Patents in Class 530/302

Matches 1 - 50 out of 138

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Match	Document	Document Title
1	7521529	Differentially protected orthogonal lanthionine technology The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of...
2	7335642	Method for treating a viral infection related or a chemical toxin related hepatic injury with deltorphin D A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a...
3	6908617	Glycosylated modified primate lentivirus envelope polypeptides A modified polypeptide corresponding to an envelope glycoprotein of a primate lentivirus is described. The polypeptide has been modified from the wild-type structure so that it has at least two of...
4	6875742	Method for treating cytokine mediated hepatic injury A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a...
5	6852834	Fusion peptides isolatable by phase transition Genetically-encodable, environmentally-responsive fusion proteins comprising ELP peptides. Such fusion proteins exhibit unique physico-chemical and functional properties that can be modulated as a...
6	6740639	Inclusion complees of a high potent opioid peptide, pharmaceutical compositions and method of treatment The invention provides novel inclusion complexes of highly potent opioid peptide of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopro pylamide with cyclodextrin, pharmaceutical...
7	6737397	Control of cancer growth through the interaction of &lsqb MET5&rsqb -enkephalin and the zeta receptor The present invention is related to the treatment and prevention of cancer including particularly gastrointestinal cancer. More specifically, the present invention describes the use of naltrexone,...
8	6673769	Lanthionine bridged peptides Disclosed are lanthionine bridged peptides having the structure methods of their preparation and their use as pharmacologically active agents.
9	6596778	β-endorphin peptides for treating muscle-wasting diseases An active β-endorphin fragment or an analog of such a fragment is provided to a patient for alleviating the effect of muscle-wasting disease and for inhibiting or reducing leakage of an enzyme...
10	6506730	Nasal transmucosal delivery of peptide conjugated with biocompatible polymers The present invention relates to a pharmaceutical composition for the nasal transmucosal delivery of a biocompatible polymer-biologically active peptide conjugate. The pharmaceutical composition of...
11	6359111	Opioid receptor targeting A compound comprising a ligand portion which has binding affinity for an opioid receptor, and a therapeutically or diagnostically effective group selected from radionuclide chelating agents,...
12	6337319	&mgr -Selective opioid peptides This invention relates to novel opioid peptides for the treatment of pain as well as a method for the preparation thereof and pharmaceutically acceptable compositions comprising these peptides. The...
13	6303578	Mu-opiate receptor peptides This invention relates to certain peptides and linear and cyclic analogs thereof that bind to the mu (morphine) opiate receptor with higher affinity, selectivity and potency than currently...
14	6251625	Process for preparing peptides and N-carbamoyl-protected peptides The invention concerns a process for the enzymatic preparation of protected di- and oligopeptides and the separation of the protective groups used. The process according to the invention enables...
15	6136780	Control of cancer growth through the interaction of [Met.sup.5 ]-enkephalin and the zeta (ζ) receptor The present invention is related to the treatment and prevention of cancer including particularly gastrointestinal cancer. More specifically, the present invention describes the use of naltrexone,...
16	6054557	Fluorescent peptides The invention provides biologically active compounds of the formula: ##STR1## where R 1 is a light-emitting moiety and R 7 is a peptide of between 2 and 200 amino acids. X is selected from the...
17	5776903	Peptide derivatives usable as zinc endopeptidase 24-15 inhibitors Peptide derivatives usable as zinc endopeptidase 24-15 inhibitors. These peptide derivatives have the following amino acid sequence: -Pheψ(PO 2 CH 2 )- (L,D) Xaa'-Yaa'-Zaa'- in which ψ(PO 2 ...
18	5747261	Protein related to but distinct from EGF receptor and antibodies reactive therewith The isolation, cloning and characterization of a human gene related to but distinct from EGF receptor gene has been described. Nucleotide sequence of the gene and amino acid sequence of the...
19	5733881	Opioid peptide antagonists Compounds of the formula I as well as methods for their preparation, their pharmaceutical preparations and their use. ##STR1## The compounds of formula I are useful in therapy, especially as...
20	5652335	Physiologically active substance well capable of permeating biomembrane A physiologically active substance well capable of permeating biomembrane according to the present invention is represented by: ##STR1## where R represents a residue of a physiologically active...
21	5627268	Hemoglobin comprising globin fusion proteins The present invention relates to a novel method for making a predetermined, desired peptide in transgenic animals and can be advantageously used for the production of large quantities of the...
22	5558987	Blood levels of CCK peptides relative to panic disorder treatment A method of treating a patient having a panic disorder, the patient having an elevated CCK peptide plasma level, by lowering the plasma CCK peptide level of the patient. A further method provides a...
23	5428128	Site specific synthesis of conjugated peptides Processes for synthesizing polypeptides containing substantially non-antigenic polymers, preferably poly(alkylene glycols) in specifically predetermined sites are disclosed. Polypeptides prepared...
24	5276137	Analgesic peptides with a trifluoronorvaline modification The present invention relates to analgesic enkephalin derivatives represented by the following formula: Tyr-A 1 -A 2 -A 3 -A 4 SEQ ID NO:5 (1) and the acid salts thereof, wherein Tyr...
25	5169833	Substituted cyclic pentapeptides The present invention provides substituted cyclic pentapeptide compounds of general Formula I: ##STR1## and the pharmaceutically-acceptable slats, esters and amides thereof, which are useful for...
26	5061691	Enkephalin analogs The invention relates to enkephalin analogs of the formula ##STR1## wherein in case of X is D-Val, D-Phe, Pro, D-Met, D-Met(O), D-Leu, D-Glu, D-Glu(Obzl), D-Lys, D-Lys(Z), or D-Arg, Y is Gly or...
27	5017689	Dynorphin analogs specific for kappa opioid receptors Cyclic disulfide and linear dynorphin Dyn A 1 -11 and dynorphin Dyn A 1 -13 analogs which are highly specific for κ opioid receptors. These analogs are useful in pharmaceutical compositions and...
28	H000810	Biologically active amides The present invention provides novel peptides of formula (I): R--(X 1 ) m --(X 2 ) n --X 3 --X 4 --X 5 --X 6 --X 7 --(X 8 ) p --(X 9 ) q --R 1 (I) together with their salts, esters,...
29	4933324	Fatty acid-neuroactive drug conjugate as a prodrug The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be...
30	4902505	Chimeric peptides for neuropeptide delivery through the blood-brain barrier Chimeric peptides adapted for delivering neuropharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides...
31	4767744	Substituted tyrosyl methionyl dipeptide amides This invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable addition salts thereof, wherein R 1 is --OH, --OCH 3 or...
32	4757153	Sulfide, sulfinyl and sulfone dipeptide amides The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R 1 is hydrogen, lower...
33	4707468	Polypeptide A novel polypeptide is defined by the below shown formula and is useful as an analgesic. ##STR1## wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom or a lower...
34	4684620	Cyclic polypeptides having mu-receptor specificity Novel compounds which are capable of binding with enhanced specificity to the mu opioid receptor are disclosed. The compounds are analogs of somatostain and have the formula: ##STR1## wherein X is...
35	4658013	Analgesic and/or opiate antagonist tripeptide amides and processes for preparation and compositions thereof A genus of tripeptide amides and fifteen species thereof of Examples 4-18, which are useful as analgesics and/or opiate antagonists, three processes for preparation thereof, pharmaceutical...
36	4657892	Pharmacologically active peptides Pharmacologically active peptides of the following formulas are described: L--Tyr--X--L--Phe--X--T L--Tyr--X--L--Phe--X--A--T L--Tyr--X--L--Phe--X--A--X--T L--Tyr--X--L--Phe--X--A--X--B--T...
37	4649039	Radiolabeling of methionine-containing proteins and peptides A process for radiolabeling methionine-containing peptides and proteins.
38	4631270	Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use Therapeutically useful pseudopeptides characterized by the replacement of at least one peptide group, both in a naturally occurring peptide or protein by a thiomethylene group are useful in the...
39	4603121	Enkephalin analogs The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.
40	4594329	CRF analogs Analogs of rCRF and oCRF are disclosed that can be administered to achieve a substantial elevation of ACTH, β-endorphin, β-lipotropin, other products of the pro-opiomelanocortin gene and...
41	4593017	Methods of treating patients using a pharmaceutical preparation containing an α-endorfine fragment The invention relates to the use of (2-9)-α-endorfine for dopaminergic and vasopressin-releasing properties.
42	4568640	Method of inserting amino acid analogs into proteins A method for substituting one amino acid for another in a protein chain to improve selected properties of the protein. Initially, an mRNA molecule capable of producing an unmodified protein of the...
43	4518711	Conformationally constrained cyclic enkephalin analogs with delta receptor specificity Novel compounds which are capable of binding with enhanced specificity to the delta receptor are disclosed. The compounds are a series of cyclic, conformationally constrained analogs of enkephalins...
44	4510082	Pharmacologically active peptides Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which R is hydrogen, methyl, ethyl, cyclopropylmethyl, or allyl; A is a residue of...
45	4483988	Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones Novel analgesic and antipsychotic agents having the formula ##STR1## in which R 1 is hydrogen, hydroxy or halogen and R 4 is hydrogen or, R 1 and R 4 are both hydroxy; Z is hydrogen or straight...
46	4469631	Fusion peptides comprising an expressible bacterial gene and β-endorphin DNA comprising the naturally occurring nucleotide sequence coding for amino acids 44-90 of β-lipotropin and including the entire coding region for β-endorphin with the exception of the C-terminal...
47	4468383	Dimeric enkephalins The compounds of the invention are symmetrical dimers of enkephalin polypeptides comprising enkephalin polypeptide monomers linked at the C-termini thereof with a difunctional amino bridging group....
48	4464358	Homocyclic derivatives Compounds of the formula: ##STR1## wherein R 1 stands for hydrogen or a defined hydrocarbyl or halogenoalkenyl radical, R 2 stands for a defined hydrocarbyl, halogenoalkenyl or furylmethyl...
49	4462941	Dynorphin amide analogs Dynorphin(1-13) has been previously reported to antagonize the analgesia induced by narcotics in naive hosts. Novel compounds are provided which differ from dynorphin(1-13) by neither potentiating...
50	4448717	Pharmacologically active peptides Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which R is hydrogen, methyl, ethyl, cyclopropylmethyl, or allyl; A is a residue of...

Matches 1 - 50 out of 138

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