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7332566 Biocompatible crosslinked polymers with visualization agents  
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having...
7211651 Proteinaceous gels having visualization agents and methods of use thereof  
Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric...
7182884 Bio-liquid crystal polymer and shaped material using same  
A bio-liquid crystal polymer is made from a tissue-derived compound or the derivatives. The bio-liquid crystal polymer has a characteristic of liquid crystal under predetermined conditions and is...
7081495 Cationic compounds and their use as macro molecular carriers  
Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C 6-24 -alkyl group containing α-amino acyl groups,...
7057019 Crosslinked albumin hydrogels  
Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an...
7022214 Carrier ampholytes of high pH range  
Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH...
7009034 Biocompatible crosslinked polymers  
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having...
6887974 Crosslinking agents and methods of use  
Polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for...
6833488 Biocompatible, biodegradable, water-absorbent material and methods for its preparation  
A bio-compatible, biodegradable macromolecular water-absorbent polymeric material having a three-dimensional configuration with intermolecular covalent bonds and containing free functional groups...
6750312 Process for the preparation of supports for solid phase synthesis  
A method for preparing a solid support material for carrying out a chemical reaction, said method comprising the following steps: (i) reacting an amino functionalised solid material with a...
6737501 Process for the preparation of copolymeric hydrophobically modified polyglutamic acid derivatives and their use  
Process for the preparation of copolymeric polypeptides, which comprises, in a first stage, reacting glutamic acid and/or derivatives thereof with amines in the absence of solvents and catalysts,...
6730293 Compositions and methods for treating inflammatory diseases of the skin  
This invention provides compositions and methods for enhancing delivery of glucocorticoids and ascomycins such as hydrocortisone, cyclosporin and FK506 across into and across one or more layers of...
6713580 Quaternary amino acids on solid supports  
The present invention relates to novel templates useful for generating novel compounds and to compounds produced utilizing the templates. The templates comprise quaternary amino acids that may be...
6689836 Process for the preparation of thermoprecipitating affinity polymers  
The present invention relates to a process for the preparation of thermoprecipitating affinity polymers useful in the enhanced recovery of enzymes. The process comprises polymerising a monomer...
6670427 Template-textured materials, methods for the production and use thereof  
Template-textured materials in the form of template-textured polymers (TGP) on various surfaces including membranes (i.e, template-textured membranes). Such materials are created by modifying the...
6620882 Solid support template for preparation of highly functionalized heterocycle compounds  
The present invention relates to a novel solid support template of Formula (I) and methods for producing novel highly functionalized imidazoles, pyrazinones and benzodiazepinones through a...
6586524 Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier  
The present invention relates to cationic polymeric conjugates and methods of preparing and using them as gene carriers. The cationic polymeric conjugates comprise a poly(ethylene glycol) (PEG)...
6552170 PEGylation reagents and compounds formed therewith  
Compounds are disclosed having the general formula R 1 -X-R 2 , wherein R 1 and R 2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R 1...
6506577 Synthesis and crosslinking of catechol containing copolypeptides  
The synthesis of moisture-resistant adhesive polypeptides, conditions for their use, and conditions for controlling characteristics of the crosslinked matrix are disclosed. By specifically...
6410643 Solid phase synthesis method and reagent  
A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable...
6359061 Amide compound libraries  
Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays...
6277957 Method for production of acylthio derivatives  
A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the...
6258275 Affinity macroligands  
Affinity macroligands (AML) comprising a reversibly water soluble poly-N-alkylacrylamide linked to a ligand, and their use in the separation of a target substance from a mixture comprising the...
6254986 Peracylated protein-based sutures and fabrics and process for making the same  
A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or...
6228988 Synthesis of hydroxamic acid derivatives  
The present invention describes processes for preparing desired synthetic products that comprise a covalently bonded hydroxamic acid group --CONHOH by forming a mixture of a liquid reaction medium...
6204326 PNA combinatorial libraries and improved methods of synthesis  
New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid...
6150461 Carriers targettable to organ  
A carrier for delivering a foreign substance to a target organ which comprises a graft copolymer in which hyaluronic acid is grafted on a polymer composing main chain, wherein the main chain has a...
6117940 Amino-ketone solid support templates  
A solid support template for solid phase synthesis of amino group containing compounds is provided that comprises amino-ketone core compounds of the general formula: A-L-NH(CR 1 R 2 ) n COR 3...
6113906 Water-soluble non-antigenic polymer linkable to biologically active material  
Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating...
6056926 Apparatus and method for parallel coupling reactions  
A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel 200 contains a suspension of substrates. The suspension is pressurized with argon and...
5932539 Biodegradable polymer matrix for tissue repair  
Novel biodegradable amphiphilic polymers are described. Preferred polymers have a lipophilic binding moiety coupled covalently to a hydrophilic tissue adhesion moiety through a divalent linker...
5912300 Poly-amino acidic oligonucleotide-carrier  
The present invention provides a poly-amino acidic oligonucleotide-carrier comprising a poly-lysine:serine random copolymer. This carrier is bonded with oligonucleotide without causing...
5910406 Manipulating nucleic acid sequences  
A method of effecting a manipulation of a nucleic acid sequence comprises (a) providing a solid support system having bonded thereto a single stranded oligonucleotide complementary to a specific...
5907016 Method of coupling ligands onto supports and products produced therefrom  
A method is disclosed for coupling a ligand within a porous support. The method involves mixing ligand and porous support under conditions sufficient to suppress coupling conditions of the ligand...
5859190 Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein  
The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by...
5853713 Biologically compatible linear block copolymers of polyalkylene oxide and peptide units  
A linear block copolymer comprising units of an alkylene oxide, linked to units of peptide via a linking group comprising a --CH 2 CHOHCH 2 N(R)-- moiety, is useful as an imaging agent, drug,...
5851494 Solid phase synthesis reaction vessel and method of using the same  
A solid phase synthesis reaction vessel includes a vessel with a first inlet, a second inlet, and an outlet. A first stopcock is disposed within the first inlet and a second stopcock is disposed...
5817716 Resins with a primary amine or guanidine function  
The process includes the reaction of a chloroformamidinium chloride with a polystyrene-divinylbenzene resin functionalized with primary amine groups. The resins which can be obtained according to...
5814700 Method for polymer synthesis in a reaction well  
A method of synthesis for building a polymer chain, oligonucleotides in particular, by sequentially adding monomer units to at least one solid support for growing and immobilizing a polymer chain...
5786428 Adsorbents for amino acid and peptide separation  
An adsorbent which selectively binds to one enantiomer of an optically active amino acid or peptide. The adsorbent includes a polymer matrix which contains one or more metal complexes that are...
5770456 Cyclic nucleic acid and polypeptide arrays  
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
H001729 Method for preparing compounds employing solid phase synthesis and novel linker-resin  
A method is provided for preparing various intermediates and final products including MTP inhibitors employing solid phase syntheses. A new dialkoxyaryl aldehyde linker-resin of the structure...
5733538 Surface-modifying copolymers having cell adhesion properties  
A hemocompatible surface-modifying additive is provided for modifying polyurethane or polyurethane urea substrates. The additive has a polyurethane or polyurethane urea hard block or an alternative...
5726243 Mild solid-phase synthesis of aligned, branched triple-helical peptides  
A triple-helical polypeptide of the formula: ##STR1## is provided wherein: Z is Hyp or Pro; each X and Y is an amino acid such that (Gly-X-Y) m is a sequence of a collagen cell adhesion site; said...
5723575 Process for the preparation of backbone cyclic peptides  
Biologically active, backbone-cyclized peptides of the formula: ##STR1## wherein AA! or A 1 A 1 ! is a naturally occurring or synthetic amino acid residue, n or e is an integer of 1-10, m or d...
5684130 Process for synthesis of organic compounds using magnetic particles  
This invention provides a process for the synthesis of a defined chemical entity, i.e., any desired chemical compound, in high yield using a solid support comprising a magnetic particle, in organic...
5643738 Method of synthesis of plurality of compounds in parallel using a partitioned solid support  
Methods are provided for synthesizing a plurality of compounds in parallel. The methods use cross-over channels for moving samples from a reservoir of starting materials into a plurality of wells....
5643575 Non-antigenic branched polymer conjugates  
Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating...
5614608 Apparatus and method for multiple synthesis of organic compounds on polymer support  
A solid phase synthesis system is provided by employing a fully automated robot that operates with a novel timing protocol for handling multiple synthetic tasks efficiently. The novel timing...
5610241 Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers  
Graft polymers with reactive groups for linking to peptides for use in tissue engineering and to drugs to provide drug delivery systems and useful per se to release amino acids and useful, for...
Matches 1 - 50 out of 222 1 2 3 4 5 >