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5494809 |
Method of producing iturin A and antifungal agent for profound mycosis
The present invention is a method of producing iturin A, in which cells of Bacillus amyloliquefaciens are incubated and iturin A is collected from the culture. It also relates to an antifungal...
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5492892 |
Endothelin antagonists
The present invention as directed to a compound which comprises an endothelin antagonist polypeptide that is at least 40% homologous to an endothelin active peptide, consisting of Et-1, Et-2, Et-3,...
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5493006 |
Cyclic CRF analogs
Improved CRF peptide antagonists have the formula: ##STR1## wherein R 20 is Cys or Glu; R 23 is Cys, Lys or Orn; provided that when R 20 is Cys, R 23 is Cys and when R 20 is Glu, R 23 is Lys...
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5491128 |
Aglycons of A/16686 antibiotics
The invention concerns the aglycons of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686, their corresponding tetrahydroderivatives and mixtures thereof. The aglycons are produced by the...
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5491129 |
Synthetic peptides derived from vitronectin and pharmaceutical compositions comprising them
The invention relates to synthetic peptides derived from the K 348 -A 380 (8-40 of SEQ ID NO:1) sequence of the vitronectin molecule. The peptides modulate the biological activities of...
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5486465 |
Teicoplanin recovery process
The present invention relates to a method for extracting teicoplanin A 2 from a whole culture fermentation broth by filtration of the mycelium in an alkaline medium and recovery by extraction of...
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5480779 |
Cyclosporine assay
A process for determining the concentration of cyclosporine in a sample, which comprises adding to the sample a predetermined amount of an isomerase which isomerizes N-terminal peptide to proline,...
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5475094 |
Salmycins, a process for their preparation and their use as a pharmaceutical
Salmycins, a process for their preparation and their use as a pharmaceutical Compounds of formula I, ##STR1## wherein R denotes NOH (a), O (b); --OH and --H (c), --NH 2 and --H (d) or...
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5470948 |
Vasopressin and vasotocin derivatives
This invention relates to new vasopressin and vasotocin derivatives of general formula I ##STR1## in which A stands for the radical Mca (=3-mercapto-3,3-cyclpentamethylenepropionyl radical) or for...
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5466667 |
Prophylactic and therapeutic methods for treating edema with antamanides
Unique methods for treating edemas in living subjects are provided comprising administering an effective amount of an antamanide or an antamanide analogue to the subject. The methods offer...
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5459236 |
Vasoactive vasotocin derivatives
The present invention relates to new vasotocin derivatives with prolonged activity compared to previous vasotocin derivatives. In particular, the vasotocin derivatives of the present invention are...
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5449750 |
Prolyl endopeptidase inhibitors SNA-115 and SNA-115T, and process for the production and productive strain thereof
Prolyl endopeptidase inhibiting compounds SNA-115 and SNA-115T are provided having molecular formulas of C 113 H 142 N 26 O 27 and C 113 H 144 N 26 O 28 respectively. SNA-115T has the...
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5447915 |
Terminally blocked antiviral peptides
This invention relates to antiviral peptide compounds and to methods of inhibiting infection of human cells by viruses. This invention pertains more specifically to peptides that are chemically...
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5444150 |
Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
A new amino acid derivative, N α -tert-butoxycarbonyl-N e -(N-bromoacetyl-β-alanyl)-L-lysine (BBAL), has been synthesized as a reagent to be used in solid-phase peptide synthesis for introducing...
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5439792 |
Cysteine thiol-protected peptides for use in immunoassays
Peptides immunoreactive with antibodies to native proteins, and which have at least two cysteine residues that contribute to mimicking an epitope of the protein, are prepared with the cysteine...
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5438117 |
Hexapeptides deriving from aglucoteicoplanin and a process for preparing them
Hexapeptides of formula (I) deriving from aglucoteicoplanin and their salts with acids and bases as well as their inner salts wherein R is hydrogen or a protecting ##STR1## group of the amino...
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5430018 |
Cyclohexapeptide with basic nitrogen containing alkylamide groups
Certain aminoalkyl substituted amides which have a cyclohexapeptidyl group and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are...
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5428009 |
Lipopeptide derivatives
The present invention is directed to water-soluble derivatives of antibiotic lipopeptides. The derivatives have good solubility properties in aqueous medium, rendering them more useful as...
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5416194 |
Polypeptide having affinity for lipopolysaccharide and method for preparing the same
This invention relates to a novel polypeptide represented by the formula: ##STR1## wherein Lys represents lysine, Trp tryptophan, Cys cystine, Phe phenylalanine, Arg arginine, Val valine, Tyr...
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5411942 |
Peptide derivative, pharmaceutical preparation containing it and method for treatment of glaucoma
Peptide derivatives of 3-5 optionally substituted amino acids, a process for preparing the peptides, a pharmaceutical composition containing at least one peptide derivative active against glaucoma...
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5411952 |
Ocular cyclosporine composition
Cyclosporine compositions for topical ophthalmic use for treatment of immune disorders, to enhance or restore tear production, and to enhance or effect normal healing of the surface of the eye,...
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5409816 |
Process for producing immunosuppressives and a novel microbial species to be employed therein
The invention relates to a process for producing a cyclosporin, especially cyclosporin A, by cultivating the strain (LEA3) of the novel Tolypocladium species aerobically at a temperature of 20°-30...
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5401649 |
2-methyl-4-hexene-and 3-methyl-5-heptene-1,2-diol derivatives
2-methyl-4-hexene- and 3-methyl-5-heptene-l,2-diol derivatives are disclosed together with methods for preparing such derivatives. Where the derivative is a 2-methyl-4-nexene- or...
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5399552 |
Antibiotic peptides bearing aminoalkylthioether moieties
Certain aminoalkyl thioethers represented by the formula ##STR1## their acid addition salts and quaternary ammonium salts are described. The compounds have useful antimicrobial properties.
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5395823 |
Neuropeptide Y agonists and partial agonists
Agonists of NPY which are derivatives of naturally occurring NPY. The agonism is confirmed using conventional competitive binding and biochemical assays and the use of these derivatives in a...
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5387670 |
Antibiotic, deoxymulundocandin, a process for its production and its use as medicament
Deoxymulundocandin, a compound of the formula I (SEQ. ID NO: 1) ##STR1## has an antiyeast, an antifungal and an immunomodulatory action.
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5387671 |
Hexa- and heptapeptide anaphylatoxin-receptor ligands
Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states....
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5386011 |
Hexapeptide anaphylatoxin-receptor ligands
Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states....
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5386010 |
Lipopeptide compounds
Antifungal and antiparasital lipopeptide compounds stable in aqueous media are described. Stability in aqueous media render lipopeptides more useful for compositions for therapeutic applications.
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5384309 |
Cyclized peptides and their use as platelet aggregation inhibitors
The invention in its broad aspects relates to peptide derivatives which are useful as inhibitors platelet function mediated by the GP llbllla receptor and for the prevention of thrombus formation....
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5382655 |
Process for the purification of cyclosporin A
A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are...
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5378803 |
Azole-fused peptides and processes for preparation thereof
Azole-fused peptides useful as Substance P antagonists and analgesics, for example ##STR1## wherein ##STR2## represents ##STR3## wherein X is O, S or NH and * is D, or as intermediates therefor are...
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5376634 |
Polypeptide compound and a process for preparation thereof
A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R 1 is hydrogen or acyl group, R 2 is hydroxy or acyloxy, R 3 is hydroxysulfonyloxy,...
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5373089 |
Oxytocin antagonist
A novel compound is disclosed for inhibiting the effects of oxytocin in a female mammal. As an analog of oxytocin the compound is named [(S)PMP 1 ,D-Trp 2 ,Pen 6 ,Arg 8 ] oxytocin. This compound...
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5371071 |
Peptide and pseudopeptide compounds which are therapeutically active in the blood coagulation cascade
The invention relates to the compounds of formula (I): X - A 1 - A 2 - A 3 - A 4 - A 5 - A 6 - A 7 - A 8 - A 9 - A 10 - Y (I) in which X, A 1 , A 2 , A 3 , A 4...
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5371070 |
Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
Peptides which have substantial bioactivity to inhibit the secretion of gonadotropins by the pituitary gland and to inhibit the release of steroids by the gonads. Administration of an effective...
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5352659 |
Endothelin analogs and uses thereof
Disclosed are a peptide represented by formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein M represents a mercaptoacyl group; P, Q, R, S, T, U, V, W, X, Y and Z each...
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5350574 |
Derivatives of cyclosporina A, antibodies directed thereto and uses thereof
This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides...
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5347001 |
Process for preparing sulphonylpristinamycin II.sub.B
Method for preparing (dialkylamino-2 alkyl)sulphonyl-26 pristinamycin II B having general formula (I) ##STR1## by oxidation of (dialkylamino-2 alkyl)thio-26 pristinamycin II B with 3,5 to 20 of...
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5344913 |
Biosurfactant cyclopeptide compound produced by culturing a specific Arthrobacter microorganism
A novel biosurfactant having a high surface activity, as well as a microorganism producing the surfactant is disclosed. The biosurfactant according to the present invention is represented by the...
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5336756 |
Process for crystalline cyclic lipopeptides
A process for obtaining a compound of the formula ##STR1## in crystalline form by solubilizing the compound in warm aqueous n-propanol and then allowing the solution to stand at ambient temperature...
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5336757 |
Antibacterial peptide and methods of use
A novel peptide, polydiscamide A, has been isolated from a marine sponge. This compound, and its derivatives, are useful as antibacterial agents.
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5334702 |
Compositions which are immunologically crossreactive with antibodies and preparative methods therefor
Compositions which are immunologically crossreactive with antibodies are provided, together with preparative and therapeutic methods therefor. The compositions preferably comprise a plurality of...
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5331089 |
Peptides useful as tachykinin agonists
A class of monomeric or dimeric peptides containing a specific hexa- or heptapeptide unit in either linear or cyclic form are active tachykinin antagonists and are therefore useful in disease...
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5326751 |
Enkephalin analogs
A new class of opioid receptor analogs is described based on an alanine substitution in the three position in the enkephalin analog DPDPE. The alanine-substituted analogs show increased selectivity...
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5318901 |
Method for the production of a modified "8-amino acid" cyclosporin derivative
A cyclosporin derivative with incorporated "8-(3-fluoro-D-alanine)" or "8-(2-deutero-3-fluoro-D-alanine)" has been isolated from the fermentation broth of incubating Tolypocladium inflatum MF5080...
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5312811 |
Peptide derivatives and antidemetia agents
A novel peptide derivative having the formula: ##STR1## wherein A between Pro and Q 2 is Arg or Lys: Q 1 is pGlu or H; Q 2 is --Gly--OH or OH; Y 1 is H or --CO--T and Y 2 is OH or T; wherein T...
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5310873 |
Cyclohexapeptide compound
A cyclohexapeptide base which is the nucleus of closely related antibiotics obtained by culturing Zalerion arboricola and its salts are described. They are useful intermediates for the preparation...
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5310727 |
Pharmaceutical compositions for parenteral use containing a calcitonin as the active ingredient
A freeze-dried pharmaceutical composition for parenteral administration which includes a therapeutically effective amount of a calcitonin, as the active ingredient, and human albumin. The...
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5304633 |
Fragments of lactoferrin having potent antimicrobial activity
An antimicrobial peptide containing at least the following amino acid sequence (a), (b), (c) or (d), an antimicrobial agent containing the said antimicrobial peptide as active components at a...
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