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7427496 |
Anti-cancer compounds
The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the...
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7371810 |
Tachykinin peptides, precursor peptides thereof and genes encoding the same
Tachykinin peptide isolated and purified from the posterior salivary gland of the mollusk Octopus vulgaris . The tachykinin peptide provides a new approach for developing medicaments and...
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7276251 |
Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in...
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7235531 |
Tachykinin-like polypeptides and use thereof
The present invention relates to amino acid sequences for novel tachykinin polypeptides and base sequences encoding them, agonists and antagonists of such polypeptides, pharmaceutical compositions...
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7074765 |
Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
The invention relates to compounds and methods for inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4 using peptide analogs of Arg-Pro-Pro-Gly-Phe that...
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7071168 |
Anti-cancer compounds and methods related thereto
The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula:
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7041785 |
B1-bradykinin receptor antagonists and use thereof
The present invention relates to novel antagonists to a B 1 -bradykinin (B 1 -BK) receptor which have a good affinity and selectivity therefor, some of which being at least partially resistant to...
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6770741 |
Bradykinin antagonist peptides
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts...
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6458923 |
Modified position (7) bradykinin antagonist peptides
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an isoquinoline derivative which converts bradykinin agonists into...
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6288036 |
Bradykinin type peptides
The substitution of the L-Pro at the 7-position with D-Phe or D-Tic and substitution of the L-Phe at the 8-position with hydroxyproline ethers and thioethers of the peptide hormone bradykinin and...
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6245736 |
Use of peptidic bradykinin antagonists for the treatment and prevention of Alzheimer's disease
The invention relates to the use of bradykinin antagonists for the production of pharmaceuticals for the treatment and prevention of Alzheimer's disease. Suitable bradykinin antagonists are...
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6242573 |
Method of producing water-insolubilized regenerated collagen fiber
A regenerated collagen fiber is subjected to water-insolubilizing treatment with a monofunctional epoxy compound to produce a water-insolubilized regenerated collagen fiber which can substantially...
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6075120 |
Bradykinin antagonist
A bradykinin antagonist of the formula: (BKAn)(X)(Y) where BKAn is a bradykinin antagonist peptide; Y is a pharmacore; and X is a bridging link chemically joining the BKAn and Y components.
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5935932 |
Bradykinin antagonists containing pentafluorophenylalanine
The present invention provides bradykin antagonists containing pentafluorophenylalanine which are therapeutically useful. Moreover, the present invention provides methods to antagonize bradykinin...
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5863901 |
Use of bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders and acute liver disorders
This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient...
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5863899 |
Bradykinin antagonists
A bradykinin antagonist of the formula: (BKAn) (X) (Y) where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.
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5849863 |
Cytolytic bradykinin antagonists
The present invention provides bradykinin antagonists effective to inhibit cancer cell growth. Also provided are methods of inhibiting lung cancer cell growth by administering a therapeutically...
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5834431 |
Des-Arg.sup.9 -BK antagonists
The present invention provides des-Arg 9 bradykinin analogs which are selective B1 receptor antagonists.
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5789383 |
Bradykinin antagonists for the prophylaxis or treatment of virus diseases
Bradykinin antagonists and their physiologically tolerated salts are suitable for the treatment or prophylaxis of virus diseases.
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5750646 |
Bradykinin analogs with non-peptide bond
A linear peptide which is an analog of a naturally occurring, biologically active peptide having an active site and a binding site responsible for the binding of the peptide to a receptor on a...
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5750506 |
Bradykinin antagonists with extended hydrophobic side chains
Bradykinin antagonists, particularly Cys 6 analogs, which have an extended hydrophobic side chain.
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5700779 |
Bradykinin antagonist peptides incorporating N-substituted glycines
The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin...
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5686416 |
Increasing blood-brain barrier permeability with permeabilizer peptides
Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or...
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5670619 |
Bradykinin-antagonists for the treatment of acute pancreatitis
The invention relates to the use of bradykinin-antagonists of the formula R 1 -A-B-C-E-F-G-J-K-R 2 wherein R 1 represents hydrogen, C 1 -C 4 -alkanoyl which can be substituted by mercapto,...
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5648336 |
Bradykinin antagonist peptides containing indane-substituted amino acids
The present invention pertains to modified bradykinin antagonist peptides of the formula X-A 0 -B 1 -C 2 -D 3 -E 4 -F 5 -G 6 -H 7 -J 8 -K 9 , where at least one of F 5 , H 7 and J 8 is...
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5648333 |
Peptides having bradykinin antagonist action
Peptides of the formula I A-B-C-E-F-K-P-G-M-F'-I (I), wherein the terms A, B, C, E, F, K, P, G, M, F', and I are defined in the specification, have bradykinin...
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5610142 |
Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids
Novel compounds with as few as three natural amino acids that incorporate a substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoyl bridge in place of selected fragments of peptidic bradykinin...
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5610140 |
Bradykinin receptor antagonists with neurokinin receptor blocking activity
The present invention provides a heterodimeric compound possessing bradykinin and neurokinin receptor antagonist activities useful in the treatment of asthma and other inflammatory diseases...
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5597803 |
Bradykinin peptides with modifications at the N terminus
Peptides of the formula I Z-P-A-B-C-E-F-K-(D)Q-G-M-F'-I (I) and the physiologically tolerated salts thereof, are described. They have an excellent...
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5585355 |
Method for increasing blood-ocular barrier permeability with permeabilizer peptides
The permeability of the blood-ocular barrier to therapeutic or diagnostic agents in the bloodstream of a host is increased by administering a permeabilizer peptide, preferably bradykinin or a...
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5558987 |
Blood levels of CCK peptides relative to panic disorder treatment
A method of treating a patient having a panic disorder, the patient having an elevated CCK peptide plasma level, by lowering the plasma CCK peptide level of the patient. A further method provides a...
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5552520 |
Therapeutic peptide derivatives
Peptide derivatives containing one or more substituents separately linked by an amide, amino or sulfonamide bond to an amino group on either the N-terminal end or side chain of a biologically...
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5543496 |
Cyclic bradykinin antagonist peptides
Cyclic compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acid substitutions are made at postions 2 and 5 or 6 to facilitate the cyclization of the...
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5541286 |
Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
Pseudopeptide compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acids at at positions 2 through 5 are replaced by olefinic aminoalkenoyl groups to...
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5521158 |
Pseudopeptide bradykinin receptor antagonists
The invention relates to peptides of up to 10 amino acids that are synthesized by substituting at least one of the bradykinin amino acids found in positions 2, 3, 4 and 5 of the bradykinin peptide...
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5434132 |
Neuropeptide antagonists
Oligopeptides have been found that antagonist cell proliferation stimulated not only by bombesin-like peptides but also other neuropeptides e.g. vasopressin and bradykinin. These oligopeptides...
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5409899 |
Pseudopeptide compounds having anti-inflammatory activity
Compound of formula: G-Arg-Pro-Hyp-Gly-Thia-Ser-Tic-Oic-Arg-OH where G, Arg, Pro, Hyp, Gly, Thia, Ser, Tic and Oic are defined in the description. Medicinal products.
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5369015 |
Method for producing an angiotensin converting enzyme inhibitor-containing composition
Disclosed is a method for producing an angiotensin converting enzyme inhibitor composition from natural materials, which composition is of use as an antihypertensive drug or diet. The method...
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5304632 |
Neuropeptides of the tachykinin family
The invention relates to a peptide, characterized in that it corresponds to the following sequence of amino acids: Xaa 1 Pro Xaa 2 Pro Xaa 3 Xaa 4 Phe Tyr Gly Leu Met in which a n with n...
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4923963 |
Bradykinin antagonist peptides
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aliphatic, cyclic or aromatic amino acid of the D-configuration...
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4728725 |
Retro-inverted peptides analogues of Bradykinin Potentiator BPP.sub.5a
Retro-inverted peptides, analogues of Bradykinin Potentiator Pentapeptide (BPP 5a ), definable by the general formula (I) ##STR1## useful as antihypertensives and diagnostics.
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4713367 |
Retro-inverso analogs of the bradykinin potentiating peptide BPP.sub.5a
New partially retro-inverso peptides of the following general formula ##STR1## wherein R 1 and R 2 are the same or different and represent, each independently, the side chain of the aminoacid...
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4522752 |
Retro-inverso analogues of the bradykinin potentiating peptide BPP.sub.5a and methods for their preparation
This invention relates to new retro-inverso peptides and peptide derivatives in the form of analogues of the bradykinin potentiating peptide (BPP 5a ), which are pharmacologically active, have long...
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4399124 |
Peptides having immunostimulating properties and pharmaceutical compositions containing them
Peptides having immunostimulating properties making them applicable to pharmaceutical compositions for the treatment or prevention of infections. They contain the sequence prolyl glycyl.
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4287185 |
Method for the detection of viruses
Certain novel polypeptides and their use as carcinostatic agents and as agents for the detection and determination of viruses. The polypeptides contain forty-five amino acid residues and have a...
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4285857 |
Cyclic analogues of callidine
Novel cyclic analogues of callidine have the following general formula: ##STR1## wherein Pro is moiety of L-proline, Gly--that of glycine, Phe--phenylalanine, Arg--L-argenine; R is a residue of α-...
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4242329 |
Bradykinin-inhibiting tripeptide derivatives
Tripeptide derivatives of the formula H-D-X-Phe-Arg-Y in which X is selected from the group consisting of Pro and Phe Y is selected from the group consisting of O--R 1 and NH--R 2 in...
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4187217 |
Bradykinin cyclic analog-cyclo-[(N.sup.ε -1-L-lysine, 6-glycine)-bradykinin]
Cyclic analog of bradykinin having the formula ##STR1## where Lys-L-lysine residue, Pro-L-proline residue, Gly-glycine residue, Phe-L-phenylalanine residue, Arg-L-arginine residue. The present...
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3997516 |
Method for protecting guanidino group and restoring the same
A guanidino group in an amino acid or a peptide can be protected with a specific protective group, i.e. lower alkoxybenzenesulfonyl group or tri-lower alkylbenzenesulfonyl group, and the protective...
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3546198 |
PROCESS FOR THE SYNTHESIS OF BRADYKININ AND OTHER ARGININE CONTAINING PEPTIDES
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