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8945896 Ligand functionalized polymers  
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
8853325 Water-soluble polymer alkanals  
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using...
8809453 Branched polymers  
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core...
8742028 Solid support for Fmoc-solid phase synthesis of peptide acids  
The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.
8674020 Process for preparing polyamides  
There is provided a novel process for preparing polyamides (in particular cyclic and hairpin polyamides) comprising the step of coupling an amine with a Boc-protected amino acid monomer in the...
8519051 Block copolymer for drug conjugates and pharmaceutical composition  
The present invention provides a block copolymer for a drug conjugate which comprises a water-soluble polymer region consisting of polyethylene glycol and a polyamino acid region having a...
8461259 Binder for materials based on wood chips and/or wood fibers, method for the production of said binder, and molded article  
The invention relates to a binder for producing materials based on wood chips and/or wood fibers. The aim of the invention is to design a binder which is used for producing and gluing materials...
8378022 Biocompatible, biodegradable, water-absorbent hybrid material  
A biocompatible, biodegradable, macromolecular water-absorbent hybrid material (WAHM), having a three-dimensional configuration with intermolecular covalent bonds and containing free functional...
8273833 Branched Polymers  
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core...
8227403 A-β immunogenic peptide carrier conjugates and methods of producing same  
The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens...
8076412 Water-soluble polymer alkanals  
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using...
8008262 β-peptides  
β-peptide regions of polypeptides can serve as structural mimics of α-helices in wild type proteins. Because α-helices of one protein often bind to a target protein in a biological pathway, a...
7989532 RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) / β tricalcium phosphate composite material and preparation method thereof  
An RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid)/β-tricalcium phosphate composite material is composed of β-tricalcium phosphate particles and RGD polypeptide grafted poly...
7838595 Water-soluble polymer alkanals  
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using...
7605232 Hydrogels for protein concentration  
A method of concentrating proteins from whole blood comprising exposing whole blood to covalently crosslinked hydrogel to remove water from the blood into the hydrogel to thereby concentrate the...
7598318 Thermosensitive and biocompatible amphiphilic poly(organophosphazenes) and preparation method thereof  
The present invention relates to a thermosensitive and biocompatible poly(organophosphazenes) represented by Formula 1, and a preparation method thereof: wherein R is a methyl or ethyl group; R′...
7332566 Biocompatible crosslinked polymers with visualization agents  
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having...
7211651 Proteinaceous gels having visualization agents and methods of use thereof  
Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric...
7182884 Bio-liquid crystal polymer and shaped material using same  
A bio-liquid crystal polymer is made from a tissue-derived compound or the derivatives. The bio-liquid crystal polymer has a characteristic of liquid crystal under predetermined conditions and is...
7081495 Cationic compounds and their use as macro molecular carriers  
Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C6-24-alkyl group containing α-amino acyl groups,...
7057019 Crosslinked albumin hydrogels  
Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an...
7022214 Carrier ampholytes of high pH range  
Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH...
7009034 Biocompatible crosslinked polymers  
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having...
6887974 Crosslinking agents and methods of use  
Polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for...
6833488 Biocompatible, biodegradable, water-absorbent material and methods for its preparation  
A bio-compatible, biodegradable macromolecular water-absorbent polymeric material having a three-dimensional configuration with intermolecular covalent bonds and containing free functional groups...
6750312 Process for the preparation of supports for solid phase synthesis  
A method for preparing a solid support material for carrying out a chemical reaction, said method comprising the following steps: (i) reacting an amino functionalised solid material with a...
6737501 Process for the preparation of copolymeric hydrophobically modified polyglutamic acid derivatives and their use  
Process for the preparation of copolymeric polypeptides, which comprises, in a first stage, reacting glutamic acid and/or derivatives thereof with amines in the absence of solvents and catalysts,...
6730293 Compositions and methods for treating inflammatory diseases of the skin  
This invention provides compositions and methods for enhancing delivery of glucocorticoids and ascomycins such as hydrocortisone, cyclosporin and FK506 across into and across one or more layers of...
6713580 Quaternary amino acids on solid supports  
The present invention relates to novel templates useful for generating novel compounds and to compounds produced utilizing the templates. The templates comprise quaternary amino acids that may be...
6689836 Process for the preparation of thermoprecipitating affinity polymers  
The present invention relates to a process for the preparation of thermoprecipitating affinity polymers useful in the enhanced recovery of enzymes. The process comprises polymerising a monomer...
6670427 Template-textured materials, methods for the production and use thereof  
Template-textured materials in the form of template-textured polymers (TGP) on various surfaces including membranes (i.e, template-textured membranes). Such materials are created by modifying the...
6620882 Solid support template for preparation of highly functionalized heterocycle compounds  
The present invention relates to a novel solid support template of Formula (I) and methods for producing novel highly functionalized imidazoles, pyrazinones and benzodiazepinones through a...
6586524 Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier  
The present invention relates to cationic polymeric conjugates and methods of preparing and using them as gene carriers. The cationic polymeric conjugates comprise a poly(ethylene glycol) (PEG)...
6552170 PEGylation reagents and compounds formed therewith  
Compounds are disclosed having the general formula R1-X-R2, wherein R1 and R2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R1 and R2...
6506577 Synthesis and crosslinking of catechol containing copolypeptides  
The synthesis of moisture-resistant adhesive polypeptides, conditions for their use, and conditions for controlling characteristics of the crosslinked matrix are disclosed. By specifically...
6410643 Solid phase synthesis method and reagent  
A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable...
6359061 Amide compound libraries  
Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays...
6277957 Method for production of acylthio derivatives  
A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the...
6258275 Affinity macroligands  
Affinity macroligands (AML) comprising a reversibly water soluble poly-N-alkylacrylamide linked to a ligand, and their use in the separation of a target substance from a mixture comprising the...
6254986 Peracylated protein-based sutures and fabrics and process for making the same  
A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or...
6228988 Synthesis of hydroxamic acid derivatives  
The present invention describes processes for preparing desired synthetic products that comprise a covalently bonded hydroxamic acid group --CONHOH by forming a mixture of a liquid reaction medium...
6204326 PNA combinatorial libraries and improved methods of synthesis  
New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid...
6150461 Carriers targettable to organ  
A carrier for delivering a foreign substance to a target organ which comprises a graft copolymer in which hyaluronic acid is grafted on a polymer composing main chain, wherein the main chain has a...
6117940 Amino-ketone solid support templates  
A solid support template for solid phase synthesis of amino group containing compounds is provided that comprises amino-ketone core compounds of the general formula: A-L-NH(CR1 R2)n COR3linked to...
6113906 Water-soluble non-antigenic polymer linkable to biologically active material  
Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating...
6056926 Apparatus and method for parallel coupling reactions  
A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel 200 contains a suspension of substrates. The suspension is pressurized with argon and...
5932539 Biodegradable polymer matrix for tissue repair  
Novel biodegradable amphiphilic polymers are described. Preferred polymers have a lipophilic binding moiety coupled covalently to a hydrophilic tissue adhesion moiety through a divalent linker...
5912300 Poly-amino acidic oligonucleotide-carrier  
The present invention provides a poly-amino acidic oligonucleotide-carrier comprising a poly-lysine:serine random copolymer.This carrier is bonded with oligonucleotide without causing...
5910406 Manipulating nucleic acid sequences  
A method of effecting a manipulation of a nucleic acid sequence comprises (a) providing a solid support system having bonded thereto a single stranded oligonucleotide complementary to a specific...
5907016 Method of coupling ligands onto supports and products produced therefrom  
A method is disclosed for coupling a ligand within a porous support. The method involves mixing ligand and porous support under conditions sufficient to suppress coupling conditions of the ligand...

Matches 1 - 50 out of 238 1 2 3 4 5 >