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7192714 |
LDL receptor signaling assays
The invention provides methods and compositions for modeling and detecting LDL receptor transmembrane signaling by detecting proteolysis of an LDL receptor transmembrane domain. The method...
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6861504 |
Compounds and methods for the modulation of CD154
The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved...
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6852834 |
Fusion peptides isolatable by phase transition
Genetically-encodable, environmentally-responsive fusion proteins comprising ELP peptides. Such fusion proteins exhibit unique physico-chemical and functional properties that can be modulated as a...
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6649171 |
Moraxella catarrahalis polynucleotides and polypeptides
The invention provides BASB021 polypeptides and polynucleotides encoding BASB021 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6465259 |
Non radioactive receptor assay suitable for quantitative and qualitative analysis of trace amounts of receptor binding analyte
A method for quantitatively and/or qualitatively assaying an analyte in a sample, wherein the analyte is a receptor binding compound, has low detection limits equivalent to those of radioreceptor...
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6428967 |
LDL receptor signaling pathways
The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction...
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5955055 |
Synthetic peptides for arterial imaging at vascular imaging sites
Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of...
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5891847 |
Treatment of degenerative eye disorders
Retinal dystrophies are treated by melanotropin peptides or analogs.
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5585352 |
Method of treating septic shock using thymosin-α 1
A method of reducing toxicity of endotoxin in a mammal including the administration of an endotoxin-reducing effective amount of Tα 1 to the mammal.
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5275814 |
Allergen-thymic hormone conjugates for treatment of IgE mediated allergies
A protein conjugate or mixture useful in immunotherapy composed of a biological response modifier (BRM) and an allergen is disclosed. In use the protein conjugate or mixture is combined with a...
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5140010 |
Stabilized aqueous formulations of thymopentin
The present invention provides a method for preparing aqueous formulations of thymopentin, which method permits the peptide to retain its biological activity during storage at room temperature.
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5132401 |
MB-35 a peptide enhancing the production of growth hormone and prolactin from the anterior pituitary
A peptide of the formula ##STR1## has been isolated from thymosin fraction 5 (TF-5) and synthetically produced. This peptide, which has 100% homology with a region of histone 2A is able to...
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4939212 |
Elasticized vinyl dispersion resins having outstanding stability
An elasticized, dispersion-grade vinyl chloride resin powder is provided which not only imparts improved elasticity and reduced hysteresis losses to fluid plastisols made therewith, but also has...
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4923964 |
Human splenin
The present invention is directed to the protein human splenin (hsP), substantially free of material associated with the protein in its natural environment in the human spleen. In particular, the...
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4904643 |
Thymus derivative active after oral administration, methods of preparation and pharmaceutical compositions
Thymolymphotropin, a thymus derivative able to stimulate the differentiation and the function of T-lymphycytes, is active after oral administration and can be prepared through a process of partial...
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4826680 |
Pharmaceutical composition containing thymus extract fractions
A pharmaceutical composition is described, which contains a fraction consisting of low molecular proteins and/or oligo peptides, and a yellow fraction containing riboflavine, which is associated...
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4711952 |
Serum thymic factor peptide analogs and process for the preparation thereof
Novel peptide analogs of the serum thymic factor are disclosed, structurally modified, in comparison with the natural substance, both in their N-terminal and C-terminal parts and inside the...
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4696915 |
Parathymosin alpha
Parathymyosin alpha is a novel peptide isolated from mammalian thymus and contains approximately 105 amino acid residues. It bears a high degree of homology to prothymosin alpha both in sequence...
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4621135 |
Novel THF compositions
Novel peptide materials having thymic humoral activity are disclosed having the respective amino acid sequences of: Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu; His-Pro-Leu-Pro-Asp-Leu-Tyr; and ...
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4614731 |
Peptide having immunopotentiating activity similar to thymosin alpha.sub.1
A new biologically active polypeptide hormone has been isolated from calf thymosin fraction 5 and has been given the designation thymosin alpha 11 . The peptide contains seven additional amino acid...
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4612365 |
Medicaments containing alpha 1-thymosin and having an immuno regulatory action and alpha 1-thymosin fragments
Peptide fragments of the alpha thymosin molecule, ranging from four to eighteen peptides in length, and salts thereof, are disclosed. These fragments possess immunostimulatory and immunoregulatory...
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4543340 |
Radioimmunoassay of thymosin β.sub.4
A radioimmunoassay for the polypeptide thymic hormone thymosin β 4 is described. The assay employs a radiolabelled Tyr-C13-thymosin β 4 -analogue as probe and a thymosin β 4 antibody.
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4517119 |
Synthesis of thymosin α.sub.1
An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.
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4512970 |
Chemorecruitins of leukocytes and inflamed tissues
The invention relates to new chemorecruitins of leukocytes and inflamed tissue which have the biological and physicochemical properties stated in the patent claims. The compounds selectively induce...
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4505853 |
Enzyme-resistant immunomodulatory peptides
Peptides which have thymopoeitin-like or splenin-like activity combined with greatly increased resistance to degradation by enzymes. The peptides are useful for treatment of immunoregulatory...
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4504415 |
Synthesis of thymosin α.sub.1 and desacetyl thymosin α.sub.1
An improved solution phase synthesis of thymosin α 1 and desacetyl thymosin α 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.
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4470926 |
Medicaments containing thymosin alpha 1 fragments and having an immunostimulant action, and fragments of thymosin alpha 1
The Thymosin alpha 1 fragment compound Glu-Ala-Glu-Asn-OH.
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4466918 |
Method of preparing thymosin alpha 1 and derivatives thereof
Polypeptides of the sequence Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile--Thr-Lys-Asp-Leu
-Lys-Glu-Lys- Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, wherein at least one of the amino acids 10,15,21,25...
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4442031 |
Immunopotentiating peptides
Novel hexapeptides corresponding to internal fragments of thymosin α 1 are active as agents which restore and stimulate immune function.
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4427783 |
Immunoassay of thymosin α.sub.1
An improved immunoassay for the polypeptide hormone thymosin α 1 is described. The assay employs an improved antibody which is elicited by an immunogen which has been prepared by coupling [Tyr 1 ...
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4426324 |
Immunopotentiating peptides
Novel di-to heptapeptides representing fragments of the carboxyl terminal of thymosin α 1 are active as agents which affect regulation, differentiation and function of thymus dependent lymphocytes.
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4369137 |
N-Protected pentapeptides useful as intermediates in the preparation of thymopoietin pentapeptide
The present invention relates to methods for preparing useful peptides, more particularly to solution synthesis methods for preparing H-ARG-X-Z-Y-TYR-R, intermediates in the preparation of this...
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4139504 |
Novel nonapeptides, intermediates therefor, and compositions and methods employing said nonapeptides
Novel nonapeptides having the following amino acid sequence: H-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Y wherein: X is a chiral residue of a D-amino acid selected from the group consisting of...
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4124700 |
Immunoassay for thymopoietin
An immunoassay for the polypeptide thymic hormone thymopoietin is described. Determination of thymopoietin levels in biological fluids provides a useful diagnostic test for myasthenia gravis...
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4002740 |
Tridecapeptide compositions and methods
There is disclosed a tridecapeptide of the following sequence: H 2 N--Gly--Glu--Gln--Arg--Lys--Asp--Val--Tyr--Val--Gln--Leu--Ty
r--Leu--COOH this tridecapeptide has the capability of including...
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3502545 |
PROCESS FOR THE SEPARATION OF WATER-SOLUBLE POLYMERIC MATERIALS FROM UNBOUND PROTEIN OR PEPTIDE USING SEMIPOROUS GEL
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