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7368502 |
Hydroxyphenyl cross-linked macromolecular network and applications thereof
A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is...
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7365127 |
Process for the preparation of polymer conjugates
A process for efficiently preparing polymer conjugates such as branched PEG-polypeptide conjugates, in large scale without column chromatography clean up of the activated PEG linkers to remove...
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7361726 |
Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles
Polymers containing poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles are disclosed along with methods of fabricating medical articles comprising these polymers. The...
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7332566 |
Biocompatible crosslinked polymers with visualization agents
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having...
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7291674 |
Superabsorbent polymer
The invention relates to a superabsorbent polymer comprising a composition comprising a polymeric resin composition comprising from about 55 to about 99.9 wt. % of polymerizable unsaturated acid...
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7259225 |
Thermosensitive poly (organophosphazenes), preparation method thereof and injectable thermosensitive polyphosphazene hydrogels using the same
Disclosed are polyphosphazenes of Formula 1 showing a sol-gel behavior with a temperature change, a preparation method thereof, and injectable thermosensitive polyphosphazene hydrogels using the same
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7252735 |
Formaldehyde-free lignocellulosic adhesives and composites made from the adhesives
Method for making lignocellulosic composites by adhering lignocellulosic substrates together. A first variant of the method involves using an adhesive composition that comprises a reaction product...
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7247314 |
Biocompatible material composition adaptable to diverse therapeutic indications
A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
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7238364 |
Compliant tissue sealants
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the...
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RE39713 |
Polymerizable biodegradable polymers including carbonate or dioxanone linkages
Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and...
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7211651 |
Proteinaceous gels having visualization agents and methods of use thereof
Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric...
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7202346 |
Antibodies to non-shed Muc1 and Muc16, and uses thereof
The present invention relates to antibodies, antibody fragments, conjugates of antibodies and antibody fragments with cytotoxic agents, and hybridomas producing the antibodies and antibody...
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7182884 |
Bio-liquid crystal polymer and shaped material using same
A bio-liquid crystal polymer is made from a tissue-derived compound or the derivatives. The bio-liquid crystal polymer has a characteristic of liquid crystal under predetermined conditions and is...
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7176256 |
Biocompatible crosslinked composition
Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups....
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7166304 |
Degradable heterobifunctional poly(ethylene glycol) acrylates
A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a...
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7163677 |
Cationic polymers having degradable crosslinks
A synthetic polymer comprises a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit (preferably acid-labile) and at least a...
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7160924 |
Protein conjugates with a water-soluble biocompatible, biodegradable polymer
The present invention broadly relates to the field of protein modification, and, more specifically, to conjugates of proteins or analogs thereof to a water-soluble biocompatible polymer and methods...
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7153896 |
Element for protein microarrays
An element for the attachment of protein arrays, the element comprising a surface to which are attached a plurality of piperazine functional groups wherein the piperazine functional groups are...
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7151135 |
Crosslinked polymer compositions
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple...
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7125960 |
Crosslinked elastin and process for producing the same
A crosslinked elastin, a water-soluble crosslinking agent to be used for crosslinking, molded elastin articles, medical instruments and regeneration tissues using the crosslinked elastin, and a...
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7112629 |
Print media products for generating high quality images and methods for making the same
Ink-receiving print media products capable of producing high quality printed images which are light-fast, humid-fast, have low coalescence (graininess) levels, and are characterized by other...
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7109166 |
Sustained release formulation of a peptide
This invention is directed to a sustained release composition comprised of Compound (A) having the formula
or a pharmaceutically acceptable salt thereof, and a copolymer comprised of...
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7094871 |
Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments...
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7087247 |
Polyesters, method for producing same, and depot medicaments produced from these polyesters
The invention relates to novel absorbable polyesters, produced by ring-opening polymerisation of hydroxycarboxylic acids in the presence of a polyol containing an electrolyte, in an extruder. In...
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7081495 |
Cationic compounds and their use as macro molecular carriers
Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C 6-24 -alkyl group containing α-amino acyl groups,...
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7057019 |
Crosslinked albumin hydrogels
Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an...
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7053150 |
Segmented polymers and their conjugates
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene...
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7052686 |
Pegylated interleukin-10
Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The...
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7041855 |
Monofunctional polyethylene glycol aldehydes
The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a...
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7038016 |
Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
The present invention employs a dissolved activated polyethylene glycol (aPEG) or related molecule that has been passed through a filtration means for the substantial reduction of bioburden or...
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7034127 |
Hydrophilic biopolymer-drug conjugates, their preparation and use
Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer...
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7022214 |
Carrier ampholytes of high pH range
Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH...
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7018624 |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates...
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7015340 |
Heat-sensitive compounds exhibitng a cloud point which can be used as extractants for the separation of metals in aqueous solution
The invention relates to a heat-sensitive compound having the property of being soluble in water below a critical temperature T c and insoluble in water above this temperature T c , this property...
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7009034 |
Biocompatible crosslinked polymers
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having...
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6992161 |
Water-soluble or water-dispersible graft polymers, their preparation and use
Cationic polyurethanes and polyureas formed from
(a) at least one diisocyanate or reaction product thereof with one or more compounds containing two or more active hydrogen atoms per molecule, and...
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6979464 |
Reversible geling co-polymer and method of making
The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic...
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6967107 |
N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use
The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric...
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6962954 |
Activated polyethylene glycol compounds
Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to...
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6962903 |
Modified annexin proteins and methods for preventing thrombosis
A modified annexin protein, preferably annexin V, is used to prevent thrombosis without increasing hemorrhage. Annexin binds to phosphatidylserine on the outer surface of cell membranes, thereby...
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6956077 |
Temperature-responsive polymer compound and process for producing the same
A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by...
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RE38827 |
Adhesive sealant composition
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first...
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6916900 |
Catalytic effects of transition metal ions in the synthesis of polyaniline grafted lignosulfonic acid
A method of making polyaniline grafted lignosulfonic acid is disclosed. The method comprises mixing of aniline and a lignosulfonate in the presence of a transition metal salt.
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6911496 |
Composition for administration of a biologically active compound
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple...
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6908963 |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating polymers specifically to the α-amine of polypeptides in high yield. The invention provides monofunctional, bifunctional, and...
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6906132 |
Low formaldehyde emission coatings and binders from formaldehyde-based resins
Disclosed is a low formaldehyde emission coating from formaldehyde-based resins that can be applied to a panel for reducing sag and enhancing the strength of the panel. Formaldehyde emissions are...
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6887974 |
Crosslinking agents and methods of use
Polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for...
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6884842 |
Molecular compounds having complementary surfaces to targets
Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites...
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6881789 |
Polyubiquitin based hydrogel and uses thereof
The present invention relates to a novel biopolymer consisting of a three-dimensional cross-linked mixture of (a) a cross-linking agent, activated with an activating agent, dissolved in a aqueous...
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6872576 |
Antigens embedded in thermoplastic
The invention relates to an immunoassays, binding assays, solid phase substrates ( 12 ) and other devices with an antigen or antibody or ligand or receptor ( 11 ) embedded into a solid phase...
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