide phosphonate derivatives  
Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without...
8058238 High purity lipopeptides  
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential...
8030445 Glycopeptide derivative  
Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions...
7897328 Blood group antigens of different types for diagnostic and therapeutic applications  
The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.
7888459 In vacuo glycation of proteins  
It has been discovered that facile glycation of proteins can be achieved by colyophilization of a protein with a reducing sugar, subjecting the lyophilized mixture to a vacuum (10 to 50 millitor)...
7879335 Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof  
The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides...
7854934 Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof  
The present invention provides novel glycosides and glycoconjugates, glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered...
7851618 Aminated complex-type sugar chain derivatives and process for the production thereof  
An aminated complex-type oligosaccharide derivative of the formula (1) wherein R1 is H—(CO)—CH2X, —NH—(CO)—(CH2)b—CH2X, isothiocyanate group, —NH—(CO)a—(CH2)b—CO2H or —NH—(CO)a—(CH2)b—CHO, X being...
7825085 Fragments of NKp44 and NKp46 for targeting viral-infected and tumor cells  
The present invention relates generally to peptides derived from the natural cytotoxicity receptors on natural killer (NK) cells and to antibodies against peptide epitopes on these receptors. In...
7824687 Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof  
The present invention provides novel clustered multi-antigenic constructs having the structure: and methods for the synthesis thereof. In still another aspect, the present invention provides...
7803764 Amphipathic glycopeptides  
Amphipathic glycopeptides, the amino acid sequence of which comprises an N-terminal opioid message sequence, a C-terminal helical address sequence, and a linker sequence between the message...
7786276 Sequestering of glycoprotein molecules and oligosaccharide moieties in lipo-glycoprotein membranes and micelles  
Spontaneous formation of a coherent membrane at the interface between a non-polar liquid and an aqueous solution of glycoprotein can be used to separate proteins and carbohydrates from tissue...
7741295 Sir2 products and activities  
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from...
7728104 Process for preparing glycopeptide phosphonate derivatives  
Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without...
7723470 Glycopeptide derivatives and pharmaceutical compositions containing the same  
Disclosed are compounds of the formula: or a trifluoroacetic acid salt thereof, wherein A, B and Fmoc are as defined herein. Such compounds are useful as synthetic intermediates for preparing...
7696326 Multiple antigen glycopeptide carbohydrate, vaccine comprising the same and use thereof  
The invention of the present application relates to a method for obtaining antibodies directed against a carbohydrate moiety contained in a carbohydrate peptide conjugate, by administering to a...
7687609 Galectin-glycosaminoglycan complex and method for controlling galectin activity  
A complex consisting of galectin-3 and chondroitin oligosaccharide and methods for seperating and detecting the chondroitin oligosaccharide in a sample using the immobilized complex.
7651997 Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them  
The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents...
7635750 Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation  
The present invention provides a method for preparing polyfunctionalized peptides and/or proteins at non-adjacent designated sites via native chemical ligation. In certain embodiments, the...
7632918 Semi-synthetic glycopeptides with antibiotic activity  
Semi-synthetic glycopeptides having antibacterial activity are based on modifications of the eremomycin, A82846B, vancomycin, teicoplanin, and A-40,926 scaffolds, in particular, acylation of the...
7615244 Glycopeptide and peptide having a kokumi taste imparting function, and method of imparting the kokumi taste to foods  
Glycopeptides and peptides having the formula: where X represents a hydrogen atom or a sugar chain, provide a taste improving function, particularly a kokumi taste imparting function. Such...
7608591 Targeted delivery to legumain-expressing cells  
The present invention relates to new agents and methods useful for preventing, treating and diagnosing diseases such as cancer. For example, the invention relates to prodrug agents useful for...
7550146 Glycopeptide conjugates and uses thereof  
The present invention provides novel glycoconjugates such as glycopeptides, as well as convergent methods for the synthesis thereof. An exemplary preparative approach is exemplified by the...
7538186 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Exendins and exendin agonists modified with polyamino acids
 
Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more molecular weight increasing compounds, for example, polyamino acids, polyethylene glycol polymers,...
7514404 PNA-neamine conjugates and methods for producing and using the same  
The present invention relates to methods and compositions pertaining to conjugates composed of a peptide nucleic acid (PNA) moiety and a neamine derivative moiety. Methods for using such...
7482018 Use of oligomers and polymers for drug solubilization, stabilization, and delivery  
The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action....
7473671 Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same  
A glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, in which each dash represents a covalent bond; wherein A1 comprises a modified or unmodified α-amino acid residue, alkyl, aryl, aralkyl,...
7470776 Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof  
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
7468420 Process for purifying glycopeptide phosphonate derivatives  
Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The...
7462687 Prodrugs of vancomycin with hydrolysis resistant polymer linkages  
Vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are hydrolysis resistant in vitro, are selectively attached to the sugar amino and/or N-methyl amino...
7439322 Glycopeptides produced using Amycolatopsis orientalis glycosyltransferase gtfE  
The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme,...
7432246 Sir2 products and activities  
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from...
7405199 Cross-linked glycopeptide-cephalosporin antibiotics  
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
7368422 Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity  
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the...
7351691 Glycopeptide phosphonate derivatives  
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide...
7351791 Intermediate for preparing glycopeptide derivatives  
This invention provides 9-fluorenylmethoxycarbonyl compounds that are useful as intermediates for preparing glycopeptide antibiotics.
7301004 Process for preparing glycopeptide phosphonate derivatives  
Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without...
RE39887 Dehydrodidemnin B  
Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.
7273845 Polymeric prodrugs of vancomycin  
Methods of preparing vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are preferably releasable, are selectively attached to the sugar amino and/or...
7265086 Glycopeptide carboxy-saccharide derivatives  
Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical...
7262177 Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use  
A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor,L represents a bifunctional linker, which does not comprise a...
7244705 Polyacid glycopeptide derivatives  
Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical...