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4310514 Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation  
Immunologically active compounds of the formula: ##STR1## wherein R1 is C1-7 alkyl, substituted C1-7 alkyl; phenyl; or substituted phenyl; R2 is hydrogen; or C1-10 alkyl; R3 and R4 may be the same...
4296107 Mildiomycin analogs and a method of production  
A compound of the formula: ##STR1## wherein R is hydrogen, a halogen atom or a lower alkyl group, or an acid salt thereof, possesses a superior fungicidal and acaricidal activity suitable for...
4289688 Protein-bound polysaccharides  
Disclosed in this invention are protein-bound polysaccharides having antitumor activities. The polysaccharides have molecular weight within a specified range and present a pattern of color...
4280953 Glycosylated analogs of somatostatin  
Somatostatin (SS) is modified to incorporate a carbohydrate moiety in the peptide chain by linkage to either Asn, Ser or Thr. The modified SS peptide analog may have the formula: ##STR1## wherein...
4272524 N-Acyl-muramyl peptide derivatives having anti-infectious infections properties  
The invention relates to a new method for increasing the resistance of the organism to pathogenic germs and to compositions to carry out said method.In this method, one administers an effective...
4271067 Glycopeptide  
The glycopeptide 31,177 RP is prepared by cultivating under aerobic conditions in an aqueous nutrient medium Streptomyces calidus DS 26,320 (NRRL 8141), a hitherto unknown microorganism. 31,177 RP...
4267102 Bleomycin group antibiotics  
N-methylbleomycins represented by the general formula ##STR1## which are useful as antitumor agents and bactericides; a method of preparing the same; and intermediate products in the preparation...
4261976 Method and glycoprotein composition for inhibition of growth of transformed cells and tumors  
A glycoprotein which inhibits the growth of malignant cells or malignant tumors is obtained from animals and humans having malignant cells or tumors. The glycoprotein has a molecular weight of...
4256632 Novel derivatives of daunomycin  
The present invention relates to novel derivatives of the anthracycline type anticancer drug daunomycin which are characterized by improved anticancer activity and by reduced toxicity compared...
RE30451 Novel process for producing antibiotics bleomycin  
A novel process for producing antibiotics bleomycins by innoculating and aerobically culturing in a nutrient source-containing medium a bleomycin-producing strain belonging to the actinomyces,...
4238391 3-[(S)-1'-phenylethylamino]propylaminobleomycin, non-toxic salt thereof, and method for producing same  
Novel 3-[(S)-1'-phenylethylamino]propylaminobleomycin obtained by reacting a reactive derivative of the carboxyl group of bleomycinic acid with N-[(S)-1'-phenylethyl]-1,3-diaminopropane, a...
RE30413 Bleomycinic acid and process for preparing thereof  
A process for preparing bleomycinic acid having a melting point of 228°-230° C. (decomposition) and an analysis of C: 40.80%, H: 5.29%, N: 16.45%, O: 24.78%, S: 4.53%, Cl: 3.37%, and Cu: 4.78%...
4225588 Antibiotic mixtures  
The use of various polycyclic nitrogen-containing compounds, such as triphenylmethane dyes to potentiate the bioactivity of antibiotics of the phleomycin series.
4220722 Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby  
Methods and compositions are provided for conjugating a wide variety of compounds, particularly polyfunctional compounds, having a mercapto group, either naturally present or synthetically...
4220637 Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents  
The invention relates more particularly to the diamide of the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-a lanyl-D-glutam ic acid, to the pharmaceutical compositions containing...
4216208 N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity  
N-Acyl derivatives of glucosamines made by linking an amino acid or oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl group, to the amino group of the glucosamines by a peptide bond,...
4185089 Immunological adjuvant constituted by the p-amino-phenyl derivative of N-acetyl-muramyl-L-alanyl-D-isoglutamine  
The adjuvant is 2-(p-amino-phenyl-2-acetamido-2-deoxy-3-O-D-glucopyranosyl)- D-propionyl-L- alanyl-D-isoglutamine, which compound in its β glucoside form, corresponds with the formula ##STR1## It...
4169141 1-Peptidyl derivatives of di-O-aminoglycosyl-1,3-diaminocyclitol antibacterial agents  
Disclosed herein are di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents having on the 1-N-position of the 1,3-diaminocyclitol moiety a dipeptidyl or a tripeptidyl substituent. The...
4158608 Fungicidally active antibiotic from Streptomyces tendae Ettlinger  
The new antibiotic Nikkomycin is produced by culturing the strain Streptomyces tendae Ettlinger et al Tu 901 in a nutrient medium at a pH of about 5.5 to 8 under aerobic conditions and isolation...
4153684 Immunizing and anti-infectious adjuvant agents constituted by N-acetyl-muramyl-L-alanyl-D-glutamic acid derivatives  
The invention relates to new water-soluble agents which are effective as immunizing adjuvants. These adjuvant agents are the methyl, ethyl or propyl esters of...
4110434 Novel immunological adjuvants, process for their production and compositions containing them  
Novel derivatives with immunological activity are obtained by reacting a hydrosoluble extract of mycobacteria with an aliphatic acid derivative containing 10 to 18 carbon atoms and isolating the...
4101649 Hydrosoluble agents having non specific immunodepressive properties  
The invention relates to N-acetylmuramyl-D-alanyl-D-isoglutamine and to N-acetylmuramyl-L-alanyl-L-isoglutamine which possess immunosuppressive or immunodepressive properties, as well as to the...
4101536 Muramyldipeptide derivatives and process for the preparation thereof  
Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched...
4094971 Immunological adjuvant agents active in aqueous solution  
Immunological adjuvants obtainable from already-known water-soluble adjuvants containing peptidoglycane fragments, which include saccharide units formed from N-acetylglucosamine and from an...
4088639 Macromolecular adenine nucleotide derivatives  
A macromolecular adenine derivative containing at least one unity having the general formula: ##STR1## wherein, n is 1, 2, 3 or 4; the radical: ##STR2## is derived from an adenine derivative...
4059572 Mucopolysaccharide having flocculating activity of protein and method for producing the same  
Microorganisms of the genus Aspergillus produce mucopolysaccharides having flocculating activity for protein.
4057615 Method of tagging excipients with 99M technetium  
A method of using 99m technetium for tagging excipients in medical diagnosis by scintigraphy comprises mixing, in an aqueous solution of alkali-metal pertechnetate, an excipient and a reducing...
4057618 Radioiodinated bleomycin  
Radioiodinated bleomycin is a useful imaging agent for body tissues. Its production by reaction of bleomycin with N-hydroxysuccinimide esters of radioiodinated hydroxyphenylalkanoic acid is described.
4042576 Extraction of glycoproteins and sialic acid from whey  
A process for the separation of sialic acid and glycoproteins from dairy or casein factory whey. The proteins are flocculated by thermal treatment, the supernatent is ultrafiltrated and the...
4024222 Nucleic acid complexes  
The present invention relates to the induction of interferon production in the cells of living organisms, including human beings. According to the invention, nucleic acid complexes, such as the...
4009264 Complexes of polysaccharides or derivatives thereof with reduced glutathione and process for preparing said complexes  
A complex of a polysaccharide or its derivative with reduced glutathione having in its infrared absorption spectrum no absorption peak at about 2500 cm-1 which appears in the infrared absorption...
3984390 Novel process for producing phleomycin group antibiotics  
By adding a specific amine in culturing under aerobic conditions actinomycetales capable of producing phleomycin group antibiotics, which have been inoculated into a nutrient medium to produce...
3975367 Arabinofuranosyl N4 -aminoacyl cytosine containing compounds  
Certain new 1-(3',5'-O-Variable-β-D-arabinofuranosyl)-N4 -α-aminoacylcytosines, for example, 1-(5'-O-palmitoyl-β-D-arabinofuranosyl)-N4 -[Nα-[N-(tert-butoxycarbonyl)glycyl]-L-arginyl]cytosine...
3971736 Cathepsin in D inhibitors  
Hexa- and heptapeptides of formula W-[X-Pro-Phe-Phe-Y-Z]n H prepared by standard synthetic peptide techniques are anti-inflammatory, anti-rheumatoid arthritic and anti-ulcer agents.
3959080 Carrier matrix for the fixation of biochemically effective substances and process for the preparation thereof  
Biochemically active compounds e.g., proteins and particulate biological materials such as bacteria and viruses, are immobilized on a water-swellable or water-insoluble matrix by covalent bonding...
3952097 Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid  
A nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid, poly-1-lysine and carboxymethylcellulose, and injectable preparations thereof in a pharmaceutically acceptable...
3929993 Process for removing copper from copper-containing bleomycin group antibiotics  
A copper-free form of phleomycin-bleomycin group antibiotics with very small residual copper content and unreduced antitumor activity may be obtained in high yields by contacting an aqueous...
3922262 N-Substituted derivatives of bleomycins  
N-Substituted derivatives of bleomycins, which are useful antibiotic substances having an extremely high anti-microbial activity and an antitumer activity with low toxicity, are easily produced by...
3886133 Process for preparing 3-aminopropyl ester of bleomycinic acid and bleomycinic acid including an acid salt and a copper complex thereof  
A process of preparing the 3-aminopropyl ester of bleomycinic acid or salts thereof and bleomycinic acid or salts thereof which comprises reacting 3-methylmercaptopropylamino bleomycin or acid...
3852413 LABELLED SULFATED AMYLOPECTINS AND METHOD OF DETERMINING ABNORMAL GASTROINTESTINAL MUCOSA  
Described herein are dye and radionuclide labelled anionic polysaccharide compositions, useful as diagnostic aids in the qualitative and quantitative detection in mammals of abnormal mucosa,...
3607650 PROCESS FOR THE ENZYMATIC EXTRACTION AND PURIFICATION OF A GLYCOPEPTIDE OBTAINED FROM ANIMAL ORGANS, USEFUL AS A DRUG  
Glycopeptides are extracted from the gastric mucosa or duodenum of swine by hydrolysis of the animal organ under specified conditions, followed by separation of acidic hydrolysis byproducts and...
3518243 SULFONATED DERIVATIVES OF A GLYCOPEPTIDE EXTRACTED FROM ANIMAL ORGANS,USEFUL AS DRUGS AND A PROCESS FOR THE PREPARATION THEREOF  
4322341 Peptide, process for preparation thereof and use thereof  
The invention relates to novel peptides and their pharmaceutically acceptable salts particularly useful for pharmaceutical purposes such as in the therapeutic treatment of infectious diseases...
3803116 COMPOUND FOR RESTORING RADIATION INJURY AND PROCESS FOR PREPARATION THEREOF  
3812092 INTERMEDIATES IN THE PREPARATION OF SECRETIN  
3795668 POLYAMINE COMPOUNDS AND METHODS FOR THEIR PRODUCTION  
3847890 ACIDIC MONOSACCHARIDE-SUBSTITUTED PROTEINS  
3646197 NOVEL PROCESS FOR REMOVING COPPER FROM COPPER-CONTAINING BLEOMYCIN  
3429868 METHOD OF PREPARING A SERIES OF PROSTHETIC GROUPS AND COENZYMES OF A NEW REDOX-ENZYME WHICH ARE PRESENT IN PLANTS,ANIMALS,OR FOODS AND HAVE VITAMIN-LIKE ACTIVITY  
3264195 Process for the preparation of septacidin and derivatives  

Matches 451 - 500 out of 500 < 1 2 3 4 5 6 7 8 9 10