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7619061 |
Antigen constructs useful in the detection and differentiation of antibodies to HIV
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env...
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7619058 |
Epitope/peptide recognized by HLA-A2402-restricted Ep-CAM-specific CTL and use of the same
A peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:1; a peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide...
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7619057 |
MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1
The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are...
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7618939 |
Compositions and methods to prevent cancer with cupredoxins
The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in...
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7618937 |
Peptidomimetic polymers for antifouling surfaces
Peptidomimetic polymers comprising one or more DOPA moieties and related coatings and composites.
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7618782 |
Methods of diagnosing muscle damage
A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage,...
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7618653 |
Biological artificial nerve guide and method of making
A biological nerve guide for implantation into a human body is made by providing a natural animal tissue membrane, crosslinking and fixing the membrane, minimizing the antigens from the membrane,...
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7618637 |
Heat shock protein-based vaccines and immunotherapies
The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in...
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7618636 |
Antigenic meningococcal peptides
WO99/36544 discloses a large number of proteins from Neisseria Meningitidis . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant....
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7618635 |
Super-antigen fusion proteins and the use thereof
The present invention relates to a super-antigen fusion protein, comprising: a peptide fragment whose sequence corresponds to a partial SARS E2 spike protein; and a translocating peptide fragment...
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7618634 |
Neurotoxic oligomers
This invention relates to methods and compositions for the treatment or alleviation of Alzheimer's disease and of other conditions related to abnormal protein aggregation. In particular, the...
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RE40988 |
Ligands of the neuropeptide receptor HFGAN72
Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or...
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7615614 |
Antigen constructs useful in the detection and differentiation of antibodies to HIV
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env...
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7615613 |
Antigen constructs useful in the detection and differentiation of antibodies to HIV
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env...
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7615533 |
TPO peptide compounds for treatment of anemia
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7615530 |
Immunogenic compositions and methods of use
Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A...
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7615527 |
Peptides which modulate blood coagulation and methods of use thereof
Peptide fragments that modulate thrombosis and methods of use thereof are provided. Also provided are synthetic bioactive anti-coagulation peptides, compositions comprising such peptides and...
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7612190 |
Method for targeting a polypeptide onto cellular surface
The present invention relates to a polypeptide having an activity for targeting a heterogeneous polypeptide to a surface of cytoplasmic membrane, a nucleic acid encoding the polypeptide, a...
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7612162 |
Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for...
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7612043 |
Method of reducing or inhibiting ObR signaling using a leptin antagonist consisting of SEQ id No: 2
Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but...
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7611720 |
Tuberculosis vaccines including recombinant BCG strains expressing alanine dehydrogenase, serine dehydratase and/or glutamine synthetase
The invention relates to a live recombinant Mycobacterium bovis -BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that...
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7611713 |
Inducing cellular immune responses to hepatitis B virus using peptide compositions
This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7608691 |
Antibodies against IL-16 antagonist peptides
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The...
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7608686 |
Human tumor necrosis factor receptor
Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as...
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7608685 |
Tumor antigen based on products of the tumor suppressor gene WT1
A tumor antigen that comprises, as an active ingredient, a product of the Wilms' tumor suppressor gene WT1 or a peptide composed of 7-30 contiguous amino acids containing an anchor amino acid for...
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7608684 |
Soluble CD14 antigen
There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3):
1) a molecular...
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7608683 |
Stress proteins and peptides and methods of use thereof
Provided are HLA pan DR-binding peptides and methods of using such peptides to modulate, block, or inhibit immune responses to effect treatment of immune-mediated diseases and conditions, such as...
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7608682 |
Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates
The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel...
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7608681 |
Methods and compositions for prolonging elimination half-times of bioactive compounds
Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may...
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7608582 |
Delivery vehicle comprising a modified MscL protein channel
The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles...
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7608581 |
Biofunctional, antimicrobial coatings for medical devices
The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least...
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7608577 |
Peptidyl ketones as inhibitors of DPIV
The present invention relates to compounds of the general formula 1
and pharmaceutically acceptable salts thereof, to the use of the compounds for the treatment of impaired glucose tolerance,...
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7608405 |
Method of selectively assaying adiponectin multimers
Methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of...
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7608404 |
Disease determination method, data generation method for disease determination and data generation system for disease determination
Supernatant of the urinary sample (SP 1 ) was mixed with an acid or alkali and heated (SP 2 ) and the sample for fluorescence assay was prepared after adjusting its acidity to alkaline (SP 3 )....
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7608277 |
Tuberculosis nucleic acids, polypeptides and immunogenic compositions
The present invention provides transcriptionally active Mtb polynucleotides, recombinant Mtb peptides and polypeptides, and immunogenic Mtb antigens. Immunogenic compositions are also provided that...
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7608256 |
Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I...
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7605248 |
Recombinant constructs of Borrelia burgdorferi
Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins...
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7605121 |
Oligopeptide lyophilisate, their preparation and use
A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the...
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7604954 |
Method for evaluating kidney function in a feline
Methods for ( 1 ) evaluating feline kidney function by determining ghrelin level in feline tissue or biofluid and correlating the ghrelin level directly to kidney function and ( 2 ) diagnosing...
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7604810 |
Conserved Neisserial antigens
To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides...
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7601810 |
Insecticidal plant cyclotide with activity against homopteran insects
The present invention relates to isolated nucleic acids encoding plant cyclotides. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant...
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7601807 |
Protease, DNA encoding the same, and method for manufacturing protease
A protease having the following characteristics:
(i) a molecular weight of 21,000±1,000 (by SDS-PAGE) and (ii) specific protease activity cutting the Gly-Phe site of a peptide or protein...
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7601800 |
Compositions and methods for monitoring breast cancer treatment
The present invention provides compositions and processes for preparing the same wherein the compositions are useful for monitoring breast cancer treatment.
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7601799 |
Methods and means to promote gut absorption
The present invention relates to epidermal growth factor (EGF) producing lactic acid bacteria and their use to increase intestinal villi height and to promote gut absorption. In particular, the...
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7601691 |
Anti-obesity agents
The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a...
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7601685 |
Growth factor modified protein matrices for tissue engineering
Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are...
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7601518 |
Secretion of neublastin
The present invention concerns improved methods and compositions for producing a Neublastin polypeptide as well as local delivery of Neublastin to specific regions of the nervous system including...
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7601491 |
Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
The present invention relates to methods for pretreating biological samples for extraction of nucleic acid therefrom The present invention employs a combination of at least one protein denaturant...
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7601358 |
Mycobacterium tuberculosis protein composition
Mycobacterium tuberculosis proteins and protein compositions that are components of a desaturase complex are provided. The Mycobacterium tuberculosis desaturase complex may include a desaturase...
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