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7470658 |
Methods for inhibiting tumor metastasis, and peptides useful therefor
In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention...
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7470769 |
Epidermal growth factor receptor antagonists and methods of use
The present invention features epidermal growth factor receptor (EGFR) antagonists. These EGFR antagonists are polypeptide variants of ligands of EGFR. The EGFR ligand polypeptide variants of the...
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7470668 |
Method of use of specific natriuretic peptide receptor c ligands, transgenic non-human mammals expressing specific natriuretic peptide receptor c antagonists and cells thereof
A method of using an osteocrin (Ostn) or a NPR-C specific Ostn peptide derivative for increasing osteogenesis in a mammal comprising administering a therapeutically effective amount of said Ostn or...
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7468186 |
Polyomavirus cellular epitopes and uses therefor
The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in...
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7468418 |
Compositions for enhancing transport of molecules into cells
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid...
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7465453 |
Polypeptide fragments of CKLF1
Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also...
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7465459 |
Piroplasmid vaccine
The invention relates to a Piroplasmid protein or an immunogenic fragment of the protein, and to a nucleic acid encoding the Piroplasmid protein or the immunogenic fragment. Furthermore, the...
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7465710 |
Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the...
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7462592 |
Compositions and methods for polynucleotide delivery
This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents....
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7462486 |
Methods of selecting T cell receptor V peptides for therapeutic use
A method is disclosed to identify a T cell receptor (TCR) variable (V) peptide of use as a therapeutic agent in a subject. A method is also disclosed for monitoring the efficacy of a T Cell...
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7462355 |
Angiogenesis regulation system
Stable water soluble polypeptides which are potent inhibitors of endothelial cell proliferation and of angiogenesis. Polypeptide inhibitors of endothelial cell growth may have important uses in the...
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7462707 |
Nucleic acids encoding a recombinant 250 kDa antigen from sporozoites/merozoites of Eimeria maxima and their uses
The present invention provides an isolated nucleic acid comprising a nucleotide sequence encoding a 250 kDa polypeptide from Sporozoites/Merozoites of Eimeria maxima , or encoding a homolog of the...
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7462598 |
Antimicrobial theta defensins, analogs thereof, and methods of use
The invention provides theta defensin analogs having antimicrobial activity. The invention also provides a method of reducing or inhibiting growth or survival of a microorganism in an environment...
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7459533 |
Human GIL-19/AE289 proteins
Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.
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7459525 |
Factor VIII glycoforms
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked...
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7459430 |
Methods of using ziconotide to treat overactive bladder
The invention relates to methods of using Cav2.2 subunit calcium channel modulators to treat painful and non-painful lower urinary tract disorders and the related genitourinary tract disorders...
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7459290 |
Methods of using functional 30S subunits
A method of preparing a peptide in vitro in a defined translation mixture is provided. The method includes providing a defined translation reaction mixture comprising isolated and/or purified 30S...
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7459165 |
Polypeptides of Pseudomonas aeruginosa
The present invention relates to polypeptides of Pseudomonas aeruginosa which may be used to prevent, diagnose and/or treat Pseudomonas aeruginosa infection.
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7459523 |
Equine P-selectin glycoprotein ligand-1 and uses thereof
A novel equine P-selectin glycoprotein ligand-1 (ePSGL-1) is disclosed having the amino acid sequence set forth in SEQ ID NO:2. DNA sequences encoding the ePSGL-1 are also disclosed, along with...
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7459424 |
Peptide inhibitors of protein kinase C γ for pain management
Peptide sequences derived from the V5 domain of isozymes of protein kinase C for use in pain management are described. Also described are compositions comprising the peptides for treating pain...
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7459522 |
Peptide dimers as agonists of the erythropoietin (EPO) receptor, and associated methods of synthesis and use
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R 1 and a second...
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7456252 |
Therapeutic peptides for demyelinating conditions
The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition.
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7456269 |
Alzheimer's disease secretase, APP substrates thereof, and uses thereof
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell...
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7456250 |
Thrombin peptide derivative dimers
Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal...
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7456251 |
HIV fusion inhibitor peptides with improved biological properties
Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and...
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7456147 |
Controlled release of active agents utilizing repeat sequence protein polymers
Systems are provided for the controlled release delivery of active agents through the use of repeat sequence protein polymers. The systems may exist as matrices, gels, hydrogels, films, emulsions...
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7456146 |
Lytic peptide prodrugs
A cytotoxin can be rendered non-toxic by charge neutralizing the amino acids salient to pore assembly and/or sterically inhibiting formation of the peptide's active conformation. In the presence of...
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7452964 |
Compositions and methods of use of targeting peptides against placenta and adipose tissues
The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides...
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7452967 |
Molecules of the card-related protein family and uses thereof
Novel CARD- 9, CARD- 10, or CARD- 11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD- 9, CARD- 10, or CARD- 11 proteins, the invention further...
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7452963 |
Replikin peptides and antibodies therefore
The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.
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7452858 |
Treatment of gestational diabetes
Methods for treating gestational diabetes which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that...
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7449191 |
Compositions and methods for detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies
The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.
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7449445 |
Conductive peptide nanofiber and method of manufacture of the same
A peptide nanofiber having conductivity is provided. A conductive peptide nanofiber which includes a nanofiber formed through a manner of self-assembly of a peptide that has a nanofiber-forming...
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7449551 |
PRO211 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7449543 |
Schizophrenia related protein
The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns...
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7446168 |
EG-VEGF nucleic acids and polypeptides and methods of use
The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells...
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7442762 |
Mutational derivatives of microcin J25
Analogs of bacteriocidal peptide microcin J25 (MccJ25) are provided that have an amino acid sequence that differs from that of MccJ25 by having at least one amino acid substitution; and that...
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7442788 |
Antisense molecules and method of controlling expression of gene function by using the same
An antisense molecule which acts on both directions of the inhibition and expression of a gene function and is capable of on-off switching of a gene function appropriately depending on the external...
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7442682 |
Transepithelial delivery of peptides with incretin hormone activities
Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is...
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7442764 |
Reversible modification of amine-containing compounds
An process for the reversible modification of an amine-containing compound is described. Modification of the compound can be used to facilitate delivery of molecules to cells in vitro and in vivo...
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7442769 |
Antifreeze proteins from basidiomy cetes
The present invention provides antifreeze proteins produced by a basidiomycete. The antifreeze protein has a high antifreeze activity such as a thermal hysteresis activity or an...
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7442761 |
Replikin peptides and uses thereof
The present invention provides a new class of peptides related to rapid replication and high human mortality, and their use in diagnosing, preventing and treating disease.
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7439319 |
Selective substrates for matrix metalloproteinases
The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2...
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7438917 |
Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or...
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7439320 |
Cripto tumour polypeptide
Compositions and methods for the therapy and diagnosis of cancer, particularly lung, colon, colorectal and breast cancer, are disclosed. Illustrative compositions comprise one or more Cripto tumor...
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7439321 |
Peptides for detection of antibody to Anaplasma phagocytophilum
The invention provides compositions and methods for the detection and quantification of A. phagocytophilum (formerly known as Ehrlichia equi ) antibodies and antibody fragments.
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7438912 |
S.agalactiae antigens I + II
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments...
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7438916 |
Therapeutic target for protozoal diseases
A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been...
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7439345 |
Supramolecular pairing system, its preparation and use
The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula:
and oligomers thereof.
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7439418 |
Anti-microbial peptide known as halocyntin, gene coding for said peptide, vector, transformed organism and composition containing said peptide
An isolated peptide having an amino acid sequence FWGHIWNAVKRVGANALHGAVTGALS (SEQ ID No. 1), its derivatives and its fragments containing at least 7 amino acids.
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