|
Match
|
Document |
Document Title |
|
|
5639852 |
Immunostimulatory agents
Compositions and methods are described for the synthesis of novel analogs of cyclosporin A, and the use of those analogs as immunostimulatory agents.
|
|
|
5635477 |
Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
This invention relates to novel cyclic compounds containing carbocyclic ring systems useful as antagonists of the platelet glycoprotein IIb/IIIa complex, to pharmaceutical compositions containing...
|
|
|
5635594 |
Gallinacins - antibiotic peptides
Peptide-based compounds containing six invariant cysteine residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection in animals and plants. These...
|
|
|
5633346 |
Process for systhesizing cyclic peptides
A process is provided for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. The cyclic peptide is represented by the...
|
|
|
5633345 |
Cyclic peptides
To provide a process for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. A process for synthesizing a cyclic...
|
|
|
5631222 |
Endothelin-antagonizing peptide
Disclosed is a peptide compound represented by the following formula (I): R 1 -R 2 -R 3 -R 4 -R 5 -R 6 -R 7 -R 8 -R 9 -R 10 -R 11 -R 12 -Phe-R 14 -R 15 -R 16 -R 17 -R 18 -Ile-R...
|
|
|
5629290 |
Cyclic peptide antifungal agents
Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I ##STR1## where: R', R", R'", R x1 , R x2 , R y1 , R y2 , R y3 , R y4...
|
|
|
5629289 |
Cyclic peptide antifungal agents
Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I: ##STR1## wherein: R z1 is hydrogen, --CH 2 OH, --CHOHCH 3 or...
|
|
|
5629288 |
Lipopeptide derivatives, a process for their preparation and their use
Lipopeptide derivatives of the formula I ##STR1## with R 1 equal to OH or NH 2 and R 2 a C 8 -C 22 -acyl radical, pharmaceutical products which are effective for bacterial infections and...
|
|
|
5618914 |
Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
The invention provides materials and methods for synthesizing novel beta-turn mimetics, as well as the novel beta-turn mimetics themselves, and peptides containing the same. Also provided are novel...
|
|
|
5616556 |
Method of treating rheumatoid arthritis and osteoarthrosis using tetrahydro WS9326A
Rheumatoid arthritis and osteoarthrosis are treated by administering an effective amount of tetrahydro-WS9326A to a human being or animal suffering from rheumatoid arthritis or osteoarthrosis.
|
|
|
5616557 |
Process for selectively inhibiting activity of endotoxin
By contacting a peptide derivative or a protein having a property of binding to endotoxin (ET) to inhibit the activity of ET, and at least one surfactant with a sample containing ET, the activity...
|
|
|
5616684 |
Cyclic peptides and use thereof
Cyclic peptides and their salts have antagonistic activity on endothelin receptors and antagonistic activity on NK2 receptors. The peptides have the formula ##STR1## wherein X and Y each represent...
|
|
|
5606030 |
Coconjugates of OMPC, HIV related peptides and anionic moieties
A novel coconjugate comprising an immunogenic protein or protein complex having a first set of covalent linkages to low molecular weight moieties, --a - -, which have an anionic or polyanionic...
|
|
|
5597894 |
Multi-tyrosinated somatostatin analogs
Disclosed are methods and compositions for the diagnosis and treatment of diseases associated with aberrant expression of a somatostatin receptor (e.g., cancer) or with increased production of a...
|
|
|
5594101 |
Anti-obesity proteins
The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live...
|
|
|
5594102 |
Chemical process for preparing antibiotic L 17932 (deglucoteicoplanin) and its salt
The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a...
|
|
|
5593960 |
Cyclic heptapeptide anti-inflammatory agent
A cyclic heptapeptide anti-inflammatory agent named cyclomarin-A is disclosed. Cyclomarin-A is produced by a specific marine actinomycete. The cyclomarin-A producing bacterium is isolated from...
|
|
|
5591714 |
Derivatives of A82846
New N-alkyl and N-acyl derivatives of A82846A, A82846B, A82846C and PA-42867-A are provided. The new glycopeptide derivatives are useful for the treatment of susceptible bacterial infections,...
|
|
|
5589459 |
Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
The present invention provides methods of using peptides of the formula R 1 --(A--B--C) n --R, wherein R 1 and R are independently H or an amino acid residue or a fatty acid residue; A is an...
|
|
|
5583108 |
Vasonatrin peptide and analogs thereof
Synthetic analogs of C-type natriuretic peptide are provided, together with methods for their production and use as natriuretics, diuretics, and/or vasodilators, or as intermediates for or...
|
|
|
5574135 |
Process for making vancomycin
A process for the manufacture of vancomycin which does not require preparation of a phosphate intermediate. The process consists of passing a vancomycin broth through a suitable adsorbent, followed...
|
|
|
5571701 |
Antibiotic, balhimycin, a process for its production and its use as pharmaceutical
Balhimycin, a compound of the molecular formula C 66 H 73 C1 2 N 9 0 24 , is a novel Glycopeptide antibiotic and has the following structure: ##STR1##
|
|
|
5569647 |
Angiopeptin cyclopeptide compounds
The invention relates to a compound selected from those of formula (I) (SEQ ID NO:1): ##STR1## in which R 1 , R 2 , X 1 and X 2 are as defined in the description, useful as inhibitor of the...
|
|
|
5569741 |
Cyclic octapeptide neuromedin B receptor antagonists
A cyclic octapeptide of the formula: ##STR1## wherein: A 1 is D-Nal or D-Trp; A 3 is Phe, F 5 -Phe, or X-Phe wherein X is a halogen, NO 2 , CH 3 , or OH; A 5 is --NH--CH(Y)--CO-- wherein Y is...
|
|
|
5569742 |
Centrally truncated NPY cyclic peptides
Centrally truncated NPY cyclic peptide analogs are described which have selective bioactivity for NPY Y1 receptors. Methods are provided for diagnosing physiological disorders manifested by...
|
|
|
5567676 |
Glycopeptide antibiotics
The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these...
|
|
|
5565423 |
Cyclopeptides and their use as absorption promoters when applied to the mucosa
Cyclopeptides and their use as absorption promoters when applied to the mucosa The invention relates to a compound of the formula I ##STR1## or a physiologically tolerated salt thereof, in which X...
|
|
|
5556940 |
Parathyroid hormone analogues for the treatment of osteoporosis
Certain analogues of human parathyroid hormone (hPTH) have been found to be effective for the treatment of osteoporosis, while showing decreased side effects. Analogues showing this effect include...
|
|
|
5552521 |
Process for preparing certain aza cyclohexapeptides
There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
|
|
|
5547934 |
WF11243 substance
The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.
|
|
|
5545721 |
Conjugates for the prevention and treatment of sepsis
Compositions and methods are described for preventing and treating sepsis in humans and other animals. Surgical patients, low birth weight infants, burn and trauma victims, as well as other...
|
|
|
5543496 |
Cyclic bradykinin antagonist peptides
Cyclic compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acid substitutions are made at postions 2 and 5 or 6 to facilitate the cyclization of the...
|
|
|
5541287 |
Pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin, as well...
|
|
|
5541160 |
Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
Compounds represented by the formula I (SEQ ID NO. 1) are disclosed: ##STR1## as well as pharmaceutically acceptable salts and hydrates thereof. R I represents C 9 to C 19 alkyl, C 9 to C 19 ...
|
|
|
5538947 |
Growth inhibitory factor
Disclosed is a non-naturally-occurring polypeptide having neural growth inhibitory action which has an amino acid sequence represented by the formula: Thr Cys Pro Cys Pro Ser Gly Gly Ser Cys Thr...
|
|
|
5539087 |
Antibiotic A/16686 recovery process
The present invention is directed to a process for recovering the antibiotics produced by fermentation of Actinoplanes sp. ATCC 33076 or a producing mutant thereof, from a fermentation broth or a...
|
|
|
5521156 |
Cyclic neurokinin A antagonists
Antagonists of neurokinin A which are novel cyclic hexapeptide and octapeptide compounds are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as...
|
|
|
5521155 |
Amides of teicoplanin compounds
The present invention is directed to an amide derivative of the glycopeptide, teicoplanin. This compound is an antibiotic that is active against gram positive bacteria. This compound is produced by...
|
|
|
5516757 |
Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
There are disclosed novel semi-synthetic lipopeptides of the formula (Seq. ID Nos. 1-6) ##STR1## wherein the substituents are defined herein, which show utility as antifungal and anti-Pneumocystis...
|
|
|
5516889 |
Synthetic thrombin receptor peptides
This invention relates to novel peptides based on a thrombin receptor sequence and novel methods for synthesis of these novel peptides. These peptides, branched-chain compounds and/or derivatized...
|
|
|
5516755 |
Antitumor and antibacterial peptide and methods of use
A novel peptide, polydiscamide A, has been isolated from a marine sponge. This compound, and its derivatives, are useful as antibacterial and antitumor agents.
|
|
|
5514773 |
Depsipeptide derivatives, production thereof and use thereof
wherein A is benzyl group which has suitable substituent(s) or phenyl group which may have suitable substituent(s), A a is benzyl group which may have suitable substituent(s) or phenyl group...
|
|
|
5508383 |
Cyclic peptide LHRH antagonists
A class of cyclic peptides are effective inhibitors of LHRH and are useful in the treatment of disease conditions which are mediated by sex hormones including prostate cancer, endometriosis,...
|
|
|
5506339 |
Octapeptide analogs of somatostatin having threonine at the sixth position
A compound of the formula: ##STR1## wherein each A 1 and A 2 , independently, is H, C 1 -12 alkyl, C 7 -10 phenylalkyl, R 1 CO (where R 1 is C 1 -20 alkyl, C 3 -20 alkenyl, C 3 -20 alkinyl,...
|
|
|
5503989 |
Production of peptide amides
Methods of preparing a peptide having a C-terminal amide group from peptides having a C-terminal carboxyl group are provided.
|
|
|
5504189 |
Peptides, their preparation and use
Antitumor peptides of the formula ##STR1## where R 1 , R 2 , R 3 , R 4 and R 5 have the meanings stated in the description, and the preparation thereof.
|
|
|
5502033 |
Antimicrobial polypeptide compound a pharmaceutical composition comprising the same, and a method for treating infectious diseases
A compound having antimicrobial activity of the following general formula: ##STR1## wherein R 1 is hydrogen or hydroxy, R 2 is hydrogen or hydroxy, R 3 is hydroxy or hydroxysulfonyloxy, with...
|
|
|
5500410 |
Substituted alkylamide derivatives of teicoplanin
The present invention is directed to new C 63 amide derivatives of teicoplanin wherein the amide moiety is derived from a di- or poly-alkylamine, and to a process for preparing them. The...
|
|
|
5494893 |
Stylostatin 2
The cytostatic cycloheptapeptide stylostatin 2 was isolated respectively, from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was...
|