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6569993 |
Process for the preparation of resin-bound cyclic peptides
This invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-related...
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6566491 |
Cyclopeptide derivatives
The invention relates to compounds of the formula (I) R 1 —Q 1 —X—Q 2 —R 2 , in which: Q 1 , Q 2 , each independent of one another, are missing or are —NH—(CH 2 ) n —CO—; R 1 , R 2...
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6562785 |
Method for overcoming bacterial antibiotic resistance
The present invention is drawn to methods of killing bacteria, including antibiotic resistant bacteria, by contacting said bacteria with a membrane permeabilizing compound or combination of...
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6562786 |
Compounds and methods for modulating apoptosis
Cyclic peptides and compositions comprising such cyclic peptides are provided. The cyclic peptides comprise a classical cadherin cell adhesion recognition sequence HAV. Methods for using such...
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6555650 |
Cyclic analogs of histatins
Cyclic analogues of histatin H-5, having from about 7-20 amino acid units exhibiting substantial homology to histatin H-5, and having a cyclic portion of from 5-16 of the amino acid units, have...
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6551994 |
Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
Modulating agents for inhibiting an interaction between α-catenin and β-catenin are provided. The modulating agents comprise one or more of: (a) a β-catenin HAV motif; (b) a peptide analogue or...
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6548479 |
Therapeutic uses of depsipeptides and congeners thereof
Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R 1 , R 2 and R 3 are as defined herein. These compounds, including FR901228, have...
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6545125 |
Compounds with antitumor activity
Compounds of the formula (1) or tautomers, stereoisomers or optical isomers thereof of the formula X—L—Y wherein X is paclitaxel or its derivative; L represents a linker having at least one...
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6541450 |
Parathyroid hormone analogues for the treatment of osteoporosis
This invention describes analogues of human parathyroid hormone which have increased activities in bone restoration, and increased bioavailability. The peptides described are derivatives of...
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6534478 |
Cyclic azapeptides with angiogenic effect
Compounds of the formula I cyclo-(aArg-aGly-aAsp-aX-aY) I in which aArg, aGly, aAsp, aX and aY have the meanings indicated in claim 1 , and their salts, can be used as integrin inhibitors, in...
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6525022 |
Receptor specific atrial natriuretic peptides
Human receptor selective atrial natriuretic factor variants containing various substitutions, especially G16R, show equal potency and binding affinity for the human A-receptor but have decreased...
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6521594 |
Method and composition for treating thrombosis
The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and...
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6521599 |
Stable pharmaceutical formulation for intravenous or intramuscular administration of active peptide compounds
A stable pharmaceutical formulation for intravenous or intramuscular administration of Octreotide, which is characterized in that the vehicle for injection of the peptide or pharmaceutically...
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6521595 |
Nonimmunosuppressive &lsqb &ggr -hydroxy-methylleucine4&rsqb cyclosporin A, hair growth stimulator and external composition for skin using the same
The present invention relates to methods for treating alopecia and stimulating hair growth and pharmaceutical compositions using nonimmunosuppressive [γ-hydroxy-methylleucine 4 ] cyclosporin A...
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6521593 |
Methods for inhibiting brain tumor growth
The present invention describes methods for inhibition of tumor growth in the brain, using antagonists of integrins such as α v β 3 and α v β 5 . Antagonists of the present invention can...
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6518242 |
Derivatives of glycopeptide antibacterial agents
Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of...
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6511961 |
Cyclic peptides and medicinal use thereof
Novel cyclic peptides having VLA-4 adhesion inhibiting activity, and their application as therapeutic agents for inflammatory disease, for example allergic inflammatory disease, or hepatitis....
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6509001 |
Calcitonin receptor binding reagents
This invention relates to calcitonin receptor binding reagents Comprising Compounds which are Covalently linked to a radiometal chelator. The invention is embodied as calcitonin receptor binding...
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6509315 |
Didemnin analogs and fragments and methods of making and using them
The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes...
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6506731 |
Elastin peptide analogs and methods of using same
The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated...
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6506726 |
Purification of Echinocandin cyclopeptide compounds
A method is described for separating and purifying a wide variety of fermentation cyclopeptide products containing at least one protonatable amino group (including the deacylated Echinocandin-type...
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6495661 |
DNA encoding the outer membrane protein of Pasteurella multocida
An isolated nucleic acid molecule encoding the outer membrane protein of Pasteurella multocida is provided. Also provided are methods to detect the presence of the nucleic acid molecule, and...
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6495680 |
Helices and nanotubes on folding compositions and method of making same
Helical oligomer and polymer compositions that form nanotubes are described. The compositions comprise a plurality of aromatic substituents linked by at least one amide group. The compositions have...
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6489440 |
Cyclic compounds
The present invention relates to novel Aerothricins represented by the Formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, Z, and m are as defined in Claim 1; and pharmaceutically...
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6476187 |
Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals
The present invention provides recombinant expression constructs comprising nucleic acid encoding mammalian melanocortin receptors, and mammalian cells into which said recombinant expression...
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6472505 |
Peptide parathyroid hormone analogs
This invention is directed to cyclic and acyclic analogs of hPTH(1-34) and hPTHrP(1-34), to pharmaceutical compositions comprising these peptide compounds, and to a method of treating diseases...
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6468966 |
Octacyclodepsipeptides having an endoparasiticidal action
The present invention relates to compounds of the general formula (I) in which R 1 and R 12 represent the same or different radicals selected from the group of C 2-9 -alkyl, C 1-8...
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6451972 |
Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
Compounds of formula (I) where n is the number 0, 1 or 2, processes for the preparation together with methods for treating pathologies related to an altered α v β 3 integrin-mediated cell...
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6447786 |
Blocking expression of virulence factors in S. aureus
This invention provides peptides which inhibit agr transcription in S. aureus and thereby block the expression of virulence factors in S. aureus , pharmaceutical compositions comprising these...
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6429286 |
Immunoregulatory molecules for costimulatory signal transduction
An immunoregulatory molecule that regulates costimulatory signal transduction through interaction with the molecules involved in costimulatory signal transduction present on antigen presenting...
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6423823 |
Organic chemical compounds and method for producing the same
The present invention relates to novel organochemical compounds, referred to as omphalotins for short, a process for their preparation by an essentially microbiological route and their use as...
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6407059 |
Conformationally constrained backbone cyclized peptide analogs
Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building...
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6399567 |
Cyclic hexapeptides having antibiotic activity
This invention relates to new polypeptide compounds represented by the following formula (I): wherein R 1 is as defined in the description or a salt thereof which have antimicrobial activities...
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6391851 |
Hydrochlorides of vancomycin antibiotics and process for producing the same
Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from −1° C. to...
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6384186 |
Cyclic dodecapeptide and process for the preparation thereof
The present invention relates to a novel organochemical compound, referred to as omphalotin for short, a process for its preparation by an essentially microbiological route and its use as...
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6384187 |
Antiproliferative activity of microsclerodermins
The subject invention pertains to a series of cyclic peptides known as the microsclerodermins, which possess unusual amino acids, and which have been observed to inhibit the proliferation of tumor...
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6384014 |
Purified form of streptogramines, preparation of same and pharmaceutical compositions containing them
Purified form of streptogramines, characterised in that it contains at least one component from group B streptogramines of general formula (I), wherein R 1 is Me or Et, R 2 is H or OH, and R 3 ...
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6380156 |
Total synthesis of the amino hip analogue of didemnin A
Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as “AipDidemnin A” (8). These compounds have the...
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6358491 |
Somatostatin analogs
The invention provides novel peptide-based pharmacophores and compounds which bind somatostatin receptors with high affinity and which exhibit improved pharmacokinetic properties over known...
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6358921 |
Antimicrobial peptide compositions and method
The invention concerns antimicrobial cyclic peptides and peptide analogs having relatively low hemolytic activity. Peptides of the invention are effective in killing and/or inhibiting growth of a...
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6346511 |
Pharmaceutical composition comprising cyclosporin
A homogenous substantially alcohol free composition of Cyclosporin which comprises a cyclosporin in a hydrophilic carrier medium comprising propylene glycol, esters of propylene glycol with C4 to...
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6346601 |
Procedure for obtaining the somatostatin analog, octreotide
A procedure for obtaining the somatostatin analog, octreotide by means of solid phase synthesis on polymer supports and by intervention of protector groups of the Fmoc/tBu type. It includes...
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6346602 |
Peptide mimics of the cytokine receptor common &ggr chain and methods and compositions for making and using the same
Peptides which mimic a loop on the γ-chain that either interact with a cytokine or a γ-chain partner receptor chain of a heterodimeric cytokine receptor are disclosed. The peptides consist of...
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6337316 |
Pharmaceutical compositions thereof, and methods of using same
The present invention relates to peptidomimetics capable of inhibiting CD28 and/or CTLA-4 interaction with CD80 (B7-1) and CD86 (B7-2) and having a core amino acid sequence,...
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6333307 |
Compounds and method for modulating neurite outgrowth
Modulating agents comprising cyclic peptides, and compositions comprising such modulating agents are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV....
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6333308 |
Cyclic peptide derivatives
Compounds of the formula I cyclo-(Arg-X-Asp-R 1 ) I in which X is Gly, Ala or NH--NH--CO, R 1 is a radical of the formula II ##STR1## and R 2 ,R 3 and R 4 have the meanings...
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6333402 |
Kallikrein-binding "Kunitz domain" proteins and analogues thereof
This invention provides: novel protein homologous of a Kunitz domain, which are capable of binding kallikrein; polynucleotides that encode such novel proteins; and vectors and transformed host...
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6331522 |
Antibacterial and antifungal peptide
The present invention provides a peptide with antibacterial and antifungal properties, and compositions containing the peptide. Methods of making and using the antibacterial and antifungal peptide...
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6331521 |
Echinocandine derivatives with antimicrobial activity
The invention relates to new polypeptide compounds represented by the following formula [I]: ##STR1## wherein R 1 is hydrogen, etc, R 2 is hydrogen, etc, R 3 is hydrogen, etc, and R...
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6331285 |
Structurally determined cyclic metallo-constructs and applications
A metallo-construct, which may be a peptide, is provided for use as a biological, therapeutic, diagnostic imaging, or radiotherapeutic agent, and for use in library or combinatorial chemistry...
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